Nature.com

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  • Scientists find protein that unites cell and egg

    NatureNews - Most recent articles - nature.com science feeds
    Erika Check Hayden
    15 Apr 2014 | 5:00 pm
    Newly discovered molecule plays crucial role in conception.Nature News doi: 10.1038/nature.2014.15058
  • Reproductive biology: Sperm protein finds its mate

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    Paul M. Wassarman
    15 Apr 2014 | 5:00 pm
    Nature advance online publication 16 April 2014. doi:10.1038/nature13227 Author: Paul M. Wassarman Knowledge of the sperm-specific protein that is required for the attachment of sperm to eggs during fertilization in mammals has led to the identification of the protein's receptor on the egg's plasma membrane.
  • Alzheimer disease: Comparable brain levels of amyloid-β and tau in asymptomatic AD and mild cognitive impairment

    Nature Reviews Neurology - Issue - nature.com science feeds
    24 Mar 2014 | 5:00 pm
    Nature Reviews Neurology 10, 181 (2014). doi:10.1038/nrneurol.2014.52 Asymptomatic Alzheimer disease (AD) is the diagnosis given to people with clear AD pathology at autopsy despite typical cognitive function in life. Iacono et al. compared levels of amyloid-β and phosphorylated tau in brain slices from recently deceased patients with asymptomatic AD or
  • Huntington disease: Possible cellular mechanism for striatal degeneration in Huntington disease

    Nature Reviews Neurology - Issue - nature.com science feeds
    24 Mar 2014 | 5:00 pm
    Nature Reviews Neurology 10, 182 (2014). doi:10.1038/nrneurol.2014.56 Huntington disease (HD) is associated with progressive degeneration of the striatum, but the cause of this cell death is unclear. Leitman and colleagues examined cultures of normal murine striatal cells, and similar cells that expressed the polyglutamine-expanded form of the huntingtin protein. Striatal cells were
  • Inflammatory syndrome ADA2 deficiency

    Nature Genetics - Issue - nature.com science feeds
    Kyle Vogan
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 325 (2014). doi:10.1038/ng.2943 Author: Kyle Vogan
 
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  • Seven days: 11–17 April 2014

    15 Apr 2014 | 5:00 pm
    Seven days: 11–17 April 2014 Nature 508, 7496 (2014). http://www.nature.com/doifinder/10.1038/508292a The week in science: Japan reapproves use of nuclear power, second sighting of an exotic tetraquark, and biotech stocks plunge.
  • Materials: Printer squirts out nanotubes

    15 Apr 2014 | 5:00 pm
    Materials: Printer squirts out nanotubes Nature 508, 7496 (2014). doi:10.1038/508291c Inkjet printers can produce thin films of carbon nanotubes for use as electrodes in stretchy electronic circuits.Yongtaek Hong and his colleagues at Seoul National University printed layers of single-walled carbon nanotubes onto a stretchable silicon-based material. The authors found that the electrical properties of
  • Cancer crossroads

    15 Apr 2014 | 5:00 pm
    Cancer crossroads Nature 508, 7496 (2014). doi:10.1038/508287b Efforts to understand cancer genomes should take on a fresh focus.
  • Civil engineering: Seismic 'shield' stops quake shake

    15 Apr 2014 | 5:00 pm
    Civil engineering: Seismic 'shield' stops quake shake Nature 508, 7496 (2014). doi:10.1038/508291a An array of deep holes in the ground seems to lessen shaking in certain locations during a simulated earthquake.Stéphane Brûlé of soil-engineering company Ménard in Nozay, France, and his colleagues drilled a grid of boreholes 5 metres deep into the soil near Grenoble. A
  • Practical nonsense

    15 Apr 2014 | 5:00 pm
    Practical nonsense Nature 508, 7496 (2014). doi:10.1038/508288a Downgrading practical science will impede UK students in the global workplace
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  • Sea-level and deep-sea-temperature variability over the past 5.3 million years

    E. J. Rohling
    15 Apr 2014 | 5:00 pm
    Nature advance online publication 16 April 2014. doi:10.1038/nature13230 Authors: E. J. Rohling, G. L. Foster, K. M. Grant, G. Marino, A. P. Roberts, M. E. Tamisiea & F. Williams
  • Reproductive biology: Sperm protein finds its mate

    Paul M. Wassarman
    15 Apr 2014 | 5:00 pm
    Nature advance online publication 16 April 2014. doi:10.1038/nature13227 Author: Paul M. Wassarman Knowledge of the sperm-specific protein that is required for the attachment of sperm to eggs during fertilization in mammals has led to the identification of the protein's receptor on the egg's plasma membrane.
  • Coordination of entorhinal–hippocampal ensemble activity during associative learning

    Kei M. Igarashi
    15 Apr 2014 | 5:00 pm
    Nature advance online publication 16 April 2014. doi:10.1038/nature13162 Authors: Kei M. Igarashi, Li Lu, Laura L. Colgin, May-Britt Moser & Edvard I. Moser Accumulating evidence points to cortical oscillations as a mechanism for mediating interactions among functionally specialized neurons in distributed brain circuits. A brain function that may use such interactions is declarative memory—that is, memory that can be consciously recalled, such as episodes and facts. Declarative memory is enabled by circuits in the entorhinal cortex that interface the hippocampus with the neocortex.
  • Juno is the egg Izumo receptor and is essential for mammalian fertilization

    Enrica Bianchi
    15 Apr 2014 | 5:00 pm
    Nature advance online publication 16 April 2014. doi:10.1038/nature13203 Authors: Enrica Bianchi, Brendan Doe, David Goulding & Gavin J. Wright
  • Dynamics and associations of microbial community types across the human body

    Tao Ding
    15 Apr 2014 | 5:00 pm
    Nature advance online publication 16 April 2014. doi:10.1038/nature13178 Authors: Tao Ding & Patrick D. Schloss A primary goal of the Human Microbiome Project (HMP) was to provide a reference collection of 16S ribosomal RNA gene sequences collected from sites across the human body that would allow microbiologists to better associate changes in the microbiome with changes in health. The HMP Consortium has reported the structure and function of the human microbiome in 300 healthy adults at 18 body sites from a single time point. Using additional data collected over the course of…
 
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    Nature China - nature.com science feeds

  • Plant biology: Jumpy DNA's role in rice traits

    Piao Li
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.27 Author: Piao Li Small interfering RNA affects agricultural traits by promoting plant hormone synthesis
  • Molecular neuroscience: Live long, live healthy

    Edward Duca
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.31 Author: Edward Duca High levels of the neurotransmitters dopamine and serotonin prevent ageing-related behavioural decline in roundworms
  • Cell biology: Magic fingers

    Piao Li
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.22 Author: Piao Li A zinc finger protein functions as a binding partner and chaperone for a protein crucial to proper cell division
  • Polymers: Patterning without burning

    Lara Reid
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.29 Author: Lara Reid A novel annealing method uses near-infrared light to produce patterns on polymers without burning
  • Structural biology: A different treatment

    Edward Duca
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.23 Author: Edward Duca The exosome complex uses its core to bind RNA molecules with longer ends
 
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    Nature Chemical Biology - AOP - nature.com science feeds

  • Glycobiology: Drifting toward polymer perfection

    Karen J Colley
    12 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1506 Author: Karen J Colley The addition of polysialic acid to proteins and cells is emerging as a promising therapeutic strategy. Polysialyltransferases synthesize polymers of widely varying lengths not optimal for therapeutic reagents, but the development of enzyme variants using neutral genetic drift offers a new way to overcome this problem.
  • Engineering the product profile of a polysialyltransferase

    Timothy G Keys
    12 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1501 Authors: Timothy G Keys, Hazel L S Fuchs, Jörg Ehrit, Jürgen Alves, Friedrich Freiberger & Rita Gerardy-Schahn
  • Dynamics and hydration explain failed functional transformation in dehalogenase design

    Jan Sykora
    12 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1502 Authors: Jan Sykora, Jan Brezovsky, Tana Koudelakova, Maryna Lahoda, Andrea Fortova, Tatsiana Chernovets, Radka Chaloupkova, Veronika Stepankova, Zbynek Prokop, Ivana Kuta Smatanova, Martin Hof & Jiri Damborsky We emphasize the importance of dynamics and hydration for enzymatic catalysis and protein design by transplanting the active site from a haloalkane dehalogenase with high enantioselectivity to nonselective dehalogenase. Protein crystallography confirms that the active site geometry of the redesigned dehalogenase matches that of the…
  • The role of distant mutations and allosteric regulation on LovD active site dynamics

    Gonzalo Jiménez-Osés
    12 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1503 Authors: Gonzalo Jiménez-Osés, Sílvia Osuna, Xue Gao, Michael R Sawaya, Lynne Gilson, Steven J Collier, Gjalt W Huisman, Todd O Yeates, Yi Tang & K N Houk
  • Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides

    Indran Mathavan
    5 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1499 Authors: Indran Mathavan, Séverine Zirah, Shahid Mehmood, Hassanul G Choudhury, Christophe Goulard, Yanyan Li, Carol V Robinson, Sylvie Rebuffat & Konstantinos Beis The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization. Here, we provide what is to our knowledge the first structural evidence on the recognition mechanism, and our biochemical data show that another closely related lasso peptide cannot interact with FhuA. Our work provides an explanation on the narrow activity spectrum…
 
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    Nature Chemistry

  • Templated assembly of photoswitches significantly increases the energy-storage capacity of solar thermal fuels

    Timothy J. Kucharski
    12 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1918 Authors: Timothy J. Kucharski, Nicola Ferralis, Alexie M. Kolpak, Jennie O. Zheng, Daniel G. Nocera & Jeffrey C. Grossman Solar thermal fuels have recently attracted an increasing amount of attention as a potential method for solar energy capture, conversion, storage and utilization. Azobenzene-functionalized single-walled carbon nanotubes demonstrate the proof-of-principle for increasing kinetic stability and energy densities by templating photoswitchable molecules on nanostructures to achieve highly (con)strained configurations.
  • Switchable enantioseparation based on macromolecular memory of a helical polyacetylene in the solid state

    Kouhei Shimomura
    12 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1916 Authors: Kouhei Shimomura, Tomoyuki Ikai, Shigeyoshi Kanoh, Eiji Yashima & Katsuhiro Maeda Reversible chirality switching and memory is demonstrated in a helical polyacetylene. Both the helicity of the polymer backbone and the axial chirality of the side chains contribute to the memory effect. When used to produce a chiral stationary phase for a chromatographic enantiomer resolution it was possible to switch the elution order under identical chromatographic conditions.
  • Structural complexity through multicomponent cycloaddition cascades enabled by dual-purpose, reactivity regenerating 1,2,3-triene equivalents

    Paul A. Wender
    12 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1917 Authors: Paul A. Wender, Dennis N. Fournogerakis, Matthew S. Jeffreys, Ryan V. Quiroz, Fuyuhiko Inagaki & Magnus Pfaffenbach Cascade reactions allow step-economical generation of molecular complexity. Here, a butatriene equivalent, TMSCH2C ≡ CCH2OH, is used to couple two powerful and convergent cycloadditions — the homologous Diels–Alder ([5 + 2]) and the Diels–Alder ([4 + 2]) reactions –– through a vinylogous Peterson elimination, en route to a series of kinase inhibitors inspired by staurosporine.
  • Self-powered enzyme micropumps

    Samudra Sengupta
    29 Mar 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1895 Authors: Samudra Sengupta, Debabrata Patra, Isamar Ortiz-Rivera, Arjun Agrawal, Sergey Shklyaev, Krishna K. Dey, Ubaldo Córdova-Figueroa, Thomas E. Mallouk & Ayusman Sen Self-powered micropumps that are turned on by the presence of their respective substrates are formed from surface-immobilized, ATP-independent enzymes. Coupling substrate-sensing with transport enables the design of devices that deliver cargo in response to specific stimuli. Demonstrated here is the release of insulin at a rate proportional to ambient glucose concentration.
  • Extremely rapid self-reaction of the simplest Criegee intermediate CH2OO and its implications in atmospheric chemistry

    Yu-Te Su
    22 Mar 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1890 Authors: Yu-Te Su, Hui-Yu Lin, Raghunath Putikam, Hiroyuki Matsui, M. C. Lin & Yuan-Pern Lee Criegee intermediates play an important role in atmospheric chemistry but their direct study has proved difficult. Transient infrared absorption spectroscopy has now been used to probe the decay kinetics of the Criegee intermediate CH2OO directly, revealing that its self-reaction is extremely rapid. This may have important consequences for the interpretation of previous laboratory experiments.
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    Nature Genetics - Issue - nature.com science feeds

  • Inflammatory syndrome ADA2 deficiency

    Kyle Vogan
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 325 (2014). doi:10.1038/ng.2943 Author: Kyle Vogan
  • Zinc transport and diabetes risk

    Ewan Pearson
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 323 (2014). doi:10.1038/ng.2934 Author: Ewan Pearson Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc transporter ZnT8, associated with diabetes risk. A rare variant association study has now established the direction of effect, surprisingly showing that loss-of-function mutations in SLC30A8 are protective against diabetes.
  • Global optimization of somatic variant identification in cancer genomes with a global community challenge

    Paul C Boutros
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 318 (2014). doi:10.1038/ng.2932 Authors: Paul C Boutros, Adam D Ewing, Kyle Ellrott, Thea C Norman, Kristen K Dang, Yin Hu, Michael R Kellen, Christine Suver, J Christopher Bare, Lincoln D Stein, Paul T Spellman, Gustavo Stolovitzky, Stephen H Friend, Adam A Margolin & Joshua M Stuart
  • Ancient human oral plaque preserves a wealth of biological data

    Jessica L Metcalf
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 321 (2014). doi:10.1038/ng.2930 Authors: Jessica L Metcalf, Luke K Ursell & Rob Knight A new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. The authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen Tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins.
  • RHOA mutations in peripheral T cell lymphoma

    Jan Cools
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 320 (2014). doi:10.1038/ng.2937 Author: Jan Cools Peripheral T cell lymphomas are rare but aggressive non-Hodgkin lymphomas derived from mature T lymphocytes or natural killer (NK) cells. New studies identify recurrent dominant-negative mutation of the RHOA GTPase gene in these lymphomas.
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  • Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

    Serena Nik-Zainal
    12 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2955 Authors: Serena Nik-Zainal, David C Wedge, Ludmil B Alexandrov, Mia Petljak, Adam P Butler, Niccolo Bolli, Helen R Davies, Stian Knappskog, Sancha Martin, Elli Papaemmanuil, Manasa Ramakrishna, Adam Shlien, Ingrid Simonic, Yali Xue, Chris Tyler-Smith, Peter J Campbell & Michael R Stratton The somatic mutations in a cancer genome are the aggregate outcome of one or more mutational processes operative through the lifetime of the individual with cancer. Each mutational process leaves a characteristic mutational signature determined by the mechanisms of…
  • Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31

    Unnur Styrkarsdottir
    12 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2957 Authors: Unnur Styrkarsdottir, Gudmar Thorleifsson, Hafdis T Helgadottir, Nils Bomer, Sarah Metrustry, S Bierma-Zeinstra, Annelieke M Strijbosch, Evangelos Evangelou, Deborah Hart, Marian Beekman, Aslaug Jonasdottir, Asgeir Sigurdsson, Finnur F Eiriksson, Margret Thorsteinsdottir, Michael L Frigge, Augustine Kong, Sigurjon A Gudjonsson, Olafur T Magnusson, Gisli Masson, Albert Hofman, Nigel K Arden, Thorvaldur Ingvarsson, Stefan Lohmander, Margreet Kloppenburg, Fernando Rivadeneira, Rob G H H Nelissen, Tim Spector, Andre Uitterlinden, P Eline Slagboom,…
  • Heritability and genomics of gene expression in peripheral blood

    Fred A Wright
    12 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2951 Authors: Fred A Wright, Patrick F Sullivan, Andrew I Brooks, Fei Zou, Wei Sun, Kai Xia, Vered Madar, Rick Jansen, Wonil Chung, Yi-Hui Zhou, Abdel Abdellaoui, Sandra Batista, Casey Butler, Guanhua Chen, Ting-Huei Chen, David D'Ambrosio, Paul Gallins, Min Jin Ha, Jouke Jan Hottenga, Shunping Huang, Mathijs Kattenberg, Jaspreet Kochar, Christel M Middeldorp, Ani Qu, Andrey Shabalin, Jay Tischfield, Laura Todd, Jung-Ying Tzeng, Gerard van Grootheest, Jacqueline M Vink, Qi Wang, Wei Wang, Weibo Wang, Gonneke Willemsen, Johannes H Smit, Eco J de Geus, Zhaoyu…
  • Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

    Kathryn R Taylor
    5 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2925 Authors: Kathryn R Taylor, Alan Mackay, Nathalène Truffaux, Yaron S Butterfield, Olena Morozova, Cathy Philippe, David Castel, Catherine S Grasso, Maria Vinci, Diana Carvalho, Angel M Carcaboso, Carmen de Torres, Ofelia Cruz, Jaume Mora, Natacha Entz-Werle, Wendy J Ingram, Michelle Monje, Darren Hargrave, Alex N Bullock, Stéphanie Puget, Stephen Yip, Chris Jones & Jacques Grill Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are…
  • Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

    Adam M Fontebasso
    5 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2950 Authors: Adam M Fontebasso, Simon Papillon-Cavanagh, Jeremy Schwartzentruber, Hamid Nikbakht, Noha Gerges, Pierre-Olivier Fiset, Denise Bechet, Damien Faury, Nicolas De Jay, Lori A Ramkissoon, Aoife Corcoran, David T W Jones, Dominik Sturm, Pascal Johann, Tadanori Tomita, Stewart Goldman, Mahmoud Nagib, Anne Bendel, Liliana Goumnerova, Daniel C Bowers, Jeffrey R Leonard, Joshua B Rubin, Tord Alden, Samuel Browd, J Russell Geyer, Sarah Leary, George Jallo, Kenneth Cohen, Nalin Gupta, Michael D Prados, Anne-Sophie Carret, Benjamin Ellezam, Louis Crevier,…
 
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  • Tropospheric ozone variations governed by changes in stratospheric circulation

    Jessica L. Neu
    12 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2138 Authors: Jessica L. Neu, Thomas Flury, Gloria L. Manney, Michelle L. Santee, Nathaniel J. Livesey & John Worden The downward transport of stratospheric ozone is an important natural source of tropospheric ozone, particularly in the upper troposphere, where changes in ozone have their largest radiative effect. Stratospheric circulation is projected to intensify over the coming century, which could lead to an increase in the flux of ozone from the stratosphere to the troposphere. However, large uncertainties in the stratospheric contribution to trends…
  • Carbon sequestration during the Palaeocene–Eocene Thermal Maximum by an efficient biological pump

    Zhongwu Ma
    12 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2139 Authors: Zhongwu Ma, Ellen Gray, Ellen Thomas, Brandon Murphy, James Zachos & Adina Paytan
  • Low palaeopressure of the martian atmosphere estimated from the size distribution of ancient craters

    Edwin S. Kite
    12 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2137 Authors: Edwin S. Kite, Jean-Pierre Williams, Antoine Lucas & Oded Aharonson The decay of the martian atmosphere—which is dominated by carbon dioxide—is a component of the long-term environmental change on Mars from a climate that once allowed rivers to flow to the cold and dry conditions of today. The minimum size of craters serves as a proxy for palaeopressure of planetary atmospheres, because thinner atmospheres permit smaller objects to reach the surface at high velocities and form craters. The Aeolis Dorsa region near Gale crater on…
  • Planetary science: Into thin martian air

    Sanjoy M. Som
    12 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2145 Author: Sanjoy M. Som A dense early atmosphere has been invoked to explain the strong greenhouse effect inferred for early Mars. Yet an analysis of the smallest impact craters suggests that the atmospheric pressure on Mars 3.6 billion years ago was surprisingly low.
  • Climate warming during Antarctic ice sheet expansion at the Middle Miocene transition

    Gregor Knorr
    5 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2119 Authors: Gregor Knorr & Gerrit Lohmann
 
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    Nature Materials - Issue - nature.com science feeds

  • Microimaging of transient guest profiles to monitor mass transfer in nanoporous materials

    Jörg Kärger
    20 Mar 2014 | 5:00 pm
    Nature Materials 13, 333 (2014). doi:10.1038/nmat3917 Authors: Jörg Kärger, Tomas Binder, Christian Chmelik, Florian Hibbe, Harald Krautscheid, Rajamani Krishna & Jens Weitkamp
  • The Arabs' scientific vision

    20 Mar 2014 | 5:00 pm
    Nature Materials 13, 317 (2014). doi:10.1038/nmat3940 Winds of change blow through research centres and universities operating in the Middle East.
  • Material witness: Soft-hearted robots

    Philip Ball
    20 Mar 2014 | 5:00 pm
    Nature Materials 13, 327 (2014). doi:10.1038/nmat3930 Author: Philip Ball
  • Dire need for a Middle Eastern science spring

    Ahmed H. Zewail
    20 Mar 2014 | 5:00 pm
    Nature Materials 13, 318 (2014). doi:10.1038/nmat3918 Author: Ahmed H. Zewail The Middle East is rich in human and natural resources, but many of its countries need a cultural and scientific transformation to reach worldwide recognition in education, research and economic productivity. Several institutions are making a positive impact, kindling hope for a successful 'science spring'.
  • Liquid crystals: Electric fields line up graphene oxide

    Ju Young Kim
    20 Mar 2014 | 5:00 pm
    Nature Materials 13, 325 (2014). doi:10.1038/nmat3929 Authors: Ju Young Kim & Sang Ouk Kim The macroscopic alignment of dilute dispersions of graphene oxide can be controlled, with extremely large optical sensitivity, through the application of weak electric fields.
 
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    Nature Medicine - AOP - nature.com science feeds

  • Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

    Alastair J O'Brien
    12 Apr 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3516 Authors: Alastair J O'Brien, James N Fullerton, Karen A Massey, Grace Auld, Gavin Sewell, Sarah James, Justine Newson, Effie Karra, Alison Winstanley, William Alazawi, Rita Garcia-Martinez, Joan Cordoba, Anna Nicolaou & Derek W Gilroy Liver disease is one of the leading causes of death worldwide. Patients with cirrhosis display an increased predisposition to and mortality from infection due to multimodal defects in the innate immune system; however, the causative mechanism has remained elusive. We present evidence that the cyclooxygenase (COX)-derived…
  • REDD1 is essential for stress-induced synaptic loss and depressive behavior

    Kristie T Ota
    12 Apr 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3513 Authors: Kristie T Ota, Rong-Jian Liu, Bhavya Voleti, Jaime G Maldonado-Aviles, Vanja Duric, Masaaki Iwata, Sophie Dutheil, Catharine Duman, Steve Boikess, David A Lewis, Craig A Stockmeier, Ralph J DiLeone, Christopher Rex, George K Aghajanian & Ronald S Duman
  • Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia

    Morgane Perdomini
    5 Apr 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3510 Authors: Morgane Perdomini, Brahim Belbellaa, Laurent Monassier, Laurence Reutenauer, Nadia Messaddeq, Nathalie Cartier, Ronald G Crystal, Patrick Aubourg & Hélène Puccio Cardiac failure is the most common cause of mortality in Friedreich's ataxia (FRDA), a mitochondrial disease characterized by neurodegeneration, hypertrophic cardiomyopathy and diabetes. FRDA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters. Impaired mitochondrial oxidative…
  • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

    Aaron M Newman
    5 Apr 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3519 Authors: Aaron M Newman, Scott V Bratman, Jacqueline To, Jacob F Wynne, Neville C W Eclov, Leslie A Modlin, Chih Long Liu, Joel W Neal, Heather A Wakelee, Robert E Merritt, Joseph B Shrager, Billy W Loo, Ash A Alizadeh & Maximilian Diehn
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    Nature Methods - AOP - nature.com science feeds

  • Rapid adaptive optical recovery of optimal resolution over large volumes

    Kai Wang
    12 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2925 Authors: Kai Wang, Daniel E Milkie, Ankur Saxena, Peter Engerer, Thomas Misgeld, Marianne E Bronner, Jeff Mumm & Eric Betzig Using a descanned, laser-induced guide star and direct wavefront sensing, we demonstrate adaptive correction of complex optical aberrations at high numerical aperture (NA) and a 14-ms update rate. This correction permits us to compensate for the rapid spatial variation in aberration often encountered in biological specimens and to recover diffraction-limited imaging over large volumes (>240 mm per side). We applied this to…
  • Multiscale representation of genomic signals

    Theo A Knijnenburg
    12 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2924 Authors: Theo A Knijnenburg, Stephen A Ramsey, Benjamin P Berman, Kathleen A Kennedy, Arian F A Smit, Lodewyk F A Wessels, Peter W Laird, Alan Aderem & Ilya Shmulevich
  • Single-molecule analysis of cell surface dynamics in Caenorhabditis elegans embryos

    François B Robin
    12 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2928 Authors: François B Robin, William M McFadden, Baixue Yao & Edwin M Munro
  • Light-sheet microscopy using an Airy beam

    Tom Vettenburg
    5 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2922 Authors: Tom Vettenburg, Heather I C Dalgarno, Jonathan Nylk, Clara Coll-Lladó, David E K Ferrier, Tomáš Čižmár, Frank J Gunn-Moore & Kishan Dholakia Light-sheet microscopy facilitates rapid, high-contrast, volumetric imaging with minimal sample exposure. However, the rapid divergence of a traditional Gaussian light sheet restricts the field of view (FOV) that provides innate subcellular resolution. We show that the Airy beam innately yields high contrast and resolution up to a tenfold larger FOV. In contrast to the…
  • Fluorescence nanoscopy by polarization modulation and polarization angle narrowing

    Nour Hafi
    5 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2919 Authors: Nour Hafi, Matthias Grunwald, Laura S van den Heuvel, Timo Aspelmeier, Jian-Hua Chen, Marta Zagrebelsky, Ole M Schütte, Claudia Steinem, Martin Korte, Axel Munk & Peter J Walla
 
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    Nature Neuroscience - Issue - nature.com science feeds

  • A solution to dependency: using multilevel analysis to accommodate nested data

    Emmeke Aarts
    25 Mar 2014 | 5:00 pm
    Nature Neuroscience 17, 491 (2014). doi:10.1038/nn.3648 Authors: Emmeke Aarts, Matthijs Verhage, Jesse V Veenvliet, Conor V Dolan & Sophie van der Sluis
  • Useful dynamic regimes emerge in recurrent networks

    Vishwa Goudar
    25 Mar 2014 | 5:00 pm
    Nature Neuroscience 17, 487 (2014). doi:10.1038/nn.3679 Authors: Vishwa Goudar & Dean V Buonomano The internal dynamics of recurrent cortical circuits is crucial to brain function. We now learn that simply increasing the strengths of recurrent connections shifts neural dynamics to a potentially powerful computational regime.
  • Following your heart

    Joel S Winston
    25 Mar 2014 | 5:00 pm
    Nature Neuroscience 17, 482 (2014). doi:10.1038/nn.3677 Authors: Joel S Winston & Geraint Rees A finding now suggests that the brain's response to heartbeats is influential in guiding reported visual experience, such that the ability to accurately report the presence or absence of a visual target is influenced by the brain's heartbeat-evoked activity.
  • Dark matter of the bulb

    Sasha Devore
    25 Mar 2014 | 5:00 pm
    Nature Neuroscience 17, 485 (2014). doi:10.1038/nn.3684 Authors: Sasha Devore & Dmitry Rinberg A study now shows that granule cells deep in the olfactory bulb exhibit wildly different response dynamics depending on behavioral state, suggesting they could configure network changes across behavioral states.
  • So many progenitors, so little myelin

    Steven A Goldman
    25 Mar 2014 | 5:00 pm
    Nature Neuroscience 17, 483 (2014). doi:10.1038/nn.3685 Authors: Steven A Goldman & Joana Osorio CNS white matter injury may cause sustained demyelination despite the persistence of oligodendrocyte progenitor cells (OPCs). A study suggests that dysregulated Wnt signaling disrupts self-renewal to yield OPC maturation arrest.
 
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    Nature Physics - Issue - nature.com science feeds

  • No coincidence

    Iulia Georgescu
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2950 Author: Iulia Georgescu
  • Electrons of a different stripe

    May Chiao
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2948 Author: May Chiao
  • Great leap outwards

    Mark Buchanan
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 243 (2014). doi:10.1038/nphys2943 Author: Mark Buchanan
  • Two by two

    Alison Wright
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2947 Author: Alison Wright
  • Razzle dazzle 'em

    Abigail Klopper
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2946 Author: Abigail Klopper
 
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Inflammation: Determinants of neoplastic sites

    Gemma K. Alderton
    23 Mar 2014 | 5:00 pm
    Nature Reviews Cancer 14, 215 (2014). doi:10.1038/nrc3719 Author: Gemma K. Alderton Why do some neoplasms form in certain sites and not in others? For example, serrated polyps develop only in the caecum of transgenic mice that express heparin-binding EGF-like growth factor (HB-EGF) throughout the intestine, indicating that non-genetic factors may be involved. Bongers et al.
  • Pluripotency: Partial reprogramming induces cancer

    Gemma K. Alderton
    23 Mar 2014 | 5:00 pm
    Nature Reviews Cancer 14, 216 (2014). doi:10.1038/nrc3713 Author: Gemma K. Alderton A paper in Cell shows that partial reprogramming of somatic cells induces epithelial tumorigenesis.
  • Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

    Amy S. Lee
    23 Mar 2014 | 5:00 pm
    Nature Reviews Cancer 14, 263 (2014). doi:10.1038/nrc3701 Author: Amy S. Lee The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs have functions that are distinct from those of the related heat shock proteins, and they can be actively translocated to other cellular
  • Tumour microenvironment: More than just a mutagen

    Nicola McCarthy
    23 Mar 2014 | 5:00 pm
    Nature Reviews Cancer 14, 213 (2014). doi:10.1038/nrc3710 Author: Nicola McCarthy Independent of its mutagenic effects, induction of an innate inflammatory response by ultraviolet radiation can promote angiotropism and metastasis in mice with melanoma.
  • Signalling: Connecting metabolism and proliferation

    Gemma K. Alderton
    23 Mar 2014 | 5:00 pm
    Nature Reviews Cancer 14, 215 (2014). doi:10.1038/nrc3718 Author: Gemma K. Alderton The metabolic enzyme pyruvate kinase M2 (PKM2) was recently shown to have protein kinase activity, and Keller et al. now report that the metabolite SAICAR, which is found in proliferating cells, binds to PKM2 and induces its kinase activity. Moreover, they found that more
 
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • Regulators defend incretin drugs

    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 247 (2014). doi:10.1038/nrd4307 GLP1 mimetics and DPP4 inhibitors do not seem to be associated with pancreatic safety events, say US and European regulators in a joint paper.The lowdown: Last year, US and European drug regulators initiated safety reviews of two approved classes of incretin-based drugs: glucagon-like
  • BioMarin nabs first paediatric priority review voucher

    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 247 (2014). doi:10.1038/nrd4305 Regulators reward company for developing an enzyme replacement therapy for a rare paediatric indication with only 800 estimated patients in the United States.The lowdown: In 2012, the FDA Safety and Innovation Act (FDASIA) introduced a new priority review voucher (PRV) to
  • Integrative knowledge management to enhance pharmaceutical R&D

    Maria Marti-Solano
    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 239 (2014). doi:10.1038/nrd4290 Authors: Maria Marti-Solano, Ewan Birney, Antoine Bril, Oscar Della Pasqua, Hiroaki Kitano, Barend Mons, Ioannis Xenarios & Ferran Sanz Information technologies already have a key role in pharmaceutical research and development (R&D), but achieving substantial advances in their use and effectiveness will depend on overcoming current challenges in sharing, integrating and jointly analysing the range of data generated at different stages of the R&D process.
  • Schizophrenia drug gets negative results for negative symptoms

    Katie Kingwell
    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 244 (2014). doi:10.1038/nrd4294 Author: Katie Kingwell Roche's bitopertin failed to improve the negative symptoms of schizophrenia in two pivotal trials, raising questions about the therapeutic potential of glycinergic neuromodulation.
  • Drug makers and NIH team up to find and validate targets

    Asher Mullard
    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 241 (2014). doi:10.1038/nrd4293 Author: Asher Mullard The $230 million AMP stakes out new target ground in Alzheimer's disease, type 2 diabetes, rheumatoid arthritis and lupus.
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • The sensory immune system: a neural twist to the antigenic discontinuity theory

    Serge Nataf
    24 Mar 2014 | 5:00 pm
    Nature Reviews Immunology 14, 280 (2014). doi:10.1038/nri3521-c1 Author: Serge Nataf In their recent Essay (The speed of change: towards a discontinuity theory of immunity?Nature Rev. Immunol.13, 764–769 (2013)), Pradeu et al. proposed that rather than antigens per se, antigenic discontinuity is a major
  • Inflammation: IL-21 stokes brain inflammation

    Olive Leavy
    24 Mar 2014 | 5:00 pm
    Nature Reviews Immunology 14, 215 (2014). doi:10.1038/nri3656 Author: Olive Leavy Much of the secondary tissue damage associated with ischaemic stroke is caused by inflammation, but the factors involved in this neuroinflammation remain unclear. This study showed that interleukin-21 (IL-21) expression is greatly increased in the brain of mice following cerebral ischaemic reperfusion injury, that Il21
  • Tumour immunology: Inflaming tumour spread

    Olive Leavy
    24 Mar 2014 | 5:00 pm
    Nature Reviews Immunology 14, 212 (2014). doi:10.1038/nri3651 Author: Olive Leavy Ultraviolet radiation-induced neutrophilic inflammation promotes melanoma metastasis.
  • HIV: Gene therapy for HIV?

    Lucy Bird
    24 Mar 2014 | 5:00 pm
    Nature Reviews Immunology 14, 215 (2014). doi:10.1038/nri3655 Author: Lucy Bird For the first time, researchers show that it is safe and effective to genetically modify cells to increase resistance to HIV infection in humans. They used a zinc-finger nuclease to target and inactivate the HIV coreceptor CC-chemokine receptor 5 (CCR5) in CD4+ T
  • Democratizing systems immunology with modular transcriptional repertoire analyses

    Damien Chaussabel
    24 Mar 2014 | 5:00 pm
    Nature Reviews Immunology 14, 271 (2014). doi:10.1038/nri3642 Authors: Damien Chaussabel & Nicole Baldwin Individual elements that constitute the immune system have been characterized over the few past decades, mostly through reductionist approaches. The introduction of large-scale profiling platforms has more recently facilitated the assessment of these elements on a global scale. However, the analysis and the interpretation of
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Synthetic biology: Building a designer yeast genome

    Christina Tobin Kåhrström
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 313 (2014). doi:10.1038/nrmicro3264 Author: Christina Tobin Kåhrström An international team of researchers has embarked on the creation of a synthetic eukaryotic genome and now report the synthesis of a redesigned Saccharomyces cerevisiae chromosome. Boeke and colleagues built a fully functional chromosome III (which they term synIII) that contained hundreds of alterations,
  • Ebola virus in West Africa

    Andrea Du Toit
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 312 (2014). doi:10.1038/nrmicro3267 Author: Andrea Du Toit Ebola virus disease is spreading in West African countries.
  • Clinical Microbiology: Recombination turns one clade into two

    Christina Tobin Kåhrström
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 313 (2014). doi:10.1038/nrmicro3265 Author: Christina Tobin Kåhrström Clinical isolates of carbapenem-resistant Klebsiella pneumoniae that belong to multilocus sequence type 258 (ST258) have emerged as important nosocomial pathogens, and it has been proposed that all of these isolates are derived from a single genetic clone that has spread globally. However, genome sequencing
  • Biotechnological domestication of pseudomonads using synthetic biology

    Pablo I. Nikel
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 368 (2014). doi:10.1038/nrmicro3253 Authors: Pablo I. Nikel, Esteban Martínez-García & Víctor de Lorenzo Much of contemporary synthetic biology research relies on the use of bacterial chassis for plugging-in and plugging-out genetic circuits and new-to-nature functionalities. However, the microorganisms that are the easiest to manipulate in the laboratory are often suboptimal for downstream industrial applications, which can involve physicochemical
  • Bacterial pathogenesis: sRNA promotes S. aureus persistence

    Christina Tobin Kåhrström
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 313 (2014). doi:10.1038/nrmicro3266 Author: Christina Tobin Kåhrström Romilly et al. report the first example of a conserved, small non-coding RNA (sRNA) that functions as a virulence suppressor in Staphylococcus aureus. The authors found that the RsaA sRNA inhibits the expression of MgrA — a master regulator of transcription — primarily
 
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Plant cell biology: Auxin signalling: ABP1 finds its pair

    Kim Baumann
    20 Mar 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 221 (2014). doi:10.1038/nrm3776 Author: Kim Baumann The membrane-associated receptor-like kinases TMKs interact with secreted ABP1 to transduce extracellular auxin signals and activate ROP GTPases.
  • Mitosis: A safety net for successful mitosis

    Kirsty Minton
    20 Mar 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 220 (2014). doi:10.1038/nrm3777 Author: Kirsty Minton Nuclear pore complexes bind the spindle assembly checkpoint protein MAD1 during interphase, which slows mitotic entry and lowers the threshold for mitotic arrest.
  • Mechanotransduction: Forcing nuclei

    Eytan Zlotorynski
    20 Mar 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 220 (2014). doi:10.1038/nrm3780 Author: Eytan Zlotorynski LINC complex structure and nucleoskeleton organization are key factors in the transmission of mechanical stress to the nucleus.
  • Metabolism: p66SHC inhibits anabolic metabolism

    Eytan Zlotorynski
    20 Mar 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 222 (2014). doi:10.1038/nrm3783 Author: Eytan Zlotorynski Increased insulin signalling can result in rapid cell growth and increased survival owing to a rise in glucose consumption. Soliman et al. studied the role of p66SHC (the p66 isoform of the adaptor protein SHC (SRC homology 2 containing)), a mediator of growth factor
  • Prime movers: the mechanochemistry of mitotic kinesins

    Robert A. Cross
    20 Mar 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 257 (2014). doi:10.1038/nrm3768 Authors: Robert A. Cross & Andrew McAinsh Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams. Different kinesins walk directionally along dynamic microtubules, anchor, crosslink, align and sort microtubules into polarized bundles, and influence microtubule dynamics
 
 
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    Nature Reviews Neurology - Issue - nature.com science feeds

  • Neuro-oncology: Pregnancy might promote progression of high-grade gliomas

    24 Mar 2014 | 5:00 pm
    Nature Reviews Neurology 10, 182 (2014). doi:10.1038/nrneurol.2014.55 New evidence suggests that women with grade II or grade III gliomas have a higher risk of tumour progression during pregnancy. Yust-Katz and colleagues retrospectively identified 23 patients who became pregnant after being diagnosed with a primary brain tumour. In this group, five women with
  • Huntington disease: Possible cellular mechanism for striatal degeneration in Huntington disease

    24 Mar 2014 | 5:00 pm
    Nature Reviews Neurology 10, 182 (2014). doi:10.1038/nrneurol.2014.56 Huntington disease (HD) is associated with progressive degeneration of the striatum, but the cause of this cell death is unclear. Leitman and colleagues examined cultures of normal murine striatal cells, and similar cells that expressed the polyglutamine-expanded form of the huntingtin protein. Striatal cells were
  • Alzheimer disease: Comparable brain levels of amyloid-β and tau in asymptomatic AD and mild cognitive impairment

    24 Mar 2014 | 5:00 pm
    Nature Reviews Neurology 10, 181 (2014). doi:10.1038/nrneurol.2014.52 Asymptomatic Alzheimer disease (AD) is the diagnosis given to people with clear AD pathology at autopsy despite typical cognitive function in life. Iacono et al. compared levels of amyloid-β and phosphorylated tau in brain slices from recently deceased patients with asymptomatic AD or
  • Parkinson disease: Gene therapy for Parkinson disease—a hope, or a dream?

    C. Warren Olanow
    24 Mar 2014 | 5:00 pm
    Nature Reviews Neurology 10, 186 (2014). doi:10.1038/nrneurol.2014.45 Author: C. Warren Olanow Gene therapy offers the potential to deliver therapeutic proteins to a target region, and is a promising treatment for Parkinson disease. A new open-label study testing ProSavin®, which encodes three rate-limiting enzymes required for dopamine biosynthesis, showed favourable safety and efficacy results, but its therapeutic potential awaits confirmation in double-blind trials.
  • Epilepsy: Mapping epileptic foci with foramen ovale electrodes

    24 Mar 2014 | 5:00 pm
    Nature Reviews Neurology 10, 181 (2014). doi:10.1038/nrneurol.2014.51 Before resective surgery, epileptic foci are conventionally localized via surface EEG, but difficult cases require invasive assessment. Sheth and colleagues used foramen ovale electrodes (FOEs) to examine 42 patients who had epileptic foci that could not be conclusively mapped using EEG. FOEs are less invasive
 
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    Nature Reviews Urology - Issue - nature.com science feeds

  • Prostate cancer: Radiotherapy—treating patients in a fast-moving field

    Sarah Payton
    24 Mar 2014 | 5:00 pm
    Nature Reviews Urology 11, 183 (2014). doi:10.1038/nrurol.2014.72 Author: Sarah Payton Two new studies comparing different radiotherapy modalities for men with localized prostate cancer highlight the difficulties associated with making treatment recommendations in such a fast-paced field. One study provides level I evidence for what might be considered an outdated technique; the other raises awareness of
  • Bladder cancer: Faster recovery after radical cystectomy with alvimopan

    Melanie Clyne
    17 Mar 2014 | 5:00 pm
    Nature Reviews Urology 11, 186 (2014). doi:10.1038/nrurol.2014.67 Author: Melanie Clyne New study data show that alvimopan—a μ-opioid antagonist that competitively binds to, but doesn't activate, the μ-opioid receptor in the gastrointestinal tract—expedites gastrointestinal recovery and improves early outcomes in patients undergoing radical cystectomy and receiving opioids, without increasing the risk of cardiovascular morbidity.For this
  • Prostate cancer: A consensus on trial design for focal therapy

    Sangeet Ghai
    17 Mar 2014 | 5:00 pm
    Nature Reviews Urology 11, 190 (2014). doi:10.1038/nrurol.2014.64 Authors: Sangeet Ghai & John Trachtenberg Focal therapy of prostate cancer enables treatment of the index lesion while sparing the rest of the gland and surrounding vital structures, thereby decreasing the risk of morbidity. As clinicians acknowledge its potential, the recently published multidisciplinary consensus is timely and provides new insight into trial design for focal therapy.
  • Bladder cancer: High precystectomy NLR, increased risk

    Sarah Payton
    17 Mar 2014 | 5:00 pm
    Nature Reviews Urology 11, 188 (2014). doi:10.1038/nrurol.2014.68 Author: Sarah Payton Presurgery neutrophil-to-lymphocyte ratio (NLR) is associated with adverse pathological and survival outcomes after cystectomy, according to new research from Matthew Tollefson and colleagues at the Mayo Clinic in Rochester, USA.Radical cystectomy is an aggressive treatment option for patients with high-risk non-muscle-invasive or muscle-invasive bladder
  • Prostate cancer: eNose—man's new best friend?

    Robert Phillips
    17 Mar 2014 | 5:00 pm
    Nature Reviews Urology 11, 187 (2014). doi:10.1038/nrurol.2014.69 Author: Robert Phillips The detection of prostate cancer using the odour of patients' urine is the subject of two new studies, and on the basis of this evidence, our furry friends could now have a serious electronic contender. An attempt to train 10 dogs to discriminate urine of
 
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    Naturejobs - Search results

  • Biology Lab Instructor – Biodiversity, Ecology, Conservation, and Physiological Zoology

    16 Apr 2014 | 1:15 pm
    Biology Lab Instructor – Biodiversity, Ecology, Conservation, and Physiological Zoology The Department of Biological Sciences at Smith College invites applications for a lab instructor to begin August 1st, 2014. This is a full-time course support position with full benefits. We seek a candidate with experience in organismal biology and ecology, with at least an M.S. in biology, ecology, physiological zoology, or a related field. The successful candidate will have strong quantitative a…
  • Tenure Track Assistant Professor in Immunology

    16 Apr 2014 | 12:38 pm
    Tenure Track Assistant Professor in Immunology The University of Texas Southwestern Medical Center Department of Immunology The Department of Immunology at the University of Texas Southwestern Medical Center invites applications for two tenure track faculty positions at the level of Assistant Professor. Successful applicants should have a PhD or MD degree, at least two years of postdoctoral training and an exceptional publication record. The candidate selected will be expected to establis…
  • Tenure Track Assistant Professor in Immunology

    16 Apr 2014 | 12:38 pm
    Tenure Track Assistant Professor in Immunology The University of Texas Southwestern Medical Center Department of Immunology The Department of Immunology at the University of Texas Southwestern Medical Center invites applications for two tenure track faculty positions at the level of Assistant Professor. Successful applicants should have a PhD or MD degree, at least two years of postdoctoral training and an exceptional publication record. The candidate selected will be expected to establis…
  • Tenure Track Assistant Professor in Immunology

    16 Apr 2014 | 12:38 pm
    Tenure Track Assistant Professor in Immunology The University of Texas Southwestern Medical Center Department of Immunology The Department of Immunology at the University of Texas Southwestern Medical Center invites applications for two tenure track faculty positions at the level of Assistant Professor. Successful applicants should have a PhD or MD degree, at least two years of postdoctoral training and an exceptional publication record. The candidate selected will be expected to establis…
  • Tenure Track Assistant Professor in Immunology

    16 Apr 2014 | 12:38 pm
    Tenure Track Assistant Professor in Immunology The University of Texas Southwestern Medical Center Department of Immunology The Department of Immunology at the University of Texas Southwestern Medical Center invites applications for two tenure track faculty positions at the level of Assistant Professor. Successful applicants should have a PhD or MD degree, at least two years of postdoctoral training and an exceptional publication record. The candidate selected will be expected to establis…
 
 
 
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    British Journal of Pharmacology

  • Immunosuppressive and anti-inflammatory properties of engineered nanomaterials

    A.N. Ilinskaya, M.A. Dobrovolskaia
    13 Apr 2014 | 8:01 pm
    Summary Nanoparticle interactions with various components of immune system are determined by their physicochemical properties such as size, charge, hydrophobicity and shape. Nanoparticles can be engineered to either specifically target the immune system or to avoid immune recognition. Nevertheless, identifying their unintended impacts on the immune system and understanding the mechanisms of such accidental effects are essential for establishing a nanoparticle's safety profile. While immunostimulatory properties have been reviewed before, little attention in the literature has been given to…
  • TRP channels and STIM/ORAI proteins: Sensors and effectors of cancer and stroma cell migration

    N Nielsen, O Lindemann, A Schwab
    13 Apr 2014 | 8:00 pm
    Summary Cancer cells are strongly influenced by host cells within the tumor stroma and vice versa. This leads to the development of a tumor microenvironment with distinct physical and chemical properties that are permissive for tumor progression. The ability to migrate plays a central role in this mutual interaction. Migration of cancer cells is considered as a prerequisite for tumor metastasis and the migration of host stromal cells is required for reaching the tumor site. Increasing evidence suggests that transient receptor potential (TRP) channels and STIM/ORAI proteins affect key calcium…
  • Agomelatine: Mechanism of action and pharmacological profile in relation to antidepressant properties

    B Guardiola-Lemaitre, C Bodinat, P Delagrange, M J Millan, C Munoz, E Mocaër
    13 Apr 2014 | 8:00 pm
    Summary Agomelatine behaves both as a potent agonist at melatonergic MT1 and MT2 receptors and as a neutral antagonist at 5-HT2C receptors. Accumulating evidence in a broad range of experimental procedures supports the notion that the psychotropic effects of agomelatine are due to the synergy between its melatonergic- and serotonergic effects. The recent demonstration of the existence of heteromeric complexes of MT1 and MT2 with 5-HT2C receptors at the cellular level may explain how these two properties of agomelatine translate into a synergistic action that, for example, leads to increases…
  • Interleukin-18 as a Target for Modulation of Irinotecan-Induced Intestinal Toxicity: A Step Towards a Better Therapeutic Index?

    B G Spyropoulos
    13 Apr 2014 | 8:00 pm
  • Eph/ephrin sytem: In the quest of novel anti-angiogenic therapies

    M Hatziapostolou, C Polytarchou
    13 Apr 2014 | 8:00 pm
 
 
 
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    European Journal of Human Genetics - AOP - nature.com science feeds

  • The SMAD-binding domain of SKI: a hotspot for de novo mutations causing Shprintzen–Goldberg syndrome

    Dorien Schepers
    15 Apr 2014 | 5:00 pm
    The SMAD-binding domain of SKI: a hotspot for de novo mutations causing Shprintzen–Goldberg syndrome European Journal of Human Genetics advance online publication, April 16 2014. doi:10.1038/ejhg.2014.61 Authors: Dorien Schepers, Alexander J Doyle, Gretchen Oswald, Elizabeth Sparks, Loretha Myers, Patrick J Willems, Sahar Mansour, Michael A Simpson, Helena Frysira, Anneke Maat-Kievit, Rick Van Minkelen, Jeanette M Hoogeboom, Geert R Mortier, Hannah Titheradge, Louise Brueton, Lois Starr, Zornitza Stark, Charlotte Ockeloen, Charles Marques Lourenco, Ed Blair, Emma Hobson, Jane Hurst,…
  • Clinical spectrum and outcomes in families with coronal synostosis and TCF12 mutations

    Federico di Rocco
    15 Apr 2014 | 5:00 pm
    Clinical spectrum and outcomes in families with coronal synostosis and TCF12 mutations European Journal of Human Genetics advance online publication, April 16 2014. doi:10.1038/ejhg.2014.57 Authors: Federico di Rocco, Geneviève Baujat, Eric Arnaud, Dominique Rénier, Jean-Louis Laplanche, Valérie Cormier Daire & Corinne Collet
  • Delineation of candidate genes responsible for structural brain abnormalities in patients with terminal deletions of chromosome 6q27

    Sirisha Peddibhotla
    15 Apr 2014 | 5:00 pm
    Delineation of candidate genes responsible for structural brain abnormalities in patients with terminal deletions of chromosome 6q27 European Journal of Human Genetics advance online publication, April 16 2014. doi:10.1038/ejhg.2014.51 Authors: Sirisha Peddibhotla, Sandesh CS Nagamani, Ayelet Erez, Jill V Hunter, J Lloyd Holder Jr, Mary E Carlin, Patricia I Bader, Helene MF Perras, Judith E Allanson, Leslie Newman, Gayle Simpson, LaDonna Immken, Erin Powell, Aaron Mohanty, Sung-Hae L Kang, Pawel Stankiewicz, Carlos A Bacino, Weimin Bi, Ankita Patel & Sau W Cheung
  • A decade of molecular genetic testing for MODY: a retrospective study of utilization in The Netherlands

    Stephanie S Weinreich
    15 Apr 2014 | 5:00 pm
    A decade of molecular genetic testing for MODY: a retrospective study of utilization in The Netherlands European Journal of Human Genetics advance online publication, April 16 2014. doi:10.1038/ejhg.2014.59 Authors: Stephanie S Weinreich, Astrid Bosma, Lidewij Henneman, Tessel Rigter, Carla MJ Spruijt, Anneliese JEMA Grimbergen, Martijn H Breuning, Eelco JP de Koning, Monique Losekoot & Martina C Cornel
  • New insights into genotype–phenotype correlation for GLI3 mutations

    Florence Démurger
    15 Apr 2014 | 5:00 pm
    New insights into genotype–phenotype correlation for GLI3 mutations European Journal of Human Genetics advance online publication, April 16 2014. doi:10.1038/ejhg.2014.62 Authors: Florence Démurger, Amale Ichkou, Soumaya Mougou-Zerelli, Martine Le Merrer, Géraldine Goudefroye, Anne-Lise Delezoide, Chloé Quélin, Sylvie Manouvrier, Geneviève Baujat, Mélanie Fradin, Laurent Pasquier, André Megarbané, Laurence Faivre, Clarisse Baumann, Sheela Nampoothiri, Joëlle Roume, Bertrand Isidor, Didier Lacombe, Marie-Ange Delrue, Sandra Mercier, Nicole…
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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