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  • WTF, Evolution?! A Theory of Unintelligible Design

    Scientific American
    15 Sep 2014 | 5:00 pm
    Scientific American 311, 96 (2014). doi:10.1038/scientificamerican1014-96a
  • Deep earth: Post-perovskite at ten

    Nature Geoscience - Issue - nature.com science feeds
    Sang-Heon Shim
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 621 (2014). doi:10.1038/ngeo2237 Authors: Sang-Heon Shim & Thorne Lay In 2004, a phase transition was discovered in the most abundant lower-mantle mineral. A decade of focused experiments, computations and seismic imaging stimulated by this discovery has revealed previously unknown complexities in Earth's deep mantle.
  • Liquid-metal batteries get boost from molten lead

    NatureNews - Most recent articles - nature.com science feeds
    Mark Peplow
    20 Sep 2014 | 5:00 pm
    Technology could provide large-scale storage for energy from erratic sources such as wind or solar.Nature News doi: 10.1038/nature.2014.15967
  • Seven days: 12–18 September 2014

    Nature - Issue - nature.com science feeds
    16 Sep 2014 | 5:00 pm
    Seven days: 12–18 September 2014 Nature 513, 7518 (2014). http://www.nature.com/doifinder/10.1038/513284a The week in science: Swiss scientists regain access to EU grants, Canadian archaeologists find long-lost ship, and Japanese regulators move to restart nuclear power.
  • Regulation of RNA polymerase II activation by histone acetylation in single living cells

    Nature - AOP - nature.com science feeds
    Timothy J. Stasevich
    20 Sep 2014 | 5:00 pm
    Nature advance online publication 21 September 2014. doi:10.1038/nature13714 Authors: Timothy J. Stasevich, Yoko Hayashi-Takanaka, Yuko Sato, Kazumitsu Maehara, Yasuyuki Ohkawa, Kumiko Sakata-Sogawa, Makio Tokunaga, Takahiro Nagase, Naohito Nozaki, James G. McNally & Hiroshi Kimura In eukaryotic cells, post-translational histone modifications have an important role in gene regulation. Starting with early work on histone acetylation, a variety of residue-specific modifications have now been linked to RNA polymerase II (RNAP2) activity, but it remains unclear if these markers are active…
 
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    Nature - Issue - nature.com science feeds

  • Seven days: 12–18 September 2014

    16 Sep 2014 | 5:00 pm
    Seven days: 12–18 September 2014 Nature 513, 7518 (2014). http://www.nature.com/doifinder/10.1038/513284a The week in science: Swiss scientists regain access to EU grants, Canadian archaeologists find long-lost ship, and Japanese regulators move to restart nuclear power.
  • Infectious disease: Mosquitoes awaken malaria

    16 Sep 2014 | 5:00 pm
    Infectious disease: Mosquitoes awaken malaria Nature 513, 7518 (2014). doi:10.1038/513283c Mosquitoes biting a malaria-carrying host coax the malaria parasite to come out of hiding, resulting in greater disease transmission.Sylvain Gandon at the National Centre of Scientific Research in Montpellier, France, and his colleagues infected canaries (Serinus canaria) with a malaria parasite that
  • A worthy ambition

    16 Sep 2014 | 5:00 pm
    A worthy ambition Nature 513, 7518 (2014). doi:10.1038/513279b Finalizing the European Research Area is still a vibrant and relevant goal.
  • Immunology: The gut improves vaccine effects

    16 Sep 2014 | 5:00 pm
    Immunology: The gut improves vaccine effects Nature 513, 7518 (2014). doi:10.1038/513283a Bacterial residents of the gut boost immune responses to vaccination in mice.Humans vaccinated against the influenza virus ramp up expression of a protein called TLR5, which is involved in detecting certain types of bacterium. To see how this protein and gut bacteria might affect
  • Amped-up plants

    16 Sep 2014 | 5:00 pm
    Amped-up plants Nature 513, 7518 (2014). doi:10.1038/513280a Bacterial enzyme supercharges photosynthesis, promising increased yields for crops.
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  • Regulation of RNA polymerase II activation by histone acetylation in single living cells

    Timothy J. Stasevich
    20 Sep 2014 | 5:00 pm
    Nature advance online publication 21 September 2014. doi:10.1038/nature13714 Authors: Timothy J. Stasevich, Yoko Hayashi-Takanaka, Yuko Sato, Kazumitsu Maehara, Yasuyuki Ohkawa, Kumiko Sakata-Sogawa, Makio Tokunaga, Takahiro Nagase, Naohito Nozaki, James G. McNally & Hiroshi Kimura In eukaryotic cells, post-translational histone modifications have an important role in gene regulation. Starting with early work on histone acetylation, a variety of residue-specific modifications have now been linked to RNA polymerase II (RNAP2) activity, but it remains unclear if these markers are active…
  • Lithium–antimony–lead liquid metal battery for grid-level energy storage

    Kangli Wang
    20 Sep 2014 | 5:00 pm
    Nature advance online publication 21 September 2014. doi:10.1038/nature13700 Authors: Kangli Wang, Kai Jiang, Brice Chung, Takanari Ouchi, Paul J. Burke, Dane A. Boysen, David J. Bradwell, Hojong Kim, Ulrich Muecke & Donald R. Sadoway The ability to store energy on the electric grid would greatly improve its efficiency and reliability while enabling the integration of intermittent renewable energy technologies (such as wind and solar) into baseload supply. Batteries have long been considered strong candidate solutions owing to their small spatial footprint, mechanical simplicity and…
  • Multiplex single-molecule interaction profiling of DNA-barcoded proteins

    Liangcai Gu
    20 Sep 2014 | 5:00 pm
    Nature advance online publication 21 September 2014. doi:10.1038/nature13761 Authors: Liangcai Gu, Chao Li, John Aach, David E. Hill, Marc Vidal & George M. Church In contrast with advances in massively parallel DNA sequencing, high-throughput protein analyses are often limited by ensemble measurements, individual analyte purification and hence compromised quality and cost-effectiveness. Single-molecule protein detection using optical methods is limited by the number of spectrally non-overlapping chromophores. Here we introduce a single-molecular-interaction sequencing (SMI-seq)…
  • A faster Rubisco with potential to increase photosynthesis in crops

    Myat T. Lin
    16 Sep 2014 | 5:00 pm
    Nature advance online publication 17 September 2014. doi:10.1038/nature13776 Authors: Myat T. Lin, Alessandro Occhialini, P. John Andralojc, Martin A. J. Parry & Maureen R. Hanson In photosynthetic organisms, d-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the major enzyme assimilating atmospheric CO2 into the biosphere. Owing to the wasteful oxygenase activity and slow turnover of Rubisco, the enzyme is among the most important targets for improving the photosynthetic efficiency of vascular plants. It has been anticipated that introducing the CO2-concentrating mechanism…
  • Artificial sweeteners induce glucose intolerance by altering the gut microbiota

    Jotham Suez
    16 Sep 2014 | 5:00 pm
    Nature advance online publication 17 September 2014. doi:10.1038/nature13793 Authors: Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A. Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal & Eran Elinav
 
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    Scientific American

  • What Is It?

    Kevin Schultz
    15 Sep 2014 | 5:00 pm
    Scientific American 311, 27 (2014). doi:10.1038/scientificamerican1014-27b Author: Kevin Schultz
  • Know the Jargon

    Jason G. Goldman
    15 Sep 2014 | 5:00 pm
    Scientific American 311, 21 (2014). doi:10.1038/scientificamerican1014-21 Author: Jason G. Goldman Human shield effect: (n.) The reduction in vigilance that prey animals exhibit when human observers are present.
  • Letters

    15 Sep 2014 | 5:00 pm
    Scientific American 311, 8 (2014). doi:10.1038/scientificamerican1014-8
  • WTF, Evolution?! A Theory of Unintelligible Design

    15 Sep 2014 | 5:00 pm
    Scientific American 311, 96 (2014). doi:10.1038/scientificamerican1014-96a
  • 50, 100 & 150 Years Ago

    Daniel C. Schlenoff
    15 Sep 2014 | 5:00 pm
    Scientific American 311, 99 (2014). doi:10.1038/scientificamerican1014-99 Author: Daniel C. Schlenoff
 
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    Nature Biotechnology - AOP - nature.com science feeds

  • Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

    Robert J Citorik
    20 Sep 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3011 Authors: Robert J Citorik, Mark Mimee & Timothy K Lu Current antibiotics tend to be broad spectrum, leading to indiscriminate killing of commensal bacteria and accelerated evolution of drug resistance. Here, we use CRISPR-Cas technology to create antimicrobials whose spectrum of activity is chosen by design. RNA-guided nucleases (RGNs) targeting specific DNA sequences are delivered efficiently to microbial populations using bacteriophage or bacteria carrying plasmids transmissible by conjugation. The DNA targets of RGNs can be undesirable genes…
  • Generation of the epicardial lineage from human pluripotent stem cells

    Alec D Witty
    20 Sep 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3002 Authors: Alec D Witty, Anton Mihic, Roger Y Tam, Stephanie A Fisher, Alexander Mikryukov, Molly S Shoichet, Ren-Ke Li, Steven J Kattman & Gordon Keller
  • De novo assembly of soybean wild relatives for pan-genome analysis of diversity and agronomic traits

    Ying-hui Li
    13 Sep 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2979 Authors: Ying-hui Li, Guangyu Zhou, Jianxin Ma, Wenkai Jiang, Long-guo Jin, Zhouhao Zhang, Yong Guo, Jinbo Zhang, Yi Sui, Liangtao Zheng, Shan-shan Zhang, Qiyang Zuo, Xue-hui Shi, Yan-fei Li, Wan-ke Zhang, Yiyao Hu, Guanyi Kong, Hui-long Hong, Bing Tan, Jian Song, Zhang-xiong Liu, Yaoshen Wang, Hang Ruan, Carol K L Yeung, Jian Liu, Hailong Wang, Li-juan Zhang, Rong-xia Guan, Ke-jing Wang, Wen-bin Li, Shou-yi Chen, Ru-zhen Chang, Zhi Jiang, Scott A Jackson, Ruiqiang Li & Li-juan Qiu
  • Global analysis of protein structural changes in complex proteomes

    Yuehan Feng
    13 Sep 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2999 Authors: Yuehan Feng, Giorgia De Franceschi, Abdullah Kahraman, Martin Soste, Andre Melnik, Paul J Boersema, Patrizia Polverino de Laureto, Yaroslav Nikolaev, Ana Paula Oliveira & Paola Picotti
  • Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

    Alireza Rezania
    10 Sep 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3033 Authors: Alireza Rezania, Jennifer E Bruin, Payal Arora, Allison Rubin, Irina Batushansky, Ali Asadi, Shannon O'Dwyer, Nina Quiskamp, Majid Mojibian, Tobias Albrecht, Yu Hsuan Carol Yang, James D Johnson & Timothy J Kieffer
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    Nature Cell Biology - Issue - nature.com science feeds

  • Following your interests: The importance of good mentors

    Daniel J. Klionsky
    31 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 823 (2014). doi:10.1038/ncb3033 Author: Daniel J. Klionsky
  • Hi-TEC reprogramming for organ regeneration

    Bruno Di Stefano
    31 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 824 (2014). doi:10.1038/ncb3032 Authors: Bruno Di Stefano & Thomas Graf The induction of cell reprogramming by transcription factors into alternative cell fates opens new avenues for regenerative medicine. Thymic epithelial cells that were obtained from fibroblasts by Foxn1 overexpression support the formation of an ectopic thymus following transplantation.
  • An ABC of ciliogenesis

    Pascal Barbry
    31 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 826 (2014). doi:10.1038/ncb3034 Authors: Pascal Barbry & Laure-Emmanuelle Zaragosi ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.
  • Reconstitution of the augmin complex provides insights into its architecture and function

    Kuo-Chiang Hsia
    30 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 852 (2014). doi:10.1038/ncb3030 Authors: Kuo-Chiang Hsia, Elizabeth M. Wilson-Kubalek, Alejandro Dottore, Qi Hao, Kuang-Lei Tsai, Scott Forth, Yuta Shimamoto, Ronald A. Milligan & Tarun M. Kapoor
  • Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

    Daqing Jin
    30 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 841 (2014). doi:10.1038/ncb3029 Authors: Daqing Jin, Terri T. Ni, Jianjian Sun, Haiyan Wan, Jeffrey D. Amack, Guangju Yu, Jonathan Fleming, Chin Chiang, Wenyan Li, Anna Papierniak, Satish Cheepala, Gwenaëlle Conseil, Susan P. C. Cole, Bin Zhou, Iain A. Drummond, John D. Schuetz, Jarema Malicki & Tao P. Zhong
 
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    Nature Chemical Biology - AOP - nature.com science feeds

  • Targeted protein destabilization reveals an estrogen-mediated ER stress response

    Kanak Raina
    20 Sep 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1638 Authors: Kanak Raina, Devin J Noblin, Yevgeniy V Serebrenik, Alison Adams, Connie Zhao & Craig M Crews
  • Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

    Chao Xu
    20 Sep 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1654 Authors: Chao Xu, Xiao Wang, Ke Liu, Ian A Roundtree, Wolfram Tempel, Yanjun Li, Zhike Lu, Chuan He & Jinrong Min N6-methyladenosine (m6A) is the most abundant internal modification of nearly all eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain family proteins. Here we present the crystal structures of the YTH domain of YTHDC1, a member of the YTH domain family, and its complex with an m6A-containing RNA. Our structural studies, together with transcriptome-wide identification of YTHDC1-binding sites and…
  • Chemomechanical coupling of human mitochondrial F1-ATPase motor

    Toshiharu Suzuki
    20 Sep 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1635 Authors: Toshiharu Suzuki, Kazumi Tanaka, Chiaki Wakabayashi, Ei-ichiro Saita & Masasuke Yoshida
  • An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

    Mihalis S Kariolis
    20 Sep 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1636 Authors: Mihalis S Kariolis, Yu Rebecca Miao, Douglas S Jones, Shiven Kapur, Irimpan I Mathews, Amato J Giaccia & Jennifer R Cochran
  • A new family of iron-dependent halogenases acts on freestanding substrates

    Matthew L Hillwig
    13 Sep 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1625 Authors: Matthew L Hillwig & Xinyu Liu Regio- and stereospecific incorporation of a halogen atom to an unactivated sp3 carbon in a freestanding molecule is a challenging transformation that is currently missing in the inventory of enzyme-mediated reactions. Here we report what is to our knowledge the first example of a nonheme iron enzyme (WelO5) in the welwitindolinone biosynthetic pathway that can monochlorinate an aliphatic carbon in 12-epi-fischerindole U and 12-epi-hapalindole C, substrates that are free from peptidyl or acyl carrier…
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    Nature Chemistry

  • 5-Hydroxymethylcytosine is a predominantly stable DNA modification

    Martin Bachman
    20 Sep 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2064 Authors: Martin Bachman, Santiago Uribe-Lewis, Xiaoping Yang, Michael Williams, Adele Murrell & Shankar Balasubramanian Reduction of 5-hydroxymethylcytosine (hmC) levels in DNA often occurs in cancers. Using isotope tracing experiments, this epigenetic DNA modification, which was thought to be an intermediate of demethylation, is now shown to be stable. A delay in the generation of hmC on newly synthesized DNA is responsible for the reduction of hmC levels in cancers.
  • A Star of David catenane

    David A. Leigh
    20 Sep 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2056 Authors: David A. Leigh, Robin G. Pritchard & Alexander J. Stephens The Star of David topology is an iconic symbol that has been used in religious and cultural contexts for thousands of years. Now it is assembled in molecular form through a hexameric circular helicate generated by six tris(bipyridine) ligands entwined about six iron(II) cations. The structure of the two triply-entwined 114-membered rings is revealed by X-ray crystallography.
  • Molecular topology: Star-crossed self-assembly

    Guido H. Clever
    20 Sep 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2065 Author: Guido H. Clever Interwoven supramolecular structures are often held up as examples of beauty in chemistry, but these assemblies can be fragile depending on the environments they are exposed to. Post-assembly covalent modification can, however, trap them in robust molecular form, and a triply entwined [2]catenane is one of the most sophisticated examples so far.
  • Dynamic covalent chemistry of bisimines at the solid/liquid interface monitored by scanning tunnelling microscopy

    Artur Ciesielski
    13 Sep 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2057 Authors: Artur Ciesielski, Mohamed El Garah, Sébastien Haar, Petr Kovaříček, Jean-Marie Lehn & Paolo Samorì Constructing molecular architectures using dynamic covalent chemistry combines the robustness of covalent bonds with the reversibility of supramolecular chemistry. Now, a surface-mediated approach has been used to control the thermodynamic and kinetic features of dynamic processes at a surface, leading to constituent selection and selective pattern formation.
  • Redox-inactive metal ions modulate the reactivity and oxygen release of mononuclear non-haem iron(III)–peroxo complexes

    Suhee Bang
    13 Sep 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2055 Authors: Suhee Bang, Yong-Min Lee, Seungwoo Hong, Kyung-Bin Cho, Yusuke Nishida, Mi Sook Seo, Ritimukta Sarangi, Shunichi Fukuzumi & Wonwoo Nam Non-haem iron(III)-peroxo complexes that bind redox-inactive metal ions are synthesized to investigate the role of the Ca2+ ion in the oxidation of water to dioxygen in photosystem II. The electrochemical properties and reactions of these compounds with an electron donor and an acceptor are found to be markedly dependent on the Lewis acidity of redox-inactive metal ions.
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    Nature Genetics - Issue - nature.com science feeds

  • Corrigendum: Genome-wide genetic changes during modern breeding of maize

    Yinping Jiao
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 1039 (2014). doi:10.1038/ng0914-1039 Author: Yinping Jiao, Hainan Zhao, Longhui Ren, Weibin Song, Biao Zeng, Jinjie Guo, Baobao Wang, Zhipeng Liu, Jing Chen, Wei Li, Mei Zhang, Shaojun Xie & Jingsheng Lai
  • Cancer gene discovery goes mobile

    Louise van der Weyden
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 928 (2014). doi:10.1038/ng.3072 Authors: Louise van der Weyden, Marco Ranzani & David J Adams A new study describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this system in combination with cancer genome data to define new genes and pathways involved in sarcoma development. Gene discovery in this way suggests that we are far from a complete catalog of cancer drivers.
  • Corrigendum: Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions

    Chen Wu
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 1040 (2014). doi:10.1038/ng0914-1040b Author: Chen Wu, Peter Kraft, Kan Zhai, Jiang Chang, Zhaoming Wang, Yun Li, Zhibin Hu, Zhonghu He, Weihua Jia, Christian C Abnet, Liming Liang, Nan Hu, Xiaoping Miao, Yifeng Zhou, Zhihua Liu, Qimin Zhan, Yu Liu, Yan Qiao, Yuling Zhou, Guangfu Jin, Chuanhai Guo, Changdong Lu, Haijun Yang, Jianhua Fu, Dianke Yu, Neal D Freedman, Ti Ding, Wen Tan, Alisa M Goldstein, Tangchun Wu, Hongbing Shen, Yang Ke, Yixin Zeng, Stephen J Chanock, Philip R Taylor & Dongxin Lin
  • RNA switch at enhancers

    Jeffrey J Quinn
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 929 (2014). doi:10.1038/ng.3074 Authors: Jeffrey J Quinn & Howard Y Chang Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.
  • Data use under the NIH GWAS Data Sharing Policy and future directions

    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 934 (2014). doi:10.1038/ng.3062 Authors:
 
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  • Genome sequence and genetic diversity of the common carp, Cyprinus carpio

    Peng Xu
    20 Sep 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3098 Authors: Peng Xu, Xiaofeng Zhang, Xumin Wang, Jiongtang Li, Guiming Liu, Youyi Kuang, Jian Xu, Xianhu Zheng, Lufeng Ren, Guoliang Wang, Yan Zhang, Linhe Huo, Zixia Zhao, Dingchen Cao, Cuiyun Lu, Chao Li, Yi Zhou, Zhanjiang Liu, Zhonghua Fan, Guangle Shan, Xingang Li, Shuangxiu Wu, Lipu Song, Guangyuan Hou, Yanliang Jiang, Zsigmond Jeney, Dan Yu, Li Wang, Changjun Shao, Lai Song, Jing Sun, Peifeng Ji, Jian Wang, Qiang Li, Liming Xu, Fanyue Sun, Jianxin Feng, Chenghui Wang, Shaolin Wang, Baosen Wang, Yan Li, Yaping Zhu, Wei Xue, Lan Zhao, Jintu Wang, Ying…
  • PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

    William Lee
    20 Sep 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3095 Authors: William Lee, Sewit Teckie, Thomas Wiesner, Leili Ran, Carlos N Prieto Granada, Mingyan Lin, Sinan Zhu, Zhen Cao, Yupu Liang, Andrea Sboner, William D Tap, Jonathan A Fletcher, Kety H Huberman, Li-Xuan Qin, Agnes Viale, Samuel Singer, Deyou Zheng, Michael F Berger, Yu Chen, Cristina R Antonescu & Ping Chi Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1 associated) or after radiotherapy. Using comprehensive…
  • Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

    Ilan Weinreb
    20 Sep 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3096 Authors: Ilan Weinreb, Salvatore Piscuoglio, Luciano G Martelotto, Daryl Waggott, Charlotte K Y Ng, Bayardo Perez-Ordonez, Nicholas J Harding, Javier Alfaro, Kenneth C Chu, Agnes Viale, Nicola Fusco, Arnaud da Cruz Paula, Caterina Marchio, Rita A Sakr, Raymond Lim, Lester D R Thompson, Simion I Chiosea, Raja R Seethala, Alena Skalova, Edward B Stelow, Isabel Fonseca, Adel Assaad, Christine How, Jianxin Wang, Richard de Borja, Michelle Chan-Seng-Yue, Christopher J Howlett, Anthony C Nichols, Y Hannah Wen, Nora Katabi, Nicholas Buchner, Laura Mullen, Thomas…
  • Refining analyses of copy number variation identifies specific genes associated with developmental delay

    Bradley P Coe
    13 Sep 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3092 Authors: Bradley P Coe, Kali Witherspoon, Jill A Rosenfeld, Bregje W M van Bon, Anneke T Vulto-van Silfhout, Paolo Bosco, Kathryn L Friend, Carl Baker, Serafino Buono, Lisenka E L M Vissers, Janneke H Schuurs-Hoeijmakers, Alex Hoischen, Rolph Pfundt, Nik Krumm, Gemma L Carvill, Deana Li, David Amaral, Natasha Brown, Paul J Lockhart, Ingrid E Scheffer, Antonino Alberti, Marie Shaw, Rosa Pettinato, Raymond Tervo, Nicole de Leeuw, Margot R F Reijnders, Beth S Torchia, Hilde Peeters, Elizabeth Thompson, Brian J O'Roak, Marco Fichera, Jayne Y Hehir-Kwa, Jay…
  • An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

    Scott W Canna
    13 Sep 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3089 Authors: Scott W Canna, Adriana A de Jesus, Sushanth Gouni, Stephen R Brooks, Bernadette Marrero, Yin Liu, Michael A DiMattia, Kristien J M Zaal, Gina A Montealegre Sanchez, Hanna Kim, Dawn Chapelle, Nicole Plass, Yan Huang, Alejandro V Villarino, Angelique Biancotto, Thomas A Fleisher, Joseph A Duncan, John J O'Shea, Susanne Benseler, Alexei Grom, Zuoming Deng, Ronald M Laxer & Raphaela Goldbach-Mansky Inflammasomes are innate immune sensors that respond to pathogen- and damage-associated signals with caspase-1 activation, interleukin (IL)-1β and…
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    Nature Geoscience - Issue - nature.com science feeds

  • Journal-to-journal shortcuts

    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 613 (2014). doi:10.1038/ngeo2246 At Nature Publishing Group we offer a transfer system that allows authors to move papers between our journals at the click of a button if their first-choice journal declined. We encourage authors to use that service.
  • Wedge approach to water stress

    Yoshihide Wada
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 615 (2014). doi:10.1038/ngeo2241 Authors: Yoshihide Wada, Tom Gleeson & Laurent Esnault Water availability and use are inherently regional concerns. However, a global-scale approach to evaluating strategies to reduce water stress can help maximize mitigation.
  • Carbon sequestration: Tiny potential

    Amy Whitchurch
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 623 (2014). doi:10.1038/ngeo2242 Author: Amy Whitchurch
  • Corrigendum: Lusi mud eruption triggered by geometric focusing of seismic waves

    M. Lupi
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 687 (2014). doi:10.1038/ngeo2239 Authors: M. Lupi, E. H. Saenger, F. Fuchs & S. A. Miller
  • Deep earth: Post-perovskite at ten

    Sang-Heon Shim
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 621 (2014). doi:10.1038/ngeo2237 Authors: Sang-Heon Shim & Thorne Lay In 2004, a phase transition was discovered in the most abundant lower-mantle mineral. A decade of focused experiments, computations and seismic imaging stimulated by this discovery has revealed previously unknown complexities in Earth's deep mantle.
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  • Earthquakes: Hydrogeochemical precursors

    S. E. Ingebritsen
    20 Sep 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2261 Authors: S. E. Ingebritsen & M. Manga Earthquake prediction is a long-sought goal. Changes in groundwater chemistry before earthquakes in Iceland highlight a potential hydrogeochemical precursor, but such signals must be evaluated in the context of long-term, multiparametric data sets.
  • Cumulative emissions and climate policy

    David J. Frame
    20 Sep 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2254 Authors: David J. Frame, Adrian H. Macey & Myles R. Allen The emerging scientific focus on cumulative carbon emissions may make climate negotiations harder. But, it serves to clarify the scale and scope of climate mitigation needed to meet potential temperature targets.
  • Palaeoceanography: Tectonically driven upwelling

    Johan Etourneau
    20 Sep 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2258 Author: Johan Etourneau Upwelling within the highly productive Benguela current off the Namibian coast began in, and intensified throughout, the Neogene epoch. Model simulations indicate its development was intimately connected to evolving topography and mountain uplift in Africa.
  • Uplift of Africa as a potential cause for Neogene intensification of the Benguela upwelling system

    Gerlinde Jung
    20 Sep 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2249 Authors: Gerlinde Jung, Matthias Prange & Michael Schulz The Benguela Current, located off the west coast of southern Africa, is tied to a highly productive upwelling system. Over the past 12 million years, the current has cooled, and upwelling has intensified. These changes have been variously linked to atmospheric and oceanic changes associated with the glaciation of Antarctica and global cooling, the closure of the Central American Seaway or the further restriction of the Indonesian Seaway. The upwelling intensification also occurred during a…
  • Atmospheric circulation as a source of uncertainty in climate change projections

    Theodore G. Shepherd
    20 Sep 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2253 Author: Theodore G. Shepherd
 
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    Nature Immunology - Issue - nature.com science feeds

  • Receptor for new PAMPs

    Ioana Visan
    17 Sep 2014 | 5:00 pm
    Nature Immunology 15, 909 (2014). doi:10.1038/ni.2998 Author: Ioana Visan
  • Continued mission of ThPOK

    Takeshi Egawa
    17 Sep 2014 | 5:00 pm
    Nature Immunology 15, 900 (2014). doi:10.1038/ni.2988 Author: Takeshi Egawa ThPOK, the critical transcription factor for differentiation of the helper T cell lineage in the thymus, continues to function as a gatekeeper to maintain helper T cell identity by repressing the transcription factor Runx3 in mature T cells.
  • Emerging functions of the unfolded protein response in immunity

    Sophie Janssens
    17 Sep 2014 | 5:00 pm
    Nature Immunology 15, 910 (2014). doi:10.1038/ni.2991 Authors: Sophie Janssens, Bali Pulendran & Bart N Lambrecht
  • Neutrophils worm their way into macrophage long-term memory

    John R Grainger
    17 Sep 2014 | 5:00 pm
    Nature Immunology 15, 902 (2014). doi:10.1038/ni.2990 Authors: John R Grainger & Richard K Grencis Neutrophil function is perhaps best studied in bacterial infection, during which they are directly involved in pathogen killing. After helminth invasion, however, neutrophils acquire an alternative transcriptional profile that allows them to 'train' macrophages to acquire long-term protective features.
  • Restricting plasma cells

    Laurie A Dempsey
    17 Sep 2014 | 5:00 pm
    Nature Immunology 15, 909 (2014). doi:10.1038/ni.3000 Author: Laurie A Dempsey
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    Nature Materials - AOP - nature.com science feeds

  • Determination of the 3D shape of a nanoscale crystal with atomic resolution from a single image

    C. L. Jia
    20 Sep 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4087 Authors: C. L. Jia, S. B. Mi, J. Barthel, D. W. Wang, R. E. Dunin-Borkowski, K. W. Urban & A. Thust
  • Benzene-derived carbon nanothreads

    Thomas C. Fitzgibbons
    20 Sep 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4088 Authors: Thomas C. Fitzgibbons, Malcolm Guthrie, En-shi Xu, Vincent H. Crespi, Stephen K. Davidowski, George D. Cody, Nasim Alem & John V. Badding Low-dimensional carbon nanomaterials such as fullerenes, nanotubes, graphene and diamondoids have extraordinary physical and chemical properties. Compression-induced polymerization of aromatic molecules could provide a viable synthetic route to ordered carbon nanomaterials, but despite almost a century of study this approach has produced only amorphous products. Here we report recovery to ambient pressure…
  • Topologically protected excitons in porphyrin thin films

    Joel Yuen-Zhou
    20 Sep 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4073 Authors: Joel Yuen-Zhou, Semion K. Saikin, Norman Y. Yao & Alán Aspuru-Guzik
  • Two-step nucleation mechanism in solid–solid phase transitions

    Yi Peng
    13 Sep 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4083 Authors: Yi Peng, Feng Wang, Ziren Wang, Ahmed M. Alsayed, Zexin Zhang, Arjun G. Yodh & Yilong Han
  • Digital metamaterials

    Cristian Della Giovampaola
    13 Sep 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4082 Authors: Cristian Della Giovampaola & Nader Engheta
 
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    Nature Medicine - AOP - nature.com science feeds

  • Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants

    Deena Gibbons
    20 Sep 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3670 Authors: Deena Gibbons, Paul Fleming, Alex Virasami, Marie-Laure Michel, Neil J Sebire, Kate Costeloe, Robert Carr, Nigel Klein & Adrian Hayday In spite of their precipitous encounter with the environment, newborn infants cannot readily mount T helper type 1 (TH1) cell antibacterial and antiviral responses. Instead, they show skewing toward TH2 responses, which, together with immunoregulatory functions, are thought to limit the potential for inflammatory damage, while simultaneously permitting intestinal colonization by commensals. However, these…
  • An extracorporeal blood-cleansing device for sepsis therapy

    Joo H Kang
    13 Sep 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3640 Authors: Joo H Kang, Michael Super, Chong Wing Yung, Ryan M Cooper, Karel Domansky, Amanda R Graveline, Tadanori Mammoto, Julia B Berthet, Heather Tobin, Mark J Cartwright, Alexander L Watters, Martin Rottman, Anna Waterhouse, Akiko Mammoto, Nazita Gamini, Melissa J Rodas, Anxhela Kole, Amanda Jiang, Thomas M Valentin, Alexander Diaz, Kazue Takahashi & Donald E Ingber
  • Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

    Lior Mayo
    13 Sep 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3681 Authors: Lior Mayo, Sunia A Trauger, Manon Blain, Meghan Nadeau, Bonny Patel, Jorge I Alvarez, Ivan D Mascanfroni, Ada Yeste, Pia Kivisäkk, Keith Kallas, Benjamin Ellezam, Rohit Bakshi, Alexandre Prat, Jack P Antel, Howard L Weiner & Francisco J Quintana
  • Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

    Jean-Sébastien Joyal
    13 Sep 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3669 Authors: Jean-Sébastien Joyal, Satra Nim, Tang Zhu, Nicholas Sitaras, José Carlos Rivera, Zhuo Shao, Przemyslaw Sapieha, David Hamel, Melanie Sanchez, Karine Zaniolo, Manon St-Louis, Johanne Ouellette, Martin Montoya-Zavala, Alexandra Zabeida, Emilie Picard, Pierre Hardy, Vikrant Bhosle, Daya R Varma, Fernand Gobeil, Christian Beauséjour, Christelle Boileau, William Klein, Morley Hollenberg, Alfredo Ribeiro-da-Silva, Gregor Andelfinger & Sylvain Chemtob
  • In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

    Ramona Rudalska
    13 Sep 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3679 Authors: Ramona Rudalska, Daniel Dauch, Thomas Longerich, Katherine McJunkin, Torsten Wuestefeld, Tae-Won Kang, Anja Hohmeyer, Marina Pesic, Josef Leibold, Anne von Thun, Peter Schirmacher, Johannes Zuber, Karl-Heinz Weiss, Scott Powers, Nisar P Malek, Martin Eilers, Bence Sipos, Scott W Lowe, Robert Geffers, Stefan Laufer & Lars Zender
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    Nature Methods - Issue - nature.com science feeds

  • Points of Significance: Replication

    Paul Blainey
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 879 (2014). doi:10.1038/nmeth.3091 Authors: Paul Blainey, Martin Krzywinski & Naomi Altman Quality is often more important than quantity.
  • Change at Nature Methods

    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 875 (2014). doi:10.1038/nmeth.3097 We announce a change in leadership at Nature Methods and wish Daniel Evanko, our departing chief editor and the new head of editorial services at Nature Publishing Group, every success.
  • The Author File: Richard Neutze

    Vivien Marx
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 877 (2014). doi:10.1038/nmeth.3074 Author: Vivien Marx Proteins 'breathe' in an ultrafast way that can be captured with XFELs.
  • A critique of methods for temperature imaging in single cells

    Guillaume Baffou
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 899 (2014). doi:10.1038/nmeth.3073 Authors: Guillaume Baffou, Hervé Rigneault, Didier Marguet & Ludovic Jullien We argue that standard thermodynamic considerations and scaling laws show that a single cell cannot substantially raise its temperature by endogenous thermogenesis. This statement seriously questions the interpretations of recent work reporting temperature heterogeneities measured in single living cells.
  • Improved reproducibility by assuring confidence in measurements in biomedical research

    Anne L Plant
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 895 (2014). doi:10.1038/nmeth.3076 Authors: Anne L Plant, Laurie E Locascio, Willie E May & Patrick D Gallagher 'Irreproducibility' is symptomatic of a broader challenge in measurement in biomedical research. From the US National Institute of Standards and Technology (NIST) perspective of rigorous metrology, reproducibility is only one aspect of establishing confidence in measurements. Appropriate controls, reference materials, statistics and informatics are required for a robust measurement process. Research is required to establish these tools for biological…
 
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    Nature Neuroscience - Issue - nature.com science feeds

  • All that glitters is not reward signal

    Benjamin Y Hayden
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1142 (2014). doi:10.1038/nn.3795 Authors: Benjamin Y Hayden & Sarah R Heilbronner In this issue, Shenhav et al. critically evaluate the idea that neural correlates of value actually represent value. They describe how, in many situations, value correlates can reflect other cognitive factors, such as decisional difficulty.
  • The epigenetic landscape of Alzheimer's disease

    Jenny Lord
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1138 (2014). doi:10.1038/nn.3792 Authors: Jenny Lord & Carlos Cruchaga Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.
  • Reward processing by the lateral habenula in normal and depressive behaviors

    Christophe D Proulx
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1146 (2014). doi:10.1038/nn.3779 Authors: Christophe D Proulx, Okihide Hikosaka & Roberto Malinow
  • CLEARance wars: PolyQ strikes back

    X William Yang
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1140 (2014). doi:10.1038/nn.3793 Authors: X William Yang & Ai Yamamoto Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.
  • Scenting Waldo: analyzing olfactory scenes

    Timothy E Holy
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1144 (2014). doi:10.1038/nn.3796 Author: Timothy E Holy Olfaction has often been described as a 'synthetic' sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects.
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    Nature Photonics - Issue - nature.com science feeds

  • Solar cell woes

    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 665 (2014). doi:10.1038/nphoton.2014.212 The pressure to publish results claiming organic solar cells with high efficiencies is leading to pervasive problems of false reporting within the community.
  • Optomechanics: Vibrating VCSELs

    David Pile
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 675 (2014). doi:10.1038/nphoton.2014.196 Author: David Pile
  • Hot photoluminescence or Raman scattering?

    Kasey J. Russell
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 666 (2014). doi:10.1038/nphoton.2014.190 Authors: Kasey J. Russell & Evelyn L. Hu
  • View from... CLEO 2014: High-performance optics

    David Pile
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 682 (2014). doi:10.1038/nphoton.2014.211 Author: David Pile Developments in optical materials and components for extreme applications such as the James Webb Space Telescope and petawatt laser systems were showcased at CLEO 2014.
  • Reply to 'Hot photoluminescence or Raman scattering?'

    Carlos O. Aspetti
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 667 (2014). doi:10.1038/nphoton.2014.191 Authors: Carlos O. Aspetti, Chang-Hee Cho, Joohee Park & Ritesh Agarwal
 
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    Nature Photonics - AOP - nature.com science feeds

  • Ultimate classical communication rates of quantum optical channels

    V. Giovannetti
    20 Sep 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.216 Authors: V. Giovannetti, R. García-Patrón, N. J. Cerf & A. S. Holevo
  • Quantum teleportation from a telecom-wavelength photon to a solid-state quantum memory

    Félix Bussières
    20 Sep 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.215 Authors: Félix Bussières, Christoph Clausen, Alexey Tiranov, Boris Korzh, Varun B. Verma, Sae Woo Nam, Francesco Marsili, Alban Ferrier, Philippe Goldner, Harald Herrmann, Christine Silberhorn, Wolfgang Sohler, Mikael Afzelius & Nicolas Gisin Quantum teleportation is a cornerstone of quantum information science due to its essential role in important tasks such as the long-distance transmission of quantum information using quantum repeaters. This requires the efficient distribution of entanglement between remote nodes of a network. Here, we…
  • High photon flux table-top coherent extreme-ultraviolet source

    Steffen Hädrich
    13 Sep 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.214 Authors: Steffen Hädrich, Arno Klenke, Jan Rothhardt, Manuel Krebs, Armin Hoffmann, Oleg Pronin, Vladimir Pervak, Jens Limpert & Andreas Tünnermann High harmonic generation (HHG) enables extreme-ultraviolet radiation with table-top set-ups. Its exceptional properties, such as coherence and (sub)-femtosecond pulse durations, have led to a diversity of applications. Some of these require a high photon flux and megahertz repetition rates, for example, to avoid space charge effects in photoelectron spectroscopy. To date, this has only been…
  • Mid-infrared supercontinuum covering the 1.4–13.3 μm molecular fingerprint region using ultra-high NA chalcogenide step-index fibre

    Christian Rosenberg Petersen
    13 Sep 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.213 Authors: Christian Rosenberg Petersen, Uffe Møller, Irnis Kubat, Binbin Zhou, Sune Dupont, Jacob Ramsay, Trevor Benson, Slawomir Sujecki, Nabil Abdel-Moneim, Zhuoqi Tang, David Furniss, Angela Seddon & Ole Bang The mid-infrared spectral region is of great technical and scientific interest because most molecules display fundamental vibrational absorptions in this region, leaving distinctive spectral fingerprints. To date, the limitations of mid-infrared light sources such as thermal emitters, low-power laser diodes, quantum cascade lasers and…
  • Direct generation of three-photon polarization entanglement

    Deny R. Hamel
    13 Sep 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.218 Authors: Deny R. Hamel, Lynden K. Shalm, Hannes Hübel, Aaron J. Miller, Francesco Marsili, Varun B. Verma, Richard P. Mirin, Sae Woo Nam, Kevin J. Resch & Thomas Jennewein
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    Nature Physics - Issue - nature.com science feeds

  • Cheap trick

    Federico Levi
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 620 (2014). doi:10.1038/nphys3091 Author: Federico Levi
  • In with the new

    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 615 (2014). doi:10.1038/nphys3100 As the ninth year of Nature Physics draws to a close, we say goodbye to our launching Chief Editor, Alison Wright, and welcome her successor, Andrea Taroni, to the team.
  • Waste knot, want knot

    Alvaro Zinos-Amaro
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 698 (2014). doi:10.1038/nphys3102 Author: Alvaro Zinos-Amaro A trip to the shops.
  • Benefits of diversity

    Abraham Loeb
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 616 (2014). doi:10.1038/nphys3089 Author: Abraham Loeb Discoveries in astronomy — or, in fact, any branch of science — can only happen when people are open-minded and willing to take risks.
  • Stacks of potential

    Bart Verberck
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 620 (2014). doi:10.1038/nphys3093 Author: Bart Verberck
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    Nature Physics - AOP - nature.com science feeds

  • Observation of electric-dipole-forbidden infrared transitions in cold molecular ions

    Matthias Germann
    20 Sep 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3085 Authors: Matthias Germann, Xin Tong & Stefan Willitsch Spectroscopic transitions in atoms and molecules that are not allowed within the electric-dipole approximation, but occur because of higher-order terms in the interaction between matter and radiation, are termed dipole-forbidden. These transitions are extremely weak and therefore exhibit very small natural linewidths. Dipole-forbidden optical transitions in atoms form the basis of next-generation atomic clocks and of high-fidelity qubits used in quantum information processors and quantum…
  • Degenerate Fermi and non-Fermi liquids near a quantum critical phase transition

    S. Kambe
    20 Sep 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3101 Authors: S. Kambe, H. Sakai, Y. Tokunaga, G. Lapertot, T. D. Matsuda, G. Knebel, J. Flouquet & R. E. Walstedt Recently there is renewed interest in quantum critical phase transitions (QCPT) at T = 0 K in metallic strongly correlated electron systems. From early experimental results, the QCPT in the Kondo-lattice compound YbRh2Si2 is not a case of the ordinary spin density wave (SDW) instability observed in Ce-based Kondo lattices, but a candidate for a novel locally critical case. Here, we observe that coexisting, static Fermi liquid (FL) and…
  • Molecular spectroscopy: Forbidden vibrations

    Jeroen C. J. Koelemeij
    20 Sep 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3113 Author: Jeroen C. J. Koelemeij Laser control of atomic ions through dipole-forbidden transitions has provided a way of probing quantum mechanics. These transitions have now been observed in molecular ions, opening the door to a new generation of spectroscopy experiments.
  • Scaling macroscopic aquatic locomotion

    Mattia Gazzola
    13 Sep 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3078 Authors: Mattia Gazzola, Médéric Argentina & L. Mahadevan Inertial aquatic swimmers that use undulatory gaits range in length L from a few millimetres to 30 metres, across a wide array of biological taxa. Using elementary hydrodynamic arguments, we uncover a unifying mechanistic principle characterizing their locomotion by deriving a scaling relation that links swimming speed U to body kinematics (tail beat amplitude A and frequency ω) and fluid properties (kinematic viscosity ν). This principle can be simply couched as the power…
  • Multilayer networks: Dangerous liaisons?

    Ginestra Bianconi
    13 Sep 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3097 Author: Ginestra Bianconi Many networks interact with one another by forming multilayer networks, but these structures can lead to large cascading failures. The secret that guarantees the robustness of multilayer networks seems to be in their correlations.
 
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • Market watch: A framework for biomedical innovation in emerging markets

    Ajay Gautam
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 646 (2014). doi:10.1038/nrd4413 Authors: Ajay Gautam & Steve Yang Recent studies have investigated public and venture-capital funding for life sciences in emerging markets to understand government policy and investment strategy (Nature Biotech.31, 195–201; 2013; N. Engl. J. Med.370, 3–6; 2014). This article describes a framework to help
  • Harnessing the informatics revolution for neuroscience drug R&D

    Husseini K. Manji
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 709 (2014). doi:10.1038/nrd4431 Author: Husseini K. Manji, Thomas R. Insel & Vaibhav A. Narayan Nature Reviews Drug Discovery13, 561–562 (2014)The middle initial of the second author was incorrect; it should be Thomas R. Insel, as above. The online versions have been corrected accordingly.
  • FDA approves second transgenic milk drug

    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 644 (2014). doi:10.1038/nrd4426 Despite regulatory success for Pharming's conestat alfa, 'farmaceuticals' continue to face an uphill battle.The lowdown: The US Food and Drug Administration (FDA) approved Pharming's conestat alfa for the treatment of hereditary angioedema, providing a second complete case study for developers of drugs from
  • Bank tests drug development waters

    Asher Mullard
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 643 (2014). doi:10.1038/nrd4412 Author: Asher Mullard The European Investment Bank has invested [euro]75 million in a risk-sharing drug development deal with the pharmaceutical company UCB, potentially opening up a new source of research and development (R&D) funding.
  • Cancer: PLK4 inhibitor shows potent antitumour activity

    Alexandra Flemming
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 654 (2014). doi:10.1038/nrd4430 Author: Alexandra Flemming Polo-like kinase 4 (PLK4) was identified as an anticancer target in an RNA interference (RNAi) screen in human breast cancers and cell lines, and the small molecule CFI-400945 was found to be a potent, selective and orally available PLK4 inhibitor. In vitro studies showed
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Identification and consequences of miRNA–target interactions — beyond repression of gene expression

    Jean Hausser
    15 Sep 2014 | 5:00 pm
    Nature Reviews Genetics 15, 702 (2014). doi:10.1038/nrg3827 Author: Jean Hausser & Mihaela Zavolan Nature Reviews Genetics15, 599–612 (2014)10.1038/nrg3765In Box 3 of this article, equation 3 was given incorrectly. The correct equation should be as follows.The article has been corrected online. The authors apologize for this error.
  • Population genomics: Determinants of genetic diversity

    Darren J. Burgess
    8 Sep 2014 | 5:00 pm
    Nature Reviews Genetics 15, 642 (2014). doi:10.1038/nrg3825 Author: Darren J. Burgess Romiguier et al. sequenced the transcriptomes of 2–10 individuals from each of 76 non-model animal species to quantify the population genetic diversity, followed by analyses of ecological, biological or geographical features that correlate with the level of diversity. They found that strong parental investment
  • Non-coding RNA: Interrogating miRNA–target interactions in vivo

    Esther Lau
    8 Sep 2014 | 5:00 pm
    Nature Reviews Genetics 15, 642 (2014). doi:10.1038/nrg3824 Author: Esther Lau Bioinformatic algorithms have predicted many microRNA (miRNA) targets known as miRNA response elements (MREs), but studying their relevance in vivo remains challenging. Bassett et al. used genome editing to disrupt endogenous MREs, which allowed them to characterize specific miRNA–target interactions in zebrafish embryos
  • Signalling: Male exosomes affect female behaviour

    Darren J. Burgess
    8 Sep 2014 | 5:00 pm
    Nature Reviews Genetics 15, 642 (2014). doi:10.1038/nrg3826 Author: Darren J. Burgess In Drosophila melanogaster, seminal peptides secreted by the male accessory glands can control post-mating behaviour in females, such as inhibiting remating. As exosomes (a type of secretory vesicle) are known to mediate intercellular signalling in various species, Corrigan et al. used a fluorescent
  • Eusocial insects as emerging models for behavioural epigenetics

    Hua Yan
    8 Sep 2014 | 5:00 pm
    Nature Reviews Genetics 15, 677 (2014). doi:10.1038/nrg3787 Authors: Hua Yan, Daniel F. Simola, Roberto Bonasio, Jürgen Liebig, Shelley L. Berger & Danny Reinberg Understanding the molecular basis of how behavioural states are established, maintained and altered by environmental cues is an area of considerable and growing interest. Epigenetic processes, including methylation of DNA and post-translational modification of histones, dynamically modulate activity-dependent gene expression in neurons and can therefore
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Ebola update

    Cláudio Nunes-Alves
    15 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 656 (2014). doi:10.1038/nrmicro3355 Author: Cláudio Nunes-Alves Outbreak news. The number of Ebola virus (EBOV; formerly known as Zaire ebolavirus) infections continues to increase in West Africa, making this the largest ever reported Ebola epidemic. The outbreak is presumed to have started in Guinea, and more than 3,000 cases and 1,500
  • Bacterial pathogenesis: Entry through a lipid zipper

    Andrea Du Toit
    15 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 657 (2014). doi:10.1038/nrmicro3358 Author: Andrea Du Toit It has been suggested that entry of bacterial pathogens into host cells depends on actin polymerization-driven deformation of the plasma membrane as well as additional host and bacterial factors. A new study now shows that binding of the host cell membrane component glycosphingolipid Gb3 to
  • Bacterial pathogenesis: In-house dining for phage

    Sheilagh Molloy
    15 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 658 (2014). doi:10.1038/nrmicro3359 Author: Sheilagh Molloy Andrew Camilli and colleagues provide the first evidence that phage predation drives genomic diversification of V. cholerae in vivo.
  • Bacterial transcription: Turning the switch on gene expression

    Andrea Du Toit
    15 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 657 (2014). doi:10.1038/nrmicro3356 Author: Andrea Du Toit Metabolite-binding riboswitches undergo structural changes to regulate transcription or translation of downstream genes. Two papers now identify a riboswitch in a non-coding small RNA (sRNA) that coordinates the expression of the ethanolamine utilization (eut) locus with the availability of essential cofactors of this
  • Microbiome: Clostridia spp. combat food allergy in mice

    Andrea Du Toit
    15 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 657 (2014). doi:10.1038/nrmicro3357 Author: Andrea Du Toit Environmentally induced changes in the composition of the intestinal microbiota have been implicated in allergic sensitization. In this report, Nagler and colleagues show that mice that have been treated with antibiotics have an altered gut microbial diversity and increased sensitization to food allergens. The selective
 
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Genes and disease: Schwann cells keep axons healthy

    Sian Lewis
    18 Sep 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 632 (2014). doi:10.1038/nrn3831 Author: Sian Lewis Charcot-Marie-Tooth disease 1A (CMT1A) is an inherited neuropathy caused by duplication of the gene encoding peripheral myelin protein 22 (PMP22). In this study, PMP22 duplication in rodents caused defects in Schwann cell differentiation in early postnatal development, which persisted into adulthood. This abnormal Schwann
  • Cation-chloride cotransporters in neuronal development, plasticity and disease

    Kai Kaila
    18 Sep 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 637 (2014). doi:10.1038/nrn3819 Authors: Kai Kaila, Theodore J. Price, John A. Payne, Martin Puskarjov & Juha Voipio Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades, research on ion transporters is in its infancy. In recent years, it has become evident that one family of
  • Visual processing: Microcircuits unmasked

    Darran Yates
    18 Sep 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 632 (2014). doi:10.1038/nrn3834 Author: Darran Yates In mouse primary visual cortex, subpopulations of layer six principal cells form distinct microcircuits that are involved in visual processing.
  • Functional organization of the hippocampal longitudinal axis

    Bryan A. Strange
    18 Sep 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 655 (2014). doi:10.1038/nrn3785 Authors: Bryan A. Strange, Menno P. Witter, Ed S. Lein & Edvard I. Moser The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) hippocampus mediates anxiety-related behaviours. However, this 'dichotomy view' may need
  • Cellular neurophysiology: Clearing away the debris

    Sian Lewis
    18 Sep 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 632 (2014). doi:10.1038/nrn3832 Author: Sian Lewis Damaged mitochondria are cleared from neurons by mitophagy. At the soma, this process is mediated by lysosomes and requires two Parkinson's disease-related proteins, parkin and PINK1. However, it remains controversial whether the same mechanisms operate in distal axons where lysosomes are sparse. The authors showed
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    Nature Reviews Cardiology - Issue - nature.com science feeds

  • Device therapy: Just IN-TIME for ICD telemonitoring

    Tim Geach
    1 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 557 (2014). doi:10.1038/nrcardio.2014.130 Author: Tim Geach New generations of implantable cardioverter–defibrillators (ICDs) and cardiac resynchronization therapy defibrillators (CRT-Ds) have telemonitoring functions. Technical and physiological information is recorded by the device and automatically sent to a clinical monitoring team via a mobile telephone link. In a new report published in The Lancet
  • Public health: An agenda to promote Hispanic cardiovascular health

    Robert C. Kaplan
    1 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 560 (2014). doi:10.1038/nrcardio.2014.126 Author: Robert C. Kaplan The Hispanic population will grow to represent nearly one-third of residents in the USA by mid-century. A new AHA Science Advisory paper provides an overview of current evidence on cardiovascular disease in this population, including prevailing risk factors and specific clinical approaches for treatment, and predicts what insights future research might reveal.
  • Stem cells for cardiac repair—should we be cautious?

    Yu-Li Huang
    1 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 615 (2014). doi:10.1038/nrcardio.2014.9-c3 Authors: Yu-Li Huang, Hong-Feng Tang & Yun-Zhao Hu We read the Review by Behfar et al. (Cell therapy for cardiac repair—lessons from clinical trials. Nat. Rev. Cardiol.11, 232–246; 2014) with great interest. We would like to highlight some important studies and meta-analyses that were not discussed in
  • Coronary artery disease: HDL and coronary heart disease—novel insights

    Ulf Landmesser
    1 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 559 (2014). doi:10.1038/nrcardio.2014.128 Author: Ulf Landmesser The association between HDL cholesterol and cardiovascular events, and the potential antiatherogenic effects of HDL particles, are altered in patients with established coronary heart disease. HDL particle composition has, therefore, gained attention after trials of therapies to increase HDL-cholesterol levels did not reduce the risk of an adverse cardiovascular event.
  • Risk factors: Sodium intake and health outcomes

    Karina Huynh
    25 Aug 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 556 (2014). doi:10.1038/nrcardio.2014.124 Author: Karina Huynh Most people around the world consume more sodium than is generally recommended by current guidelines. In three articles published in the New England Journal of Medicine, researchers sought to evaluate the relationship between sodium intake and health outcomes.Investigators from the NUTRICODE study quantified
 
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    Nature Reviews Endocrinology - Issue - nature.com science feeds

  • Genetics: Vitamin D and blood pressure—a preliminary verdict

    Michal L. Melamed
    25 Aug 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 579 (2014). doi:10.1038/nrendo.2014.149 Authors: Michal L. Melamed & JoAnn E. Manson Vitamin D administration lowers blood pressure in animal models, but findings from studies in humans are inconsistent. Vimaleswaran and colleagues used a Mendelian randomization approach to show that alleles associated with increased plasma levels of 25-hydroxyvitamin D3 are associated with a reduced risk of hypertension, suggesting a causal relationship in humans.
  • Obesity: Targeting fat deposits—one step closer

    David Holmes
    18 Aug 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 576 (2014). doi:10.1038/nrendo.2014.147 Author: David Holmes A new study published in Science Translational Medicine reports the identification of three new cell surface proteins that are selectively expressed on, and thus capable of discriminating between, white, beige and brown adipocytes. In addition to their diagnostic potential, these markers might facilitate therapeutic
  • Thyroid hormone receptors and resistance to thyroid hormone disorders

    Tânia M. Ortiga-Carvalho
    18 Aug 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 582 (2014). doi:10.1038/nrendo.2014.143 Authors: Tânia M. Ortiga-Carvalho, Aniket R. Sidhaye & Fredric E. Wondisford Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β
  • Biomarkers: Sclerostin levels linked to CKD outcomes

    David Holmes
    11 Aug 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 577 (2014). doi:10.1038/nrendo.2014.145 Author: David Holmes Serum levels of the anti-anabolic bone protein sclerostin are associated with an increased risk of cardiovascular events and mortality in patients with chronic kidney disease (CKD), according to a new study.Alterations in mineral homeostasis that accompany worsening of kidney function—leading to CKD–mineral and bone
  • Diabetes: Protective role of autophagy in pancreatic β cells

    Joana Osório
    11 Aug 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 575 (2014). doi:10.1038/nrendo.2014.144 Author: Joana Osório The results of three studies published simultaneously in The Journal of Clinical Investigation highlight the importance of autophagy in protecting the function of pancreatic β cells and preventing the development of type 2 diabetes mellitus (T2DM).“For many years it was proposed that T2DM
 
 
 
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    Naturejobs - Search results

  • Field Service Engineer LSMS Benelux Home Office

    22 Sep 2014 | 12:14 am
    Job Code : 15910 Location : Amsterdam NH NL Category : Customer Service, Field Services, Operations, Engineering, Sales, Applications/Sales Specialist Career Level : Experienced (Non-Manager) Job Type : Full Time Job Description : Company Information Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner an...
  • Field Service Engineer Molecular Home Office

    22 Sep 2014 | 12:14 am
    Job Code : 15908 Location : Nürnberg Bayern DE Category : Kundenservice, Außendienst, Operativer Betrieb, Ingenieurswesen, Vertrieb, Professional Services, Applications/Sales Specialist Career Level : Berufserfahren Job Type : Vollzeit Job Description : Company Information Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the worl...
  • Consultant IP Counsel

    22 Sep 2014 | 12:14 am
    Thermo Fisher Scientific has an exciting opportunity for an experienced Intellectual Property Litigation Attorney to join its Life Sciences Solutions Group at its headquarters in Carlsbad, CA. This position reports to the IP Litigation Lead Counsel and is responsible for intellectual property litigation in various forums (including U.S. and foreign courts, arbitrators, and administrative agencies), with an emphasis on U.S. patent infringement litigation. This position provides substantial oppor...
  • Inside Sales Specialist native Dutch fluent German and English

    22 Sep 2014 | 12:14 am
    Job Code : 15907 Location : Breda NB NL Category : Administrative Services, Communications, Customer Service, Sales, Other, Marketing, Applications/Sales Specialist Career Level : Experienced (Non-Manager) Job Type : Full Time Job Description : Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. W...
  • Sr Consumable Sales Representative

    22 Sep 2014 | 12:14 am
    Position Title: Sr. Consumable Sales RepresentativePosition Location: Boston, MASales Territory: Harvard UniversityReq-ID: 18269BR Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increa...
 
 
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    British Journal of Pharmacology

  • Selective Targeting of Glucagon-Like Peptide-1 Signalling As a Novel Therapeutic Approach for Cardiovascular Disease in Diabetes

    Mitchel Tate, Aaron Chong, Emma Robinson, Brian D. Green, David J. Grieve
    17 Sep 2014 | 11:31 pm
    Summary Glucagon-like peptide-1 (GLP-1) is an incretin hormone whose glucose-dependent insulinotropic actions have been harnessed as a novel therapy for glycaemic control in type 2 diabetes. Although it has been known for some time that the GLP-1 receptor is expressed in the cardiovascular system where it mediates important physiological actions, it is only recently that specific cardiovascular effects of GLP-1 in the setting of diabetes have been described. GLP-1 confers indirect benefits in cardiovascular disease (CVD) under both normal and hyperglycaemic conditions via reducing established…
  • Hunting for the function of orphan G protein-coupled receptors – beyond the search for the endogenous ligand

    Raise Ahmad, Stefanie Wojciech, Ralf Jockers
    17 Sep 2014 | 11:31 pm
    Abstract Seven transmembrane-spanning proteins (7TM), also called G protein-coupled receptors (GPCRs), are among the most versatile and evolutionary successful protein families. Out of the 400 non-odorant members identified in the human genome, approximately 100 remain orphans that have not been matched with an endogenous ligand. Apart from the classical deorphanization strategies, several alternative strategies provided recent new insights into the function of these proteins, which hold promise for high therapeutic potential. These alternative strategies consist of the phenotypic…
  • Rare platelet G protein-coupled receptor variants: What Can We Learn?

    S. P. Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell,
    17 Sep 2014 | 11:30 pm
    Summary Platelet expressed G protein-coupled receptors (GPCRs) are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti-thrombotic drug therapy is associated with high inter-patient variability in therapeutic response and adverse bleeding side-effects. In order to optimise the use of existing antiplatelet drugs and to develop new therapies more detailed knowledge is required relating to the…
  • Protective role of olesoxime against wild type alpha-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells

    C Gouarné, J Tracz, M Giraudon Paoli, V Deluca, M Seimandi, G Tardif, M Xilouri, L Stefanis, T Bordet, R M Pruss
    14 Sep 2014 | 8:21 pm
    Abstract Background and purposeParkinson's disease (PD) is usually diagnosed clinically based on classical motor symptoms, while definitive diagnosis is made post-mortem, based on the presence of Lewy bodies and nigral neuron cell loss. Alpha-synuclein (ASYN), the main protein component of Lewy bodies, clearly plays a role in the neurodegeneration that characterizes PD. Additionaly, mutation in the SNCA gene or copy number variations are associated with some forms of familial PD. Here, the objective of the study was to evaluate whether olesoxime, a promising neuroprotective drug can prevent…
  • FTY720 is neuroprotective after cuprizone-induced central nervous system demyelination

    A Slowik, T Schmidt, C Beyer, S Amor, T Clarner, M Kipp
    14 Sep 2014 | 8:20 pm
    Summary BackgroundThe sphingosine 1-phosphate (S1P) receptor modulator is an approved treatment of relapsing multiple sclerosis (MS) because of its anti-inflammatory effect to retain lymphocytes within the lymph nodes. Here, we evaluated the potential of FTY720 (fingolimod; Gilenya™, Novartis Pharma AG) to activate pro-myelinating pathways within the brain to encourage remyelination and neuroprotection. ExperimentalAPPROACH: In this study, we used the cuprizone model and tested pro-myelinating and neuroprotective effects of FTY720 after acute and chronic toxin-induced experimental…
 
 
 
 
 
 
 
 
 
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    Immunology and Cell Biology - AOP - nature.com science feeds

  • Killing without collateral damage: new hope for sepsis therapy

    Alastair G Proudfoot
    15 Sep 2014 | 5:00 pm
    Killing without collateral damage: new hope for sepsis therapy Immunology and Cell Biology advance online publication, September 16 2014. doi:10.1038/icb.2014.73 Authors: Alastair G Proudfoot & Charlotte Summers
  • Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10

    Filipe M de Melo
    15 Sep 2014 | 5:00 pm
    Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10 Immunology and Cell Biology advance online publication, September 16 2014. doi:10.1038/icb.2014.74 Authors: Filipe M de Melo, Catarina JM Braga, Felipe V Pereira, Juliana T Maricato, Clarice ST Origassa, Mariana F Souza, Amanda C Melo, Priscila Silva, Samanta L Tomaz, Karina P Gimenes, Jorge AB Scutti, Maria A Juliano, Dario S Zamboni, Niels O Câmara, Luiz R Travassos, Luis CS Ferreira & Elaine G Rodrigues
  • The protein DIIIC-2, aggregated with a specific oligodeoxynucleotide and adjuvanted in alum, protects mice and monkeys against DENV-2

    Lázaro Gil
    1 Sep 2014 | 5:00 pm
    The protein DIIIC-2, aggregated with a specific oligodeoxynucleotide and adjuvanted in alum, protects mice and monkeys against DENV-2 Immunology and Cell Biology advance online publication, September 2 2014. doi:10.1038/icb.2014.63 Authors: Lázaro Gil, Ernesto Marcos, Alienys Izquierdo, Laura Lazo, Iris Valdés, Peris Ambala, Lucy Ochola, Rikoi Hitler, Edith Suzarte, Mayling Álvarez, Prisilla Kimiti, James Ndung'u, Thomas Kariuki, María Guadalupe Guzmán, Gerardo Guillén & Lisset Hermida
  • A healthy appetite for Toxoplasma at the cellular level

    Motti Gerlic
    1 Sep 2014 | 5:00 pm
    A healthy appetite for Toxoplasma at the cellular level Immunology and Cell Biology advance online publication, September 2 2014. doi:10.1038/icb.2014.72 Authors: Motti Gerlic & Seth L Masters
  • Contractile activity of human follicular dendritic cells

    Raquel Muñoz-Fernández
    25 Aug 2014 | 5:00 pm
    Contractile activity of human follicular dendritic cells Immunology and Cell Biology advance online publication, August 26 2014. doi:10.1038/icb.2014.61 Authors: Raquel Muñoz-Fernández, Alejandro Prados, Irene Tirado-González, Francisco Martín, Ana C Abadía & Enrique G Olivares
 
 
 
 
 
 
 
 
 
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    Neuropsychopharmacology - Issue - nature.com science feeds

  • Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition

    Ja Wook Koo
    14 Sep 2014 | 5:00 pm
    Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition Neuropsychopharmacology 39, 2646 (October 2014). doi:10.1038/npp.2014.118 Authors: Ja Wook Koo, Mary Kay Lobo, Dipesh Chaudhury, Benoit Labonté, Allyson Friedman, Elizabeth Heller, Catherine Jensen Peña, Ming-Hu Han & Eric J Nestler Keywords:
  • Improved Long-Term Memory via Enhancing cGMP-PKG Signaling Requires cAMP-PKA Signaling

    Eva Bollen
    14 Sep 2014 | 5:00 pm
    Improved Long-Term Memory via Enhancing cGMP-PKG Signaling Requires cAMP-PKA Signaling Neuropsychopharmacology 39, 2497 (October 2014). doi:10.1038/npp.2014.106 Authors: Eva Bollen, Daniela Puzzo, Kris Rutten, Lucia Privitera, Jochen De Vry, Tim Vanmierlo, Gunter Kenis, Agostino Palmeri, Rudi D'Hooge, Detlef Balschun, Harry MW Steinbusch, Arjan Blokland & Jos Prickaerts Keywords:
  • Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome

    Bianca De Filippis
    14 Sep 2014 | 5:00 pm
    Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome Neuropsychopharmacology 39, 2506 (October 2014). doi:10.1038/npp.2014.105 Authors: Bianca De Filippis, Paola Nativio, Alessia Fabbri, Laura Ricceri, Walter Adriani, Enza Lacivita, Marcello Leopoldo, Francesca Passarelli, Andrea Fuso & Giovanni Laviola Keywords:
  • In Vivo Amphetamine Action is Contingent on αCaMKII

    Thomas Steinkellner
    14 Sep 2014 | 5:00 pm
    In Vivo Amphetamine Action is Contingent on αCaMKII Neuropsychopharmacology 39, 2681 (October 2014). doi:10.1038/npp.2014.124 Authors: Thomas Steinkellner, Liudmilla Mus, Birgit Eisenrauch, Andreea Constantinescu, Damiana Leo, Lisa Konrad, Mattias Rickhag, Gunnar Sørensen, Evgenia V Efimova, Eryan Kong, Matthäus Willeit, Tatyana D Sotnikova, Oliver Kudlacek, Ulrik Gether, Michael Freissmuth, Daniela D Pollak, Raul R Gainetdinov & Harald H Sitte Keywords:
  • Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors

    Robert H Pietrzak
    14 Sep 2014 | 5:00 pm
    Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors Neuropsychopharmacology 39, 2519 (October 2014). doi:10.1038/npp.2014.110 Authors: Robert H Pietrzak, Yiyun Huang, Stefani Corsi-Travali, Ming-Qiang Zheng, Shu-fei Lin, Shannan Henry, Marc N Potenza, Daniele Piomelli, Richard E Carson & Alexander Neumeister Keywords:
 
 
 
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    PSI-Nature Structural Biology Knowledgebase

  • Protein and Peptide Synthesis: Sensing Energy Balance

    Angela K. Eggleston
    17 Sep 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.223 Author: Angela K. Eggleston Complementary structural, genetic, biochemical and biophysical approaches identify a new translation regulator that responds to changing ATP/ADP ratios.
  • Protein and Peptide Synthesis: Coming Full Circle

    Catherine Goodman
    17 Sep 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.224 Author: Catherine Goodman A search for a plant peptidase ends with the discovery of one of the fastest peptide ligases.
  • Modeling the synapse

    Allison Doerr
    29 Jul 2014 | 5:00 pm
    Nature Methods 11, 788 (2014). doi:10.1038/nmeth.3057 Author: Allison Doerr A combination of experimental protein analysis and imaging techniques is used to create a three-dimensional model of a synaptic bouton.
  • Unlocking AP2 activity

    Katharine H. Wrighton
    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 560 (2014). doi:10.1038/nrm3863 Author: Katharine H. Wrighton The clathrin adaptor assembly polypeptide 2 (AP2) cannot bind to clathrin in the cytoplasm owing to an autoinhibitory mechanism.
  • Predicting Protein Crystal Candidates

    Tal Nawy
    17 Sep 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.225 Author: Tal Nawy An improved algorithm predicts whether a protein will be amenable to crystallization for structural studies.
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