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  • The danger model: questioning an unconvincing theory

    Immunology and Cell Biology - AOP - nature.com science feeds
    Szczepan Józefowski
    27 Jul 2015 | 5:00 pm
    The danger model: questioning an unconvincing theory Immunology and Cell Biology advance online publication, July 28 2015. doi:10.1038/icb.2015.68 Author: Szczepan Józefowski
  • Magnetospherically driven optical and radio aurorae at the end of the stellar main sequence

    Nature - Issue - nature.com science feeds
    G. Hallinan
    29 Jul 2015 | 5:00 pm
    Magnetospherically driven optical and radio aurorae at the end of the stellar main sequence Nature 523, 7562 (2015). doi:10.1038/nature14619 Authors: G. Hallinan, S. P. Littlefair, G. Cotter, S. Bourke, L. K. Harding, J. S. Pineda, R. P. Butler, A. Golden, G. Basri, J. G. Doyle, M. M. Kao, S. V. Berdyugina, A. Kuznetsov, M. P. Rupen & A. Antonova Aurorae are detected from all the magnetized planets in our Solar System, including Earth. They are powered by magnetospheric current systems that lead to the precipitation of energetic electrons into the high-latitude regions of the upper…
  • Obama orders stronger limits on power-plant emissions

    NatureNews - Most recent articles - nature.com science feeds
    Jeff Tollefson
    2 Aug 2015 | 5:00 pm
    White House's latest action on climate change will cut greenhouse-gas output from the US electricity sector.Nature News doi: 10.1038/nature.2015.18030
  • Graphene kirigami

    Nature - AOP - nature.com science feeds
    Melina K. Blees
    28 Jul 2015 | 5:00 pm
    Nature advance online publication 29 July 2015. doi:10.1038/nature14588 Authors: Melina K. Blees, Arthur W. Barnard, Peter A. Rose, Samantha P. Roberts, Kathryn L. McGill, Pinshane Y. Huang, Alexander R. Ruyack, Joshua W. Kevek, Bryce Kobrin, David A. Muller & Paul L. McEuen For centuries, practitioners of origami (‘ori’, fold; ‘kami’, paper) and kirigami (‘kiru’, cut) have fashioned sheets of paper into beautiful and complex three-dimensional structures. Both techniques are scalable, and scientists and engineers are adapting them to different…
  • Book Review: Genius at Play

    Scientific American
    Sarah Lewin
    13 Jul 2015 | 5:00 pm
    Scientific American 313, 82 (2015). doi:10.1038/scientificamerican0815-82d Author: Sarah Lewin
 
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    Nature - Issue - nature.com science feeds

  • Magnetospherically driven optical and radio aurorae at the end of the stellar main sequence

    G. Hallinan
    29 Jul 2015 | 5:00 pm
    Magnetospherically driven optical and radio aurorae at the end of the stellar main sequence Nature 523, 7562 (2015). doi:10.1038/nature14619 Authors: G. Hallinan, S. P. Littlefair, G. Cotter, S. Bourke, L. K. Harding, J. S. Pineda, R. P. Butler, A. Golden, G. Basri, J. G. Doyle, M. M. Kao, S. V. Berdyugina, A. Kuznetsov, M. P. Rupen & A. Antonova Aurorae are detected from all the magnetized planets in our Solar System, including Earth. They are powered by magnetospheric current systems that lead to the precipitation of energetic electrons into the high-latitude regions of the upper…
  • Secret service

    28 Jul 2015 | 5:00 pm
    Secret service Nature 523, 7562 (2015). doi:10.1038/523501b Government labs should be subject to the same transparent oversight as academic facilities.
  • Realistic risks

    28 Jul 2015 | 5:00 pm
    Realistic risks Nature 523, 7562 (2015). doi:10.1038/523502a The communication of risk in disease outbreaks is too often neglected; that must change.
  • Stem cells: Stomach tissue made in a dish

    28 Jul 2015 | 5:00 pm
    Stem cells: Stomach tissue made in a dish Nature 523, 7562 (2015). doi:10.1038/523504c Mouse embryonic stem cells can develop into 3D 'mini stomachs' in the lab.Researchers have previously used stem cells to make parts of the stomach, but not the whole organ. Taka-aki Noguchi, Akira Kurisaki at the University of Tsukuba in Japan and their team made
  • Astronomy: Telescope spies early galaxy's birth

    28 Jul 2015 | 5:00 pm
    Astronomy: Telescope spies early galaxy's birth Nature 523, 7562 (2015). doi:10.1038/523505a Astronomers have spotted the glow from one of the most distant galaxies ever seen in the early Universe.Roberto Maiolino at the University of Cambridge, UK, and his colleagues used the high-resolution Atacama Large Millimeter/submillimeter Array (ALMA) telescope in Chile to observe three faint galaxies
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  • Graphene kirigami

    Melina K. Blees
    28 Jul 2015 | 5:00 pm
    Nature advance online publication 29 July 2015. doi:10.1038/nature14588 Authors: Melina K. Blees, Arthur W. Barnard, Peter A. Rose, Samantha P. Roberts, Kathryn L. McGill, Pinshane Y. Huang, Alexander R. Ruyack, Joshua W. Kevek, Bryce Kobrin, David A. Muller & Paul L. McEuen For centuries, practitioners of origami (‘ori’, fold; ‘kami’, paper) and kirigami (‘kiru’, cut) have fashioned sheets of paper into beautiful and complex three-dimensional structures. Both techniques are scalable, and scientists and engineers are adapting them to different…
  • RNA degradation paths in a 12-subunit nuclear exosome complex

    Debora Lika Makino
    28 Jul 2015 | 5:00 pm
    Nature advance online publication 29 July 2015. doi:10.1038/nature14865 Authors: Debora Lika Makino, Benjamin Schuch, Elisabeth Stegmann, Marc Baumgärtner, Claire Basquin & Elena Conti
  • Synthetic biology: Ribosomal ties that bind

    Joseph D. Puglisi
    28 Jul 2015 | 5:00 pm
    Nature advance online publication 29 July 2015. doi:10.1038/nature14642 Author: Joseph D. Puglisi The ribosome is the cellular complex of proteins and RNA molecules that synthesizes proteins. An artificial ribosome in which the two main subunits are tethered together creates opportunities for engineering this process.
  • Structure of the eukaryotic MCM complex at 3.8 Å

    Ningning Li
    28 Jul 2015 | 5:00 pm
    Nature advance online publication 29 July 2015. doi:10.1038/nature14685 Authors: Ningning Li, Yuanliang Zhai, Yixiao Zhang, Wanqiu Li, Maojun Yang, Jianlin Lei, Bik-Kwoon Tye & Ning Gao
  • Microbiology: Cyanate fuels the nitrogen cycle

    Lisa Y. Stein
    28 Jul 2015 | 5:00 pm
    Nature advance online publication 29 July 2015. doi:10.1038/nature14639 Author: Lisa Y. Stein Cyanate, a degradation product of urea and cyanide, has been found to be a sufficient single substrate for the growth and reciprocal feeding of microorganisms that are essential to the global nitrogen cycle.
 
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    Scientific American

  • Book Review: Genius at Play

    Sarah Lewin
    13 Jul 2015 | 5:00 pm
    Scientific American 313, 82 (2015). doi:10.1038/scientificamerican0815-82d Author: Sarah Lewin
  • The Great Flower Fabrication

    Debra Weiner
    13 Jul 2015 | 5:00 pm
    Scientific American 313, 24 (2015). doi:10.1038/scientificamerican0815-24 Author: Debra Weiner 3-D printing may save a threatened thistle
  • Letters

    13 Jul 2015 | 5:00 pm
    Scientific American 313, 6 (2015). doi:10.1038/scientificamerican0815-6
  • Remembering the Blast

    Clara Moskowitz
    13 Jul 2015 | 5:00 pm
    Scientific American 313, 20 (2015). doi:10.1038/scientificamerican0815-20 Author: Clara Moskowitz Survivors of World War II's Hiroshima and Nagasaki bombings speak out on the 70th anniversary of the detonations
  • 50, 100 & 150 Years Ago

    Daniel C. Schlenoff
    13 Jul 2015 | 5:00 pm
    Scientific American 313, 86 (2015). doi:10.1038/scientificamerican0815-86 Author: Daniel C. Schlenoff
 
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    Nature Cell Biology - Issue - nature.com science feeds

  • Condensing chromosome condensation

    Jason C. Bell
    30 Jul 2015 | 5:00 pm
    Nature Cell Biology 17, 964 (2015). doi:10.1038/ncb3212 Authors: Jason C. Bell & Aaron F. Straight Mitotic chromosome condensation has fascinated biologists since Flemming's early illustrations of mitosis in the late nineteenth century. Now — 130 years later — chromatid condensation is reconstituted in vitro with the minimum components. The results are remarkably and beautifully simple, requiring only core histones, three histone chaperones, topoisomerase II and condensin I.
  • Building stomach in a dish

    Meritxell Huch
    30 Jul 2015 | 5:00 pm
    Nature Cell Biology 17, 966 (2015). doi:10.1038/ncb3211 Author: Meritxell Huch Modelling organs in culture has great potential to improve our understanding of development, organogenesis and disease. While some endodermal derived organs have been modelled, the corpus region of the stomach, where acid-producing cells reside, remained an invincible target. A 60-day differentiation protocol now enables the generation of functional acid-producing cells in culture, conquering the challenge.
  • RB-loss puts focus on Myc

    Wayne O. Miles
    30 Jul 2015 | 5:00 pm
    Nature Cell Biology 17, 968 (2015). doi:10.1038/ncb3213 Authors: Wayne O. Miles & Nicholas J. Dyson Activator E2Fs and Myc cooperate as master regulators of proliferation. A new study sheds light on one of the fundamental questions in cancer biology: how do oncogenic changes, such as Retinoblastoma (RB)-mutation, modify E2F and Myc activity?
  • Erratum: Proteostasis control by the unfolded protein response

    Claudio Hetz
    30 Jul 2015 | 5:00 pm
    Nature Cell Biology 17, 1088 (2015). doi:10.1038/ncb3221 Author: Claudio Hetz, Eric Chevet & Scott A. Oakes
  • Corrigendum: Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

    Derrick Gibbings
    30 Jul 2015 | 5:00 pm
    Nature Cell Biology 17, 1088 (2015). doi:10.1038/ncb3208 Author: Derrick Gibbings, Serge Mostowy, Florence Jay, Yannick Schwab, Pascale Cossart & Olivier Voinnet
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    Nature Chemical Biology - Issue - nature.com science feeds

  • Lipid metabolism: Working out SCD's kinks

    Stéphane Larochelle
    20 Jul 2015 | 5:00 pm
    Nature Chemical Biology 11, 548 (2015). doi:10.1038/nchembio.1874 Author: Stéphane Larochelle
  • Voices of chemical biology

    20 Jul 2015 | 5:00 pm
    Nature Chemical Biology 11, 546 (2015). doi:10.1038/nchembio.1880 We asked a collection of chemical biologists: “What is the most significant challenge facing chemical biology as a discipline?”
  • Curation of chemogenomics data

    Denis Fourches
    20 Jul 2015 | 5:00 pm
    Nature Chemical Biology 11, 535 (2015). doi:10.1038/nchembio.1881 Authors: Denis Fourches, Eugene Muratov & Alexander Tropsha
  • Probing the epigenome

    Andrea Huston
    20 Jul 2015 | 5:00 pm
    Nature Chemical Biology 11, 542 (2015). doi:10.1038/nchembio.1871 Authors: Andrea Huston, Cheryl H Arrowsmith, Stefan Knapp & Matthieu Schapira Epigenetic chemical probes are having a strong impact in biological discovery and target validation. Systematic coverage of emerging epigenetic target classes with these potent, selective, cell-active chemical tools will profoundly influence understanding of the human biology and pathology of chromatin-templated mechanisms.
  • The promise and peril of chemical probes

    Cheryl H Arrowsmith
    20 Jul 2015 | 5:00 pm
    Nature Chemical Biology 11, 536 (2015). doi:10.1038/nchembio.1867 Authors: Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke…
 
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    Nature Chemistry

  • Synthetic biology: Six pack and stack

    Cheulhee Jung
    22 Jul 2015 | 5:00 pm
    Nature Chemistry 7, 617 (2015). doi:10.1038/nchem.2313 Authors: Cheulhee Jung & Andrew D. Ellington A pair of artificial DNA bases have now been shown to adopt an edge-to-edge geometry in DNA which is similar that found in Watson–Crick base pairing. Aptamers containing these bases have also been shown to bind more strongly to a target than those developed using only the four naturally occurring bases.
  • Polymer chemistry: Put a ring on it

    Claire Hansell
    22 Jul 2015 | 5:00 pm
    Nature Chemistry 7, 614 (2015). doi:10.1038/nchem.2317 Author: Claire Hansell
  • Energy storage: Better together

    Gavin Armstrong
    22 Jul 2015 | 5:00 pm
    Nature Chemistry 7, 615 (2015). doi:10.1038/nchem.2318 Author: Gavin Armstrong
  • Metal–metal bonding: Zinc on the line

    Anne Pichon
    22 Jul 2015 | 5:00 pm
    Nature Chemistry 7, 614 (2015). doi:10.1038/nchem.2319 Author: Anne Pichon
  • Stretching the comfort zone

    Bruce C. Gibb
    22 Jul 2015 | 5:00 pm
    Nature Chemistry 7, 611 (2015). doi:10.1038/nchem.2312 Author: Bruce C. Gibb Bruce C. Gibb is organizing a workshop for two groups of scientists that study a similar topic, but rarely get together. The different perspectives they bring and the unusual set up of the meeting will hopefully lead to new ideas, but, as he suggests, they will also lead to the attendees leaving their comfort zones.
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    Nature Chemistry

  • Significantly shorter Fe–S bond in cytochrome P450-I is consistent with greater reactivity relative to chloroperoxidase

    Courtney M. Krest
    2 Aug 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2306 Authors: Courtney M. Krest, Alexey Silakov, Jonathan Rittle, Timothy H. Yosca, Elizabeth L. Onderko, Julio C. Calixto & Michael T. Green Cytochrome P450 (P450) and chloroperoxidase (CPO) are both thiolate-ligated haem proteins that form a ferryl radical species called compound I. P450-I is, however, significantly more reactive than CPO-I. Variable-temperature Mössbauer and X-ray absorption measurements have now shown that increased electron donation from the axial thiolate ligand in P450-I may explain its greater propensity for C–H bond…
  • Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides

    Teigo Asai
    2 Aug 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2308 Authors: Teigo Asai, Kento Tsukada, Satomi Ise, Naoki Shirata, Makoto Hashimoto, Isao Fujii, Katsuya Gomi, Kosuke Nakagawara, Eiichi N. Kodama & Yoshiteru Oshima The complexity and diversity of natural product structures make them an ideal starting point for the creation of chemical libraries. Now it is shown that a semi-synthetic process can combine heterologous expression of a multipotent biosynthetic intermediate with multiple non-enzymatic steps to produce libraries of pseudo-natural products.
  • Organocatalytic removal of formaldehyde adducts from RNA and DNA bases

    Saswata Karmakar
    2 Aug 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2307 Authors: Saswata Karmakar, Emily M. Harcourt, David S. Hewings, Alexander F. Lovejoy, David M. Kurtz, Thomas Ehrenschwender, Luzi J. Barandun, Caroline Roost, Ash A. Alizadeh & Eric T. Kool Formaldehyde is universally employed in the fixation of tissue specimens, where it forms adducts with biomolecules, but this hinders the analysis of nucleic acids in the specimen. Bifunctional organocatalysts that speed the reversal of formaldehyde adducts of RNA and DNA are now reported, and show promise for general use in clinical specimens.
  • Synthesis of marmycin A and investigation into its cellular activity

    Tatiana Cañeque
    19 Jul 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2302 Authors: Tatiana Cañeque, Filipe Gomes, Trang Thi Mai, Giovanni Maestri, Max Malacria & Raphaël Rodriguez Marmycin A is an anthraquinone natural product with antiproliferative properties. Now the chemical synthesis of marmycin A—through a Diels–Alder cycloaddition, an Ullmann aromatic amination and a Friedel–Crafts cyclization—has enabled a study of its biological activity. Fluorescence microscopy reveals that marmycin A accumulates in lysosomes and promotes cell death independently of genome targeting.
 
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    Nature Genetics - Issue - nature.com science feeds

  • Pediatric cancer genomics, a play rather than a portrait

    Vijay Ramaswamy
    28 Jul 2015 | 5:00 pm
    Nature Genetics 47, 851 (2015). doi:10.1038/ng.3366 Authors: Vijay Ramaswamy & Michael D Taylor Relapsed neuroblastoma is common, frequently lethal and poorly studied and poses a major treatment challenge. Two new studies shed light on the genomic landscape of recurrent neuroblastoma and demonstrate profound differences between the disease at diagnosis and relapse.
  • Running spell-check to identify regulatory variants

    Martin Kircher
    28 Jul 2015 | 5:00 pm
    Nature Genetics 47, 853 (2015). doi:10.1038/ng.3364 Authors: Martin Kircher & Jay Shendure A major challenge in human genetics is pinpointing which non-coding genetic variants affect gene expression and disease risk. A new study in this issue describes a broadly applicable approach for this task that explicitly models cell type–specific regulatory motifs and generates variant effect predictions that are more accurate and interpretable than those of alternative tools.
  • Richard Graham Hay Cotton 1940–2015

    Tim Smith
    28 Jul 2015 | 5:00 pm
    Nature Genetics 47, 850 (2015). doi:10.1038/ng.3369 Authors: Tim Smith & Graham Taylor
  • Counting copy number and calories

    Stefan White
    28 Jul 2015 | 5:00 pm
    Nature Genetics 47, 852 (2015). doi:10.1038/ng.3365 Author: Stefan White Copy number variation (CNV) at several genomic loci has been associated with different human traits and diseases, but in many cases the findings could not be replicated. A new study provides insights into the degree of variation present at the amylase locus and calls into question a previous association between amylase copy number and body mass index.
  • Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception

    Ya-Chun Chen
    28 Jul 2015 | 5:00 pm
    Nature Genetics 47, 962 (2015). doi:10.1038/ng0815-962b Author: Ya-Chun Chen, Michaela Auer-Grumbach, Shinya Matsukawa, Manuela Zitzelsberger, Andreas C Themistocleous, Tim M Strom, Chrysanthi Samara, Adrian W Moore, Lily Ting-Yin Cho, Gareth T Young, Caecilia Weiss, Maria Schabhüttl, Rolf Stucka, Annina B Schmid, Yesim Parman, Luitgard Graul-Neumann, Wolfram Heinritz, Eberhard Passarge, Rosemarie M Watson, Jens Michael Hertz, Ute Moog, Manuela Baumgartner, Enza Maria Valente, Diego Pereira, Carlos M Restrepo, Istvan Katona, Marina Dusl, Claudia Stendel, Thomas Wieland, Fay Stafford,…
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    Nature Genetics - AOP - nature.com science feeds

  • The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

    Vincent-Philippe Lavallée
    2 Aug 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3371 Authors: Vincent-Philippe Lavallée, Irène Baccelli, Jana Krosl, Brian Wilhelm, Frédéric Barabé, Patrick Gendron, Geneviève Boucher, Sébastien Lemieux, Anne Marinier, Sylvain Meloche, Josée Hébert & Guy Sauvageau
  • Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

    Matthew H Law
    2 Aug 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3373 Authors: Matthew H Law, D Timothy Bishop, Jeffrey E Lee, Myriam Brossard, Nicholas G Martin, Eric K Moses, Fengju Song, Jennifer H Barrett, Rajiv Kumar, Douglas F Easton, Paul D P Pharoah, Anthony J Swerdlow, Katerina P Kypreou, John C Taylor, Mark Harland, Juliette Randerson-Moor, Lars A Akslen, Per A Andresen, Marie-Françoise Avril, Esther Azizi, Giovanna Bianchi Scarrà, Kevin M Brown, Tadeusz De¸bniak, David L Duffy, David E Elder, Shenying Fang, Eitan Friedman, Pilar Galan, Paola Ghiorzo, Elizabeth M Gillanders, Alisa M Goldstein,…
  • A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer

    Folefac Aminkeng
    2 Aug 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3374 Authors: Folefac Aminkeng, Amit P Bhavsar, Henk Visscher, Shahrad R Rassekh, Yuling Li, Jong W Lee, Liam R Brunham, Huib N Caron, Elvira C van Dalen, Leontien C Kremer, Helena J van der Pal, Ursula Amstutz, Michael J Rieder, Daniel Bernstein, Bruce C Carleton, Michael R Hayden, Colin J D Ross, Michael Hayden, Bruce Carleton, Colin Ross, Stuart MacLeod, Anne Smith, Claudette Hildebrand, Reza Ghannadan, Shahrad Rassekh, Henk Visscher, Folefac Aminkeng, Fudan Miao, Michelle Higginson, Nasim Massah, Adrienne Borrie, Ursula Amstutz, Shevaun Hughes, Kaitlyn…
  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

    Martin Hrabě de Angelis
    26 Jul 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3360 Authors: Martin Hrabě de Angelis, George Nicholson, Mohammed Selloum, Jacqueline K White, Hugh Morgan, Ramiro Ramirez-Solis, Tania Sorg, Sara Wells, Helmut Fuchs, Martin Fray, David J Adams, Niels C Adams, Thure Adler, Antonio Aguilar-Pimentel, Dalila Ali-Hadji, Gregory Amann, Philippe André, Sarah Atkins, Aurelie Auburtin, Abdel Ayadi, Julien Becker, Lore Becker, Elodie Bedu, Raffi Bekeredjian, Marie-Christine Birling, Andrew Blake, Joanna Bottomley, Michael R Bowl, Véronique Brault, Dirk H Busch, James N Bussell, Julia Calzada-Wack,…
  • Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

    Thomas G P Grünewald
    26 Jul 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3363 Authors: Thomas G P Grünewald, Virginie Bernard, Pascale Gilardi-Hebenstreit, Virginie Raynal, Didier Surdez, Marie-Ming Aynaud, Olivier Mirabeau, Florencia Cidre-Aranaz, Franck Tirode, Sakina Zaidi, Gaëlle Perot, Anneliene H Jonker, Carlo Lucchesi, Marie-Cécile Le Deley, Odile Oberlin, Perrine Marec-Bérard, Amélie S Véron, Stephanie Reynaud, Eve Lapouble, Valentina Boeva, Thomas Rio Frio, Javier Alonso, Smita Bhatia, Gaëlle Pierron, Geraldine Cancel-Tassin, Olivier Cussenot, David G Cox, Lindsay M Morton, Mitchell J…
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    Nature Geoscience - Issue - nature.com science feeds

  • Education: Literacy from writing

    Alicia Newton
    29 Jul 2015 | 5:00 pm
    Nature Geoscience 8, 584 (2015). doi:10.1038/ngeo2503 Author: Alicia Newton
  • All hands on deck

    29 Jul 2015 | 5:00 pm
    Nature Geoscience 8, 575 (2015). doi:10.1038/ngeo2506 Reforms in science teaching are building a stronger, more flexible student population ready to face the challenges of the future. We must remove the barriers that prevent these talented students from entering the geosciences.
  • Games and climate literacy

    Megan K. Fung
    29 Jul 2015 | 5:00 pm
    Nature Geoscience 8, 576 (2015). doi:10.1038/ngeo2499 Authors: Megan K. Fung, Laura R. Tedesco & Miriam E. Katz
  • Impact of inclusive field trips

    Brett Gilley
    29 Jul 2015 | 5:00 pm
    Nature Geoscience 8, 579 (2015). doi:10.1038/ngeo2500 Authors: Brett Gilley, Chris Atchison, Anthony Feig & Alison Stokes The geosciences benefit from diverse student perspectives and backgrounds, but the field-based learning requirements pose barriers to students with disabilities. If carefully designed, fieldwork can be made accessible while still meeting expectations of academic rigour.
  • From recruitment to retention

    Rebecca Haacker
    29 Jul 2015 | 5:00 pm
    Nature Geoscience 8, 577 (2015). doi:10.1038/ngeo2501 Author: Rebecca Haacker Increased efforts in recruiting minority students have not proven to be enough to address the lack of diversity in the geosciences. A collaborative mentoring culture is needed to permanently change the make-up of our field.
 
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    Nature Geoscience - AOP - nature.com science feeds

  • Experimental demonstration of a semi-brittle origin for crustal strain transients

    Jacqueline E. Reber
    2 Aug 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2496 Authors: Jacqueline E. Reber, Luc L. Lavier & Nicholas W. Hayman Tectonic motions give rise to destructive earthquakes and transient slip events. These movements are often described by friction laws for stick–slip motion on brittle fault surfaces and gouge-filled zones. Yet, many transient slip events, such as slow earthquakes and aseismic creep, occur in rocks that exhibit mixed brittle–ductile rheology, where these friction laws are not clearly applicable. Here we describe the flow and evolution of fractures as observed in a…
  • Triggered earthquakes suppressed by an evolving stress shadow from a propagating dyke

    Robert G. Green
    26 Jul 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2491 Authors: Robert G. Green, Tim Greenfield & Robert S. White Large earthquakes can generate small changes in static stress: increases that trigger aftershock swarms, or reductions that create a region of reduced seismicity—a stress shadow. However, seismic waves from large earthquakes also cause transient dynamic stresses that may trigger seismicity. This makes it difficult to separate the relative influence of static and dynamic stress changes on aftershocks. Dyke intrusions do not generate dynamic stresses, so provide an unambiguous test of…
  • The frictional, hydrologic, metamorphic and thermal habitat of shallow slow earthquakes

    Demian M. Saffer
    26 Jul 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2490 Authors: Demian M. Saffer & Laura M. Wallace
  • Importance of latent heat release in ascending air streams for atmospheric blocking

    S. Pfahl
    19 Jul 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2487 Authors: S. Pfahl, C. Schwierz, M. Croci-Maspoli, C. M. Grams & H. Wernli Atmospheric blocking is a key component of extratropical weather variability and can contribute to various types of extreme weather events. Changes in blocking frequencies due to Arctic amplification and sea ice loss may enhance extreme events, but the mechanisms potentially involved in such changes are under discussion. Current theories for blocking are essentially based on dry dynamics and do not directly take moist processes into account. Here we analyse a 21-year…
  • Increased Arctic sea ice volume after anomalously low melting in 2013

    Rachel L. Tilling
    19 Jul 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2489 Authors: Rachel L. Tilling, Andy Ridout, Andrew Shepherd & Duncan J. Wingham
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    Nature Immunology - Issue - nature.com science feeds

  • XBP1, a determinant of the eosinophil lineage

    Zhong-Jian Shen
    20 Jul 2015 | 5:00 pm
    Nature Immunology 16, 793 (2015). doi:10.1038/ni.3214 Authors: Zhong-Jian Shen & James S Malter Targeted deletion of the transcription factor XBP1 in hematopoietic stem cells selectively prevents eosinophil maturation in the bone marrow without affecting other lineages of the immune system.
  • Tuning up FALCs: immunological shielding in the body cavities

    Christian Perez-Shibayama
    20 Jul 2015 | 5:00 pm
    Nature Immunology 16, 796 (2015). doi:10.1038/ni.3228 Authors: Christian Perez-Shibayama & Burkhard Ludewig Fat-associated lymphoid clusters (FALCs) are non-classical secondary lymphoid organs of the body cavities. The formation and maturation of FALCs are driven by tumor-necrosis factor and are further enhanced by invariant natural killer T cells.
  • DPP4 in anti-tumor immunity: going beyond the enzyme

    Kei Ohnuma
    20 Jul 2015 | 5:00 pm
    Nature Immunology 16, 791 (2015). doi:10.1038/ni.3210 Authors: Kei Ohnuma, Ryo Hatano & Chikao Morimoto Effective anti-tumor immune therapy in solid tumors relies on the presence of effector T cells. Inhibition of the dipeptidylpeptidase DPP4 (CD26) enhances chemokine CXCL10–mediated infiltration of lymphocytes into the tumor parenchyma, which results in diminished tumor growth.
  • NLRP3 moonlights in TH2 polarization

    Jenny P Y Ting
    20 Jul 2015 | 5:00 pm
    Nature Immunology 16, 794 (2015). doi:10.1038/ni.3223 Authors: Jenny P Y Ting & Jonathan A Harton As the cytosolic guardian for many microbial and sterile inflammatory insults, NLRP3 is best appreciated for its innate immunological role mediating inflammasome activation. Now NLRP3 debuts as a transcription factor key for TH2 polarization.
  • Thymoproteasome bias

    Ioana Visan
    20 Jul 2015 | 5:00 pm
    Nature Immunology 16, 801 (2015). doi:10.1038/ni.3243 Author: Ioana Visan
 
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    Nature Materials - Issue - nature.com science feeds

  • DNA–nanoparticle crystals: Flip-flop lattices

    Erika Eiser
    22 Jul 2015 | 5:00 pm
    Nature Materials 14, 751 (2015). doi:10.1038/nmat4370 Author: Erika Eiser The structure of crystals made of DNA-bridged nanoparticles can be selectively switched between various lattices by reprogramming the DNA-mediated interactions between the nanoparticles.
  • DNA-linked superlattices get into shape

    Bert Nickel
    22 Jul 2015 | 5:00 pm
    Nature Materials 14, 746 (2015). doi:10.1038/nmat4376 Authors: Bert Nickel & Tim Liedl Advances in the control of the shape, bonding direction and valency of DNA-coated nanoparticles allow the synthesis of nanoparticle crystallites of ever increasing complexity.
  • Dislocation networks: Shedding coherent light on defects

    Felix Hofmann
    22 Jul 2015 | 5:00 pm
    Nature Materials 14, 756 (2015). doi:10.1038/nmat4334 Author: Felix Hofmann With Bragg coherent diffractive imaging it is now possible to image the evolution of the entire dislocation network within a microcrystal during growth and dissolution.
  • Spintronics: Detecting the switch

    David Ciudad
    22 Jul 2015 | 5:00 pm
    Nature Materials 14, 750 (2015). doi:10.1038/nmat4379 Author: David Ciudad
  • Material witness: Liquid-state particle physics

    Philip Ball
    22 Jul 2015 | 5:00 pm
    Nature Materials 14, 754 (2015). doi:10.1038/nmat4373 Author: Philip Ball
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  • Nanocapillarity-mediated magnetic assembly of nanoparticles into ultraflexible filaments and reconfigurable networks

    Bhuvnesh Bharti
    2 Aug 2015 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4364 Authors: Bhuvnesh Bharti, Anne-Laure Fameau, Michael Rubinstein & Orlin D. Velev The fabrication of multifunctional materials with tunable structure and properties requires programmed binding of their building blocks. For example, particles organized in long-ranged structures by external fields can be bound permanently into stiff chains through electrostatic or van der Waals attraction, or into flexible chains through soft molecular linkers such as surface-grafted DNA or polymers. Here, we show that capillarity-mediated binding between magnetic…
  • Unjamming and cell shape in the asthmatic airway epithelium

    Jin-Ah Park
    2 Aug 2015 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4357 Authors: Jin-Ah Park, Jae Hun Kim, Dapeng Bi, Jennifer A. Mitchel, Nader Taheri Qazvini, Kelan Tantisira, Chan Young Park, Maureen McGill, Sae-Hoon Kim, Bomi Gweon, Jacob Notbohm, Robert Steward Jr, Stephanie Burger, Scott H. Randell, Alvin T. Kho, Dhananjay T. Tambe, Corey Hardin, Stephanie A. Shore, Elliot Israel, David A. Weitz, Daniel J. Tschumperlin, Elizabeth P. Henske, Scott T. Weiss, M. Lisa Manning, James P. Butler, Jeffrey M. Drazen & Jeffrey J. Fredberg
  • Epitaxial growth of two-dimensional stanene

    Feng-feng Zhu
    2 Aug 2015 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4384 Authors: Feng-feng Zhu, Wei-jiong Chen, Yong Xu, Chun-lei Gao, Dan-dan Guan, Can-hua Liu, Dong Qian, Shou-Cheng Zhang & Jin-feng Jia
  • Fast and long-range triplet exciton diffusion in metal–organic frameworks for photon upconversion at ultralow excitation power

    Prasenjit Mahato
    2 Aug 2015 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4366 Authors: Prasenjit Mahato, Angelo Monguzzi, Nobuhiro Yanai, Teppei Yamada & Nobuo Kimizuka
  • Metal–organic frameworks: Framing upconversion materials

    Yoan C. Simon
    2 Aug 2015 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4375 Authors: Yoan C. Simon & Christoph Weder Solid-state organic materials that convert low-power visible light into higher-energy radiation have been synthesized using metal–organic frameworks. This approach could be used to make polymers that increase the efficiency of photovoltaic devices.
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  • Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

    Sara Lovisa
    2 Aug 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3902 Authors: Sara Lovisa, Valerie S LeBleu, Björn Tampe, Hikaru Sugimoto, Komal Vadnagara, Julienne L Carstens, Chia-Chin Wu, Yohannes Hagos, Birgitta C Burckhardt, Tsvetelina Pentcheva-Hoang, Hersharan Nischal, James P Allison, Michael Zeisberg & Raghu Kalluri
  • Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

    M Teresa Grande
    2 Aug 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3901 Authors: M Teresa Grande, Berta Sánchez-Laorden, Cristina López-Blau, Cristina A De Frutos, Agnès Boutet, Miguel Arévalo, R Grant Rowe, Stephen J Weiss, José M López-Novoa & M Angela Nieto
  • Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

    Jesmond Dalli
    2 Aug 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3911 Authors: Jesmond Dalli, Nan Chiang & Charles N Serhan Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest. Here we elucidate the structures of four new host-protective molecules produced in neutrophil-endothelial cocultures and present in human and mouse tissues after sterile inflammation or infection. The bioactive molecules contain conjugated triene and diene double bonds, carry an alcohol at C13 and are derived from n-3 docosapentaenoic acid (DPA, C22:5). These compounds,…
  • Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

    Berno Dankbar
    2 Aug 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3917 Authors: Berno Dankbar, Michelle Fennen, Daniela Brunert, Silvia Hayer, Svetlana Frank, Corinna Wehmeyer, Denise Beckmann, Peter Paruzel, Jessica Bertrand, Kurt Redlich, Christina Koers-Wunrau, Athanasios Stratis, Adelheid Korb-Pap & Thomas Pap Myostatin (also known as growth and differentiation factor 8) is a secreted member of the transforming growth factor-β (TGF-β) family that is mainly expressed in skeletal muscle, which is also its primary target tissue. Deletion of the myostatin gene (Mstn) in mice leads to muscle hypertrophy, and…
  • The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

    Xuan Zhang
    26 Jul 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3914 Authors: Xuan Zhang, Dongya Zhang, Huijue Jia, Qiang Feng, Donghui Wang, Di Liang, Xiangni Wu, Junhua Li, Longqing Tang, Yin Li, Zhou Lan, Bing Chen, Yanli Li, Huanzi Zhong, Hailiang Xie, Zhuye Jie, Weineng Chen, Shanmei Tang, Xiaoqiang Xu, Xiaokai Wang, Xianghang Cai, Sheng Liu, Yan Xia, Jiyang Li, Xingye Qiao, Jumana Yousuf Al-Aama, Hua Chen, Li Wang, Qing-jun Wu, Fengchun Zhang, Wenjie Zheng, Yongzhe Li, Mingrong Zhang, Guangwen Luo, Wenbin Xue, Liang Xiao, Jun Li, Wanting Chen, Xun Xu, Ye Yin, Huanming Yang, Jian Wang, Karsten Kristiansen, Liang Liu,…
 
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  • ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

    Aaron E Cozen
    2 Aug 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3508 Authors: Aaron E Cozen, Erin Quartley, Andrew D Holmes, Eva Hrabeta-Robinson, Eric M Phizicky & Todd M Lowe
  • EEG and functional ultrasound imaging in mobile rats

    Lim-Anna Sieu
    2 Aug 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3506 Authors: Lim-Anna Sieu, Antoine Bergel, Elodie Tiran, Thomas Deffieux, Mathieu Pernot, Jean-Luc Gennisson, Mickaël Tanter & Ivan Cohen We developed an integrated experimental framework that extends the brain exploration capabilities of functional ultrasound imaging to awake and mobile rats. In addition to acquiring hemodynamic data, this method further allows parallel access to electroencephalography (EEG) recordings of neuronal activity. We illustrate this approach with two proofs of concept: a behavioral study on theta rhythm activation in a…
  • Mutational interference mapping experiment (MIME) for studying RNA structure and function

    Redmond P Smyth
    2 Aug 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3490 Authors: Redmond P Smyth, Laurence Despons, Gong Huili, Serena Bernacchi, Marcel Hijnen, Johnson Mak, Fabrice Jossinet, Li Weixi, Jean-Christophe Paillart, Max von Kleist & Roland Marquet
  • ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

    Ashwin Chari
    2 Aug 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3493 Authors: Ashwin Chari, David Haselbach, Jan-Martin Kirves, Juergen Ohmer, Elham Paknia, Niels Fischer, Oleg Ganichkin, Vanessa Möller, Jeremiah J Frye, Georg Petzold, Marc Jarvis, Michael Tietzel, Clemens Grimm, Jan-Michael Peters, Brenda A Schulman, Kai Tittmann, Jürgen Markl, Utz Fischer & Holger Stark
  • Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells

    Daniel Paull
    2 Aug 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3507 Authors: Daniel Paull, Ana Sevilla, Hongyan Zhou, Aana Kim Hahn, Hesed Kim, Christopher Napolitano, Alexander Tsankov, Linshan Shang, Katie Krumholz, Premlatha Jagadeesan, Chris M Woodard, Bruce Sun, Thierry Vilboux, Matthew Zimmer, Eliana Forero, Dorota N Moroziewicz, Hector Martinez, May Christine V Malicdan, Keren A Weiss, Lauren B Vensand, Carmen R Dusenberry, Hannah Polus, Karla Therese L Sy, David J Kahler, William A Gahl, Susan L Solomon, Stephen Chang, Alexander Meissner, Kevin Eggan & Scott A Noggle
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    Nature Neuroscience - Issue - nature.com science feeds

  • Reassessing VMPFC: full of confidence?

    Helen C Barron
    27 Jul 2015 | 5:00 pm
    Nature Neuroscience 18, 1064 (2015). doi:10.1038/nn.4076 Authors: Helen C Barron, Mona M Garvert & Timothy E J Behrens The confidence that we place in our decisions can affect the judgments themselves. The BOLD signal in ventromedial prefrontal cortex automatically reflects the relationship between confidence and judgments on a range of tasks.
  • The binding solution?

    Mark E J Sheffield
    27 Jul 2015 | 5:00 pm
    Nature Neuroscience 18, 1060 (2015). doi:10.1038/nn.4075 Authors: Mark E J Sheffield & Daniel A Dombeck How do neurons combine distinct information streams and form long-lasting associations? Dendritic plateau potentials may allow the integration and storage of coincident location and contextual information in hippocampal neurons.
  • Sex, drugs and pain control

    Victoria E Brings
    27 Jul 2015 | 5:00 pm
    Nature Neuroscience 18, 1059 (2015). doi:10.1038/nn.4057 Authors: Victoria E Brings & Mark J Zylka A study finds that pain hypersensitivity in male and female mice is differentially dependent on microglia and T cells, and describes a sex-specific response to microglia-targeted pain treatments. This sex difference will be important to consider when developing treatments for pain and other neurological disorders involving microglia and immune cells.
  • Removing synaptic brakes on learning

    Federico W Grillo
    27 Jul 2015 | 5:00 pm
    Nature Neuroscience 18, 1062 (2015). doi:10.1038/nn.4073 Authors: Federico W Grillo, Lucien West & Vincenzo De Paola Imaging experiments in awake mice reveal striking, circuit-specific synaptic structural remodeling of inhibitory axons during learning.
  • The RNAs of ALS

    Sébastien Thuault
    27 Jul 2015 | 5:00 pm
    Nature Neuroscience 18, 1066 (2015). doi:10.1038/nn0815-1066 Author: Sébastien Thuault
 
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    Nature Photonics - Issue - nature.com science feeds

  • Status and prospects for ternary organic photovoltaics

    Luyao Lu
    29 Jul 2015 | 5:00 pm
    Nature Photonics 9, 491 (2015). doi:10.1038/nphoton.2015.128 Authors: Luyao Lu, Mary Allison Kelly, Wei You & Luping Yu
  • Nanophotonics: Liquid quantum photonics

    Mark Tame
    29 Jul 2015 | 5:00 pm
    Nature Photonics 9, 485 (2015). doi:10.1038/nphoton.2015.130 Author: Mark Tame Researchers have observed light propagation in which photons glide smoothly along a one-dimensional chain of electrons known as a Luttinger liquid — a many-body interacting quantum system held within a single-walled carbon nanotube.
  • Characterization of tandem organic solar cells

    Ronny Timmreck
    29 Jul 2015 | 5:00 pm
    Nature Photonics 9, 478 (2015). doi:10.1038/nphoton.2015.124 Authors: Ronny Timmreck, Toni Meyer, Jan Gilot, Holger Seifert, Toni Mueller, Alice Furlan, Martijn M. Wienk, David Wynands, Jochen Hohl-Ebinger, Wilhelm Warta, René A. J. Janssen, Moritz Riede & Karl Leo
  • Atomic physics: Fermions under the microscope

    Christian Groß
    29 Jul 2015 | 5:00 pm
    Nature Photonics 9, 482 (2015). doi:10.1038/nphoton.2015.133 Author: Christian Groß The observation of individual atoms with single-lattice-site resolution has proved to be an enormously powerful detection method for optical lattice-based quantum simulators. Such a technique has now been demonstrated with fermionic atoms.
  • New titles at a glance

    29 Jul 2015 | 5:00 pm
    Nature Photonics 9, 480 (2015). doi:10.1038/nphoton.2015.134
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  • Direct optical nanoscopy with axially localized detection

    N. Bourg
    2 Aug 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.132 Authors: N. Bourg, C. Mayet, G. Dupuis, T. Barroca, P. Bon, S. Lécart, E. Fort & S. Lévêque-Fort
  • All-plasmonic Mach–Zehnder modulator enabling optical high-speed communication at the microscale

    C. Haffner
    26 Jul 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.127 Authors: C. Haffner, W. Heni, Y. Fedoryshyn, J. Niegemann, A. Melikyan, D. L. Elder, B. Baeuerle, Y. Salamin, A. Josten, U. Koch, C. Hoessbacher, F. Ducry, L. Juchli, A. Emboras, D. Hillerkuss, M. Kohl, L. R. Dalton, C. Hafner & J. Leuthold Optical modulators encode electrical signals to the optical domain and thus constitute a key element in high-capacity communication links. Ideally, they should feature operation at the highest speed with the least power consumption on the smallest footprint, and at low cost. Unfortunately, current…
  • Intracellular microlasers

    Matjaž Humar
    26 Jul 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.129 Authors: Matjaž Humar & Seok Hyun Yun Optical microresonators, which confine light within a small cavity, are widely exploited for various applications ranging from the realization of lasers and nonlinear devices to biochemical and optomechanical sensing. Here we use microresonators and suitable optical gain materials inside biological cells to demonstrate various optical functions in vitro including lasing. We explore two distinct types of microresonator—soft and hard—that support whispering-gallery modes. Soft droplets formed by…
  • Observation of a Luttinger-liquid plasmon in metallic single-walled carbon nanotubes

    Zhiwen Shi
    19 Jul 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.123 Authors: Zhiwen Shi, Xiaoping Hong, Hans A. Bechtel, Bo Zeng, Michael C. Martin, Kenji Watanabe, Takashi Taniguchi, Yuen-Ron Shen & Feng Wang Surface plasmons, collective oscillations of conduction electrons, hold great promise for the nanoscale integration of photonics and electronics. However, nanophotonic circuits based on plasmons have been significantly hampered by the difficulty in achieving broadband plasmonic waveguides that simultaneously exhibit strong spatial confinement, a high quality factor and low dispersion. Quantum plasmons,…
  • Super high power mid-infrared femtosecond light bullet

    Paris Panagiotopoulos
    19 Jul 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.125 Authors: Paris Panagiotopoulos, Patrick Whalen, Miroslav Kolesik & Jerome V. Moloney
 
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    Nature Physics - Issue - nature.com science feeds

  • Complex networks: Bring the noise

    Abigail Klopper
    30 Jul 2015 | 5:00 pm
    Nature Physics 11, 620 (2015). doi:10.1038/nphys3438 Author: Abigail Klopper
  • Hubble's biggest fan

    Luis C. Ho
    30 Jul 2015 | 5:00 pm
    Nature Physics 11, 607 (2015). doi:10.1038/nphys3409 Author: Luis C. Ho What is it about the Hubble Space Telescope that so captivates its users and the public at large? I offer my personal views on this iconic telescope.
  • Random walks: Competitive advantage

    Andrea Taroni
    30 Jul 2015 | 5:00 pm
    Nature Physics 11, 620 (2015). doi:10.1038/nphys3442 Author: Andrea Taroni
  • Exploring the dwarf planets

    William B. McKinnon
    30 Jul 2015 | 5:00 pm
    Nature Physics 11, 608 (2015). doi:10.1038/nphys3394 Author: William B. McKinnon This year, NASA's Dawn and New Horizons rendezvoused with Ceres and Pluto, respectively. These worlds, despite their modest sizes, have much to teach us about the accretion of the Solar System and its dynamical evolution.
  • Spectrometry: Connect the dots

    Iulia Georgescu
    30 Jul 2015 | 5:00 pm
    Nature Physics 11, 620 (2015). doi:10.1038/nphys3440 Author: Iulia Georgescu
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  • Long-lived nanosecond spin relaxation and spin coherence of electrons in monolayer MoS2 and WS2

    Luyi Yang
    2 Aug 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3419 Authors: Luyi Yang, Nikolai A. Sinitsyn, Weibing Chen, Jiangtan Yuan, Jing Zhang, Jun Lou & Scott A. Crooker The recently discovered monolayer transition metal dichalcogenides (TMDCs) provide a fertile playground to explore new coupled spin–valley physics. Although robust spin and valley degrees of freedom are inferred from polarized photoluminescence (PL) experiments, PL timescales are necessarily constrained by short-lived (3–100 ps) electron–hole recombination. Direct probes of spin/valley polarization dynamics of…
  • Cover times of random searches

    Marie Chupeau
    2 Aug 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3413 Authors: Marie Chupeau, Olivier Bénichou & Raphaël Voituriez How long must one undertake a random search to visit all sites of a given domain? This time, known as the cover time, is a key observable to quantify the efficiency of exhaustive searches, which require a complete exploration of an area and not only the discovery of a single target. Examples range from immune-system cells chasing pathogens to animals harvesting resources, from robotic exploration for cleaning or demining to the task of improving search algorithms. Despite its broad…
  • Statistical physics: Universal exploration

    Eli Barkai
    2 Aug 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3445 Author: Eli Barkai We're well versed on the first-passage time for a random process, but the time required to cover more than one site in a system is a different problem altogether. It turns out that the two measures have more in common than we thought.
  • Linear relation between Heisenberg exchange and interfacial Dzyaloshinskii–Moriya interaction in metal films

    Hans T. Nembach
    2 Aug 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3418 Authors: Hans T. Nembach, Justin M. Shaw, Mathias Weiler, Emilie Jué & Thomas J. Silva Proposals for novel spin-orbitronic logic and memory devices are often predicated on assumptions as to how materials with large spin–orbit coupling interact with ferromagnets when in contact. Such interactions give rise to a host of novel phenomena, such as spin–orbit torques, chiral spin structures and chiral spin torques. These chiral properties are related to the antisymmetric exchange, also referred to as the interfacial…
  • Strong mechanical driving of a single electron spin

    A. Barfuss
    2 Aug 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3411 Authors: A. Barfuss, J. Teissier, E. Neu, A. Nunnenkamp & P. Maletinsky Quantum devices for sensing and computing applications require coherent quantum systems, which can be manipulated in fast and robust ways. Such quantum control is typically achieved using external electromagnetic fields, which drive the system’s orbital, charge or spin degrees of freedom. However, most existing approaches require complex and unwieldy gate structures, and with few exceptions are limited to the regime of weak coherent driving. Here, we present a novel approach…
 
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Genetics: The importance of mitochondrial tRNA

    M. Teresa Villanueva
    23 Jul 2015 | 5:00 pm
    Nature Reviews Cancer 15, 456 (2015). doi:10.1038/nrc3997 Author: M. Teresa Villanueva Although altered mitochondrial function is a feature of tumour cells, not many somatic mutations in the mitochondrial genome have been characterized. Stewart et al. used both genomic and transcriptomic sequencing data from 527 tumour samples from 14 different cancer types to reveal imbalances that
  • Diagnosis: Fishing for exosomes

    Gemma K. Alderton
    23 Jul 2015 | 5:00 pm
    Nature Reviews Cancer 15, 453 (2015). doi:10.1038/nrc3990 Author: Gemma K. Alderton A paper in Nature identifies glypican 1 as a marker of circulating exosomes derived from pancreatic ductal adenocarcinoma (and from some breast cancers) that could be an effective biomarker for early diagnosis and treatment monitoring.
  • In this issue

    23 Jul 2015 | 5:00 pm
    Nature Reviews Cancer 15, 449 (2015). doi:10.1038/nrc3994 A clearer understanding of the biological underpinnings of cancer origins might help us to design more effective cancer prevention methods or improve early detection of tumours that are likely to become malignant. It might also improve our ability to design effective therapies for those tumours.
  • Metabolism: Mutant BRAF feels the burn

    Nicola McCarthy
    23 Jul 2015 | 5:00 pm
    Nature Reviews Cancer 15, 454 (2015). doi:10.1038/nrc3992 Author: Nicola McCarthy A paper published in Molecular Cell indicates that the production of ketones can promote the BRAFV600E–MEK–ERK oncogenic pathway and identifies a potential Achilles' heel.
  • Breast cancer: A mouse model for metaplastic breast carcinoma

    M. Teresa Villanueva
    23 Jul 2015 | 5:00 pm
    Nature Reviews Cancer 15, 456 (2015). doi:10.1038/nrc3998 Author: M. Teresa Villanueva Metaplastic breast carcinoma (MBC) is a rare subset of triple-negative breast cancer characterized by a mesenchymal-like phenotype and poor clinical outcome. As BRCA1 deficiency sensitizes tumours to poly(ADP-ribose) polymerase (PARP) inhibitors and most MBCs harbour mutations in BRCA1, Jos Jonkers and colleagues wondered whether
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • Combination cancer immunotherapy and new immunomodulatory targets

    Kathleen M. Mahoney
    30 Jul 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 561 (2015). doi:10.1038/nrd4591 Authors: Kathleen M. Mahoney, Paul D. Rennert & Gordon J. Freeman Targeting immune checkpoints such as programmed cell death protein 1 (PD1), programmed cell death 1 ligand 1 (PDL1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has achieved noteworthy benefit in multiple cancers by blocking immunoinhibitory signals and enabling patients to produce an effective antitumour response.
  • Vertex combo scores a broader cystic fibrosis approval

    Asher Mullard
    30 Jul 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 517 (2015). doi:10.1038/nrd4704 Author: Asher Mullard Vertex broke new ground in 2012 when regulators approved its ivacaftor as the first disease-modifying cystic fibrosis drug. But this initial approval was only for use in the ∼4% of cystic-fibrosis patients that have G551D mutations in the gene encoding the cystic fibrosis transmembrane conductance
  • NCI-MATCH trial pushes cancer umbrella trial paradigm

    Asher Mullard
    30 Jul 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 513 (2015). doi:10.1038/nrd4694 Author: Asher Mullard An umbrella trial of 25 targeted treatments in all cancer types tackles treatment selection on the basis of genetic events rather than by tumour histology.
  • Pierre Meulien

    30 Jul 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 521 (2015). doi:10.1038/nrd4698 The Innovative Medicines Initiative (IMI) is the largest pharmaceutical-focused public–private partnership (PPP) in the world. Last year, funders committed a further [euro]3.3 billion to the 7-year-old initiative, which already spent [euro]2 billion in its first phase of operations. The IMI now has 50 projects in its pipeline, spanning neurological conditions, oncology, antimicrobials and more. Starting in September, it will also have a new executive director, with Pierre Meulien stepping into the role. Meulien has…
  • Bacteriophage therapies re-enter clinical trials

    Katie Kingwell
    30 Jul 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 515 (2015). doi:10.1038/nrd4695 Author: Katie Kingwell After decades of delays, biotechs hope that bacteria-attacking viruses could provide an alternative to traditional antibiotics.
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Stem cells: Chimpanzee induced pluripotent stem cells

    Denise Waldron
    16 Jul 2015 | 5:00 pm
    Nature Reviews Genetics 16, 439 (2015). doi:10.1038/nrg3988 Author: Denise Waldron To facilitate the study of comparative genomics in primates, Romero et al. generated a panel of seven induced pluripotent stem cell (iPSC) lines derived from chimpanzees. RNA sequencing and DNA methylation analysis of chimp and human iPSCs and their respective source lines revealed reduced
  • Genetic testing: Low-cost clinical testing for Mendelian diseases

    Denise Waldron
    16 Jul 2015 | 5:00 pm
    Nature Reviews Genetics 16, 439 (2015). doi:10.1038/nrg3989 Author: Denise Waldron Alkuraya et al. describe the Mendeliome Assay, a new low-cost multiplex assay based on next-generation sequencing of 3,070 known Mendelian genes, and demonstrate its utility in more than 2,300 patients with a broad range of suspected diagnoses. The authors suggest that, owing to its
  • Human genetics: Gene expression and functional brain networks

    Denise Waldron
    16 Jul 2015 | 5:00 pm
    Nature Reviews Genetics 16, 439 (2015). doi:10.1038/nrg3986 Author: Denise Waldron To identify the genes that determine brain connectivity, Richiardi et al. mapped microarray-based gene expression data from human brain samples onto functional brain networks that were computed using resting-state fMRI data. Functional brain networks were recapitulated by gene networks based on the correlated expression
  • Evolutionary genetics: Becoming human — identifying human accelerated regulatory DNA

    Bryony Jones
    16 Jul 2015 | 5:00 pm
    Nature Reviews Genetics 16, 438 (2015). doi:10.1038/nrg3985 Author: Bryony Jones Changes in gene regulation are thought to have had a role in the evolution of many human-specific traits such as bipedalism, speech and increased cognition. However, identifying the regulatory genetic changes that might be responsible for such human-specific traits is more complex than identifying coding
  • Microbial genetics: Bimodal regulation of genetic competence

    Denise Waldron
    16 Jul 2015 | 5:00 pm
    Nature Reviews Genetics 16, 439 (2015). doi:10.1038/nrg3987 Author: Denise Waldron The regulation of genetic competence in Bacillus subtilis involves a positive feedback loop, whereby the competence factor ComK activates its own transcription, but only when its levels exceed a certain threshold. Expression 'noise' results in bimodal expression by ensuring that only a subpopulation of
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • T cells: A killer cytokine

    Lucy Bird
    23 Jul 2015 | 5:00 pm
    Nature Reviews Immunology 15, 466 (2015). doi:10.1038/nri3895 Author: Lucy Bird Interleukin-26 mediates direct antimicrobial and immunostimulatory activities of T helper 17 cells.
  • Mucosal immunology: Microbiota-induced T cells block allergic inflammation

    Yvonne Bordon
    23 Jul 2015 | 5:00 pm
    Nature Reviews Immunology 15, 468 (2015). doi:10.1038/nri3894 Author: Yvonne Bordon The intestinal microbiota restrains type 2 immune responses by inducing the development of RORγt-expressing T cells.
  • Molecular and cellular insights into T cell exhaustion

    E. John Wherry
    23 Jul 2015 | 5:00 pm
    Nature Reviews Immunology 15, 486 (2015). doi:10.1038/nri3862 Authors: E. John Wherry & Makoto Kurachi In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called 'exhaustion'. Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined
  • Dcs tailor T cells to the tissue

    Allan Mowat
    23 Jul 2015 | 5:00 pm
    Nature Reviews Immunology 15, 469 (2015). doi:10.1038/nri3893 Author: Allan Mowat Allan Mowat describes a 2005 study that identified the ability of CD103+ dendritic cells to imprint T cells with gut-homing specificity.
  • Asthma and allergy: An IFNγ bias in severe asthma

    Olive Leavy
    16 Jul 2015 | 5:00 pm
    Nature Reviews Immunology 15, 466 (2015). doi:10.1038/nri3891 Author: Olive Leavy An interferon-γ-mediated immune response is dominant in severe asthma.
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Bacterial evolution: An intriguing new bacterial phylum

    Naomi Attar
    15 Jul 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 459 (2015). doi:10.1038/nrmicro3534 Author: Naomi Attar Metagenomic surveys have identified uncultivated microbial species whose genomes are predicted to correspond to ultra-small cell sizes. In a new study, Brown et al. describe the genomes of 797 ultra-small bacteria obtained by metagenomic sequencing of 0.2 μm filtrates from aquifier samples. The genomes
  • Structural biology: CRISPR preorders for Cas

    Naomi Attar
    15 Jul 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 459 (2015). doi:10.1038/nrmicro3535 Author: Naomi Attar In type II CRISPR−Cas adaptive immunity systems, a CRISPR RNA (crRNA) forms a hybrid structure with a trans-activating crRNA (tracrRNA) that, together with recognition of a protospacer adjacent motif (PAM), guides the Cas9 endonuclease protein to foreign DNA. Jiang et al. solved a
  • HIV-1 capsid: the multifaceted key player in HIV-1 infection

    Edward M. Campbell
    15 Jul 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 471 (2015). doi:10.1038/nrmicro3503 Authors: Edward M. Campbell & Thomas J. Hope In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core made from the viral capsid (CA) protein. The CA protein and the structure into which it assembles facilitate virtually every step of infection through a series of interactions with
  • Viral infection: TRIMming immune responses to dengue

    Cláudio Nunes-Alves
    15 Jul 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 458 (2015). doi:10.1038/nrmicro3533 Author: Cláudio Nunes-Alves Dengue virus (DENV) outbreaks can occur when new DENV strains emerge and replace endemic strains, as during a 1994 epidemic when a foreign dominant (PR-2B) replaced the endemic (PR-1) viral clade. To understand the changes that resulted in the increased fitness of PR-2B, Manokaran et
  • Malaria: Hitting all stages of the parasite life cycle

    Alexandra Flemming
    15 Jul 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 458 (2015). doi:10.1038/nrmicro3530 Author: Alexandra Flemming This study describes a novel antimalarial drug that targets Plasmodium falciparum translation elongation factor 2 and therefore acts against all stages of the parasite life cycle.
 
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Cytoskeleton: Controlling microtubules with light

    Katharine H. Wrighton
    22 Jul 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 454 (2015). doi:10.1038/nrm4036 Author: Katharine H. Wrighton The activity of traditional small-molecule inhibitors of microtubules cannot be restricted to target cells in research and chemotherapy. Borowiak et al. have developed optically controlled photostatins against microtubules by chemically modifying the microtubule inhibitor combretastatin A4 so that it can be reversibly switched between
  • Chromosomes: Transgenerational remodelling of sperm DNA

    Kim Baumann
    22 Jul 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 453 (2015). doi:10.1038/nrm4033 Author: Kim Baumann The chromosomes supplied by sperm and egg undergo different chromatin reorganization events in the embryo. The paternal chromosomes transition from a highly compacted protamine-rich state to a mitosis-competent histone-rich state. This process involves several maternally-deposited proteins, but the paternal contribution to paternal genome remodelling is
  • Cytoskeleton: Degrading proteins at the primary cilium

    Katharine H. Wrighton
    22 Jul 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 453 (2015). doi:10.1038/nrm4035 Author: Katharine H. Wrighton As mutations in the gene encoding the ciliary protein RPGRIP1L cause ciliopathies, Gerhardt et al. characterized this protein further. They confirmed its presence at the ciliary transition zone of cilia in mouse embryonic fibroblasts (MEFs) and in the limbs of mouse embryos; cilia were
  • Cell signalling: One kinase targets many secreted proteins

    Katharine H. Wrighton
    22 Jul 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 452 (2015). doi:10.1038/nrm4031 Author: Katharine H. Wrighton A study now shows that the secretory pathway kinase FAM20C phosphorylates the majority of secreted proteins.
  • Exosomes: Apoptotic beads on a string

    Kirsty Minton
    22 Jul 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 453 (2015). doi:10.1038/nrm4034 Author: Kirsty Minton During apoptosis, cells can disassemble into smaller membrane-bound extracellular vesicles that promote apoptotic cell clearance and mediate intercellular communication. Previous work by Poon and colleagues showed that the generation of such apoptotic bodies in T cells is a highly regulated, multistep process that involves string-like
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Neurogliaform cells in cortical circuits

    Linda Overstreet-Wadiche
    19 Jul 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 458 (2015). doi:10.1038/nrn3969 Authors: Linda Overstreet-Wadiche & Chris J. McBain Recent research into local-circuit GABAergic inhibitory interneurons of the mammalian central nervous system has provided unprecedented insight into the mechanics of neuronal circuitry and its dysfunction. Inhibitory interneurons consist of a broad array of anatomically and neurochemically diverse cell types, and this suggests that each
  • Immune mediators in the brain and peripheral tissues in autism spectrum disorder

    Myka L. Estes
    19 Jul 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 469 (2015). doi:10.1038/nrn3978 Authors: Myka L. Estes & A. Kimberley McAllister Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD). Several ASD risk genes encode components of the immune system and many maternal immune system-related risk factors — including autoimmunity, infection and fetal reactive antibodies — are associated with ASD.
  • Neurodegenerative disease: Impeding deposition

    Darran Yates
    19 Jul 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 443 (2015). doi:10.1038/nrn3998 Author: Darran Yates A study shows that α-synuclein can inhibit the formation of amyloid plaques in mice.
  • Neuronal circuits: Connecting to innate knowledge

    Sian Lewis
    19 Jul 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 441 (2015). doi:10.1038/nrn3999 Author: Sian Lewis Specific ensembles of neurons in the basolateral amydala representing unconditioned stimuli that mediate innate behaviours are also found to be necessary for the expression learned behaviours.
  • Development and functions of the choroid plexus–cerebrospinal fluid system

    Melody P. Lun
    14 Jul 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 445 (2015). doi:10.1038/nrn3921 Authors: Melody P. Lun, Edwin S. Monuki & Maria K. Lehtinen The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insights into how the ChP–CSF system develops and matures. In addition,
 
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    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • Tumour response, correlates of survival and clinical benefit

    Lisa Hutchinson
    28 Jul 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 433 (2015). doi:10.1038/nrclinonc.2015.134 Author: Lisa Hutchinson We are all familiar with the metrics of tumour shrinkage and time to the development of disease progression as important end points in clinical trials. This tenet is based on findings of numerous studies over several decades that have demonstrated a link between agents that
  • Pancreatic cancer: Targeting KRAS and the vitamin D receptor via microtubules

    Agnes Basseville
    13 Jul 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 442 (2015). doi:10.1038/nrclinonc.2015.125 Authors: Agnes Basseville, Susan Bates & Tito Fojo Pancreatic cancer remains a difficult-to-treat malignancy, yet nab-paclitaxel plus gemcitabine prolongs survival. Closer examination of the mechanism of action of nab-paclitaxel hints at a role for targeting KRAS. We discuss how nab-paclitaxel may be active in pancreatic cancer and how this informs the way forward to better treat patients with pancreatic cancer.
  • Lung cancer: Squiring immunotherapy to CheckMate

    Lisa Hutchinson
    29 Jun 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 436 (2015). doi:10.1038/nrclinonc.2015.110 Author: Lisa Hutchinson In patients with advanced-stage squamous non-small-cell lung cancer (NSCLC) there remains a high unmet need to improve outcomes: over the past two decades, no new standard-of-care therapy has been approved. Now, two phase III studies of two different targeted agents for NSCLC show great promise
  • Breast cancer: PALOMA-3 confirms that CDK4/6 is a key therapeutic target

    Alessia Errico
    29 Jun 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 436 (2015). doi:10.1038/nrclinonc.2015.113 Author: Alessia Errico Activation of cyclin-dependent kinases 4 and 6 (CDK4/6)—key proteins that upon binding to cyclin D1, promote cell-cycle entry—seems to drive proliferation of breast cancer cells in hormone-receptor positive (HR+) disease. Now, the initial results of the PALOMA-3 trial confirm that the CDK4/6 inhibitor palbociclib, in
  • Advances in targeted therapies for hepatocellular carcinoma in the genomic era

    Josep M. Llovet
    22 Jun 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 436 (2015). doi:10.1038/nrclinonc.2015.121 Author: Josep M. Llovet, Augusto Villanueva, Anja Lachenmayer & Richard S. Finn
 
 
 
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    Naturejobs - Search results

  • Open Faculty Postions-INSTITUTE OF MOLECULAR BIOLOGY,ACADEMIA SINICA

    3 Aug 2015 | 8:41 pm
    OPEN FACULTY POSITIONS INSTITUTE OF MOLECULAR BIOLOGYACADEMIA SINICA, TAIWAN, ROC One tenure-track faculty position is open for a highly qualified individual to establish independent research programs in all disciplines of molecular and cellular biology. Applicants should hold a Ph.D. degree or its equivalent, with appropriate postdoctoral research experience. The successful recruit will be appointed at the levels of Assistant, Associate, or Full Research Fellows (equivalent to …
  • Postdoctoral Fellow

    3 Aug 2015 | 6:47 pm
    We are seeking a qualified individual for a newly available Postdoctoral position in the Wainwright Laboratory at Northwestern University – Feinberg School of Medicine (http://labs.feinberg.northwestern.edu/wainwright/). Our lab focuses on brain tumor immunology research and our goals are to explore the interactions between key novel regulators of immunosuppression, including IDO1, CTLA-4 and PD-L1, in malignant brain tumors. These goals encompass the mechanistic investigation of interaction(s) …
  • Postdoctoral Research Fellow - Physiological Chemistry

    3 Aug 2015 | 3:13 pm
    Passionate About Science We’re passionate and rigorous about our science. For more than 30 years, Genentech has been at the forefront of the biotechnology industry, using innovative science to develop breakthrough medicines that improve the lives of people with serious or life-threatening diseases. The following opportunity exists in our South San Francisco, CA headquarters: Postdoctoral Research Fellow – Physiological Chemistry Description: Genentech is seeking an independ…
  • Faculty Positions in Developmental and Pediatric Systems Biology

    3 Aug 2015 | 1:51 pm
    The Division of Developmental Biology (DB) at Cincinnati Children's Research Foundation (CCRF) is launching a major new initiative to recruit 3-5 outstanding junior investigators focused on Quantitative Systems-level analysis of Developmental Processes and/or Pediatric Disease. We are seeking individuals who address fundamental cutting-edge questions by combining quantitative and/or theoretical approaches with wet bench experiments. Candidates must have completed a postdoctoral training period, …
  • Assistant, Associate, or Full Professor- Mechanical Engineering

    3 Aug 2015 | 1:17 pm
    The Department of Mechanical Engineering at Iowa State University (www.me.iastate.edu) invites applications for multiple tenure-track or tenured faculty positions at the Assistant, Associate, or Full Professor ranks. Exceptional candidates with specializations relevant to traditional and emerging areas of mechanical engineering will be considered. The department's core expertise is in the areas of Design and Optimization, Dynamic Systems and Controls, Manufacturing and Mechanics and Thermofluids…
 
 
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    British Journal of Pharmacology

  • The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo

    Scott Boitano, Justin Hoffman, Andrea N Flynn, Marina N Asiedu, Dipti V Tillu, Zhenyu Zhang, Cara L Sherwood, Candy M Rivas, Kathryn A DeFea, Josef Vagner, Theodore J Price
    3 Aug 2015 | 2:50 am
    Background and PurposeProteinase-activated receptor-2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of the extracellular amino terminus, resulting in an exposed, tethered peptide agonist. Several peptide and peptidomimetic agonists, with high potency and efficacy, have been developed to probe the functions of PAR2, in vitro and in vivo. However, few similarly potent and effective antagonists have been described. Experimental ApproachWe modified the peptidomimetic PAR2 agonist,…
  • A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet

    Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Yuzuru Ohshiro, Hideaki Tanaka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Shogo Ishiuchi, Masanori Nakata, Toshihiko Yada, Jun-ichi Miyazaki, Seiichi Oyadomari, Michio Shimabukuro, Hiroaki Masuzaki
    3 Aug 2015 | 2:50 am
    Background and Purposeγ-Oryzanol, derived from unrefined rice, attenuated the preference for dietary fat in mice, by decreasing hypothalamic endoplasmic reticulum stress. However, no peripheral mechanisms, whereby γ-oryzanol could ameliorate glucose dyshomeostasis were explored. Dopamine D2 receptor signalling locally attenuates insulin secretion in pancreatic islets, presumably via decreased levels of intracellular cAMP. We therefore hypothesized that γ-oryzanol would improve high-fat diet (HFD)-induced dysfunction of islets through the suppression of local D2 receptor signalling.
  • Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-κB- and MAPK-ERK1/2-mediated COX-2 expression

    Chun-Kuang Lin, Chin-Kai Tseng, Kai-Hsun Chen, Shih-Hsiung Wu, Chih-Chuang Liaw, Jin-Ching Lee
    3 Aug 2015 | 2:49 am
    Background and PurposeThis study was designed to evaluate the effect of betulinic acid (BA), extracted from Avicennia marina, on the replication of hepatitis C virus (HCV) and to investigate the mechanism of this BA-mediated anti-HCV activity. Experimental ApproachHCV replicon and infectious systems were used to evaluate the anti-HCV activity of BA. Exogenous COX-2 or knock-down of COX-2 expression was used to investigate the role of COX-2 in the anti-HCV activity of BA. The effects of BA on the phosphorylation of NF-κB and on kinases in the MAPK signalling pathway were determined. The…
  • Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells

    Luigia Di Francesco, Melania Dovizio, Annalisa Trenti, Emanuela Marcantoni, Ashleigh Moore, Peadar O'Gaora, Cathal McCarthy, Stefania Tacconelli, Annalisa Bruno, Sara Alberti, Salvatore Gizzo, Giovanni Battista Nardelli, Genny Orso, Orina Belton, Lucia Trevisi, Dan A Dixon, Paola Patrignani
    3 Aug 2015 | 2:49 am
    Background and PurposeHyperglycaemic memory describes the progression of diabetic complications during subsequent periods of improved glycaemia. We addressed the hypothesis that transient hyperglycaemia causes aberrant COX-2 expression in HUVEC in response to IL-1β through the induction of long-lasting epigenetic changes involving microRNA-16 (miR-16), a post-transcriptional modulator of COX-2 expression. Experimental ApproachStudies were performed on HUVEC collected from women with gestational diabetes mellitus (GDM) (dHUVEC) and normal women (nHUVEC). Key ResultsIn dHUVEC treated with…
  • Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischemia

    Jingru Zhao, Xiangjian Zhang, Lipeng Dong, Ya Wen, Xiufen Zheng, Cong Zhang, Rong Chen, Ye Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Litao Li
    31 Jul 2015 | 10:27 pm
    Background and PurposeRecent findings suggest the importance of inflammation in the pathogenesis of cerebral ischemia and its potential as a therapeutic target. Cinnamaldehyde is a diterpene with a wide range of anti-inflammatory effects, thus may be advantageous in the treatment of cerebral ischemia. The present study examined the potential therapeutic effects of cinnamaldehyde on cerebral ischemia using a mouse model with permanent middle cerebral artery occlusion (pMCAO). Experimental ApproachMale CD-1 mice were administered (i. p.) with cinnamaldehyde. The neuroprotection of…
 
 
 
 
 
 
 
 
 
 
 
 
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    Kidney International - AOP - nature.com science feeds

  • Comorbidity as a driver of adverse outcomes in people with chronic kidney disease

    Marcello Tonelli
    28 Jul 2015 | 5:00 pm
    Comorbidity as a driver of adverse outcomes in people with chronic kidney disease Kidney International advance online publication, July 29 2015. doi:10.1038/ki.2015.228 Authors: Marcello Tonelli, Natasha Wiebe, Bruce Guthrie, Matthew T James, Hude Quan, Martin Fortin, Scott W Klarenbach, Peter Sargious, Sharon Straus, Richard Lewanczuk, Paul E Ronksley, Braden J Manns & Brenda R Hemmelgarn
  • Key role of the kidney in the regulation of fibroblast growth factor 23

    Maria L Mace
    28 Jul 2015 | 5:00 pm
    Key role of the kidney in the regulation of fibroblast growth factor 23 Kidney International advance online publication, July 29 2015. doi:10.1038/ki.2015.231 Authors: Maria L Mace, Eva Gravesen, Jacob Hofman-Bang, Klaus Olgaard & Ewa Lewin
  • Effectiveness of mycophenolate mofetil in C3 glomerulonephritis

    Cristina Rabasco
    28 Jul 2015 | 5:00 pm
    Effectiveness of mycophenolate mofetil in C3 glomerulonephritis Kidney International advance online publication, July 29 2015. doi:10.1038/ki.2015.227 Authors: Cristina Rabasco, Teresa Cavero, Elena Román, Jorge Rojas-Rivera, Teresa Olea, Mario Espinosa, Virginia Cabello, Gema Fernández-Juarez, Fayna González, Ana Ávila, José María Baltar, Montserrat Díaz, Raquel Alegre, Sandra Elías, Monserrat Antón, Miguel Angel Frutos, Alfonso Pobes, Miguel Blasco, Francisco Martín, Carmen Bernis, Manuel Macías, Sergio Barroso, Alberto de Lorenzo, Gema…
  • A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010

    Katherine T Mills
    28 Jul 2015 | 5:00 pm
    A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010 Kidney International advance online publication, July 29 2015. doi:10.1038/ki.2015.230 Authors: Katherine T Mills, Yu Xu, Weidong Zhang, Joshua D Bundy, Chung-Shiuan Chen, Tanika N Kelly, Jing Chen & Jiang He
  • An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy

    Eva-Maria Nichols
    28 Jul 2015 | 5:00 pm
    An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy Kidney International advance online publication, July 29 2015. doi:10.1038/ki.2015.233 Authors: Eva-Maria Nichols, Thomas D Barbour, Isabel Y Pappworth, Edwin K S Wong, Jeremy M Palmer, Neil S Sheerin, Matthew C Pickering & Kevin J Marchbank
 
 
 
 
 
 
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