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  • Parallel domestication of the Shattering1 genes in cereals

    Nature Genetics - AOP - nature.com science feeds
    Zhongwei Lin
    12 May 2012 | 7:00 pm
    Parallel domestication of the Shattering1 genes in cereals Nature Genetics. doi:10.1038/ng.2281 Authors: Zhongwei Lin, Xianran Li, Laura M Shannon, Cheng-Ting Yeh, Ming L Wang, Guihua Bai, Zhao Peng, Jiarui Li, Harold N Trick, Thomas E Clemente, John Doebley, Patrick S Schnable, Mitchell R Tuinstra, Tesfaye T Tesso, Frank White & Jianming Yu A key step during crop domestication is the loss of seed shattering. Here, we show that seed shattering in sorghum is controlled by a single gene, Shattering1 (Sh1), which encodes a YABBY transcription factor. Domesticated sorghums harbor three…

  • Postmenopausal Sex Hormones in Relation to Body Fat Distribution

    Obesity - Issue - nature.com science feeds
    Stefanie Liedtke
    24 Apr 2012 | 7:00 pm
    Postmenopausal Sex Hormones in Relation to Body Fat Distribution Obesity 20, 1088 (May 2012). doi:10.1038/oby.2011.383 Authors: Stefanie Liedtke, Martina E. Schmidt, Alina Vrieling, Annekatrin Lukanova, Susen Becker, Rudolf Kaaks, Aida K. Zaineddin, Katharina Buck, Axel Benner, Jenny Chang-Claude & Karen Steindorf

  • A search model for topological insulators with high-throughput robustness descriptors

    Nature Materials - AOP - nature.com science feeds
    Kesong Yang
    12 May 2012 | 7:00 pm
    A search model for topological insulators with high-throughput robustness descriptors Nature Materials. doi:10.1038/nmat3332 Authors: Kesong Yang, Wahyu Setyawan, Shidong Wang, Marco Buongiorno Nardelli & Stefano Curtarolo

  • Heart repair by reprogramming non-myocytes with cardiac transcription factors

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    Kunhua Song
    12 May 2012 | 7:00 pm
    Heart repair by reprogramming non-myocytes with cardiac transcription factors Nature advance online publication 13 May 2012. doi:10.1038/nature11139 Authors: Kunhua Song, Young-Jae Nam, Xiang Luo, Xiaoxia Qi, Wei Tan, Guo N. Huang, Asha Acharya, Christopher L. Smith, Michelle D. Tallquist, Eric G. Neilson, Joseph A. Hill, Rhonda Bassel-Duby & Eric N. Olson

  • Rational design of true monomeric and bright photoactivatable fluorescent proteins

    Nature Methods - AOP - nature.com science feeds
    Mingshu Zhang
    12 May 2012 | 7:00 pm
    Rational design of true monomeric and bright photoactivatable fluorescent proteins Nature Methods. doi:10.1038/nmeth.2021 Authors: Mingshu Zhang, Hao Chang, Yongdeng Zhang, Junwei Yu, Lijie Wu, Wei Ji, Juanjuan Chen, Bei Liu, Jingze Lu, Yingfang Liu, Junlong Zhang, Pingyong Xu & Tao Xu Monomeric (m)Eos2 is an engineered photoactivatable fluorescent protein widely used for super-resolution microscopy. We show that mEos2 forms oligomers at high concentrations and forms aggregates when labeling membrane proteins, limiting its application as a fusion partner. We solved the crystal structure…
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  • EU agencies accused of conflicts of interest

    Declan Butler
    14 May 2012 | 7:00 pm
    EU agencies accused of conflicts of interestNature 485, 294 15052012 doi: 10.1038/485294aDeclan ButlerEuropean Parliament reprimands food advisory body for industry links.

  • Malaria surge feared

    Amy Maxmen
    14 May 2012 | 7:00 pm
    Malaria surge fearedNature 485, 293 15052012 doi: 10.1038/485293aAmy MaxmenThe WHO releases action plan to tackle the spread of insecticide-resistant mosquitoes.

  • Chinese university wins degree of freedom

    Li Jiao
    14 May 2012 | 7:00 pm
    Chinese university wins degree of freedomNature News , 15052012 doi: 10.1038/nature.2012.10631Li JiaoSouth University of Science and Technology of China to pioneer educational reform without government control.

  • Iranian physicist sentenced to prison

    Michele Catanzaro
    14 May 2012 | 7:00 pm
    Iranian physicist sentenced to prisonNature News , 15052012 doi: 10.1038/nature.2012.10642Michele CatanzaroOmid Kokabee gets 10 years in jail for ‘communicating with a hostile government’.

  • Geoengineering experiment cancelled amid patent row

    Daniel Cressey
    14 May 2012 | 7:00 pm
    Geoengineering experiment cancelled amid patent rowNature News , 15052012 doi: 10.1038/nature.2012.10645Daniel CresseyBalloon-based ‘test bed’ for climate-change mitigation abandoned.
 
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  • With transparency comes trust

    8 May 2012 | 7:00 pm
    With transparency comes trust Nature 485, 7397 (2012). doi:10.1038/485147a International development experts say that the Millennium Villages Project's claims of progress should be interpreted with caution.

  • Misplaced protest

    8 May 2012 | 7:00 pm
    Misplaced protest Nature 485, 7397 (2012). doi:10.1038/485147b Rothamsted's genetically engineered wheat should be allowed to grow.

  • Price of freedom

    8 May 2012 | 7:00 pm
    Price of freedom Nature 485, 7397 (2012). doi:10.1038/485148a The latest mission to Jupiter highlights the benefits and pitfalls of collaboration.

  • Beware the creeping cracks of bias

    Daniel Sarewitz
    Beware the creeping cracks of bias Nature 485, 7397 (2012). http://www.nature.com/doifinder/10.1038/485149a Author: Daniel Sarewitz Evidence is mounting that research is riddled with systematic errors. Left unchecked, this could erode public trust, warns Daniel Sarewitz.

  • Climate science: A check on speeding glaciers

    8 May 2012 | 7:00 pm
    Climate science: A check on speeding glaciers Nature 485, 7397 (2012). doi:10.1038/485150a Analysis of a decade-long record of Greenland's glaciers suggests that the ice sheets are not accelerating towards the ocean as much as previously forecast.Earlier work on a small number of glaciers had uncovered large increases in speed. Using satellite radar data to calculate the
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  • Compartmentalized calcium dynamics in a C. elegans interneuron encode head movement

    Michael Hendricks
    12 May 2012 | 7:00 pm
    Compartmentalized calcium dynamics in a C. elegans interneuron encode head movement Nature advance online publication 13 May 2012. doi:10.1038/nature11081 Authors: Michael Hendricks, Heonick Ha, Nicolas Maffey & Yun Zhang The confinement of neuronal activity to specific subcellular regions is a mechanism for expanding the computational properties of neurons. Although the circuit organization underlying compartmentalized activity has been studied in several systems, its cellular basis is still unknown. Here we characterize compartmentalized activity in Caenorhabditis elegans RIA…

  • Heart repair by reprogramming non-myocytes with cardiac transcription factors

    Kunhua Song
    12 May 2012 | 7:00 pm
    Heart repair by reprogramming non-myocytes with cardiac transcription factors Nature advance online publication 13 May 2012. doi:10.1038/nature11139 Authors: Kunhua Song, Young-Jae Nam, Xiang Luo, Xiaoxia Qi, Wei Tan, Guo N. Huang, Asha Acharya, Christopher L. Smith, Michelle D. Tallquist, Eric G. Neilson, Joseph A. Hill, Rhonda Bassel-Duby & Eric N. Olson

  • Recurrent network activity drives striatal synaptogenesis

    Yevgenia Kozorovitskiy
    12 May 2012 | 7:00 pm
    Recurrent network activity drives striatal synaptogenesis Nature advance online publication 13 May 2012. doi:10.1038/nature11052 Authors: Yevgenia Kozorovitskiy, Arpiar Saunders, Caroline A. Johnson, Bradford B. Lowell & Bernardo L. Sabatini Neural activity during development critically shapes postnatal wiring of the mammalian brain. This is best illustrated by the sensory systems, in which the patterned feed-forward excitation provided by sensory organs and experience drives the formation of mature topographic circuits capable of extracting specific features of sensory stimuli. In…

  • Genetic recombination is directed away from functional genomic elements in mice

    Kevin Brick
    12 May 2012 | 7:00 pm
    Genetic recombination is directed away from functional genomic elements in mice Nature advance online publication 13 May 2012. doi:10.1038/nature11089 Authors: Kevin Brick, Fatima Smagulova, Pavel Khil, R. Daniel Camerini-Otero & Galina V. Petukhova Genetic recombination occurs during meiosis, the key developmental programme of gametogenesis. Recombination in mammals has been recently linked to the activity of a histone H3 methyltransferase, PR domain containing 9 (PRDM9), the product of the only known speciation-associated gene in mammals. PRDM9 is thought to determine the preferred…

  • α2δ expression sets presynaptic calcium channel abundance and release probability

    Michael B. Hoppa
    12 May 2012 | 7:00 pm
    α2δ expression sets presynaptic calcium channel abundance and release probability Nature advance online publication 13 May 2012. doi:10.1038/nature11033 Authors: Michael B. Hoppa, Beatrice Lana, Wojciech Margas, Annette C. Dolphin & Timothy A. Ryan Synaptic neurotransmitter release is driven by Ca2+ influx through active zone voltage-gated calcium channels (VGCCs). Control of active zone VGCC abundance and function remains poorly understood. Here we show that a trafficking step probably sets synaptic VGCC levels in rats, because overexpression of the pore-forming α1A VGCC…
 
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    Nature China - nature.com science feeds

  • Cell migration: Dead in its tracks

    Edward Duca
    1 May 2012 | 7:00 pm
    Cell migration: Dead in its tracks Nature China(2012). doi:10.1038/nchina.2012.29 Author: Edward Duca The protein kinase p38 gives the green light to immune cell migration, whereas the protein kinase Erk puts on the brakes

  • Chemical biology: Nature's way of combating leukaemia

    Felix Cheung
    1 May 2012 | 7:00 pm
    Chemical biology: Nature's way of combating leukaemia Nature China(2012). doi:10.1038/nchina.2012.30 Author: Felix Cheung The natural compound adenanthin represses tumour growth and prolongs the survival of mice with acute promyelocytic leukaemia

  • Behavioural neuroscience: A drug-free way to overcome addiction

    Felix Cheung
    1 May 2012 | 7:00 pm
    Behavioural neuroscience: A drug-free way to overcome addiction Nature China(2012). doi:10.1038/nchina.2012.34 Author: Felix Cheung Memory reconsolidation helps reduce drug cravings and prevent future relapses

  • Molecular biology: Expecting mothers beware!

    Felix Cheung
    1 May 2012 | 7:00 pm
    Molecular biology: Expecting mothers beware! Nature China(2012). doi:10.1038/nchina.2012.31 Author: Felix Cheung Corin deficiency can lead to high blood pressure during pregnancy

  • Polymer: Carbon curlers

    Felix Cheung
    1 May 2012 | 7:00 pm
    Polymer: Carbon curlers Nature China(2012). doi:10.1038/nchina.2012.33 Author: Felix Cheung A photodeformable polymer containing highly aligned carbon nanotubes curls along the length of the carbon nanotubes
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    Nature Biotechnology - Issue - nature.com science feeds

  • Zinc-finger nucleases hone tumor cell therapy

    Jason Kreisberg
    6 May 2012 | 7:00 pm
    Zinc-finger nucleases hone tumor cell therapy Nature Biotechnology 30, 411 (2012). doi:10.1038/nbt.2227 Author: Jason Kreisberg

  • In this issue

    6 May 2012 | 7:00 pm
    In this issue Nature Biotechnology 30, vii (2012). doi:10.1038/nbt.2233

  • Shining a light on trial data

    6 May 2012 | 7:00 pm
    Shining a light on trial data Nature Biotechnology 30, 371 (2012). doi:10.1038/nbt.2237 The European Medicines Agency's request to make all clinical trial data available is key to countering bias in publication, drug prescription practice and health policy.

  • A work in progress

    Bill Polvino
    6 May 2012 | 7:00 pm
    A work in progress Nature Biotechnology 30, 388 (2012). doi:10.1038/nbt.2178 Author: Bill Polvino In life sciences, a successful company very often looks markedly different from what was envisioned at founding.

  • Biomarkers unbound

    6 May 2012 | 7:00 pm
    Biomarkers unbound Nature Biotechnology 30, 372 (2012). doi:10.1038/nbt.2221 Controversies surrounding government walk-in rights or patent eligibility that grabbed headlines in recent weeks presage broader changes in biomarker patenting.
 
 
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  • Reference genome sequence of the model plant Setaria

    Jeffrey L Bennetzen
    12 May 2012 | 7:00 pm
    Reference genome sequence of the model plant Setaria Nature Biotechnology. doi:10.1038/nbt.2196 Authors: Jeffrey L Bennetzen, Jeremy Schmutz, Hao Wang, Ryan Percifield, Jennifer Hawkins, Ana C Pontaroli, Matt Estep, Liang Feng, Justin N Vaughn, Jane Grimwood, Jerry Jenkins, Kerrie Barry, Erika Lindquist, Uffe Hellsten, Shweta Deshpande, Xuewen Wang, Xiaomei Wu, Therese Mitros, Jimmy Triplett, Xiaohan Yang, Chu-Yu Ye, Margarita Mauro-Herrera, Lin Wang, Pinghua Li, Manoj Sharma, Rita Sharma, Pamela C Ronald, Olivier Panaud, Elizabeth A Kellogg, Thomas P Brutnell, Andrew N Doust, Gerald A…

  • Genome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential

    Gengyun Zhang
    12 May 2012 | 7:00 pm
    Genome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential Nature Biotechnology. doi:10.1038/nbt.2195 Authors: Gengyun Zhang, Xin Liu, Zhiwu Quan, Shifeng Cheng, Xun Xu, Shengkai Pan, Min Xie, Peng Zeng, Zhen Yue, Wenliang Wang, Ye Tao, Chao Bian, Changlei Han, Qiuju Xia, Xiaohua Peng, Rui Cao, Xinhua Yang, Dongliang Zhan, Jingchu Hu, Yinxin Zhang, Henan Li, Hua Li, Ning Li, Junyi Wang, Chanchan Wang, Renyi Wang, Tao Guo, Yanjie Cai, Chengzhang Liu, Haitao Xiang, Qiuxiang Shi, Ping Huang, Qingchun Chen, Yingrui Li, Jun Wang, Zhihai Zhao…
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    Nature Chemical Biology - AOP - nature.com science feeds

  • Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII

    Wojciech Jankowski
    12 May 2012 | 7:00 pm
    Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII Nature Chemical Biology. doi:10.1038/nchembio.954 Authors: Wojciech Jankowski, Tamjeed Saleh, Ming-Tao Pai, Ganapathy Sriram, Raymond B Birge & Charalampos G Kalodimos

  • Fluorescent castasterone reveals BRI1 signaling from the plasma membrane

    Niloufer G Irani
    5 May 2012 | 7:00 pm
    Fluorescent castasterone reveals BRI1 signaling from the plasma membrane Nature Chemical Biology. doi:10.1038/nchembio.958 Authors: Niloufer G Irani, Simone Di Rubbo, Evelien Mylle, Jos Van den Begin, Joanna Schneider-Pizoń, Jaroslava Hniliková, Miroslav Šíša, Dieter Buyst, Josep Vilarrasa-Blasi, Anna-Mária Szatmári, Daniël Van Damme, Kiril Mishev, Mirela-Corina Codreanu, Ladislav Kohout, Miroslav Strnad, Ana I Caño-Delgado, Jiří Friml, Annemieke Madder & Eugenia Russinova

  • A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

    Giovanna Bergamini
    28 Apr 2012 | 7:00 pm
    A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation Nature Chemical Biology. doi:10.1038/nchembio.957 Authors: Giovanna Bergamini, Kathryn Bell, Satoko Shimamura, Thilo Werner, Andrew Cansfield, Katrin Müller, Jessica Perrin, Christina Rau, Katie Ellard, Carsten Hopf, Carola Doce, Daniel Leggate, Raffaella Mangano, Toby Mathieson, Alison O'Mahony, Ivan Plavec, Faiza Rharbaoui, Friedrich Reinhard, Mikhail M Savitski, Nigel Ramsden, Emilio Hirsch, Gerard Drewes, Oliver Rausch, Marcus Bantscheff & Gitte Neubauer

  • Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase

    Yi-Fan Xu
    21 Apr 2012 | 7:00 pm
    Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase Nature Chemical Biology. doi:10.1038/nchembio.941 Authors: Yi-Fan Xu, Daniel Amador-Noguez, Marshall Louis Reaves, Xiao-Jiang Feng & Joshua D Rabinowitz

  • YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations

    Kyle L Dunbar
    21 Apr 2012 | 7:00 pm
    YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations Nature Chemical Biology. doi:10.1038/nchembio.944 Authors: Kyle L Dunbar, Joel O Melby & Douglas A Mitchell
 
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    Nature Chemistry

  • Metal–organic frameworks with dynamic interlocked components

    V. Nicholas Vukotic
    12 May 2012 | 7:00 pm
    Metal–organic frameworks with dynamic interlocked components Nature Chemistry. doi:10.1038/nchem.1354 Authors: V. Nicholas Vukotic, Kristopher J. Harris, Kelong Zhu, Robert W. Schurko & Stephen J. Loeb The dynamics of mechanically interlocked molecules such as catenanes and rotaxanes have been studied in solution as examples of rudimentary molecular switches and machines. A metal–organic framework with a [2]rotaxane as a building block demonstrates that such dynamic processes can also operate inside a solid-state material.

  • A soluble copper–bipyridine water-oxidation electrocatalyst

    Shoshanna M. Barnett
    5 May 2012 | 7:00 pm
    A soluble copper–bipyridine water-oxidation electrocatalyst Nature Chemistry. doi:10.1038/nchem.1350 Authors: Shoshanna M. Barnett, Karen I. Goldberg & James M. Mayer Copper and bipyridine (bpy) self-assemble in aqueous solutions at high pH into an active electrocatalyst for the oxidation of water to O2, one of the great challenges in energy catalysis. These solutions contain primarily (bpy)Cu(OH)2, and are robust and active catalysts, albeit at high overpotentials.

  • Ultrafast dynamics in the power stroke of a molecular rotary motor

    Jamie Conyard
    5 May 2012 | 7:00 pm
    Ultrafast dynamics in the power stroke of a molecular rotary motor Nature Chemistry. doi:10.1038/nchem.1343 Authors: Jamie Conyard, Kiri Addison, Ismael A. Heisler, Arjen Cnossen, Wesley R. Browne, Ben L. Feringa & Stephen R. Meech The light-driven power stroke of a unidirectional molecular motor is studied using ultrafast fluorescence spectroscopy. The evolution on the excited-state energy surface is observed on the 100 fs timescale and is accompanied by damped coherent molecular motion. The implications of these observations for the operation of the molecular motors are discussed.

  • Protein camouflage in cytochrome c–calixarene complexes

    Róise E. McGovern
    28 Apr 2012 | 7:00 pm
    Protein camouflage in cytochrome c–calixarene complexes Nature Chemistry. doi:10.1038/nchem.1342 Authors: Róise E. McGovern, Humberto Fernandes, Amir R. Khan, Nicholas P. Power & Peter B. Crowley A calixarene–protein host–guest complex has been characterized in detail by using a combination of NMR spectroscopy and X-ray crystallography. The water-soluble sulfonato-calix[4]arene binds to cytochrome c at various lysine residues to yield a dynamic complex. This interaction may serve to facilitate crystallization by mediating protein–protein contacts.

  • Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

    Hans Raj
    28 Apr 2012 | 7:00 pm
    Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids Nature Chemistry. doi:10.1038/nchem.1338 Authors: Hans Raj, Wiktor Szymański, Jandré de Villiers, Henriëtte J. Rozeboom, Vinod Puthan Veetil, Carlos R. Reis, Marianne de Villiers, Frank J. Dekker, Stefaan de Wildeman, Wim J. Quax, Andy-Mark W. H. Thunnissen, Ben L. Feringa, Dick B. Janssen & Gerrit J. Poelarends Substituted aspartic acids are highly valuable as tools for biological research and as chiral building blocks for pharmaceuticals. Here, engineering of the enzyme methylaspartate…
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    Nature Genetics - Issue - nature.com science feeds

  • Super-PTEN mice

    Pamela Feliciano
    25 Apr 2012 | 7:00 pm
    Super-PTEN mice Nature Genetics 44, 481 (2012). doi:10.1038/ng.2265 Author: Pamela Feliciano

  • Germline RAD51C mutations confer susceptibility to ovarian cancer

    Chey Loveday
    25 Apr 2012 | 7:00 pm
    Germline RAD51C mutations confer susceptibility to ovarian cancer Nature Genetics 44, 475 (2012). doi:10.1038/ng.2224 Authors: Chey Loveday, Clare Turnbull, Elise Ruark, Rosa Maria Munoz Xicola, Emma Ramsay, Deborah Hughes, Margaret Warren-Perry, Katie Snape, Diana Eccles, D Gareth Evans, Martin Gore, Anthony Renwick, Sheila Seal, Antonis C Antoniou & Nazneen Rahman

  • Straightforward recessive BBS

    Myles Axton
    25 Apr 2012 | 7:00 pm
    Straightforward recessive BBS Nature Genetics 44, 481 (2012). doi:10.1038/ng.2267 Author: Myles Axton

  • Germline RAD51C mutations confer susceptibility to ovarian cancer

    Alfons Meindl
    25 Apr 2012 | 7:00 pm
    Germline RAD51C mutations confer susceptibility to ovarian cancer Nature Genetics 44, 476 (2012). doi:10.1038/ng.2223 Authors: Alfons Meindl, Katharina Eirich, Stefanie Engert, Alexandra Becker, Daniela Endt, Nina Ditsch, Rita K Schmutzler & Detlev Schindler

  • Familial diarrhea syndrome

    Kyle Vogan
    25 Apr 2012 | 7:00 pm
    Familial diarrhea syndrome Nature Genetics 44, 481 (2012). doi:10.1038/ng.2266 Author: Kyle Vogan
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  • CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms

    Jennifer R Panizzi
    12 May 2012 | 7:00 pm
    CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms Nature Genetics. doi:10.1038/ng.2277 Authors: Jennifer R Panizzi, Anita Becker-Heck, Victoria H Castleman, Dalal A Al-Mutairi, Yan Liu, Niki T Loges, Narendra Pathak, Christina Austin-Tse, Eamonn Sheridan, Miriam Schmidts, Heike Olbrich, Claudius Werner, Karsten Häffner, Nathan Hellman, Rahul Chodhari, Amar Gupta, Albrecht Kramer-Zucker, Felix Olale, Rebecca D Burdine, Alexander F Schier, Christopher O'Callaghan, Eddie M K Chung, Richard Reinhardt, Hannah M Mitchison, Stephen M King, Heymut…

  • A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

    Alisa K Manning
    12 May 2012 | 7:00 pm
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance Nature Genetics. doi:10.1038/ng.2274 Authors: Alisa K Manning, Marie-France Hivert, Robert A Scott, Jonna L Grimsby, Nabila Bouatia-Naji, Han Chen, Denis Rybin, Ching-Ti Liu, Lawrence F Bielak, Inga Prokopenko, Najaf Amin, Daniel Barnes, Gemma Cadby, Jouke-Jan Hottenga, Erik Ingelsson, Anne U Jackson, Toby Johnson, Stavroula Kanoni, Claes Ladenvall, Vasiliki Lagou, Jari Lahti, Cecile Lecoeur, Yongmei Liu, Maria Teresa Martinez-Larrad, May E Montasser,…

  • Parallel domestication of the Shattering1 genes in cereals

    Zhongwei Lin
    12 May 2012 | 7:00 pm
    Parallel domestication of the Shattering1 genes in cereals Nature Genetics. doi:10.1038/ng.2281 Authors: Zhongwei Lin, Xianran Li, Laura M Shannon, Cheng-Ting Yeh, Ming L Wang, Guihua Bai, Zhao Peng, Jiarui Li, Harold N Trick, Thomas E Clemente, John Doebley, Patrick S Schnable, Mitchell R Tuinstra, Tesfaye T Tesso, Frank White & Jianming Yu A key step during crop domestication is the loss of seed shattering. Here, we show that seed shattering in sorghum is controlled by a single gene, Shattering1 (Sh1), which encodes a YABBY transcription factor. Domesticated sorghums harbor three…

  • Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1

    Carine Bonnard
    12 May 2012 | 7:00 pm
    Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1 Nature Genetics. doi:10.1038/ng.2259 Authors: Carine Bonnard, Anna C Strobl, Mohammad Shboul, Hane Lee, Barry Merriman, Stanley F Nelson, Osama H Ababneh, Elif Uz, Tülay Güran, Hülya Kayserili, Hanan Hamamy & Bruno Reversade Using homozygosity mapping and locus resequencing, we found that alterations in the homeodomain of the IRX5 transcription factor cause a recessive congenital disorder affecting face, brain, blood, heart, bone and gonad development. We found through in vivo modeling in…

  • Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

    Ying Jin
    5 May 2012 | 7:00 pm
    Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo Nature Genetics. doi:10.1038/ng.2272 Authors: Ying Jin, Stanca A Birlea, Pamela R Fain, Tracey M Ferrara, Songtao Ben, Sheri L Riccardi, Joanne B Cole, Katherine Gowan, Paulene J Holland, Dorothy C Bennett, Rosalie M Luiten, Albert Wolkerstorfer, J P Wietze van der Veen, Anke Hartmann, Saskia Eichner, Gerold Schuler, Nanja van Geel, Jo Lambert, E Helen Kemp, David J Gawkrodger, Anthony P Weetman, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Margaret R Wallace, Wayne T McCormack, Mauro Picardo,…
 
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  • Rapid rates of growth and collapse of Monowai submarine volcano in the Kermadec Arc

    A. B. Watts
    12 May 2012 | 7:00 pm
    Rapid rates of growth and collapse of Monowai submarine volcano in the Kermadec Arc Nature Geoscience. doi:10.1038/ngeo1473 Authors: A. B. Watts, C. Peirce, I. Grevemeyer, M. Paulatto, W. Stratford, D. Bassett, J. A. Hunter, L. M. Kalnins & C. E. J. de Ronde

  • Cryospheric science: Vulnerable ice in the Weddell Sea

    Angelika Humbert
    8 May 2012 | 7:00 pm
    Cryospheric science: Vulnerable ice in the Weddell Sea Nature Geoscience. doi:10.1038/ngeo1484 Author: Angelika Humbert Of the West Antarctic ice shelves, those in the Amundsen Sea sector have given the most cause for concern. Ocean modelling of the Weddell Sea region, together with a detailed survey of the ice bed morphology, indicates that this region, too, may change soon.

  • Steep reverse bed slope at the grounding line of the Weddell Sea sector in West Antarctica

    Neil Ross
    8 May 2012 | 7:00 pm
    Steep reverse bed slope at the grounding line of the Weddell Sea sector in West Antarctica Nature Geoscience. doi:10.1038/ngeo1468 Authors: Neil Ross, Robert G. Bingham, Hugh F. J. Corr, Fausto Ferraccioli, Tom A. Jordan, Anne Le Brocq, David M. Rippin, Duncan Young, Donald D. Blankenship & Martin J. Siegert The bed of the West Antarctic Ice Sheet is, in places, more than 1.5 km below sea level. It has been suggested that a positive ice-loss feedback may occur when an ice sheet’s grounding line retreats across a deepening bed. Applied to the West Antarctic Ice Sheet, this…

  • Regional atmospheric circulation shifts induced by a grand solar minimum

    Celia Martin-Puertas
    5 May 2012 | 7:00 pm
    Regional atmospheric circulation shifts induced by a grand solar minimum Nature Geoscience. doi:10.1038/ngeo1460 Authors: Celia Martin-Puertas, Katja Matthes, Achim Brauer, Raimund Muscheler, Felicitas Hansen, Christof Petrick, Ala Aldahan, Göran Possnert & Bas van Geel Large changes in solar ultraviolet radiation can indirectly affect climate by inducing atmospheric changes. Specifically, it has been suggested that centennial-scale climate variability during the Holocene epoch was controlled by the Sun. However, the amplitude of solar forcing is small when compared with the climatic…

  • Aftershocks halted by static stress shadows

    Shinji Toda
    5 May 2012 | 7:00 pm
    Aftershocks halted by static stress shadows Nature Geoscience. doi:10.1038/ngeo1465 Authors: Shinji Toda, Ross S. Stein, Gregory C. Beroza & David Marsan Earthquakes impart static and dynamic stress changes to the surrounding crust. Sudden fault slip causes small but permanent—static—stress changes, and passing seismic waves cause large, but brief and oscillatory—dynamic—stress changes. Because both static and dynamic stresses can trigger earthquakes within several rupture dimensions of a mainshock, it has proven difficult to disentangle their contributions to the…
 
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    Nature Materials - Issue - nature.com science feeds

  • Spin caloritronics

    Gerrit E. W. Bauer
    22 Apr 2012 | 7:00 pm
    Spin caloritronics Nature Materials 11, 391 (2012). doi:10.1038/nmat3301 Authors: Gerrit E. W. Bauer, Eiji Saitoh & Bart J. van Wees

  • Nanoferronics is a winning combination

    Manuel Bibes
    22 Apr 2012 | 7:00 pm
    Nanoferronics is a winning combination Nature Materials 11, 354 (2012). doi:10.1038/nmat3318 Author: Manuel Bibes Progress in controlling different ferroic orders such as ferromagnetism and ferroelectricity on the nanoscale could offer unprecedented possibilities for electronic applications.

  • Spintronics

    Fabio Pulizzi
    22 Apr 2012 | 7:00 pm
    Spintronics Nature Materials 11, 367 (2012). doi:10.1038/nmat3327 Author: Fabio Pulizzi

  • Beaten to action

    Joerg Heber
    22 Apr 2012 | 7:00 pm
    Beaten to action Nature Materials 11, 358 (2012). doi:10.1038/nmat3325 Author: Joerg Heber

  • Material witness: Material computation

    Philip Ball
    22 Apr 2012 | 7:00 pm
    Material witness: Material computation Nature Materials 11, 362 (2012). doi:10.1038/nmat3321 Author: Philip Ball
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  • Blue-phase templated fabrication of three-dimensional nanostructures for photonic applications

    F. Castles
    12 May 2012 | 7:00 pm
    Blue-phase templated fabrication of three-dimensional nanostructures for photonic applications Nature Materials. doi:10.1038/nmat3330 Authors: F. Castles, F. V. Day, S. M. Morris, D-H. Ko, D. J. Gardiner, M. M. Qasim, S. Nosheen, P. J. W. Hands, S. S. Choi, R. H. Friend & H. J. Coles A promising approach to the fabrication of materials with nanoscale features is the transfer of liquid-crystalline structure to polymers. However, this has not been achieved in systems with full three-dimensional periodicity. Here we demonstrate the fabrication of self-assembled three-dimensional…

  • A search model for topological insulators with high-throughput robustness descriptors

    Kesong Yang
    12 May 2012 | 7:00 pm
    A search model for topological insulators with high-throughput robustness descriptors Nature Materials. doi:10.1038/nmat3332 Authors: Kesong Yang, Wahyu Setyawan, Shidong Wang, Marco Buongiorno Nardelli & Stefano Curtarolo

  • Scanning tunnelling microscopy imaging of symmetry-breaking structural distortion in the bismuth-based cuprate superconductors

    Ilija Zeljkovic
    5 May 2012 | 7:00 pm
    Scanning tunnelling microscopy imaging of symmetry-breaking structural distortion in the bismuth-based cuprate superconductors Nature Materials. doi:10.1038/nmat3315 Authors: Ilija Zeljkovic, Elizabeth J. Main, Tess L. Williams, M. C. Boyer, Kamalesh Chatterjee, W. D. Wise, Yi Yin, Martin Zech, Adam Pivonka, Takeshi Kondo, T. Takeuchi, Hiroshi Ikuta, Jinsheng Wen, Zhijun Xu, G. D. Gu, E. W. Hudson & Jennifer E. Hoffman A complicating factor in unravelling the theory of high-temperature (high-Tc) superconductivity is the presence of a ‘pseudogap’ in the density of states, the origin of…

  • Possible valence-bond condensation in the frustrated cluster magnet LiZn2Mo3O8

    J. P. Sheckelton
    5 May 2012 | 7:00 pm
    Possible valence-bond condensation in the frustrated cluster magnet LiZn2Mo3O8 Nature Materials. doi:10.1038/nmat3329 Authors: J. P. Sheckelton, J. R. Neilson, D. G. Soltan & T. M. McQueen The emergence of complex electronic behaviour from simple ingredients has resulted in the discovery of numerous states of matter. Many examples are found in systems exhibiting geometric magnetic frustration, which prevents simultaneous satisfaction of all magnetic interactions. This frustration gives rise to complex magnetic properties such as chiral spin structures, orbitally driven magnetism,…

  • Room-temperature metastability of multilayer graphene oxide films

    Suenne Kim
    5 May 2012 | 7:00 pm
    Room-temperature metastability of multilayer graphene oxide films Nature Materials. doi:10.1038/nmat3316 Authors: Suenne Kim, Si Zhou, Yike Hu, Muge Acik, Yves J. Chabal, Claire Berger, Walt de Heer, Angelo Bongiorno & Elisa Riedo
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    Nature Medicine - Issue - nature.com science feeds

  • Innate and adaptive immune responses in asthma

    Stephen T Holgate
    3 May 2012 | 7:00 pm
    Innate and adaptive immune responses in asthma Nature Medicine 18, 673 (2012). doi:10.1038/nm.2731 Author: Stephen T Holgate

  • Topic: Guts over glory—why diets fail

    Rachel Larder
    3 May 2012 | 7:00 pm
    Topic: Guts over glory—why diets fail Nature Medicine 18, 666 (2012). doi:10.1038/nm.2747 Authors: Rachel Larder & Stephen O'Rahilly Losing weight can pose a challenge, but how to avoid putting those pounds back on can be a real struggle. A major health problem for obese people is that diseases linked to obesity, such as type 2 diabetes and cardiovascular disease, put their lives at risk, even in young individuals. Although bariatric surgery—a surgical method to reduce or modify the gastrointestinal tract—was originally envisioned for the most severe cases of obesity,…

  • Hopes soar as cholesterol plummets with new drug class

    David Holmes
    3 May 2012 | 7:00 pm
    Hopes soar as cholesterol plummets with new drug class Nature Medicine 18, 633 (2012). doi:10.1038/nm0512-633 Author: David Holmes

  • Protective inflammasome activation in AMD

    Jing Chen
    3 May 2012 | 7:00 pm
    Protective inflammasome activation in AMD Nature Medicine 18, 658 (2012). doi:10.1038/nm.2761 Authors: Jing Chen & Lois E H Smith Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. AMD progression is associated with alterations in inflammatory pathways and the immune system. A new study identifies a protective role for inflammasomes in AMD, suggesting that inflammasome activation might be manipulated as a potential therapeutic strategy for this condition (pages 791–798).

  • Malaria subsidy pilot soars, but some see turbulence ahead

    Amy Maxmen
    3 May 2012 | 7:00 pm
    Malaria subsidy pilot soars, but some see turbulence ahead Nature Medicine 18, 634 (2012). doi:10.1038/nm0512-634 Author: Amy Maxmen
 
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    Nature Methods - Issue - nature.com science feeds

  • Structural biology: Tags to disentangle Dicer

    26 Apr 2012 | 7:00 pm
    Structural biology: Tags to disentangle Dicer Nature Methods 9, 436 (2012). doi:10.1038/nmeth.1995

  • The author file: Taekjip Ha

    Monya Baker
    26 Apr 2012 | 7:00 pm
    The author file: Taekjip Ha Nature Methods 9, 421 (2012). doi:10.1038/nmeth.1980 Author: Monya Baker Labeling proteins for single-molecule studies.

  • Reprogramming in suspension

    Jiekai Chen
    26 Apr 2012 | 7:00 pm
    Reprogramming in suspension Nature Methods 9, 449 (2012). doi:10.1038/nmeth.1989 Authors: Jiekai Chen & Duanqing Pei Current practice for the generation and maintenance of induced pluripotent stem cells (iPSCs) involves static culture in dishes. Two groups now report that mouse iPSCs can be generated efficiently in stirred suspension culture.

  • Points of view: Representing the genome

    Cydney Nielsen
    26 Apr 2012 | 7:00 pm
    Points of view: Representing the genome Nature Methods 9, 423 (2012). doi:10.1038/nmeth.1992 Authors: Cydney Nielsen & Bang Wong The choice of visual representation of the linear genome is guided by the question being asked.

  • A home for raw proteomics data

    26 Apr 2012 | 7:00 pm
    A home for raw proteomics data Nature Methods 9, 419 (2012). doi:10.1038/nmeth.2011 A new repository for raw data from proteomics mass spectrometry experiments is available and needs community participation.
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  • M-Track: detecting short-lived protein-protein interactions in vivo

    Aurora Zuzuarregui
    12 May 2012 | 7:00 pm
    M-Track: detecting short-lived protein-protein interactions in vivo Nature Methods. doi:10.1038/nmeth.2017 Authors: Aurora Zuzuarregui, Thomas Kupka, Bhumika Bhatt, Ilse Dohnal, Ingrid Mudrak, Christina Friedmann, Stefan Schüchner, Ingrid E Frohner, Gustav Ammerer & Egon Ogris We developed a protein-proximity assay in yeast based on fusing a histone lysine methyltransferase onto a bait and its substrate onto a prey. Upon binding, the prey is stably methylated and detected by methylation-specific antibodies. We applied this approach to detect varying interaction affinities among…

  • Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy

    Andrew G York
    12 May 2012 | 7:00 pm
    Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy Nature Methods. doi:10.1038/nmeth.2025 Authors: Andrew G York, Sapun H Parekh, Damian Dalle Nogare, Robert S Fischer, Kelsey Temprine, Marina Mione, Ajay B Chitnis, Christian A Combs & Hari Shroff

  • Rational design of true monomeric and bright photoactivatable fluorescent proteins

    Mingshu Zhang
    12 May 2012 | 7:00 pm
    Rational design of true monomeric and bright photoactivatable fluorescent proteins Nature Methods. doi:10.1038/nmeth.2021 Authors: Mingshu Zhang, Hao Chang, Yongdeng Zhang, Junwei Yu, Lijie Wu, Wei Ji, Juanjuan Chen, Bei Liu, Jingze Lu, Yingfang Liu, Junlong Zhang, Pingyong Xu & Tao Xu Monomeric (m)Eos2 is an engineered photoactivatable fluorescent protein widely used for super-resolution microscopy. We show that mEos2 forms oligomers at high concentrations and forms aggregates when labeling membrane proteins, limiting its application as a fusion partner. We solved the crystal structure…

  • Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex

    Kristina Schulz
    5 May 2012 | 7:00 pm
    Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex Nature Methods. doi:10.1038/nmeth.2013 Authors: Kristina Schulz, Esther Sydekum, Roland Krueppel, Christoph J Engelbrecht, Felix Schlegel, Aileen Schröter, Markus Rudin & Fritjof Helmchen

  • Automated whole-cell patch-clamp electrophysiology of neurons in vivo

    Suhasa B Kodandaramaiah
    5 May 2012 | 7:00 pm
    Automated whole-cell patch-clamp electrophysiology of neurons in vivo Nature Methods. doi:10.1038/nmeth.1993 Authors: Suhasa B Kodandaramaiah, Giovanni Talei Franzesi, Brian Y Chow, Edward S Boyden & Craig R Forest Whole-cell patch-clamp electrophysiology of neurons is a gold-standard technique for high-fidelity analysis of the biophysical mechanisms of neural computation and pathology, but it requires great skill to perform. We have developed a robot that automatically performs patch clamping in vivo, algorithmically detecting cells by analyzing the temporal sequence of electrode…
 
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    Nature Nanotechnology - Issue - nature.com science feeds

  • Nanoelectronics: Nanotubes throw their heat around

    Amin Salehi-Khojin
    8 May 2012 | 7:00 pm
    Nanoelectronics: Nanotubes throw their heat around Nature Nanotechnology 7, 280 (2012). doi:10.1038/nnano.2012.68 Authors: Amin Salehi-Khojin, Wei Zhu & Richard I. Masel A direct current flowing through a carbon nanotube on a substrate heats the substrate but not the nanotube, and it may be possible to exploit this phenomenon in the thermal management of nanoelectronic devices.

  • Our choice from the recent literature

    8 May 2012 | 7:00 pm
    Our choice from the recent literature Nature Nanotechnology 7, 275 (2012). doi:10.1038/nnano.2012.75

  • Mass sensing: Devices reach single-proton limit

    Wayne Hiebert
    8 May 2012 | 7:00 pm
    Mass sensing: Devices reach single-proton limit Nature Nanotechnology 7, 278 (2012). doi:10.1038/nnano.2012.66 Author: Wayne Hiebert An ultrasensitive nanomechanical mass sensor based on a single carbon nanotube could have applications in mass spectrometry and surface science.

  • Nanoelectromechanical contact switches

    Owen Y. Loh
    28 Apr 2012 | 7:00 pm
    Nanoelectromechanical contact switches Nature Nanotechnology 7, 283 (2012). doi:10.1038/nnano.2012.40 Authors: Owen Y. Loh & Horacio D. Espinosa

  • Red, green and blue lasing enabled by single-exciton gain in colloidal quantum dot films

    Cuong Dang
    28 Apr 2012 | 7:00 pm
    Red, green and blue lasing enabled by single-exciton gain in colloidal quantum dot films Nature Nanotechnology 7, 335 (2012). doi:10.1038/nnano.2012.61 Authors: Cuong Dang, Joonhee Lee, Craig Breen, Jonathan S. Steckel, Seth Coe-Sullivan & Arto Nurmikko
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    Nature Neuroscience - Issue - nature.com science feeds

  • Fat incites tanycytes to neurogenesis

    Marcelo O Dietrich
    24 Apr 2012 | 7:00 pm
    Fat incites tanycytes to neurogenesis Nature Neuroscience 15, 651 (2012). doi:10.1038/nn.3091 Authors: Marcelo O Dietrich & Tamas L Horvath Tanycytes in the hypothalamic median eminence have now been found to form a metabolically sensitive neurogenic niche in the brain. In adult mice, tanycytes give rise to hypothalamic regulatory neurons in response to a high-fat diet.

  • Is the reward really worth it?

    Steven W Kennerley
    24 Apr 2012 | 7:00 pm
    Is the reward really worth it? Nature Neuroscience 15, 647 (2012). doi:10.1038/nn.3096 Author: Steven W Kennerley How does the brain evaluate whether the benefits of a decision outweigh the costs? A study now reveals that neurons in the anterior cingulate cortex encode costs and benefits, and altering brain activity here biases choices away from negative outcomes. These results link anterior cingulate cortex with the regulation of emotional states.

  • Astrocytes join the plasticity party

    David J Rossi
    24 Apr 2012 | 7:00 pm
    Astrocytes join the plasticity party Nature Neuroscience 15, 649 (2012). doi:10.1038/nn.3095 Author: David J Rossi In the developing cortex, spike timing–dependent long-term depression requires cannabinoid-induced glutamate release from astrocytes. Astrocytes may be integral to the coincidence detection that guides plasticity and map formation.

  • On the scent of mitochondrial calcium

    Frank Zufall
    24 Apr 2012 | 7:00 pm
    On the scent of mitochondrial calcium Nature Neuroscience 15, 653 (2012). doi:10.1038/nn.3090 Author: Frank Zufall Odorants are now shown to elevate mitochondrial Ca2+ in sensory neurons; moreover, blocking this Ca2+ sequestration impairs dynamic range. Acute stimulation rapidly recruits mitochondria from the soma to the dendritic knob.

  • Focus on social neuroscience

    24 Apr 2012 | 7:00 pm
    Focus on social neuroscience Nature Neuroscience 15, 645 (2012). doi:10.1038/nn0512-645 We present a special focus on social neuroscience, bringing together several strands of research to highlight recent progress in the field.
 
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    Nature Photonics - Issue - nature.com science feeds

  • Laser fusion on the horizon

    1 May 2012 | 7:00 pm
    Laser fusion on the horizon Nature Photonics 6, 267 (2012). doi:10.1038/nphoton.2012.106 Could 2012 be the year that laser fusion becomes a reality? Progress at the National Ignition Facility in the USA certainly gives cause for optimism.

  • Microfluidics: High-speed cell sorter

    James Baxter
    1 May 2012 | 7:00 pm
    Microfluidics: High-speed cell sorter Nature Photonics 6, 269 (2012). doi:10.1038/nphoton.2012.99 Author: James Baxter

  • Materials: Topological electrodes

    Oliver Graydon
    1 May 2012 | 7:00 pm
    Materials: Topological electrodes Nature Photonics 6, 268 (2012). doi:10.1038/nphoton.2012.91 Author: Oliver Graydon

  • Compact X-ray sources: X-rays from self-reflection

    Stuart P. D. Mangles
    1 May 2012 | 7:00 pm
    Compact X-ray sources: X-rays from self-reflection Nature Photonics 6, 280 (2012). doi:10.1038/nphoton.2012.86 Author: Stuart P. D. Mangles Laser-based particle acceleration offers a way to reduce the size of hard-X-ray sources. Scientists have now developed a simple scheme that produces a bright flash of hard X-rays by using a single laser pulse both to generate and to scatter an electron beam.

  • X-rays: Orbital angular momentum

    David Pile
    1 May 2012 | 7:00 pm
    X-rays: Orbital angular momentum Nature Photonics 6, 268 (2012). doi:10.1038/nphoton.2012.92 Author: David Pile
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  • Photovoltaic retinal prosthesis with high pixel density

    Keith Mathieson
    12 May 2012 | 7:00 pm
    Photovoltaic retinal prosthesis with high pixel density Nature Photonics. doi:10.1038/nphoton.2012.104 Authors: Keith Mathieson, James Loudin, Georges Goetz, Philip Huie, Lele Wang, Theodore I. Kamins, Ludwig Galambos, Richard Smith, James S. Harris, Alexander Sher & Daniel Palanker

  • First lasing of an echo-enabled harmonic generation free-electron laser

    Z. T. Zhao
    12 May 2012 | 7:00 pm
    First lasing of an echo-enabled harmonic generation free-electron laser Nature Photonics. doi:10.1038/nphoton.2012.105 Authors: Z. T. Zhao, D. Wang, J. H. Chen, Z. H. Chen, H. X. Deng, J. G. Ding, C. Feng, Q. Gu, M. M. Huang, T. H. Lan, Y. B. Leng, D. G. Li, G. Q. Lin, B. Liu, E. Prat, X. T. Wang, Z. S. Wang, K. R. Ye, L. Y. Yu, H. O. Zhang, J. Q. Zhang, Me. Zhang, Mi. Zhang, T. Zhang, S. P. Zhong & Q. G. Zhou

  • Speckle-free laser imaging using random laser illumination

    Brandon Redding
    28 Apr 2012 | 7:00 pm
    Speckle-free laser imaging using random laser illumination Nature Photonics. doi:10.1038/nphoton.2012.90 Authors: Brandon Redding, Michael A. Choma & Hui Cao

  • Laser-driven acceleration of neutral particles

    C. Maher-McWilliams
    28 Apr 2012 | 7:00 pm
    Laser-driven acceleration of neutral particles Nature Photonics. doi:10.1038/nphoton.2012.87 Authors: C. Maher-McWilliams, P. Douglas & P. F. Barker
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    Nature Physics - Issue - nature.com science feeds

  • Publish and be damned

    1 May 2012 | 7:00 pm
    Publish and be damned Nature Physics 8, 351 (2012). doi:10.1038/nphys2323 Controversial and out-of-line results should not be discarded or hidden — even though revealing them may come at some recriminatory cost, as the OPERA collaboration has discovered.

  • Damper on fireball

    Alison Wright
    1 May 2012 | 7:00 pm
    Damper on fireball Nature Physics 8, 358 (2012). doi:10.1038/nphys2316 Author: Alison Wright

  • Origin of logarithmic resistance correction in graphene

    Johannes Jobst
    1 May 2012 | 7:00 pm
    Origin of logarithmic resistance correction in graphene Nature Physics 8, 352 (2012). doi:10.1038/nphys2297 Authors: Johannes Jobst & Heiko B. Weber

  • Caught in a trap

    Iulia Georgescu
    1 May 2012 | 7:00 pm
    Caught in a trap Nature Physics 8, 358 (2012). doi:10.1038/nphys2314 Author: Iulia Georgescu

  • Reply to "Origin of logarithmic resistance correction in graphene"

    Jian-Hao Chen
    1 May 2012 | 7:00 pm
    Reply to "Origin of logarithmic resistance correction in graphene" Nature Physics 8, 353 (2012). doi:10.1038/nphys2306 Authors: Jian-Hao Chen, Liang Li, William G. Cullen, Ellen D. Williams & Michael S. Fuhrer
 
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  • Spin and valley quantum Hall ferromagnetism in graphene

    A. F. Young
    12 May 2012 | 7:00 pm
    Spin and valley quantum Hall ferromagnetism in graphene Nature Physics. doi:10.1038/nphys2307 Authors: A. F. Young, C. R. Dean, L. Wang, H. Ren, P. Cadden-Zimansky, K. Watanabe, T. Taniguchi, J. Hone, K. L. Shepard & P. Kim

  • Equal-spin Andreev reflection and long-range coherent transport in high-temperature superconductor/half-metallic ferromagnet junctions

    C. Visani
    12 May 2012 | 7:00 pm
    Equal-spin Andreev reflection and long-range coherent transport in high-temperature superconductor/half-metallic ferromagnet junctions Nature Physics. doi:10.1038/nphys2318 Authors: C. Visani, Z. Sefrioui, J. Tornos, C. Leon, J. Briatico, M. Bibes, A. Barthélémy, J. Santamaría & Javier E. Villegas Conventional superconductivity is incompatible with ferromagnetism, because the magnetic exchange field tends to spin-polarize electrons and breaks apart the opposite-spin singlet Cooper pairs. Yet, the possibility of a long-range penetration of superconducting correlations into…

  • Free randomness can be amplified

    Roger Colbeck
    5 May 2012 | 7:00 pm
    Free randomness can be amplified Nature Physics. doi:10.1038/nphys2300 Authors: Roger Colbeck & Renato Renner Are there fundamentally random processes in nature? Theoretical predictions, confirmed experimentally, such as the violation of Bell inequalities, point to an affirmative answer. However, these results are based on the assumption that measurement settings can be chosen freely at random, so assume the existence of perfectly free random processes from the outset. Here we consider a scenario in which this assumption is weakened and show that partially free random bits can be…

  • Quantum mechanics: Get real

    Scott Aaronson
    5 May 2012 | 7:00 pm
    Quantum mechanics: Get real Nature Physics. doi:10.1038/nphys2325 Author: Scott Aaronson Do quantum states offer a faithful representation of reality or merely encode the partial knowledge of the experimenter? A new theorem illustrates how the latter can lead to a contradiction with quantum mechanics.

  • Quantum information: Bad randomness comes good

    Serge Massar
    5 May 2012 | 7:00 pm
    Quantum information: Bad randomness comes good Nature Physics. doi:10.1038/nphys2310 Author: Serge Massar Quantum non-locality can improve the quality of sources of randomness.
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • BRCA1 and BRCA2: a common pathway of genome protection but different breast cancer subtypes

    Simon A. Joosse
    23 May 2012 | 7:00 pm
    BRCA1 and BRCA2: a common pathway of genome protection but different breast cancer subtypes Nature Reviews Cancer 12, 372 (2012). doi:10.1038/nrc3181-c2 Author: Simon A. Joosse I read with great interest the recent Opinion article (BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nature Rev. Cancer12, 68–78 (2012)) by Roy and colleagues. Both BRCA1 and BRCA2

  • Running a MUC1

    Nicola McCarthy
    23 May 2012 | 7:00 pm
    Running a MUC1 Nature Reviews Cancer 12, 317 (2012). doi:10.1038/nrc3274 Author: Nicola McCarthy The UK press got carried away with a cancer story this week. It seems that a universal cancer vaccine is on its way, despite the fact that it has only been trialled in ten patients (with five more still to be recruited).The news stories

  • BRCA1 and BRCA2: important differences with common interests

    Rohini Roy
    23 May 2012 | 7:00 pm
    BRCA1 and BRCA2: important differences with common interests Nature Reviews Cancer 12, 372 (2012). doi:10.1038/nrc3181-c3 Authors: Rohini Roy, Jarin Chun & Simon N. Powell The Opinion article we wrote (BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nature Rev. Cancer12, 68–78 (2012)) on the functions of BRCA1 and BRCA2 and their different roles in

  • Initiation, evolution, phenotype and outcome of BRCA1 and BRCA2 mutation-associated breast cancer

    Ke-Da Yu
    23 May 2012 | 7:00 pm
    Initiation, evolution, phenotype and outcome of BRCA1 and BRCA2 mutation-associated breast cancer Nature Reviews Cancer 12, 372 (2012). doi:10.1038/nrc3181-c1 Authors: Ke-Da Yu & Zhi-Ming Shao We read with great interest the recent Opinion article (BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nature Rev. Cancer12, 68–78 (2012)) by Roy et al., in which the

  • Metastasis: SIX1 of the best

    Nicola McCarthy
    23 May 2012 | 7:00 pm
    Metastasis: SIX1 of the best Nature Reviews Cancer 12, 316 (2012). doi:10.1038/nrc3272 Author: Nicola McCarthy The transcription factor SIX1 can promote lymphangiogenesis and metastasis through regulating the expression of vascular endothelial growth factor C.
 
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • In this issue

    29 Apr 2012 | 7:00 pm
    In this issue Nature Reviews Drug Discovery 11, 333 (2012). doi:10.1038/nrd3724 The importance of epigenetic processes in many diseases has been increasingly appreciated in the past decade. In their Review, Arrowsmith and colleagues focus on protein families that mediate epigenetic signalling pathways through histone acetylation and methylation, discussing their links with disease and recent progress in

  • Innovation and value-driven engineering

    Frank L. Douglas
    29 Apr 2012 | 7:00 pm
    Innovation and value-driven engineering Nature Reviews Drug Discovery 11, 335 (2012). doi:10.1038/nrd3725 Author: Frank L. Douglas Emerging strategies to simultaneously catalyse rewardable innovation in the field of medical devices and reduce health-care costs could also be applicable in drug development.

  • Anti-NGF painkillers back on track?

    David Holmes
    29 Apr 2012 | 7:00 pm
    Anti-NGF painkillers back on track? Nature Reviews Drug Discovery 11, 337 (2012). doi:10.1038/nrd3732 Author: David Holmes Following an FDA advisory committee vote to restart clinical development of nerve growth factor antagonists, could this novel class of analgesics still fulfil its once-anticipated potential?

  • Oncology trials gear up for high-throughput sequencing

    Asher Mullard
    29 Apr 2012 | 7:00 pm
    Oncology trials gear up for high-throughput sequencing Nature Reviews Drug Discovery 11, 339 (2012). doi:10.1038/nrd3733 Author: Asher Mullard Researchers are starting to use high-throughput genomic technologies to guide patients into trials of experimental cancer therapies, but is our understanding of the cancer genome ready yet?

  • News in brief

    29 Apr 2012 | 7:00 pm
    News in brief Nature Reviews Drug Discovery 11, 341 (2012). doi:10.1038/nrd3734 PCSK9 inhibitor space starts to heat upA slew of results on lipid-lowering PCSK9-targeting mAbs, presented at the annual American College of Cardiology meeting in Chicago, highlighted one of the next big hopes for cardiologists.The lowdown: Proprotein convertase subtilisin kexin 9 (PCSK9) is
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Immunotherapy: Therapeutic targeting of IL-17 for psoriasis

    Olive Leavy
    24 Apr 2012 | 7:00 pm
    Immunotherapy: Therapeutic targeting of IL-17 for psoriasis Nature Reviews Immunology 12, 322 (2012). doi:10.1038/nri3220 Author: Olive Leavy Data from two Phase II double-blind, placebo-controlled clinical trials suggest that inhibition of interleukin-17 (IL-17) may be an effective and targeted therapy for psoriasis. The IL-17 receptor-specific antibody brodalumab (AMG 827; Amgen) and the IL-17A-specific monoclonal antibody ixekizumab (LY2439821; Eli Lilly) were given subcutaneously at

  • Dendritic cells: Changing of the guard

    Kirsty Minton
    24 Apr 2012 | 7:00 pm
    Dendritic cells: Changing of the guard Nature Reviews Immunology 12, 323 (2012). doi:10.1038/nri3223 Author: Kirsty Minton Immunostimulatory conventional dendritic cells can differentiate into immunosuppressive macrophage-like cells.

  • Reducing variability in flow cytometry

    Holden T. Maecker
    24 Apr 2012 | 7:00 pm
    Reducing variability in flow cytometry Nature Reviews Immunology 12, 396 (2012). doi:10.1038/nri3158-c2 Authors: Holden T. Maecker, J. Philip McCoy & Robert Nussenblatt In regard to our recent Review (Standardizing immunophenotyping for the Human Immunology Project. Nature Rev. Immunol.12, 191–200 (2012)), we appreciate the comments by Jordi Petriz and colleagues (Subjectivity and flow cytometric variability.

  • Multipotent mesenchymal stromal cells and the innate immune system

    Katarina Le Blanc
    24 Apr 2012 | 7:00 pm
    Multipotent mesenchymal stromal cells and the innate immune system Nature Reviews Immunology 12, 383 (2012). doi:10.1038/nri3209 Authors: Katarina Le Blanc & Dimitrios Mougiakakos Multipotent mesenchymal stromal cells (MSCs) have unique immunoregulatory and regenerative properties that make them an attractive tool for the cellular treatment of autoimmunity and inflammation. Their underlying molecular mechanisms of action together with their clinical benefit — for example, in autoimmunity — are being revealed

  • Subjectivity and flow cytometric variability

    Gisela Pachón
    24 Apr 2012 | 7:00 pm
    Subjectivity and flow cytometric variability Nature Reviews Immunology 12, 396 (2012). doi:10.1038/nri3158-c1 Authors: Gisela Pachón, Isabel Caragol & Jordi Petriz We read the Review article by Holden T. Maecker and colleagues (Standardizing immunophenotyping for the Human Immunology Project. Nature Rev. Immunol.12, 191–200 (2012)) with great interest. Over the years, scientists have built up expertise
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Environmental microbiology: Dinner for two

    Andrew Jermy
    15 May 2012 | 7:00 pm
    Environmental microbiology: Dinner for two Nature Reviews Microbiology 10, 377 (2012). doi:10.1038/nrmicro2807 Author: Andrew Jermy Bacteriophages and predatory bacteria that target the same bacterial prey species had been assumed to compete with each other for infection of an individual cell. However, in a microcosm experiment in which the prey bacterium, Vibrio vulnificus, was incubated with both bacteriophage CK-2 and

  • Techniques and applications: Sequencing platforms put to the test

    Andrew Jermy
    15 May 2012 | 7:00 pm
    Techniques and applications: Sequencing platforms put to the test Nature Reviews Microbiology 10, 376 (2012). doi:10.1038/nrmicro2810 Author: Andrew Jermy In the past couple of years, sequencing technologies have changed at a rapid pace, and there are now three bench-top high-throughput sequencing platforms that are capable of sequencing bacterial genomes in just a few days. Loman et al. compared the performance of the 454

  • Biofilms: Disassembly instructions included

    Andrew Jermy
    15 May 2012 | 7:00 pm
    Biofilms: Disassembly instructions included Nature Reviews Microbiology 10, 376 (2012). doi:10.1038/nrmicro2808 Author: Andrew Jermy When nutrients become scarce, biofilms are disassembled, allowing the bacterial inhabitants to move on in search of a new home. It was recently shown that during biofilm disassembly Bacillus subtilis cells produce a mixture of D-amino acids, and their incorporation into cell wall

  • Fungal pathogenesis: Pact of the titans

    Andrew Jermy
    15 May 2012 | 7:00 pm
    Fungal pathogenesis: Pact of the titans Nature Reviews Microbiology 10, 376 (2012). doi:10.1038/nrmicro2809 Author: Andrew Jermy Infection with the human fungal pathogen Cryptococcus neoformans typically begins with the inhalation of spores into the lungs, where a pulmonary infection is established before fungal cells escape from the lungs and disseminate throughout the body. Exposure to the lung environment can trigger a

  • 35 years of resistance

    15 May 2012 | 7:00 pm
    35 years of resistance Nature Reviews Microbiology 10, 373 (2012). doi:10.1038/nrmicro2813 The misuse of antibiotics is not only a medical problem, but also a major agricultural one. The US Food and Drug Administration has recently shifted its focus to voluntary oversight.
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Signalling: Stop refilling (Ca2+ stores)

    Kim Baumann
    22 Apr 2012 | 7:00 pm
    Signalling: Stop refilling (Ca2+ stores) Nature Reviews Molecular Cell Biology 13, 277 (2012). doi:10.1038/nrm3343 Author: Kim Baumann SARAF inactivates store-operated Ca2+ entry and prevents excessive ER Ca2+ refill.

  • Technique: Live imaging of sugars

    Rachel David
    22 Apr 2012 | 7:00 pm
    Technique: Live imaging of sugars Nature Reviews Molecular Cell Biology 13, 281 (2012). doi:10.1038/nrm3345 Author: Rachel David Despite advances in imaging, visualizing non-genetically encoded molecules such as glycans has been challenging. Attreed et al. have developed a technique that allows the visualization of the complex modification patterns of heparan sulphates — polysaccharides that interact with and modify the function of many

  • Development: Musical chairs at the epithelium

    Maria Papatriantafyllou
    22 Apr 2012 | 7:00 pm
    Development: Musical chairs at the epithelium Nature Reviews Molecular Cell Biology 13, 279 (2012). doi:10.1038/nrm3344 Author: Maria Papatriantafyllou Epithelium maintenance through overcrowding-induced extrusion of live cells.

  • Stem cells: Holding tight onto the niche

    Kim Baumann
    22 Apr 2012 | 7:00 pm
    Stem cells: Holding tight onto the niche Nature Reviews Molecular Cell Biology 13, 278 (2012). doi:10.1038/nrm3342 Author: Kim Baumann ID and RAP1 activities maintain anchorage of the neural stem cells to their niche.

  • DNA repair: How chromosomes find their 'soul mate'

    Rachel David
    22 Apr 2012 | 7:00 pm
    DNA repair: How chromosomes find their 'soul mate' Nature Reviews Molecular Cell Biology 13, 281 (2012). doi:10.1038/nrm3346 Author: Rachel David In eukaryotes, DNA damage is frequently repaired by homologous recombination. In this study the authors asked whether there are any changes in chromosome dynamics that facilitate the search for a homologous sequence, using budding yeast as a model. They showed that induction of a DNA
 
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    Nature Reviews Cardiology - AOP - nature.com science feeds

  • Cardiac resuscitation: Epinephrine to treat cardiac arrest—a double-edged sword

    Hans-Richard Arntz
    14 May 2012 | 7:00 pm
    Cardiac resuscitation: Epinephrine to treat cardiac arrest—a double-edged sword Nature Reviews Cardiology. doi:10.1038/nrcardio.2012.71 Authors: Hans-Richard Arntz & Jan Breckwoldt Randomized studies and evaluations of large registries have repeatedly shown that epinephrine used as a standard vasopressor for cardiopulmonary resuscitation increases the rate of return of spontaneous circulation. By contrast, epinephrine might decrease long-term survival and impair neurological outcome.

  • Risk factors: Is measurement of change in cIMT useful?

    Bryony M. Mearns
    14 May 2012 | 7:00 pm
    Risk factors: Is measurement of change in cIMT useful? Nature Reviews Cardiology. doi:10.1038/nrcardio.2012.73 Author: Bryony M. Mearns

  • Acute coronary syndromes: A BRIDGE-ACS over troubled water

    Antonio P. Mansur
    14 May 2012 | 7:00 pm
    Acute coronary syndromes: A BRIDGE-ACS over troubled water Nature Reviews Cardiology. doi:10.1038/nrcardio.2012.70 Authors: Antonio P. Mansur & José Antonio F. Ramires The BRIDGE-ACS study showed benefits of a quality improvement initiative in adherence to evidence-based therapy for acute coronary syndromes at public hospitals in Brazil. No mortality benefit was observed, but this finding might have been different if all effective therapies for in-hospital treatment of myocardial infarction were included.

  • Device therapy: Clinical sequelae of cardiac device-related endocarditis

    Alexandra King
    14 May 2012 | 7:00 pm
    Device therapy: Clinical sequelae of cardiac device-related endocarditis Nature Reviews Cardiology. doi:10.1038/nrcardio.2012.72 Author: Alexandra King

  • Anticoagulation during pregnancy in patients with a prosthetic heart valve

    Jose M. Castellano
    14 May 2012 | 7:00 pm
    Anticoagulation during pregnancy in patients with a prosthetic heart valve Nature Reviews Cardiology. doi:10.1038/nrcardio.2012.69 Authors: Jose M. Castellano, Rajeev L. Narayan, Prashant Vaishnava & Valentin Fuster
 
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    Nature Reviews Gastroenterology and Hepatology - Issue - nature.com science feeds

  • Liver transplantation: Left lobe living donor liver transplantation could improve donor outcomes

    Claire Greenhill
    23 Apr 2012 | 7:00 pm
    Liver transplantation: Left lobe living donor liver transplantation could improve donor outcomes Nature Reviews Gastroenterology & Hepatology 9, 241 (2012). doi:10.1038/nrgastro.2012.75 Author: Claire Greenhill The findings of two recent studies suggest that left lobe living donor liver transplantation (LDLT) could reduce the risk of death and complications in the donor, while maintaining good outcomes for the recipient. Liver transplants in adults usually involve the right lobe being taken from

  • Motility: Role for ghrelin in preventing levodopa-induced inhibition of gastric emptying in patients with Parkinson disease?

    16 Apr 2012 | 7:00 pm
    Motility: Role for ghrelin in preventing levodopa-induced inhibition of gastric emptying in patients with Parkinson disease? Nature Reviews Gastroenterology & Hepatology 9, 245 (2012). doi:10.1038/nrgastro.2012.72 Patients with Parkinson disease are frequently treated with levodopa (L-dopa), but L-dopa delays gastric emptying, which lessens its absorption. In fasted rats, Wang et al. have shown that intravenous ghrelin can counteract the inhibition of gastric emptying by L-dopa

  • Dyspepsia: No association between dyspepsia and increased mortality in the community

    16 Apr 2012 | 7:00 pm
    Dyspepsia: No association between dyspepsia and increased mortality in the community Nature Reviews Gastroenterology & Hepatology 9, 245 (2012). doi:10.1038/nrgastro.2012.78 Multivariate analysis of the data from a longitudinal 10-year follow-up study by Ford et al. shows that the likelihood of death in individuals with dyspepsia is not significantly different from the likelihood of death in individuals who do not have dyspepsia. The authors

  • Esophagus: Biodegradable stents deliver good dysphagia relief in patients with esophageal strictures

    16 Apr 2012 | 7:00 pm
    Esophagus: Biodegradable stents deliver good dysphagia relief in patients with esophageal strictures Nature Reviews Gastroenterology & Hepatology 9, 245 (2012). doi:10.1038/nrgastro.2012.71 Griffiths et al. attempted to place 25 biodegradable stents in 23 patients identified from a prospective interventional radiological database. The technical success rate was 96% and the clinical success rate was 76%. The authors suggest using such stents might help avoid the need

  • Imaging: Differentiation of colorectal lesions

    Andy McLarnon
    16 Apr 2012 | 7:00 pm
    Imaging: Differentiation of colorectal lesions Nature Reviews Gastroenterology & Hepatology 9, 246 (2012). doi:10.1038/nrgastro.2012.68 Author: Andy McLarnon The accuracy and feasibility of novel endoscopic techniques must be shown to be adequate before they can be adopted into clinical practice. Teaco Kuiper and colleagues from Amsterdam, The Netherlands, compared probe-based confocal laser endomicroscopy (pCLE) with narrow-band imaging (NBI) and chromoendoscopy for the differentiation
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    Nature Reviews Gastroenterology and Hepatology - AOP

  • Colonoscopy: Reducing faecal incontinence following colonoscopy

    Felix W. Leung
    14 May 2012 | 7:00 pm
    Colonoscopy: Reducing faecal incontinence following colonoscopy Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2012.93 Author: Felix W. Leung Faecal incontinence can occur in patients who have undergone a colonoscopy. The incidence of postexamination faecal incontinence in a large Norwegian cohort has now been reported, and the risk of faecal incontinence found to be reduced if CO2 is used instead of air to insufflate the colon.

  • Pancreatic cancer: USP9X can be used to predict pancreatic cancer outcomes

    Claire Greenhill
    14 May 2012 | 7:00 pm
    Pancreatic cancer: USP9X can be used to predict pancreatic cancer outcomes Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2012.92 Author: Claire Greenhill

  • Coeliac disease: Lack of consensus regarding definitions of coeliac disease

    Markku Mäki
    14 May 2012 | 7:00 pm
    Coeliac disease: Lack of consensus regarding definitions of coeliac disease Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2012.91 Author: Markku Mäki A lack of consensus exists on definitions of coeliac disease and related disorders. A paper published in Gut provides guidance to the scientific and clinical community on the terms to be used. However, new nomenclature and different classifications have been proposed in two other publications. Is there a way out of the confusion?

  • Contributions of the microbial hydrogen economy to colonic homeostasis

    Franck Carbonero
    14 May 2012 | 7:00 pm
    Contributions of the microbial hydrogen economy to colonic homeostasis Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2012.85 Authors: Franck Carbonero, Ann C. Benefiel & H. Rex Gaskins

  • IBD: Optimizing vaccination strategies against HBV in patients with IBD

    Isobel Franks
    14 May 2012 | 7:00 pm
    IBD: Optimizing vaccination strategies against HBV in patients with IBD Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2012.94 Author: Isobel Franks
 
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    Nature Reviews Rheumatology - Issue - nature.com science feeds

  • Rheumatoid arthritis: Add-on treatment after methotrexate failure in early RA—the debate continues

    Katrina Ray
    1 May 2012 | 7:00 pm
    Rheumatoid arthritis: Add-on treatment after methotrexate failure in early RA—the debate continues Nature Reviews Rheumatology 8, 245 (2012). doi:10.1038/nrrheum.2012.57 Author: Katrina Ray In the treatment of early rheumatoid arthritis (RA), methotrexate is generally considered to be the initial drug of choice. But how to proceed when patients do not respond to methotrexate monotherapy is less clear. Now, updated findings from the multicenter Swedish pharmacotherapy (Swefot) trial, published

  • Osteoarthritis: New knee raises pain threshold

    Emma Leah
    1 May 2012 | 7:00 pm
    Osteoarthritis: New knee raises pain threshold Nature Reviews Rheumatology 8, 246 (2012). doi:10.1038/nrrheum.2012.51 Author: Emma Leah Patients with symptomatic knee osteoarthritis (OA) are more sensitive to various pain stimuli, new data confirm, but the good news is that joint replacement can normalize the pain response. The study, by Thomas Graven-Nielsen and colleagues, published in Arthritis & Rheumatism, provides new insight

  • Spondyloarthritis: Is methotrexate effective in psoriatic arthritis?

    Philip J. Mease
    1 May 2012 | 7:00 pm
    Spondyloarthritis: Is methotrexate effective in psoriatic arthritis? Nature Reviews Rheumatology 8, 251 (2012). doi:10.1038/nrrheum.2012.56 Author: Philip J. Mease Although methotrexate is the most widely used medication for psoriatic arthritis (PsA), evidence for its effectiveness is scant. The recent MIPA trial failed to show disease-modifying effects. Was this outcome due to true inefficacy, or to trial issues? Data on symptom-modulating and disease-modifying effects of methotrexate in PsA are explored.

  • The transition of acute to chronic bowel inflammation in spondyloarthritis

    Liesbet Van Praet
    16 Apr 2012 | 7:00 pm
    The transition of acute to chronic bowel inflammation in spondyloarthritis Nature Reviews Rheumatology 8, 288 (2012). doi:10.1038/nrrheum.2012.42 Authors: Liesbet Van Praet, Peggy Jacques, Filip Van den Bosch & Dirk Elewaut That gut and joint inflammation are linked in spondyloarthritis (SpA) has been recognized for almost three decades. Intriguingly, microscopic gut inflammation, which occurs frequently in patients with SpA, is an important risk factor for clinically overt Crohn's disease and ankylosing spondylitis. This Review describes current

  • Spondyloarthritis: Evidence from animal studies supports the 'entheseal stress' hypothesis of ankylosing spondylitis

    Sarah Onuora
    9 Apr 2012 | 7:00 pm
    Spondyloarthritis: Evidence from animal studies supports the 'entheseal stress' hypothesis of ankylosing spondylitis Nature Reviews Rheumatology 8, 248 (2012). doi:10.1038/nrrheum.2012.52 Author: Sarah Onuora The results of experiments carried out in mice could provide new insight into the relationship between inflammation and ankylosis in spondyloarthritis (SpA). In a model of spontaneous arthritis, treatment with glucocorticoids inhibited inflammation but did not halt the formation of new bone that leads to
 
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    Nature Reviews Urology - Issue - nature.com science feeds

  • Prostatitis: Insights into chronic pelvic pain

    Annette Fenner
    23 Apr 2012 | 7:00 pm
    Prostatitis: Insights into chronic pelvic pain Nature Reviews Urology 9, 239 (2012). doi:10.1038/nrurol.2012.81 Author: Annette Fenner Two studies in the Scandinavian Journal of Urology and Nephrology have sought to improve our understanding of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).CP/CPPS is often associated with a severe reduction in quality of life, with patients reporting persistent and relapsing pain, irritative urinary

  • Prostate cancer: Bone Scan Index made easy, at last

    Bertrand Tombal
    23 Apr 2012 | 7:00 pm
    Prostate cancer: Bone Scan Index made easy, at last Nature Reviews Urology 9, 245 (2012). doi:10.1038/nrurol.2012.79 Author: Bertrand Tombal The Bone Scan Index (BSI) is a methodology used to quantify bone metastases and monitor changes under treatment. However, BSI is manually calculated and is, therefore, tedious and time-consuming to use, so it is not routinely implemented. A new automated platform to calculate BSI should help to increase its use.

  • Prostate cancer: New light shed on the anticancer effects of zoledronic acid

    Melanie Clyne
    23 Apr 2012 | 7:00 pm
    Prostate cancer: New light shed on the anticancer effects of zoledronic acid Nature Reviews Urology 9, 235 (2012). doi:10.1038/nrurol.2012.70 Author: Melanie Clyne According to new research published in Prostate Cancer and Prostatic Diseases, zoledronic acid—an osteoclast-targeting bisphosphonate that prevents loss of bone mass—directly inhibits prostate cancer proliferation and motility, without disrupting interactions between the tumor and the vascular wall.Previous preclinical studies have reported anticancer activities

  • Prostate cancer: One step closer to personalized therapy with cell capturing

    Mina Razzak
    23 Apr 2012 | 7:00 pm
    Prostate cancer: One step closer to personalized therapy with cell capturing Nature Reviews Urology 9, 236 (2012). doi:10.1038/nrurol.2012.80 Author: Mina Razzak A major challenge in treating metastatic prostate cancer is that secondary tumors, and the circulating cells that seed them, are fundamentally different to the primary lesion from which they are thought to originate. In the current era of intense research into personalized therapy, understanding the

  • Bladder cancer: LASP-1—a promising urine marker for detection of bladder cancer

    Sarah Payton
    23 Apr 2012 | 7:00 pm
    Bladder cancer: LASP-1—a promising urine marker for detection of bladder cancer Nature Reviews Urology 9, 240 (2012). doi:10.1038/nrurol.2012.84 Author: Sarah Payton LASP-1 (LIM and SH3 domain protein 1) is a focal adhesion protein that has previously been linked to cancers of the colon, ovary and breast. Now, in a study published in Urologic Oncology, a research team led by Peter Ardelt at the University of
 
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    Naturejobs - Search results

  • Medical Writer - Permanent Job

    29 May 2012 | 11:00 pm
    We have changed the way in which you can search through our database of jobs and have also updated our RSS feeds. You should still see relevant jobs in your RSS feed as before; but it's worth checking Yoh has a direct hire opportunity for a Medical Writer to join our client in Princeton, NJ.Job Overview: The Medical Writer participates as a member of clinical teams and serves as team specialist in matters pertaining to clinical documentation. The medical writer leads the documentation proce...

  • Senior Research Associate Job

    29 May 2012 | 11:00 pm
    We have changed the way in which you can search through our database of jobs and have also updated our RSS feeds. You should still see relevant jobs in your RSS feed as before; but it's worth checking Yoh has a contract opportunity for Senior Research Associate to join our client in Fremont, CA.Job Responsibilities: - Design and execute various cell-, protein- and bead-based assays applying flow cytometry, optical/fluorescence microscopy/spectroscopy and biochemical methods to support produc...

  • Clinical Trial Assistant Job

    29 May 2012 | 11:00 pm
    We have changed the way in which you can search through our database of jobs and have also updated our RSS feeds. You should still see relevant jobs in your RSS feed as before; but it's worth checking Yoh has a (6) month contract opening for a Clinical Trial Assistant in the East Hanover, NJ area.Company Overview: Our customer is dedicated to making a major positive impact on the lives of people with serious diseases by enhancing the quality of life.Job Responsibilities: - Assist in the comp...

  • Assistant Chemist Job

    29 May 2012 | 11:00 pm
    We have changed the way in which you can search through our database of jobs and have also updated our RSS feeds. You should still see relevant jobs in your RSS feed as before; but it's worth checking Yoh has a contract opportunity for an Assistant Chemist to join our client in Carlsbad, CA. This temporary / contract position is for approximately 12 months.Job Responsibilities: - The assistant chemist performs analyses and sample preparation of chemical samples for ultra-trace impurities to ...

  • Regulatory Affairs Specialist - Submissions Job

    29 May 2012 | 11:00 pm
    We have changed the way in which you can search through our database of jobs and have also updated our RSS feeds. You should still see relevant jobs in your RSS feed as before; but it's worth checking Yoh has a contract opportunity for a Regulatory Affairs Specialist - Submissions to join our client in Lexington, MA.Job Overview: Works on special projects related to archival of regulatory submissions and correspondence. May provide support for administrative aspects of submission preparation...
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    NatureJobs

  • More US success

    8 May 2012 | 7:00 pm
    More US success NatureJobs 485, 270 (2012). doi:10.1038/nj7397-270c Technology-transfer model best for inventors who need commercialization support.

  • Mobility boost

    8 May 2012 | 7:00 pm
    Mobility boost NatureJobs 485, 270 (2012). doi:10.1038/nj7397-270a European student group calls for funding to support mobility.

  • Best practice

    8 May 2012 | 7:00 pm
    Best practice NatureJobs 485, 270 (2012). doi:10.1038/nj7397-270b Agreement to improve UK research careers yields some positives.

  • Enterprising science

    Peter Fiske
    8 May 2012 | 7:00 pm
    Enterprising science NatureJobs 485, 269 (2012). doi:10.1038/nj7397-269a Author: Peter Fiske Graduate students and postdocs are often best placed to turn basic research into entrepreneurial gold, argues Peter Fiske.
 
 
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    British Journal of Pharmacology

  • Sexual dimorphism in rodent models of hypertension and atherosclerosis

    Kristen J Bubb, Rayomand S Khambata, Amrita Ahluwalia
    15 May 2012 | 3:00 am
    AbstractApproximately one third of all deaths are attributed to cardiovascular disease (CVD), making it the biggest killer worldwide. Despite a number of therapeutic options available, the burden of CVD morbidity continues to grow indicating the need for continued research to address this unmet need. In this respect investigation of the mechanisms underlying the protection that pre-menopausal females enjoy from cardiovascular-related disease and mortality is of interest. In this review we discuss the essential role that rodent animal models play in enabling this field of research. In…

  • Response to ‘When biostatisticis is a neo-inductionist barrier to science’

    Gordon B. Drummond, Sarah L. Vowler
    15 May 2012 | 3:00 am
    AbstractWe can understand some of the sentiments expressed by Dr Ashton, and agree that classical statistics considered in the early perspectives in the series are indeed inappropriate for some laboratory experiments. Our defence is that we addressed first the topics we believed were known to our readers, those that are still widely used and mis-used by scientists. Later perspectives introduce more relevant materials.© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society

  • When biostatisticis is a neo-inductionist barrier to science

    John C Ashton
    15 May 2012 | 1:57 am
    AbstractRecent editorials have presented the case for scientific reform on biostatistical principles. But rather than science lagging behind statistics, statistics continually fails to engage with scientific experimentation as an iterative and indeterminate discovery process. For biostatistics to reform scientific reporting, it will require advances in biostatistics that engage with science as it is, rather than as inductionist philosophy imagines it to be.© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society

  • Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms

    O Burk, R Piedade, L Ghebreghiorghis, J T Fait, A K Nussler, J P Gil, B Windshügel, M Schwab
    11 May 2012 | 7:25 am
    SummaryBackground and purpose: Wide-spread drug resistance requires combination therapies with an increasing risk for pharmacokinetic drug-drug interactions in treatment of malaria. We here explore the capacity of antimalarial drugs for induction of drug metabolism via activation of constitutive androstane receptor (CAR) by ligand binding.Experimental approach: A total of 21 selected antimalarials and 11 major metabolites were screened for ligand-binding to CAR isoforms using cellular and in vitro CAR-coactivator interaction assays, combined with in silico molecular docking. Identified…

  • Pharmacology of S1P3 ligands using the DiscoverRx PathHunterTM and Ca2+ release functional assays: Re-assessment of the pharmacology of VPC24191 and VPC23019.

    D M Riddy, C Stamp, D A Sykes, S J Charlton, M R Dowling
    11 May 2012 | 7:23 am
    SummaryBackground and purpose: DiscoverRx's PathHunterTM assay permits the assessment of G protein coupled receptor agonist potency, via the recruitment of β-arrestin, independent of the subtype of G activated. This assay is frequently incorporated into drug discovery flow-charts; however little investigation into agonist pharmacology has been performed. This study compares agonist potency, efficacy and affinity values obtained in this assay with those from more established radioligand binding and functional techniques.Experimental approach: Using cells expressing the human S1P3 receptor at…
 
 
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    The EMBO Journal - AOP - nature.com science feeds

  • Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation

    Chun-I Chen
    14 May 2012 | 7:00 pm
    Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation The EMBO Journal. doi:10.1038/emboj.2012.143 Authors: Chun-I Chen, Jeremy J Keusch, Dominique Klein, Daniel Hess, Jan Hofsteenge & Heinz Gut

  • miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling

    Kristin Franke
    14 May 2012 | 7:00 pm
    miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling The EMBO Journal. doi:10.1038/emboj.2012.130 Authors: Kristin Franke, Wolfgang Otto, Sascha Johannes, Jan Baumgart, Robert Nitsch & Stefan Schumacher

  • Innate immunity: regulation of caspases by IAP-dependent ubiquitylation

    Christina Falschlehner
    14 May 2012 | 7:00 pm
    Innate immunity: regulation of caspases by IAP-dependent ubiquitylation The EMBO Journal. doi:10.1038/emboj.2012.148 Authors: Christina Falschlehner & Michael Boutros Caspases are widely known as initiators and executioners of cell death. Full activation of caspases leading to cleavage of many cellular substrates was long considered to be a point-of-no-return in the apoptosis pathway. However, it also has been known that activated caspases do not always have the ability to kill, but instead initiate non-apoptotic processes such as cell differentiation or activation of innate immune…

  • A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis

    Ruth Simon
    14 May 2012 | 7:00 pm
    A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis The EMBO Journal. doi:10.1038/emboj.2012.142 Authors: Ruth Simon, Heike Brylka, Herbert Schwegler, Sathish Venkataramanappa, Jacqueline Andratschke, Christoph Wiegreffe, Pentao Liu, Elaine Fuchs, Nancy A Jenkins, Neal G Copeland, Carmen Birchmeier & Stefan Britsch

  • Intestinal stem cells: no longer immortal but ever so clever….

    Bruce A Edgar
    10 May 2012 | 7:00 pm
    Intestinal stem cells: no longer immortal but ever so clever…. The EMBO Journal. doi:10.1038/emboj.2012.133 Author: Bruce A Edgar EMBO J advance online publication 20 April 2012; doi:10.1038/emboj.2012.106To maintain tissue homeostasis, stem cells must balance self-renewal with differentiation. In some stem cell lineages this process is ‘hard-wired’ by the asymmetric partitioning of determinants at division, such that one stem cell daughter always remains pluripotent and other differentiates. But in a dynamic tissue like the intestinal epithelium, which might need to repair…
 
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    EMBO Reports

  • The changing hypothesis of the gut

    Philip Hunter
    14 May 2012 | 7:00 pm
    The changing hypothesis of the gut EMBO Reports. doi:10.1038/embor.2012.68 Author: Philip Hunter

  • Reply to J.N. Perry et al

    Brian Wynne
    14 May 2012 | 7:00 pm
    Reply to J.N. Perry et al EMBO Reports. doi:10.1038/embor.2012.71 Authors: Brian Wynne & Fern Wickson

  • The effects of artificial gender imbalance

    Therese Hesketh
    14 May 2012 | 7:00 pm
    The effects of artificial gender imbalance EMBO Reports. doi:10.1038/embor.2012.62 Authors: Therese Hesketh & Jiang Min Min

  • Response to “The anglerfish deception”

    Joe N Perry
    14 May 2012 | 7:00 pm
    Response to “The anglerfish deception” EMBO Reports. doi:10.1038/embor.2012.70 Authors: Joe N Perry, Salvatore Arpaia, Detlef Bartsch, Jozsef Kiss, Antoine Messéan, Marco Nuti, Jeremy B Sweet & Christoph C Tebbe

  • Molecular ecology in Vienna: hot topics in a chilly place

    Thomas Städler
    14 May 2012 | 7:00 pm
    Molecular ecology in Vienna: hot topics in a chilly place EMBO Reports. doi:10.1038/embor.2012.63 Author: Thomas Städler The international VIPCA conference on ‘Molecular Ecology’ took place in Vienna, Austria, in early February 2012. The meeting showcased the diversity of molecular tools and conceptual approaches at the disposal of practitioners in this flourishing field, which lies at the interface of ecology, evolution and molecular biology.
 
 
 
 
 
 
 
 
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    Neuropsychopharmacology - AOP - nature.com science feeds

  • Early Prefrontal Functional Blockade in Rats Results in Schizophrenia-Related Anomalies in Behavior and Dopamine

    Francisca Meyer
    15 May 2012 | 7:00 pm
    Early Prefrontal Functional Blockade in Rats Results in Schizophrenia-Related Anomalies in Behavior and Dopamine Neuropsychopharmacology advance online publication, May 16, 2012. doi:10.1038/npp.2012.74 Authors: Francisca Meyer & Alain Louilot Keywords: psychiatry & behavioral sciences; animal models; dopamine; development/developmental disorders; neonatal functional inactivation; prefrontal cortex; latent inhibition; D-amphetamine; nucleus accumbens

  • Alpha-1 Adrenergic Receptors are Localized on Presynaptic Elements in the Nucleus Accumbens and Regulate Mesolimbic Dopamine Transmission

    Darlene A Mitrano
    15 May 2012 | 7:00 pm
    Alpha-1 Adrenergic Receptors are Localized on Presynaptic Elements in the Nucleus Accumbens and Regulate Mesolimbic Dopamine Transmission Neuropsychopharmacology advance online publication, May 16, 2012. doi:10.1038/npp.2012.68 Authors: Darlene A Mitrano, Jason P Schroeder, Yoland Smith, James J Cortright, Nancy Bubula, Paul Vezina & David Weinshenker Keywords: addiction & substance abuse, psychostimulants, catecholamines, dopamine, norepinephrine, rat, morphine, adrenergic receptor, microdialysis

  • Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats

    Laura Piccoli
    8 May 2012 | 7:00 pm
    Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats Neuropsychopharmacology advance online publication, May 9, 2012. doi:10.1038/npp.2012.48 Authors: Laura Piccoli, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Vivian J A Costantini, Mario Massagrande, Dino Montanari, Prisca Martinelli, Marinella Antolini, Roberto Ciccocioppo, Maurizio Massi, Emilio Merlo-Pich, Romano Di Fabio & Mauro Corsi Keywords: animal models; eating/metabolic disorders; psychopharmacology; behavioral science; orexin-1 receptor antagonist; orexin-2…

  • Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making

    Naghmeh Shafiei
    8 May 2012 | 7:00 pm
    Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making Neuropsychopharmacology advance online publication, May 9, 2012. doi:10.1038/npp.2012.69 Authors: Naghmeh Shafiei, Megan Gray, Victor Viau & Stan B Floresco Keywords: animal models; mood; anxiety; stress disorders; cognition; dopamine; restraint stress; decision making; delay discounting; corticosterone; rats

  • N-Acetylcysteine Normalizes Glutamate Levels in Cocaine-Dependent Patients: A Randomized Crossover Magnetic Resonance Spectroscopy Study

    Lianne Schmaal
    1 May 2012 | 7:00 pm
    N-Acetylcysteine Normalizes Glutamate Levels in Cocaine-Dependent Patients: A Randomized Crossover Magnetic Resonance Spectroscopy Study Neuropsychopharmacology advance online publication, May 2, 2012. doi:10.1038/npp.2012.66 Authors: Lianne Schmaal, Dick J Veltman, Aart Nederveen, Wim van den Brink & Anna E Goudriaan Keywords: cocaine dependence; N-acetylcysteine; glutamate; magnetic resonance spectroscopy; impulsivity
 
 
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    Cell Migration Gateway - Update - nature.com science feeds

  • Other CMC Publications

    Nikki Watson
    30 Apr 2012 | 7:00 pm
    Other CMC Publications Cell Migration Gateway (2012). http://www.cellmigration.org/cmcnews/cmcnews12.shtml#may12c Author: Nikki Watson Kim J, Sherman NE, Fox JW, Ginsberg MH. Phosphorylation sites in the cerebral cavernous malformations complex. J Cell Sci 2012; 124 (Pt 23):3929-32. Welf ES, Haugh JM. Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics. Methods Cell Biol 2012; 110:223-41.

  • Kinase sensors demonstrate their power to shine

    Nikki Watson
    30 Apr 2012 | 7:00 pm
    Kinase sensors demonstrate their power to shine Cell Migration Gateway (2012). http://www.cellmigration.org/cmcnews/cmcnews12.shtml#may12a Author: Nikki Watson Currently available techniques for assessing the activities of protein kinases in biological samples rely on the use of indirect proxies for catalytic activity in antibody- or mass spectrometry-based approaches, so the development of sensors that can report directly on enzymatic activity would be highly advantageous. Barbara Imperiali’s group recently extended a strategy based on chelation-enhanced fluorescence to monitor kinase…

  • Cells need Arp2/3 to remain en route from A to B

    Katrin Legg
    30 Apr 2012 | 7:00 pm
    Cells need Arp2/3 to remain en route from A to B Cell Migration Gateway (2012). http://www.cellmigration.org/cmg_update/2012/120501/full/cmg157.shtml Author: Katrin Legg A deficiency in ARPC3 reveals a requirement for the Arp2/3 complex in the generation of lamellipodia and in fibroblast persistent directional migration.

  • Cells change tack through branch-and-pivot mechanism

    Nikki Watson
    30 Apr 2012 | 7:00 pm
    Cells change tack through branch-and-pivot mechanism Cell Migration Gateway (2012). http://www.cellmigration.org/cmcnews/cmcnews12.shtml#may12b Author: Nikki Watson During random migration, fibroblasts and other mesenchymal cells move slowly and show relatively long-lived directionality, with changes in orientation being induced by stochastic turning behavior. In The Journal of Cell Biology, Welf et al. outline a mechanism for reorientation that is mediated by phosphoinositide 3-kinase (PI3K)-dependent branching and pivoting of lamellipodial protrusions. The authors used a fluorescent…

  • Upcoming Conferences & Workshops

    Nikki Watson
    30 Apr 2012 | 7:00 pm
    Upcoming Conferences & Workshops Cell Migration Gateway (2012). http://www.cellmigration.org/cmcnews/cmcnews12.shtml#may12d Author: Nikki Watson Gordon Research Conferences: Signaling by Adhesion Receptors June 24 - 29, 2012 Maine, USA: For more details and to register, visit the meeting web site at http://www.grc.org/programs.aspx?year=2012&program=signadhe 7th Abercrombie Meeting June 25 - 27, 2012 Oxford, UK: The 7th Abercrombie meeting "Multi-dimensional cell migration in development and disease” will be held at St Catherine’s College, Oxford from 24th-27thJune 2012. For…
 
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    Lipidomics Gateway - Update - nature.com science feeds

  • Vitamin K

    Katrin Legg
    24 Apr 2012 | 7:00 pm
    Vitamin K Lipidomics Gateway (2012). doi:10.1038/lipidmaps.2012.10 Author: Katrin Legg An essential cofactor for the carboxylation of glutamic acid residues in several proteins, vitamin K is most renowned for its role in blood clotting but is gaining recognition for its involvement in other cellular processes such as apoptosis and signal transduction.

  • Diabetes-accelerated atherosclerosis: Myeloid ACSL1 is a key perpetrator

    Katrin Legg
    24 Apr 2012 | 7:00 pm
    Diabetes-accelerated atherosclerosis: Myeloid ACSL1 is a key perpetrator Lipidomics Gateway (2012). doi:10.1038/lipidmaps.2012.11 Author: Katrin Legg Myeloid-specific deficiency of ACSL1, which promotes the production of the lipid-derived inflammatory mediator PGE2 and inflammatory cytokines, prevents diabetes-accelerated atherosclerosis.

  • Type 2 diabetes: Fatty acids deliver double whammy

    Katrin Legg
    24 Apr 2012 | 7:00 pm
    Type 2 diabetes: Fatty acids deliver double whammy Lipidomics Gateway (2012). doi:10.1038/lipidmaps.2012.12 Author: Katrin Legg In response to increased palmitate levels, β cells secrete chemokines, thereby promoting macrophage recruitment, inflammation and subsequent dysfunction.

  • Lipids: Monoclonal antibody therapy lowers LDL-cholesterol levels

    Ellen F. Carney
    9 Apr 2012 | 7:00 pm
    Lipids: Monoclonal antibody therapy lowers LDL-cholesterol levels Nature Reviews Cardiology , (2012). doi:10.1038/nrcardio.2012.55 Author: Ellen F. Carney

  • Apoptosis: Sphingolipid cofactors

    Amy Donner
    16 Apr 2012 | 7:00 pm
    Apoptosis: Sphingolipid cofactors Nature Chemical Biology 8, 410 (2012). doi:10.1038/nchembio.945 Author: Amy Donner
 
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    PSI-Nature Structural Biology Knowledgebase

  • Methyl maintenance

    Michael A. Durney
    18 Apr 2012 | 7:00 pm
    Methyl maintenance PSI-Nature Structural Biology Knowledgebase (2012). doi:10.1038/sbkb.2011.76 Author: Michael A. Durney A structure of a DNA methyltransferase complex highlights how autoinhibitory and active mechanisms ensure substrate selectivity.

  • A Pseudomonas L-Serine dehydrogenase

    Natalie De Souza
    18 Apr 2012 | 7:00 pm
    A Pseudomonas L-serine dehydrogenase PSI-Nature Structural Biology Knowledgebase (2012). doi:10.1038/sbkb.2011.77 Author: Natalie De Souza Structural studies of an uncharacterized Pseudomonas aeruginosa enzyme reveal a dehydrogenase with a substrate preference for L-serine.

  • A glimpse at toxicity

    Michelle Montoya
    3 Apr 2012 | 7:00 pm
    A glimpse at toxicity Nature Structural & Molecular Biology 19, 369 (2012). doi:10.1038/nsmb.2280 Author: Michelle Montoya A crystallographic study provides a structural model for toxic amyloid oligomers.

  • Bacterial secretion: Highly sprung secretion

    Andrew Jermy
    15 Mar 2012 | 7:00 pm
    Bacterial secretion: Highly sprung secretion Nature Reviews Microbiology 10, 238 (2012). doi:10.1038/nrmicro2775 Author: Andrew Jermy Cryo-electron tomography reveals the contractile sheath structure of a T6SS.

  • EM for the (small) masses

    Michelle Montoya
    18 Apr 2012 | 7:00 pm
    EM for the (small) masses PSI-Nature Structural Biology Knowledgebase (2012). doi:10.1038/sbkb.2011.78 Author: Michelle Montoya A new strategy using Fabs allows visualization of small protein molecules by cryoEM.
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