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  • Predicting protein networks in cancer

    Nature Genetics - Issue - nature.com science feeds
    Andrea Califano
    23 Nov 2014 | 4:00 pm
    Nature Genetics 46, 1252 (2014). doi:10.1038/ng.3156 Author: Andrea Califano Characterization of the mutational landscape of tumors is important to understanding disease etiology but does not provide mechanistic insight into the functional role of specific mutations. A new study introduces a statistical mechanical framework that draws on biophysical data from SH2 domain–phosphoprotein interactions to predict the functional effects of mutations in cancer.
  • Bullet-proof armour and hydrogen sieve add to graphene’s promise

    NatureNews - Most recent articles - nature.com science feeds
    Richard Van Noorden
    26 Nov 2014 | 4:00 pm
    One-atom-thick material blocks 'bullet' strikes but allows protons to pass through.Nature News doi: 10.1038/nature.2014.16425
  • Moon on a stick

    Nature - Issue - nature.com science feeds
    25 Nov 2014 | 4:00 pm
    Moon on a stick Nature 515, 7528 (2014). doi:10.1038/515466a A crowdfunded lunar mission might seem like a long shot — but there is no harm in trying.
  • Materials science: Breakthrough for protons

    Nature - AOP - nature.com science feeds
    Rohit N. Karnik
    25 Nov 2014 | 4:00 pm
    Nature advance online publication 26 November 2014. doi:10.1038/nature14074 Author: Rohit N. Karnik The atomically thin material called graphene is impermeable to atoms as small as helium. The finding that protons can pass through it might enable new kinds of membrane to be developed and aid research into fuel cells.
  • Biotech on the bounce in 3Q14

    Nature Biotechnology - Issue - nature.com science feeds
    Walter Yang
    6 Nov 2014 | 4:00 pm
    Nature Biotechnology 32, 1079 (2014). doi:10.1038/nbt.3068 Author: Walter Yang
 
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    Nature - Issue - nature.com science feeds

  • Moon on a stick

    25 Nov 2014 | 4:00 pm
    Moon on a stick Nature 515, 7528 (2014). doi:10.1038/515466a A crowdfunded lunar mission might seem like a long shot — but there is no harm in trying.
  • Ebola opportunity

    25 Nov 2014 | 4:00 pm
    Ebola opportunity Nature 515, 7528 (2014). doi:10.1038/515465b A slowdown in new cases offers a chance for control efforts to get ahead of the epidemic.
  • Haemophilia

    Herb Brody
    25 Nov 2014 | 4:00 pm
    Haemophilia Nature. doi:10.1038/515S157a Author: Herb Brody
  • US regulators move on thought-controlled prosthetics

    Sara Reardon
    25 Nov 2014 | 4:00 pm
    US regulators move on thought-controlled prosthetics Nature 515, 7528 (2014). http://www.nature.com/doifinder/10.1038/515476a Author: Sara Reardon Robotic limb advances are attracting serious attention from the FDA.
  • Old papers find new life online

    25 Nov 2014 | 4:00 pm
    Old papers find new life online Nature 515, 7528 (2014). doi:10.1038/515469f Search engines have revolutionized how scientists find papers — especially articles that have been around for a while. A team of researchers at Google has documented a surge in the citation rate for older papers. The study found that 36% of citations in 2013
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  • Materials science: Breakthrough for protons

    Rohit N. Karnik
    25 Nov 2014 | 4:00 pm
    Nature advance online publication 26 November 2014. doi:10.1038/nature14074 Author: Rohit N. Karnik The atomically thin material called graphene is impermeable to atoms as small as helium. The finding that protons can pass through it might enable new kinds of membrane to be developed and aid research into fuel cells.
  • Malaria: How vector mosquitoes beat the heat

    Nora J. Besansky
    25 Nov 2014 | 4:00 pm
    Nature advance online publication 26 November 2014. doi:10.1038/nature14073 Author: Nora J. Besansky Intensive longitudinal sampling of malaria mosquitoes in the African semi-desert reveals that three morphologically indistinguishable species have distinctive strategies for surviving the dry season.
  • Signatures of aestivation and migration in Sahelian malaria mosquito populations

    A. Dao
    25 Nov 2014 | 4:00 pm
    Nature advance online publication 26 November 2014. doi:10.1038/nature13987 Authors: A. Dao, A. S. Yaro, M. Diallo, S. Timbiné, D. L. Huestis, Y. Kassogué, A. I. Traoré, Z. L. Sanogo, D. Samaké & T. Lehmann During the long Sahelian dry season, mosquito vectors of malaria are expected to perish when no larval sites are available; yet, days after the first rains, mosquitoes reappear in large numbers. How these vectors persist over the 3–6-month long dry season has not been resolved, despite extensive research for over a century. Hypotheses for vector persistence…
  • Microbiology: A beacon for bacterial tubulin

    Elizabeth J. Harry
    25 Nov 2014 | 4:00 pm
    Nature advance online publication 26 November 2014. doi:10.1038/nature14071 Author: Elizabeth J. Harry The protein FtsZ forms a ring structure that constricts to allow bacterial cells to divide. A second protein, MapZ, has now been found to guide FtsZ to the correct mid-cell position in the bacterium Streptococcus pneumoniae.
  • Structural biology: Photosynthetic complex in close-up

    Ilme Schlichting
    25 Nov 2014 | 4:00 pm
    Nature advance online publication 26 November 2014. doi:10.1038/nature14072 Author: Ilme Schlichting Photosystem II, a photosynthetic protein complex, is prone to X-ray damage during crystallography. A high-resolution structure of the undamaged complex now offers a detailed view of its catalytic centre.
 
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    Nature Biotechnology - AOP - nature.com science feeds

  • Functional optimization of gene clusters by combinatorial design and assembly

    Michael J Smanski
    23 Nov 2014 | 4:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3063 Authors: Michael J Smanski, Swapnil Bhatia, Dehua Zhao, YongJin Park, Lauren B A Woodruff, Georgia Giannoukos, Dawn Ciulla, Michele Busby, Johnathan Calderon, Robert Nicol, D Benjamin Gordon, Douglas Densmore & Christopher A Voigt
  • A load driver device for engineering modularity in biological networks

    Deepak Mishra
    23 Nov 2014 | 4:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3044 Authors: Deepak Mishra, Phillip M Rivera, Allen Lin, Domitilla Del Vecchio & Ron Weiss The behavior of gene modules in complex synthetic circuits is often unpredictable. After joining modules to create a circuit, downstream elements (such as binding sites for a regulatory protein) apply a load to upstream modules that can negatively affect circuit function. Here we devised a genetic device named a load driver that mitigates the impact of load on circuit function, and we demonstrate its behavior in Saccharomyces cerevisiae. The load driver…
  • Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

    Weida Li
    16 Nov 2014 | 4:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3082 Authors: Weida Li, Claudia Cavelti-Weder, Yinying Zhang, Kendell Clement, Scott Donovan, Gabriel Gonzalez, Jiang Zhu, Marianne Stemann, Ke Xu, Tatsu Hashimoto, Takatsugu Yamada, Mio Nakanishi, Yuemei Zhang, Samuel Zeng, David Gifford, Alexander Meissner, Gordon Weir & Qiao Zhou
  • Tunable protein degradation in bacteria

    D Ewen Cameron
    16 Nov 2014 | 4:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3053 Authors: D Ewen Cameron & James J Collins Tunable control of protein degradation in bacteria would provide a powerful research tool. Here we use components of the Mesoplasma florum transfer-messenger RNA system to create a synthetic degradation system that provides both independent control of steady-state protein level and inducible degradation of targeted proteins in Escherichia coli. We demonstrate application of this system in synthetic circuit development and control of core bacterial processes and antibacterial targets, and we transfer the…
  • The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease

    Xinxia Peng
    16 Nov 2014 | 4:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3079 Authors: Xinxia Peng, Jessica Alföldi, Kevin Gori, Amie J Eisfeld, Scott R Tyler, Jennifer Tisoncik-Go, David Brawand, G Lynn Law, Nives Skunca, Masato Hatta, David J Gasper, Sara M Kelly, Jean Chang, Matthew J Thomas, Jeremy Johnson, Aaron M Berlin, Marcia Lara, Pamela Russell, Ross Swofford, Jason Turner-Maier, Sarah Young, Thibaut Hourlier, Bronwen Aken, Steve Searle, Xingshen Sun, Yaling Yi, M Suresh, Terrence M Tumpey, Adam Siepel, Samantha M Wisely, Christophe Dessimoz, Yoshihiro Kawaoka, Bruce W Birren, Kerstin Lindblad-Toh, Federica Di…
 
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    Nature Chemistry

  • Gregarious gallium

    Marshall Brennan
    19 Nov 2014 | 4:00 pm
    Nature Chemistry 6, 1108 (2014). doi:10.1038/nchem.2116 Author: Marshall Brennan Trick cutlery and mobile phones have one peculiar element in common, as Marshall Brennan explains.
  • 2014 Nobel Prize in Chemistry: No limit

    Gavin Armstrong
    19 Nov 2014 | 4:00 pm
    Nature Chemistry 6, 1027 (2014). doi:10.1038/nchem.2125 Author: Gavin Armstrong
  • Artificial metalloenzymes: Encoding copper catalysts

    Russell Johnson
    19 Nov 2014 | 4:00 pm
    Nature Chemistry 6, 1027 (2014). doi:10.1038/nchem.2127 Author: Russell Johnson
  • Biomass conversion: Lignin up for break-down

    Pieter C. A. Bruijnincx
    19 Nov 2014 | 4:00 pm
    Nature Chemistry 6, 1035 (2014). doi:10.1038/nchem.2120 Authors: Pieter C. A. Bruijnincx & Bert M. Weckhuysen Lignin is an abundant renewable resource, but its intrinsic recalcitrant nature has so far hampered its conversion into higher value chemicals. Now, a two-step strategy, oxidation followed by bond cleavage, has been shown to deconstruct lignin into high yields of low-molecular-weight aromatics.
  • On-surface assembly: The squeezed middle

    Claire Hansell
    19 Nov 2014 | 4:00 pm
    Nature Chemistry 6, 1027 (2014). doi:10.1038/nchem.2126 Author: Claire Hansell
 
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    Nature Chemistry

  • Substrate control in stereoselective lanthionine biosynthesis

    Weixin Tang
    23 Nov 2014 | 4:00 pm
    Nature Chemistry. doi:10.1038/nchem.2113 Authors: Weixin Tang, Gonzalo Jiménez-Osés, K. N. Houk & Wilfred A. van der Donk The stereochemical outcome of enzyme-catalysed reactions with physiological substrates is typically governed by the well-defined geometry of the enzyme active site. Now, a rare example is reported where the substrate controls the stereoselectivity of a Michael-type addition during lanthipeptide biosynthesis.
  • Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

    Jürgen Brem
    16 Nov 2014 | 4:00 pm
    Nature Chemistry. doi:10.1038/nchem.2110 Authors: Jürgen Brem, Sander S. van Berkel, WeiShen Aik, Anna M. Rydzik, Matthew B. Avison, Ilaria Pettinati, Klaus-Daniel Umland, Akane Kawamura, James Spencer, Timothy D. W. Claridge, Michael A. McDonough & Christopher J. Schofield The use of β-lactam antibiotics is severely threatened by metallo-β-lactamases (MBLs), which contribute to the development of resistance. Now, crystallographic and solution studies reveal that recently reported MBL inhibition with a rhodanine can be attributed to fragmentation and complex formation with the…
  • Towards greener and more sustainable batteries for electrical energy storage

    D. Larcher
    16 Nov 2014 | 4:00 pm
    Nature Chemistry. doi:10.1038/nchem.2085 Authors: D. Larcher & J-M. Tarascon Energy storage using batteries offers a solution to the intermittent nature of energy production from renewable sources; however, such technology must be sustainable. This Review discusses battery development from a sustainability perspective, considering the energy and environmental costs of state-of-the-art Li-ion batteries and the design of new systems beyond Li-ion. Images: batteries, car, globe: © iStock/Thinkstock.
  • Halogen bonding in water results in enhanced anion recognition in acyclic and rotaxane hosts

    Matthew J. Langton
    16 Nov 2014 | 4:00 pm
    Nature Chemistry. doi:10.1038/nchem.2111 Authors: Matthew J. Langton, Sean W. Robinson, Igor Marques, Vítor Félix & Paul D. Beer The ability to achieve strong molecular recognition in water is a key challenge for supramolecular chemistry. Now, halogen bonding — the attractive interaction between an electron-deficient halogen atom and a Lewis base — has been shown to be superior to hydrogen bonding for strong anion binding in water. Ripple image: © PhotoDisc/Getty Images.
  • Pseudopterosin synthesis from a chiral cross-conjugated hydrocarbon through a series of cycloadditions

    Christopher G. Newton
    16 Nov 2014 | 4:00 pm
    Nature Chemistry. doi:10.1038/nchem.2112 Authors: Christopher G. Newton, Samuel L. Drew, Andrew L. Lawrence, Anthony C. Willis, Michael N. Paddon-Row & Michael S. Sherburn The pseudopterosins are a family of natural products whose interesting anti-inflammatory and pain-relieving properties have inspired many synthetic approaches. Now, an unusual approach that starts with an axially chiral hydrocarbon that engages in a triple Diels–Alder sequence has been shown to result in the shortest total synthesis of a pseudopterosin so far.
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    Nature Genetics - Issue - nature.com science feeds

  • Cohesin and chromosome loops

    Emily Niemitz
    23 Nov 2014 | 4:00 pm
    Nature Genetics 46, 1257 (2014). doi:10.1038/ng.3159 Author: Emily Niemitz
  • Single-haplotype genome assembly

    Orli Bahcall
    23 Nov 2014 | 4:00 pm
    Nature Genetics 46, 1257 (2014). doi:10.1038/ng.3157 Author: Orli Bahcall
  • Predicting protein networks in cancer

    Andrea Califano
    23 Nov 2014 | 4:00 pm
    Nature Genetics 46, 1252 (2014). doi:10.1038/ng.3156 Author: Andrea Califano Characterization of the mutational landscape of tumors is important to understanding disease etiology but does not provide mechanistic insight into the functional role of specific mutations. A new study introduces a statistical mechanical framework that draws on biophysical data from SH2 domain–phosphoprotein interactions to predict the functional effects of mutations in cancer.
  • Persimmon sex determination

    Brooke LaFlamme
    23 Nov 2014 | 4:00 pm
    Nature Genetics 46, 1257 (2014). doi:10.1038/ng.3161 Author: Brooke LaFlamme
  • A shared architecture for promoters and enhancers

    Shira Weingarten-Gabbay
    23 Nov 2014 | 4:00 pm
    Nature Genetics 46, 1253 (2014). doi:10.1038/ng.3152 Authors: Shira Weingarten-Gabbay & Eran Segal A new study detects unstable nascent RNAs and uncovers thousands of transcription initiation sites in promoters and enhancers. Detailed analysis shows that these initiation sites have a similar architecture and that they are differentiated by post-transcriptional regulation rather than transcription initiation.
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  • Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

    Cas Simons
    23 Nov 2014 | 4:00 pm
    Nature Genetics. doi:10.1038/ng.3153 Authors: Cas Simons, Lachlan D Rash, Joanna Crawford, Linlin Ma, Ben Cristofori-Armstrong, David Miller, Kelin Ru, Gregory J Baillie, Yasemin Alanay, Adeline Jacquinet, François-Guillaume Debray, Alain Verloes, Joseph Shen, Gözde Yesil, Serhat Guler, Adnan Yuksel, John G Cleary, Sean M Grimmond, Julie McGaughran, Glenn F King, Michael T Gabbett & Ryan J Taft Temple-Baraitser syndrome (TBS) is a multisystem developmental disorder characterized by intellectual disability, epilepsy, and hypoplasia or aplasia of the nails of the thumb and great…
  • Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

    Stéphanie Debette
    23 Nov 2014 | 4:00 pm
    Nature Genetics. doi:10.1038/ng.3154 Authors: Stéphanie Debette, Yoichiro Kamatani, Tiina M Metso, Manja Kloss, Ganesh Chauhan, Stefan T Engelter, Alessandro Pezzini, Vincent Thijs, Hugh S Markus, Martin Dichgans, Christiane Wolf, Ralf Dittrich, Emmanuel Touzé, Andrew M Southerland, Yves Samson, Shérine Abboud, Yannick Béjot, Valeria Caso, Anna Bersano, Andreas Gschwendtner, Maria Sessa, John Cole, Chantal Lamy, Elisabeth Medeiros, Simone Beretta, Leo H Bonati, Armin J Grau, Patrik Michel, Jennifer J Majersik, Pankaj Sharma, Ludmila Kalashnikova, Maria Nazarova, Larisa…
  • The genome sequence of the orchid Phalaenopsis equestris

    Jing Cai
    23 Nov 2014 | 4:00 pm
    Nature Genetics. doi:10.1038/ng.3149 Authors: Jing Cai, Xin Liu, Kevin Vanneste, Sebastian Proost, Wen-Chieh Tsai, Ke-Wei Liu, Li-Jun Chen, Ying He, Qing Xu, Chao Bian, Zhijun Zheng, Fengming Sun, Weiqing Liu, Yu-Yun Hsiao, Zhao-Jun Pan, Chia-Chi Hsu, Ya-Ping Yang, Yi-Chin Hsu, Yu-Chen Chuang, Anne Dievart, Jean-Francois Dufayard, Xun Xu, Jun-Yi Wang, Jun Wang, Xin-Ju Xiao, Xue-Min Zhao, Rong Du, Guo-Qiang Zhang, Meina Wang, Yong-Yu Su, Gao-Chang Xie, Guo-Hui Liu, Li-Qiang Li, Lai-Qiang Huang, Yi-Bo Luo, Hong-Hwa Chen, Yves Van de Peer & Zhong-Jian Liu
  • Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

    Rasmus Lykke Marvig
    16 Nov 2014 | 4:00 pm
    Nature Genetics. doi:10.1038/ng.3148 Authors: Rasmus Lykke Marvig, Lea Mette Sommer, Søren Molin & Helle Krogh Johansen
  • Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

    Steffen Durinck
    16 Nov 2014 | 4:00 pm
    Nature Genetics. doi:10.1038/ng.3146 Authors: Steffen Durinck, Eric W Stawiski, Andrea Pavía-Jiménez, Zora Modrusan, Payal Kapur, Bijay S Jaiswal, Na Zhang, Vanina Toffessi-Tcheuyap, Thong T Nguyen, Kanika Bajaj Pahuja, Ying-Jiun Chen, Sadia Saleem, Subhra Chaudhuri, Sherry Heldens, Marlena Jackson, Samuel Peña-Llopis, Joseph Guillory, Karen Toy, Connie Ha, Corissa J Harris, Eboni Holloman, Haley M Hill, Jeremy Stinson, Celina Sanchez Rivers, Vasantharajan Janakiraman, Weiru Wang, Lisa N Kinch, Nick V Grishin, Peter M Haverty, Bernard Chow, Julian S Gehring, Jens Reeder,…
 
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    Nature Geoscience - Issue - nature.com science feeds

  • Reply to 'Is sand in the Mississippi River delta a sustainable resource?'

    Jeffrey A. Nittrouer
    26 Nov 2014 | 4:00 pm
    Nature Geoscience 7, 852 (2014). doi:10.1038/ngeo2311 Authors: Jeffrey A. Nittrouer & Enrica Viparelli
  • The elements of marine life

    Noah J. Planavsky
    26 Nov 2014 | 4:00 pm
    Nature Geoscience 7, 855 (2014). doi:10.1038/ngeo2307 Author: Noah J. Planavsky Today, the ratio of carbon to nitrogen and phosphorus in marine organic matter is relatively constant. But this ratio probably varied during the Earth's history as a consequence of changes in the phytoplankton community and ocean oxygen levels.
  • Is sand in the Mississippi River delta a sustainable resource?

    M. D. Blum
    26 Nov 2014 | 4:00 pm
    Nature Geoscience 7, 851 (2014). doi:10.1038/ngeo2310 Authors: M. D. Blum & H. H. Roberts
  • Redfield's evolving legacy

    Nicolas Gruber
    26 Nov 2014 | 4:00 pm
    Nature Geoscience 7, 853 (2014). doi:10.1038/ngeo2308 Authors: Nicolas Gruber & Curtis A. Deutsch The ratio of nitrogen to phosphorus in organic matter is close to that in seawater, a relationship maintained through a set of biological feedbacks. The rapid delivery of nutrients from human activities may test the efficacy of these processes.
  • Eighty years of Redfield

    26 Nov 2014 | 4:00 pm
    Nature Geoscience 7, 849 (2014). doi:10.1038/ngeo2319 The outstanding lifespan of the canonical Redfield ratio has shown the power of elemental stoichiometry in describing ocean life. But the biological mechanisms governing this consistency remain unknown.
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    Nature Geoscience - AOP - nature.com science feeds

  • Ocean chemistry: Biogeochemical regimes in focus

    Raymond N. Sambrotto
    23 Nov 2014 | 4:00 pm
    Nature Geoscience. doi:10.1038/ngeo2309 Author: Raymond N. Sambrotto The ocean's biological pump transfers carbon to long-term storage in deep waters and sediments. Two inverse modelling studies describe the export of organic matter throughout the surface layer of the world's oceans in exceptional detail.
  • Global-scale variations of the ratios of carbon to phosphorus in exported marine organic matter

    Yi-Cheng Teng
    23 Nov 2014 | 4:00 pm
    Nature Geoscience. doi:10.1038/ngeo2303 Authors: Yi-Cheng Teng, François W. Primeau, J. Keith Moore, Michael W. Lomas & Adam C. Martiny The ratio of carbon (C) to phosphorus (P) in marine phytoplankton is thought to be constant throughout the worlds’ oceans. Known as the Redfield ratio, this relationship describes the links between carbon and phosphorus cycling and marine ecosystems. However, variations in the stoichiometry of phytoplankton have recently been identified, in particular strong latitudinal variability. Here we assess the impact of this variability in the C:P ratio…
  • Thick and deformed Antarctic sea ice mapped with autonomous underwater vehicles

    G. Williams
    23 Nov 2014 | 4:00 pm
    Nature Geoscience. doi:10.1038/ngeo2299 Authors: G. Williams, T. Maksym, J. Wilkinson, C. Kunz, C. Murphy, P. Kimball & H. Singh
  • Large-scale variations in the stoichiometry of marine organic matter respiration

    Tim DeVries
    23 Nov 2014 | 4:00 pm
    Nature Geoscience. doi:10.1038/ngeo2300 Authors: Tim DeVries & Curtis Deutsch The elemental composition of marine organic matter governs resource competition among plankton, and couples the global cycles of carbon, nutrients and oxygen. Observations have revealed systematic large-scale variation in the ratios of these essential elements removed from surface waters by phytoplankton. However, an impact of this variability on deep ocean properties has not been detected. Here we use a data-constrained ocean circulation model and observed long-term mean distributions of dissolved oxygen and…
  • Deep carbon: Subduction goes organic

    Jay J. Ague
    16 Nov 2014 | 4:00 pm
    Nature Geoscience. doi:10.1038/ngeo2301 Author: Jay J. Ague Aqueous subduction-zone fluids contain CO2 and methane. New calculations indicate that these fluids also host a wide array of organic carbon species, in concentrations sufficient to influence the deep carbon cycle.
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    Nature Immunology - Issue - nature.com science feeds

  • Fatty acid regulation of TH17 cells

    Zoltan Fehervari
    13 Nov 2014 | 4:00 pm
    Nature Immunology 15, 1103 (2014). doi:10.1038/ni.3037 Author: Zoltan Fehervari
  • Ray D. Owen 1915–2014

    Michael P Cancro
    13 Nov 2014 | 4:00 pm
    Nature Immunology 15, 1091 (2014). doi:10.1038/ni.3033 Author: Michael P Cancro
  • The physician scientist: balancing clinical and research duties

    Penelope A Morel
    13 Nov 2014 | 4:00 pm
    Nature Immunology 15, 1092 (2014). doi:10.1038/ni.3010 Authors: Penelope A Morel & Gillian Ross Physician scientists bridge the gap between biomedical research and clinical practice. However, the continuing decrease in number of people who choose this career path poses a threat to the advancement of biomedical science and the translation of research findings to clinical practice.
  • Computational toolbox

    Laurie A Dempsey
    13 Nov 2014 | 4:00 pm
    Nature Immunology 15, 1103 (2014). doi:10.1038/ni.3039 Author: Laurie A Dempsey
  • Beyond the age of cellular discovery

    Jonathan Michael Irish
    13 Nov 2014 | 4:00 pm
    Nature Immunology 15, 1095 (2014). doi:10.1038/ni.3034 Author: Jonathan Michael Irish The combination of machine-learning tools and mass-cytometry measurements of more than 30 protein markers per cell comprehensively maps cell identity in the heterogeneous myeloid cell system and reveals the global effect of deletion of the gene encoding the receptor for the growth factor GM-CSF.
 
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    Nature Materials - Issue - nature.com science feeds

  • 2D crystal semiconductors: Intimate contacts

    Debdeep Jena
    19 Nov 2014 | 4:00 pm
    Nature Materials 13, 1076 (2014). doi:10.1038/nmat4121 Authors: Debdeep Jena, Kaustav Banerjee & Grace Huili Xing High electrical contact resistance had stalled the promised performance of two-dimensional layered devices. Low-resistance metal–semiconductor contacts are now obtained by interfacing semiconducting MoS2 layers with the metallic phase of this material.
  • Butterfly-inspired gratings

    Pep Pàmies
    19 Nov 2014 | 4:00 pm
    Nature Materials 13, 1074 (2014). doi:10.1038/nmat4158 Author: Pep Pàmies
  • Chalcogenides fill the gap

    19 Nov 2014 | 4:00 pm
    Nature Materials 13, 1073 (2014). doi:10.1038/nmat4163 Two-dimensional semiconductors such as transition metal dichalcogenides can complement graphene in applications where a sizeable natural energy bandgap is required. Recent studies aim at bringing these materials to a higher level of maturity.
  • Protease probe

    Alison Stoddart
    19 Nov 2014 | 4:00 pm
    Nature Materials 13, 1074 (2014). doi:10.1038/nmat4159 Author: Alison Stoddart
  • Electromagnetic metamaterials: Simplicity unlocks complexity

    Luca Dal Negro
    19 Nov 2014 | 4:00 pm
    Nature Materials 13, 1080 (2014). doi:10.1038/nmat4146 Author: Luca Dal Negro By carefully selecting only two elemental 'building block materials' at the nanoscale, it is possible to digitally design composite electromagnetic media with properties vastly different from their individual constituents and suitable for performing complex optical functions.
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  • High thermal conductivity in amorphous polymer blends by engineered interchain interactions

    Gun-Ho Kim
    23 Nov 2014 | 4:00 pm
    Nature Materials. doi:10.1038/nmat4141 Authors: Gun-Ho Kim, Dongwook Lee, Apoorv Shanker, Lei Shao, Min Sang Kwon, David Gidley, Jinsang Kim & Kevin P. Pipe Thermal conductivity is an important property for polymers, as it often affects product reliability (for example, electronics packaging), functionality (for example, thermal interface materials) and/or manufacturing cost. However, polymer thermal conductivities primarily fall within a relatively narrow range (0.1–0.5 W m−1 K−1) and are largely unexplored. Here, we show that a blend of two polymers with high miscibility and…
  • Superconductivity above 100 K in single-layer FeSe films on doped SrTiO3

    Jian-Feng Ge
    23 Nov 2014 | 4:00 pm
    Nature Materials. doi:10.1038/nmat4153 Authors: Jian-Feng Ge, Zhi-Long Liu, Canhua Liu, Chun-Lei Gao, Dong Qian, Qi-Kun Xue, Ying Liu & Jin-Feng Jia Recent experiments on FeSe films grown on SrTiO3 (STO) suggest that interface effects can be used as a means to reach superconducting critical temperatures (Tc) of up to 80 K (ref. ). This is nearly ten times the Tc of bulk FeSe and higher than the record value of 56 K for known bulk Fe-based superconductors. Together with recent studies of superconductivity at oxide heterostructure interfaces, these results rekindle the long-standing idea…
  • Ultrahigh mobility and giant magnetoresistance in the Dirac semimetal Cd3As2

    Tian Liang
    23 Nov 2014 | 4:00 pm
    Nature Materials. doi:10.1038/nmat4143 Authors: Tian Liang, Quinn Gibson, Mazhar N. Ali, Minhao Liu, R. J. Cava & N. P. Ong Dirac and Weyl semimetals are 3D analogues of graphene in which crystalline symmetry protects the nodes against gap formation. Na3Bi and Cd3As2 were predicted to be Dirac semimetals, and recently confirmed to be so by photoemission experiments. Several novel transport properties in a magnetic field have been proposed for Dirac semimetals. Here, we report a property of Cd3As2 that was unpredicted, namely a remarkable protection mechanism that strongly suppresses…
  • Magneto-ionic control of interfacial magnetism

    Uwe Bauer
    16 Nov 2014 | 4:00 pm
    Nature Materials. doi:10.1038/nmat4134 Authors: Uwe Bauer, Lide Yao, Aik Jun Tan, Parnika Agrawal, Satoru Emori, Harry L. Tuller, Sebastiaan van Dijken & Geoffrey S. D. Beach In metal/oxide heterostructures, rich chemical, electronic, magnetic and mechanical properties can emerge from interfacial chemistry and structure. The possibility to dynamically control interface characteristics with an electric field paves the way towards voltage control of these properties in solid-state devices. Here, we show that electrical switching of the interfacial oxidation state allows for voltage control…
  • Breaking of macroscopic centric symmetry in paraelectric phases of ferroelectric materials and implications for flexoelectricity

    Alberto Biancoli
    16 Nov 2014 | 4:00 pm
    Nature Materials. doi:10.1038/nmat4139 Authors: Alberto Biancoli, Chris M. Fancher, Jacob L. Jones & Dragan Damjanovic
 
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    Nature Medicine - AOP - nature.com science feeds

  • A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

    Monica K Wetzel-Smith
    23 Nov 2014 | 4:00 pm
    Nature Medicine. doi:10.1038/nm.3736 Authors: Monica K Wetzel-Smith, Julie Hunkapiller, Tushar R Bhangale, Karpagam Srinivasan, Janice A Maloney, Jasvinder K Atwal, Susan M Sa, Murat B Yaylaoglu, Oded Foreman, Ward Ortmann, Nisha Rathore, David V Hansen, Marc Tessier-Lavigne, Richard Mayeux, Margaret Pericak-Vance, Jonathan Haines, Lindsay A Farrer, Gerard D Schellenberg, Alison Goate, Timothy W Behrens, Carlos Cruchaga, Ryan J Watts & Robert R Graham We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an…
  • Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

    Siddappa N Byrareddy
    23 Nov 2014 | 4:00 pm
    Nature Medicine. doi:10.1038/nm.3715 Authors: Siddappa N Byrareddy, Brianne Kallam, James Arthos, Claudia Cicala, Fatima Nawaz, Joseph Hiatt, Ellen N Kersh, Janet M McNicholl, Debra Hanson, Keith A Reimann, Markus Brameier, Lutz Walter, Kenneth Rogers, Ann E Mayne, Paul Dunbar, Tara Villinger, Dawn Little, Tristram G Parslow, Philip J Santangelo, Francois Villinger, Anthony S Fauci & Aftab A Ansari α4β7 integrin–expressing CD4+ T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV)…
  • Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

    Ana Paula Arruda
    23 Nov 2014 | 4:00 pm
    Nature Medicine. doi:10.1038/nm.3735 Authors: Ana Paula Arruda, Benedicte M Pers, Güneş Parlakgül, Ekin Güney, Karen Inouye & Gökhan S Hotamisligil Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states, including metabolic diseases. Although the ER and mitochondria play distinct cellular roles, these organelles also form physical interactions with each other at sites defined as mitochondria-associated ER membranes (MAMs), which are…
  • Disruption of the PRKCD–FBXO25–HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis

    Ursula Baumann
    23 Nov 2014 | 4:00 pm
    Nature Medicine. doi:10.1038/nm.3740 Authors: Ursula Baumann, Vanesa Fernández-Sáiz, Martina Rudelius, Simone Lemeer, Roland Rad, Anna-Maria Knorn, Jolanta Slawska, Katharina Engel, Irmela Jeremias, Zhoulei Li, Viktoriya Tomiatti, Anna-Lena Illert, Bianca-Sabrina Targosz, Martin Braun, Sven Perner, Michael Leitges, Wolfram Klapper, Martin Dreyling, Cornelius Miething, Georg Lenz, Andreas Rosenwald, Christian Peschel, Ulrich Keller, Bernhard Kuster & Florian Bassermann
  • Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

    Rintaro Hashizume
    16 Nov 2014 | 4:00 pm
    Nature Medicine. doi:10.1038/nm.3716 Authors: Rintaro Hashizume, Noemi Andor, Yuichiro Ihara, Robin Lerner, Haiyun Gan, Xiaoyue Chen, Dong Fang, Xi Huang, Maxwell W Tom, Vy Ngo, David Solomon, Sabine Mueller, Pamela L Paris, Zhiguo Zhang, Claudia Petritsch, Nalin Gupta, Todd A Waldman & C David James Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K27M cells and…
 
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    Nature Methods - AOP - nature.com science feeds

  • Grease matrix as a versatile carrier of proteins for serial crystallography

    Michihiro Sugahara
    9 Nov 2014 | 4:00 pm
    Nature Methods. doi:10.1038/nmeth.3172 Authors: Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masuda, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno, Kentaro Ihara, Dongqing Pan, Keisuke Kakinouchi, Shigeru Sugiyama, Michio Murata, Tsuyoshi Inoue, Kensuke Tono, Changyong Song, Jaehyun Park, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi & So Iwata Serial femtosecond X-ray crystallography (SFX) has revolutionized atomic-resolution structural investigation by expanding applicability to micrometer-sized protein crystals,…
  • Rovers minimize human disturbance in research on wild animals

    Yvon Le Maho
    1 Nov 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3173 Authors: Yvon Le Maho, Jason D Whittington, Nicolas Hanuise, Louise Pereira, Matthieu Boureau, Mathieu Brucker, Nicolas Chatelain, Julien Courtecuisse, Francis Crenner, Benjamin Friess, Edith Grosbellet, Laëtitia Kernaléguen, Frédérique Olivier, Claire Saraux, Nathanaël Vetter, Vincent A Viblanc, Bernard Thierry, Pascale Tremblay, René Groscolas & Céline Le Bohec Investigating wild animals while minimizing human disturbance remains an important methodological challenge. When approached by a remote-operated vehicle…
  • A robust pipeline for rapid production of versatile nanobody repertoires

    Peter C Fridy
    1 Nov 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3170 Authors: Peter C Fridy, Yinyin Li, Sarah Keegan, Mary K Thompson, Ilona Nudelman, Johannes F Scheid, Marlene Oeffinger, Michel C Nussenzweig, David Fenyö, Brian T Chait & Michael P Rout
  • Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing

    Michael J Ziller
    1 Nov 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3152 Authors: Michael J Ziller, Kasper D Hansen, Alexander Meissner & Martin J Aryee Whole-genome bisulfite sequencing (WGBS) allows genome-wide DNA methylation profiling, but the associated high sequencing costs continue to limit its widespread application. We used several high-coverage reference data sets to experimentally determine minimal sequencing requirements. We present data-derived recommendations for minimum sequencing depth for WGBS libraries, highlight what is gained with increasing coverage and discuss the trade-off between sequencing depth…
  • Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex

    Arnaud Muller
    25 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3151 Authors: Arnaud Muller, Victory Joseph, Paul A Slesinger & David Kleinfeld
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    Nature Neuroscience - Issue - nature.com science feeds

  • Paul Fatt 1924–2014

    Stuart Cull-Candy
    20 Nov 2014 | 4:00 pm
    Nature Neuroscience 17, 1634 (2014). doi:10.1038/nn.3873 Authors: Stuart Cull-Candy & Jonathan Ashmore
  • Flavanol-rich food for thought

    Judy Pa
    20 Nov 2014 | 4:00 pm
    Nature Neuroscience 17, 1624 (2014). doi:10.1038/nn.3876 Authors: Judy Pa & Adam Gazzaley A randomized clinical trial in older adults shows that high dietary intake of cocoa flavanols enhances memory performance on an object-recognition task and neural activity as assessed by functional magnetic resonance imaging in the dentate gyrus of the hippocampus, a region that is critical for learning and memory.
  • Cortical geography is destiny

    Charles E Connor
    20 Nov 2014 | 4:00 pm
    Nature Neuroscience 17, 1631 (2014). doi:10.1038/nn.3877 Author: Charles E Connor A study demonstrates that learning different character sets produces a repeatable arrangement of distinct cortical modules, suggesting that a preexisting cortical architecture is repurposed during learning.
  • Reading dendritic activity with gap junctions

    Frederic Lanore
    20 Nov 2014 | 4:00 pm
    Nature Neuroscience 17, 1625 (2014). doi:10.1038/nn.3880 Authors: Frederic Lanore & R Angus Silver Patch-clamp recordings and imaging in retina show that electrical synapses between dendrites of neighboring ganglion cells transform spatial patterns of light activated synaptic input into a temporal population code.
  • Replay to remember: a boost from dopamine

    Laura A Ewell
    20 Nov 2014 | 4:00 pm
    Nature Neuroscience 17, 1629 (2014). doi:10.1038/nn.3875 Authors: Laura A Ewell & Stefan Leutgeb A study links transient activation of the brain's reward system during a novel experience to frequent reactivation of memory traces during sleep and shows that artificial activation of the reward circuit can strengthen memories.
 
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    Nature Photonics - Issue - nature.com science feeds

  • Black holes: On the lab table

    Maria Maragkou
    26 Nov 2014 | 4:00 pm
    Nature Photonics 8, 881 (2014). doi:10.1038/nphoton.2014.296 Author: Maria Maragkou
  • Nanophotonics is big

    26 Nov 2014 | 4:00 pm
    Nature Photonics 8, 878 (2014). doi:10.1038/nphoton.2014.281 Nature Photonics spoke to Pierre Berini — pioneer of plasmon waveguides — to get some perspective on how nanophotonics has evolved over the past decade and where it is heading.
  • Optical computing: The optical Ising machine

    Claude Fabre
    26 Nov 2014 | 4:00 pm
    Nature Photonics 8, 883 (2014). doi:10.1038/nphoton.2014.292 Author: Claude Fabre A network of optical parametric oscillators has been harnessed to find solutions to a complex problem in statistical physics that is difficult to solve using numerical computing algorithms.
  • Optical fibres: Silicon engineering

    Maria Maragkou
    26 Nov 2014 | 4:00 pm
    Nature Photonics 8, 880 (2014). doi:10.1038/nphoton.2014.295 Author: Maria Maragkou
  • Sensors: Nanoscale magnetometer

    Noriaki Horiuchi
    26 Nov 2014 | 4:00 pm
    Nature Photonics 8, 881 (2014). doi:10.1038/nphoton.2014.302 Author: Noriaki Horiuchi
 
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    Nature Physics - AOP - nature.com science feeds

  • Carrier dynamics in Landau-quantized graphene featuring strong Auger scattering

    Martin Mittendorff
    23 Nov 2014 | 4:00 pm
    Nature Physics. doi:10.1038/nphys3164 Authors: Martin Mittendorff, Florian Wendler, Ermin Malic, Andreas Knorr, Milan Orlita, Marek Potemski, Claire Berger, Walter A. de Heer, Harald Schneider, Manfred Helm & Stephan Winnerl
  • Hunting for topological dark matter with atomic clocks

    A. Derevianko
    16 Nov 2014 | 4:00 pm
    Nature Physics. doi:10.1038/nphys3137 Authors: A. Derevianko & M. Pospelov The cosmological applications of atomic clocks so far have been limited to searches for the uniform-in-time drift of fundamental constants. We point out that a transient-in-time change of fundamental constants can be induced by dark-matter objects that have large spatial extent, such as stable topological defects built from light non-Standard Model fields. Networks of correlated atomic clocks, some of them already in existence, such as the Global Positioning System, can be used as a powerful tool to search for…
  • Dark matter: Time for detection

    Rana Adhikari
    16 Nov 2014 | 4:00 pm
    Nature Physics. doi:10.1038/nphys3175 Authors: Rana Adhikari, Paul Hamiton & Holger Müller Dark matter remains experimentally elusive. But what if it is more classical than expected, resembling a spatially varying field? A network of atomic clocks would be able to detect its variations.
  • Modular entanglement of atomic qubits using photons and phonons

    D. Hucul
    16 Nov 2014 | 4:00 pm
    Nature Physics. doi:10.1038/nphys3150 Authors: D. Hucul, I. V. Inlek, G. Vittorini, C. Crocker, S. Debnath, S. M. Clark & C. Monroe Quantum entanglement is the central resource behind quantum information science, from quantum computation and simulation to enhanced metrology and secure communication. These applications require the quantum control of large networks of qubits to realize gains and speed increases over conventional devices. However, propagating entanglement becomes difficult or impossible as the system grows in size. Here, we demonstrate the first step in a modular approach to…
  • Topological defects as relics of emergent continuous symmetry and Higgs condensation of disorder in ferroelectrics

    Shi-Zeng Lin
    16 Nov 2014 | 4:00 pm
    Nature Physics. doi:10.1038/nphys3142 Authors: Shi-Zeng Lin, Xueyun Wang, Yoshitomo Kamiya, Gia-Wei Chern, Fei Fan, David Fan, Brian Casas, Yue Liu, Valery Kiryukhin, Wojciech H. Zurek, Cristian D. Batista & Sang-Wook Cheong
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Microenvironment: Small containers, important cargo

    M. Teresa Villanueva
    23 Nov 2014 | 4:00 pm
    Nature Reviews Cancer 14, 764 (2014). doi:10.1038/nrc3864 Author: M. Teresa Villanueva Two papers have revealed new roles of exosomes in cancer progression: as mediators of therapeutic resistance signals from the stroma and as microRNA generators.
  • Therapeutic resistance: Blocking the gatekeeper

    Sarah Seton-Rogers
    23 Nov 2014 | 4:00 pm
    Nature Reviews Cancer 14, 766 (2014). doi:10.1038/nrc3871 Author: Sarah Seton-Rogers Tan et al. have identified covalent inhibitors of the fibroblast growth factor receptor (FGFR) that can block the proliferation of cells expressing FGFR1 or FGFR2 gatekeeper mutants, which are resistant to the first generation FGFR inhibitors that are being tested clinically for a variety
  • Cell signalling: Migration fizzles out

    Tesi Villanueva
    23 Nov 2014 | 4:00 pm
    Nature Reviews Cancer 14, 767 (2014). doi:10.1038/nrc3872 Author: Tesi Villanueva Uncovering the signalling pathways by which growth factors regulate epithelial–mesenchymal transition (EMT) could guide the development of new therapies for cancer metastasis. Gujral et al. found that the WNT receptor Frizzled 2 (FZD2) and its ligands WNT5a and WNT5b are elevated in human samples
  • Hypermutation in human cancer genomes: footprints and mechanisms

    Steven A. Roberts
    23 Nov 2014 | 4:00 pm
    Nature Reviews Cancer 14, 786 (2014). doi:10.1038/nrc3816 Authors: Steven A. Roberts & Dmitry A. Gordenin A role for somatic mutations in carcinogenesis is well accepted, but the degree to which mutation rates influence cancer initiation and development is under continuous debate. Recently accumulated genomic data have revealed that thousands of tumour samples are riddled by hypermutation, broadening support for the
  • Aryl hydrocarbon receptor ligands in cancer: friend and foe

    Iain A. Murray
    23 Nov 2014 | 4:00 pm
    Nature Reviews Cancer 14, 801 (2014). doi:10.1038/nrc3846 Authors: Iain A. Murray, Andrew D. Patterson & Gary H. Perdew The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly referred to as 'dioxin'. AHR influences the major stages of tumorigenesis — initiation, promotion, progression and metastasis
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Disease genomics: Triaging risk variants in the non-coding genome

    Linda Koch
    10 Nov 2014 | 4:00 pm
    Nature Reviews Genetics 15, 779 (2014). doi:10.1038/nrg3862 Author: Linda Koch Over the past decade, genome-wide association studies (GWASs) have linked hundreds of loci to diseases, but pinpointing the actual disease-causing variants has been less straightforward. A new algorithm reported in Nature promises to aid the identification of causal risk variants in non-coding sequences.Recent
  • Model organisms: Host determinants of Ebola virus pathogenicity

    Darren J. Burgess
    10 Nov 2014 | 4:00 pm
    Nature Reviews Genetics 15, 781 (2014). doi:10.1038/nrg3865 Author: Darren J. Burgess Laboratory studies of Ebola virus infection have suffered from a lack of mouse models that recapitulate some of the pathology seen in humans, such as Ebola haemorrhagic fever (EHF). Using genetically diverse mouse strains from the Collaborative Cross project, Rasmussen and Okumura et al.
  • Chromosome biology: A high-quality mouse Y chromosome sequence

    Darren J. Burgess
    10 Nov 2014 | 4:00 pm
    Nature Reviews Genetics 15, 781 (2014). doi:10.1038/nrg3866 Author: Darren J. Burgess The male-specific region of the Y chromosome (MSY) in mice has been difficult to sequence because its repetitive nature and resistance to recombination preclude the accurate mapping of sequence reads. Soh et al. developed the single-haplotype iterative mapping and sequencing (SHIMS) method and report
  • Circadian genetics: Timing is everything

    Bryony Jones
    10 Nov 2014 | 4:00 pm
    Nature Reviews Genetics 15, 780 (2014). doi:10.1038/nrg3864 Author: Bryony Jones A high-resolution spatiotemporal gene expression atlas that chronicles the 24-hour transcriptional oscillations of thousands of 'rhythmic' genes in mice may help to improve drug efficacy.Researchers measured gene expression profiles in 12 mouse organs over time by RNA sequencing and DNA arrays to investigate the
  • Disease genetics: New insights into the genetic architecture of ASDs

    Linda Koch
    10 Nov 2014 | 4:00 pm
    Nature Reviews Genetics 15, 781 (2014). doi:10.1038/nrg3867 Author: Linda Koch De novo mutations are spontaneous mutations that are detected in a child but not in either parent. Two well-powered family-based exome sequencing studies targeting de novo mutations reveal novel insights into the genetic architecture of autism spectrum disorders (ASDs). The first study by
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Infectious disease: Fungal restriction of renal T cell migration

    Olive Leavy
    24 Nov 2014 | 4:00 pm
    Nature Reviews Immunology 14, 779 (2014). doi:10.1038/nri3782 Author: Olive Leavy Although CD4+ T cells, particularly T helper 17 (TH17) cells, have a crucial role in antifungal immunity, it has been thought that T cells are redundant for the control of renal Candida albicans infection. Drummond et al. characterized the
  • Innate immunity: IFNs lead TLR4 responses down the TRIF path

    Yvonne Bordon
    24 Nov 2014 | 4:00 pm
    Nature Reviews Immunology 14, 779 (2014). doi:10.1038/nri3783 Author: Yvonne Bordon Toll-like receptor 4 (TLR4) signals via two distinct pathways — one engages the adaptor protein MYD88 and the other is driven by TRIF. The MYD88 pathway is associated with the induction of pro-inflammatory gene expression, whereas the TRIF pathway is considered to be less inflammatory
  • Antiviral immunity: Whipping up a remedy for rotavirus infection

    Yvonne Bordon
    24 Nov 2014 | 4:00 pm
    Nature Reviews Immunology 14, 777 (2014). doi:10.1038/nri3780 Author: Yvonne Bordon Rotavirus infection is a major cause of gastroenteritis and 600,000 infants die from this infection each year. This study shows that treatment with bacterial flagellin can protect mice against subsequent infection with rotavirus and promote the clearance of this virus from chronically infected mice. Flagellin
  • Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology

    Nicolas Buchon
    24 Nov 2014 | 4:00 pm
    Nature Reviews Immunology 14, 796 (2014). doi:10.1038/nri3763 Authors: Nicolas Buchon, Neal Silverman & Sara Cherry Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila melanogaster has proven to be a powerful model for the study of innate immunity. Early work focused on innate immune mechanisms of microbial recognition and subsequent nuclear factor-κB signal transduction.
  • Immune tolerance: Regulatory T cells require constant reassurance

    Yvonne Bordon
    24 Nov 2014 | 4:00 pm
    Nature Reviews Immunology 14, 777 (2014). doi:10.1038/nri3778 Author: Yvonne Bordon Regulatory T (TReg) cells require T cell receptor (TCR) signalling for their development, but it has been unclear how TCR signals contribute to their functions in the periphery. Vahl et al. used an inducible deletion system to specifically ablate TCR expression on
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Microbiome: Bile provides key to CDI resistance

    Cláudio Nunes Alves
    13 Nov 2014 | 4:00 pm
    Nature Reviews Microbiology 12, 794 (2014). doi:10.1038/nrmicro3394 Author: Cláudio Nunes Alves To investigate the link between antibiotic treatment and susceptibility to intestinal Clostridium difficile infection (CDI), Buffie et al. treated mice with different antibiotics and correlated the observed differences in intestinal bacterial composition with susceptibility to CDI. This analysis revealed that the presence of
  • Parasite biology: Early social behaviour in T. b. brucei

    Sheilagh Molloy
    13 Nov 2014 | 4:00 pm
    Nature Reviews Microbiology 12, 794 (2014). doi:10.1038/nrmicro3395 Author: Sheilagh Molloy The causative agent of sleeping sickness in humans, Trypanosome brucei brucei, has been shown to exhibit social motility, or coordinated migration, on semi-solid surfaces. Imhof et al. used a series of mutants to investigate when T. b. brucei displays social motility during
  • Fungal pathogenicity: Role for TLOs in fungal virulence

    Sheilagh Molloy
    13 Nov 2014 | 4:00 pm
    Nature Reviews Microbiology 12, 794 (2014). doi:10.1038/nrmicro3396 Author: Sheilagh Molloy The human fungal pathogen Candida albicans contain 15 telomeric ORF (TLO) genes that encode proteins with homology to the Med2 component of the mediator complex, which functions in transcriptional regulation. Using the related fungal pathogen Candida dubliniensis as a model, Haran
  • Ebola Crisis continues

    Christina Tobin Kåhrström
    13 Nov 2014 | 4:00 pm
    Nature Reviews Microbiology 12, 792 (2014). doi:10.1038/nrmicro3392 Author: Christina Tobin Kåhrström Outbreak update. The ongoing epidemic of Ebola virus (EBOV), which has infected more than 13,000 people and has claimed approximately 5,000 lives so far, is now showing the first signs of regression in Liberia, the worst affected country in West Africa. The WHO has
  • The fate and biogeochemical cycling of viral elements

    Rui Zhang
    13 Nov 2014 | 4:00 pm
    Nature Reviews Microbiology 12, 850 (2014). doi:10.1038/nrmicro3384 Authors: Rui Zhang, Wei Wei & Lanlan Cai In a recent Analysis article (The elemental composition of virus particles: implications for marine biogeochemical cycles. Nature Rev. Microbiol.12, 519–52810.1038/nrmicro3289(2014)), Jover et al. highlight the generally overlooked potential biogeochemical importance of the
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Remodelling the extracellular matrix in development and disease

    Caroline Bonnans
    20 Nov 2014 | 4:00 pm
    Nature Reviews Molecular Cell Biology 15, 786 (2014). doi:10.1038/nrm3904 Authors: Caroline Bonnans, Jonathan Chou & Zena Werb The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and continuously undergoes controlled remodelling. This process involves quantitative and qualitative changes in the ECM, mediated by specific enzymes that are responsible for ECM degradation, such as metalloproteinases. The ECM
  • Chromosome biology: Short telomeres can't reach

    Eytan Zlotorynski
    20 Nov 2014 | 4:00 pm
    Nature Reviews Molecular Cell Biology 15, 766 (2014). doi:10.1038/nrm3914 Author: Eytan Zlotorynski Robin et al. describe telomere position effect over long distances (TPE–OLD), a phenomenon in which long (but not short) telomeres control gene expression by forming chromatin loops with genes located several Mb away.
  • Microscopy: Advancing imaging

    Andrea Du Toit
    20 Nov 2014 | 4:00 pm
    Nature Reviews Molecular Cell Biology 15, 769 (2014). doi:10.1038/nrm3910 Author: Andrea Du Toit Betzig and colleagues created ultrathin light sheets to visualize dynamic processes at high speed and high spatiotemporal resolution.
  • Cell migration: Moving towards ECM with LKB1

    Katharine H. Wrighton
    20 Nov 2014 | 4:00 pm
    Nature Reviews Molecular Cell Biology 15, 767 (2014). doi:10.1038/nrm3911 Author: Katharine H. Wrighton Chan et al. investigated the mechanism by which loss of the Ser/Thr kinase LKB1 facilitates the invasion and metastasis of melanoma cells. Using scratch wound assays, which remove the extracellular matrix (ECM), they found that LKB1 null melanoma cells migrated into the wound, but
  • Cell adhesion: Basement membranes stick together

    Kim Baumann
    20 Nov 2014 | 4:00 pm
    Nature Reviews Molecular Cell Biology 15, 767 (2014). doi:10.1038/nrm3912 Author: Kim Baumann The basement membrane is a specialized sheet-like extracellular matrix (ECM) that surrounds most tissues. The mechanisms underlying adhesion between basement membranes, which is important for neighbouring tissue alignment, are unclear. Studying Caenorhabditis elegans uterine–vulval attachments, Morrissey et al. found that the ECM component
 
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Psychiatric disorders: A feat of epigenetic engineering

    Katherine Whalley
    19 Nov 2014 | 4:00 pm
    Nature Reviews Neuroscience 15, 768 (2014). doi:10.1038/nrn3869 Author: Katherine Whalley Study uses in vivo gene-specific chromatin remodelling to elucidate the role of Fosb in addiction- and depression-related changes in the brain.
  • Dendrites: Regenerating space

    Darran Yates
    19 Nov 2014 | 4:00 pm
    Nature Reviews Neuroscience 15, 766 (2014). doi:10.1038/nrn3870 Author: Darran Yates Place-cell firing in mice can be accompanied by regenerative dendritic events, which predict some of the properties of place fields.
  • Psychiatric disorders: GluN2B mediates ketamine's antidepressant effect

    Leonie Welberg
    19 Nov 2014 | 4:00 pm
    Nature Reviews Neuroscience 15, 769 (2014). doi:10.1038/nrn3871 Author: Leonie Welberg The cellular mechanisms underlying the rapid antidepressant effects of the NMDA receptor (NMDAR) antagonist ketamine are not well understood. Miller et al. showed that mice lacking the NMDAR subunit GluN2B from principal cortical neurons showed reduced despair-like behaviour and that ketamine had no antidepressant
  • Glia: Glial ankyrins function at the junction

    Leonie Welberg
    19 Nov 2014 | 4:00 pm
    Nature Reviews Neuroscience 15, 769 (2014). doi:10.1038/nrn3872 Author: Leonie Welberg The mechanisms involved in the assembly and maintenance of paranodal axon–glial junctions that flank nodes of Ranvier are not completely understood. Rasband and colleagues showed that the scaffolding proteins ankyrin B (ANKB) and ankyrin G (ANKG) are enriched on the glial, rather than the neuronal
  • Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

    Mauro Maccarrone
    19 Nov 2014 | 4:00 pm
    Nature Reviews Neuroscience 15, 786 (2014). doi:10.1038/nrn3846 Authors: Mauro Maccarrone, Manuel Guzmán, Ken Mackie, Patrick Doherty & Tibor Harkany Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic
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    Nature Reviews Cardiology - Issue - nature.com science feeds

  • Stem cells: BMMC treatment safe but not an improvement on standard therapy

    Tim Geach
    3 Nov 2014 | 4:00 pm
    Nature Reviews Cardiology 11, 686 (2014). doi:10.1038/nrcardio.2014.175 Author: Tim Geach Intracoronary infusion of bone marrow-derived mononuclear cells (BMMCs) has long been hoped to improve cardiac function in patients after an acute myocardial infarction (AMI). However, the results have been mixed, and the debate surrounding mononuclear-cell treatment is still open. In a new paper from investigators
  • Risk factors: Women living near to a road at increased risk of sudden cardiac death

    Gregory B. Lim
    3 Nov 2014 | 4:00 pm
    Nature Reviews Cardiology 11, 687 (2014). doi:10.1038/nrcardio.2014.176 Author: Gregory B. Lim Women who live close to a major roadway might have an increased risk of sudden cardiac death, according to an analysis of data from the prospective Nurses' Health Study in the USA. These women also have an elevated risk of other forms of cardiovascular disease.
  • Balancing ischaemia and bleeding risks with novel oral anticoagulants

    Usman Baber
    3 Nov 2014 | 4:00 pm
    Nature Reviews Cardiology 11, 693 (2014). doi:10.1038/nrcardio.2014.170 Authors: Usman Baber, Ioannis Mastoris & Roxana Mehran Vitamin K antagonists (VKAs) have long been the standard of care for treatment of venous thromboembolism (VTE), and thromboprophylaxis in atrial fibrillation (AF). Despite their efficacy, their use requires frequent monitoring and is complicated by drug–drug interactions and the need to maintain a narrow therapeutic
  • Atherosclerosis: Carotid artery stenting versus endarterectomy—no difference in long-term outcomes

    Karina Huynh
    3 Nov 2014 | 4:00 pm
    Nature Reviews Cardiology 11, 685 (2014). doi:10.1038/nrcardio.2014.174 Author: Karina Huynh Carotid artery stenosis results from a build-up of atherosclerotic plaques within the carotid artery wall and is responsible for approximately 10% of all strokes. Carotid endarterectomy, the surgical removal of fatty deposits from the vessel, has been the treatment of choice for patients with symptomatic
  • Interventional cardiology: Restenosis predictive of 4-year mortality after stenting

    Tim Geach
    27 Oct 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 688 (2014). doi:10.1038/nrcardio.2014.172 Author: Tim Geach Restenosis of a stented lesion detected by routine follow-up angiography can be used to predict mortality, according to the investigators of a new study published in the European Heart Journal. While the introduction of drug-eluting stents has improved outcomes for patients, including reducing the
 
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    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • The little C

    Mina Razzak
    23 Nov 2014 | 4:00 pm
    Nature Reviews Clinical Oncology 11, 689 (2014). doi:10.1038/nrclinonc.2014.176 Author: Mina Razzak A cancer diagnosis is life changing at any age, but a diagnosis at a young age can alter an individual's life path completely. A child thrown into the world of hospitals, tests and treatments also opens technical challenges from the medical perspective—dosing issues, preservation of
  • Breast cancer: Paradoxical role of angiogenesis in breast cancer metastasis

    10 Nov 2014 | 4:00 pm
    Nature Reviews Clinical Oncology 11, 682 (2014). doi:10.1038/nrclinonc.2014.197 The tumour microenvironment has a key role in cancer growth. A high number of macrophages is associated with poor patient prognosis and survival, and with high expression levels of the chemoattractant CCL2. Inhibition of CCL2 reduces metastasis in mice; however, a study has now shown
  • Gastrointestinal cancer: FOLFOXIRI—improving outcomes of metastatic colorectal cancer

    Alessia Errico
    10 Nov 2014 | 4:00 pm
    Nature Reviews Clinical Oncology 11, 684 (2014). doi:10.1038/nrclinonc.2014.194 Author: Alessia Errico Firstline bevacizumab plus 5-fluorouracil (5-FU), folinic acid and either irinotecan (FOLFIRI) or oxaliplatin (FOLFOX), are widely adopted treatment regimens for metastatic colorectal cancer. Now, the TRIBE trial, led by Alfredo Falcone, has shown that FOLFOXIRI (5-FU plus folinic acid, oxaliplatin, and irinotecan) plus bevacizumab improves
  • Genetics: The Cancer Genome Atlas maps papillary thyroid cancer

    David Killock
    10 Nov 2014 | 4:00 pm
    Nature Reviews Clinical Oncology 11, 681 (2014). doi:10.1038/nrclinonc.2014.193 Author: David Killock The most-common form of thyroid cancer is papillary thyroid carcinoma (PTC), the incidence of which is increasing. Although PTC generally has a good prognosis, with 5-year survival often exceeding 95%, some cases dedifferentiate into more-aggressive tumours. The Cancer Genome Atlas (TCGA) Research Network have turned
  • Immunotherapy: Treatment of aggressive lymphomas with anti-CD19 CAR T cells

    Christopher A. Klebanoff
    10 Nov 2014 | 4:00 pm
    Nature Reviews Clinical Oncology 11, 685 (2014). doi:10.1038/nrclinonc.2014.190 Authors: Christopher A. Klebanoff, Tori N. Yamamoto & Nicholas P. Restifo Adoptive immunotherapy using T cells genetically engineered to express a chimeric antigen receptor that targets CD19, a B-cell differentiation antigen, has demonstrated impressive efficacy in a range of B-lymphoid malignancies. The latest results demonstrate the potential of this approach in patients with chemotherapy-refractory diffuse large B-cell lymphoma.
 
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    Nature Reviews Endocrinology - Issue - nature.com science feeds

  • Pituitary gland: Mortality in acromegaly reduced with multimodal therapy

    Nienke R. Biermasz
    3 Nov 2014 | 4:00 pm
    Nature Reviews Endocrinology 10, 708 (2014). doi:10.1038/nrendo.2014.193 Author: Nienke R. Biermasz The treatment of patients with acromegaly has progressed to encompass multimodal strategies that can include selective transsphenoidal adenomectomy, radiotherapy and somatostatin analogues. As a result, disease control and survival of these patients has improved.
  • Diabetes: Getting personal with type 2 diabetes mellitus—from genetics to targeted therapy

    Jennifer Sargent
    27 Oct 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 699 (2014). doi:10.1038/nrendo.2014.189 Author: Jennifer Sargent Research published in Science Translational Medicine has demonstrated that defective insulin secretion in patients with type 2 diabetes mellitus (T2DM) who carry a genetic risk variant in the gene that codes for the α2A-adrenergic receptor (α2AAR; encoded by ADRA2A)
  • Neuroendocrinology: Cholesterol metabolites regulate motor neuron function

    David Holmes
    20 Oct 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 700 (2014). doi:10.1038/nrendo.2014.184 Author: David Holmes Cholestenoic acids—intermediates in the metabolism of cholesterol to bile acids —differentially regulate motor neuron survival in mice and possibly in humans, show Theofilopoulos et al. in The Journal of Clinical Investigation. The findings have potential implications for the diagnosis and treatment of
  • Diabetes: Antihelminthic drug for T2DM therapy?

    Joana Osório
    20 Oct 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 702 (2014). doi:10.1038/nrendo.2014.183 Author: Joana Osório Niclosamide, a drug used to treat intestinal tapeworm infections, has potential as a new antidiabetic therapy, suggest findings published in Nature Medicine. Niclosamide ethanolamine, a salt form of niclosamide, improved features of type 2 diabetes mellitus (T2DM) in mice by inducing mitochondrial uncoupling.“Developing
  • Genetics: Telomere length and the metabolic syndrome—a causal link?

    Peter M. Nilsson
    20 Oct 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 706 (2014). doi:10.1038/nrendo.2014.182 Author: Peter M. Nilsson Shortening of leukocyte telomeres is considered a molecular marker for ageing and is suggested to be linked with increased risk of cardiovascular and metabolic disease. A large population-based study with 6 years of follow-up by Révész and colleagues reveals that short telomeres, at both baseline and during follow-up, are associated with an increased risk of metabolic abnormalities.
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    Nature Reviews Endocrinology - AOP - nature.com science feeds

  • Diabetes: Epigenetic changes lead to impaired wound healing in patients with T2DM

    Peter Sidaway
    24 Nov 2014 | 4:00 pm
    Nature Reviews Endocrinology. doi:10.1038/nrendo.2014.207 Author: Peter Sidaway
  • Gastric emptying and glycaemia in health and diabetes mellitus

    Liza K. Phillips
    24 Nov 2014 | 4:00 pm
    Nature Reviews Endocrinology. doi:10.1038/nrendo.2014.202 Authors: Liza K. Phillips, Adam M. Deane, Karen L. Jones, Chris K. Rayner & Michael Horowitz
  • Genetics: The genomic landscape of papillary thyroid carcinoma

    Massimo Santoro
    24 Nov 2014 | 4:00 pm
    Nature Reviews Endocrinology. doi:10.1038/nrendo.2014.209 Authors: Massimo Santoro & Rosa M. Melillo A landmark article by The Cancer Genome Atlas Research network describes the genetic landscape of papillary thyroid carcinoma (PTC). This study identifies oncogenic driver lesions, highlights molecular pathways that drive cancer formation and defines clinically relevant disease subtypes. These findings have far-reaching implications with respect to molecular diagnosis and targeted therapies for PTC.
  • Genetics: Vitamin D and type 2 diabetes mellitus—hype or hope?

    Klaus Badenhoop
    24 Nov 2014 | 4:00 pm
    Nature Reviews Endocrinology. doi:10.1038/nrendo.2014.206 Author: Klaus Badenhoop Vitamin D deficiency is a global health concern, which might affect the pathogenesis of diabetes mellitus. Previous studies suggest vitamin D has some potential in the treatment of type 2 diabetes mellitus. A new combined genetic study and meta-analysis reveals conflicting results regarding the effects of circulating levels of vitamin D on type 2 diabetes mellitus risk.
  • Therapy: PCSK9 inhibitors for treating familial hypercholesterolaemia

    Hiroshi Mabuchi
    17 Nov 2014 | 4:00 pm
    Nature Reviews Endocrinology. doi:10.1038/nrendo.2014.205 Authors: Hiroshi Mabuchi & Atsushi Nohara Familial hypercholesterolaemia is caused by mutations in genes that code for proteins involved in cholesterol metabolism. Patients heterozygous for mutations in LDLR respond to statin treatment, whereas individuals with homozygous LDLR mutations do not. PCSK9 inhibitors have been developed for treating familial hypercholesterolaemia, and results are promising for patients with either heterozygous or homozygous familial hypercholesterolaemia.
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    Nature Reviews Gastroenterology and Hepatology - Issue - nature.com science feeds

  • Viral hepatitis: A new model to study chronic HCV infection

    10 Nov 2014 | 4:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 702 (2014). doi:10.1038/nrgastro.2014.191 A study published in The Journal of Clinical Investigation has demonstrated the potential of a novel mouse model of HCV infection. Hepatocyte-like cells (HLCs) differentiated from human embryonic stems cells and induced pluripotent stem cells were engrafted in the liver parenchyma of immune-deficient mice.
  • NAFLD: Ketogenesis could be a determinant of steatohepatitis

    Gillian Patman
    10 Nov 2014 | 4:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 702 (2014). doi:10.1038/nrgastro.2014.189 Author: Gillian Patman A new study published in The Journal of Clinical Investigation has linked impaired ketogenesis (the production of alternative energy from fatty acid metabolism) to altered hepatic glucose and lipid metabolism. Mice with ketogenic insufficiency had increased de novo lipogenesis (DNL) and gluconeogenesis, and
  • Infection: Treating Clostridium difficile infection: a bitter pill to swallow

    10 Nov 2014 | 4:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 702 (2014). doi:10.1038/nrgastro.2014.193 Faecal microbiota transplantation (FMT) has a role in treating recurrent Clostridium difficile infection; however, practical concerns regarding modes of administration have limited its widespread use. Youngster and colleagues investigated the safety and efficacy of frozen FMT capsules (from prescreened unrelated donors) for the treatment
  • Colorectal cancer: New treatment combination for metastatic colorectal cancer

    10 Nov 2014 | 4:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 702 (2014). doi:10.1038/nrgastro.2014.190 508 patients with untreated metastatic colorectal cancer were randomly assigned to receive either FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin and irinotecan) plus bevacizumab or FOLFIRI (fluorouracil, leucovorin and irinotecan) and bevacizumab (control group). Patients who received FOLFOXIRI and bevacizumab had improved progression-free survival compared with control patients
  • IBD: Sniffing out paediatric IBD

    10 Nov 2014 | 4:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 702 (2014). doi:10.1038/nrgastro.2014.192 An electronic nose was used to study the patterns of faecal volatile organic compounds (VOCs) in children with IBD. Children with newly diagnosed IBD were assessed at baseline and upon achieving remission at 6-weeks follow-up. Analysis of these VOC patterns was able to discriminate patients
 
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    Nature Reviews Nephrology - Issue - nature.com science feeds

  • Dialysis: Sex-specific differences in haemodialysis practices

    3 Nov 2014 | 4:00 pm
    Nature Reviews Nephrology 10, 674 (2014). doi:10.1038/nrneph.2014.207 An analysis of 35,964 patients by Dialysis Outcomes and Practice Patterns Study (DOPPS) researchers has revealed sex--specific differences in haemodialysis use. Among these patients, more men than women were on haemodialysis (59% versus 41%, respectively). The researchers also found that the survival advantage of women
  • Diabetes: Statins for microvascular complications—all but the kidney

    Kumar Sharma
    3 Nov 2014 | 4:00 pm
    Nature Reviews Nephrology 10, 680 (2014). doi:10.1038/nrneph.2014.203 Authors: Kumar Sharma & Loki Natarajan A new study shows that statin therapy before diagnosis of diabetes mellitus is not associated with an increased risk of microvascular disease and might even be beneficial for retinopathy and neuropathy. These data suggest a potential protective effect of statins in specific complications, which should be further investigated in randomized controlled trials.
  • Genetics: New risk loci for IgAN suggests role for intestinal pathogens

    3 Nov 2014 | 4:00 pm
    Nature Reviews Nephrology 10, 674 (2014). doi:10.1038/nrneph.2014.205 A genome-wide analysis of 20,612 individuals of European and East Asian descent has revealed new risk loci that suggest a role for pathways involved in intestinal pathogen immunity in susceptibility to IgA nephropathy (IgAN). Kiryluk et al. identified six new signals that contribute
  • Acute kidney injury: TRPM2 and RAC1: mediators of oxidative stress in AKI

    3 Nov 2014 | 4:00 pm
    Nature Reviews Nephrology 10, 674 (2014). doi:10.1038/nrneph.2014.206 Kidney ischaemia is associated with a loss of intracellular potassium and an increase in intracellular levels of sodium, chloride and calcium; however, the mechanisms involved in the loss of cellular ion homeostasis are unknown. A new study has revealed a critical role for the nonselective
  • Cardiovascular disease: Role for Klotho and phosphate in cardiac remodelling

    3 Nov 2014 | 4:00 pm
    Nature Reviews Nephrology 10, 674 (2014). doi:10.1038/nrneph.2014.208 Klotho deficiency is a mediator of pathologic cardiac remodelling, and fibroblast growth factor (FGF)-23 might contribute to this process in the settings of chronic kidney disease (CKD) and ageing, conclude the authors of a new study. Hu et al. found that mice with
 
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    Nature Reviews Rheumatology - Issue - nature.com science feeds

  • Connective tissue diseases: Deficient antigen-specific T cell responses in SLE-prone mice

    João H. Duarte
    10 Nov 2014 | 4:00 pm
    Nature Reviews Rheumatology 10, 700 (2014). doi:10.1038/nrrheum.2014.196 Author: João H. Duarte Systemic lupus erythematosus (SLE) is associated with increased susceptibility to infections, a major cause of morbidity and mortality in patients with this disease. In a study published in PLoS ONE, Lieberman and Tsokos show that lupus-prone mice have lower antigen-specific T cell responses to
  • Rheumatoid arthritis: Methotrexate and bridging glucocorticoids in early RA

    Sarah Onuora
    10 Nov 2014 | 4:00 pm
    Nature Reviews Rheumatology 10, 698 (2014). doi:10.1038/nrrheum.2014.197 Author: Sarah Onuora Intensive treat-to-target strategies are widely recommended for the initial treatment of patients with early rheumatoid arthritis (RA), but questions remain about the ideal dosage and combination of drugs. The 16-week results of the care in early RA (CareRA) study suggest that, in a tight control
  • Inflammatory arthritis: Blood coagulation factor drives arthritis pathogenesis

    Sarah Onuora
    10 Nov 2014 | 4:00 pm
    Nature Reviews Rheumatology 10, 700 (2014). doi:10.1038/nrrheum.2014.192 Author: Sarah Onuora Research now published in Blood reveals that the thrombin-activated coagulation transglutaminase factor XIII (fXIII) is an important factor in the pathogenesis of inflammatory arthritis, contributing to the disease through distinct mechanisms linked to local joint inflammation and altered osteoclast function.“Elevated coagulation system activity,
  • Autoimmunity: Engineering mice to identify autoreactive T-cell antigens

    Nicholas J. Bernard
    3 Nov 2014 | 4:00 pm
    Nature Reviews Rheumatology 10, 697 (2014). doi:10.1038/nrrheum.2014.190 Author: Nicholas J. Bernard Now published in the journal Science, Professor Shimon Sakaguchi and colleagues present a novel method of autoantigen discovery and a proof-of-principle, showing that the 60S ribosomal protein L23a (RPL23A) is an arthritogenic T-cell autoantigen. “By attenuation of T-cell receptor (TCR) signal strength,” says Sakaguchi,
  • Rheumatoid arthritis: Anti-TNF and anti-IL-17 antibodies—better together!

    Jenny Buckland
    27 Oct 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 699 (2014). doi:10.1038/nrrheum.2014.183 Author: Jenny Buckland Combined blockade of TNF and IL-17 could be a therapeutic approach for patients with rheumatoid arthritis (RA) who fail to respond, or who lose responsiveness, to single-cytokine inhibition, according to a paper now published in Arthritis & Rheumatology.Georg Schett and colleagues from the
 
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    Naturejobs - Search results

  • Project Leader in Cell Biology

    27 Nov 2014 | 8:56 am
    Decode Genetics is looking for a project leader in the field of molecular biology/cell biology with extensive experience in cell based research. The project leader will join a new department within the company that will utilize methods in biochemistry and molecular biology for further exploring the effect of sequence variants on human diversity. Role Setting up and running a new research facility in cell biology at deCODE Genetics. Development of protocols for cell culture and bioas…
  • Research Associate

    27 Nov 2014 | 8:32 am
    Job Title: Postdoctoral Research Associate Applications are invited for a Post-doctoral Research Associate position in the group of Professor Helariutta at The Sainsbury Laboratory, Cambridge University, to work on an ERC funded project investigating the role of symplastic communication during root development. The overall aim of this project is to assess the role of symplastic communication, i.e. plasmodesmata-mediated molecular trafficking in regulating root development. It is based on a…
  • PostDoc Lead Discovery

    27 Nov 2014 | 8:28 am
    YOUR TASKS AND RESPONSIBILITIES • Responsible for the investigation of small molecule-drug target interactions focusing on the driving forces of binding affinity and binding kinetics • Drive project progression by determining Structure-Activity and Structure-Kinetic Relationships (SAR and SKR) of a selected set of target proteins and small molecules • Application of a wide variety of technologies, including Surface Plasmon Resonance and cell-based assays as well as X-ray structure analysis t…
  • The Channel 4 Data Planning & Analytics PhD Scholarship 2015

    27 Nov 2014 | 8:21 am
    The Channel 4 Data Planning & Analytics PhD Scholarship 2015 What’s the Hadoop stack got to do with Gogglebox? An opportunity to work with cutting-edge data science technologies while carrying out pioneering research at University College London. This five-year scholarship programme is giving two graduates the opportunity to study for a PhD in Statistics at UCL, fully funded by Channel 4. To learn more about the faculty and research at UCL, please visit: http://www.ucl.ac.uk/statistics…
  • Technical Specialist

    27 Nov 2014 | 7:34 am
    Applications are invited for the above post based within the School of Biosciences at the Sutton Bonington Campus. The successful candidate will provide specialist technical support to the programme of work within the EPSRC Centre for Innovative Manufacturing (CIM) in Food & plan and oversee the strategic direction of activities related to the programme in the Food Processing Facility and the Biomaterials laboratory. The person appointed will be responsible for allocating resources and pro…
 
 
 
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    British Journal of Pharmacology

  • The CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779

    Belinda Nedjai, Jonathan M Viney, Hubert Li, Caroline Hull, Caroline A. Anderson, Tomoki Horie, Richard Horuk, Nagarajan Vaidehi, James E Pease
    26 Nov 2014 | 2:52 am
    Summary Background and purposeThe chemokine receptor CXCR3 is implicated in a variety of clinically important diseases, notably rheumatoid arthritis and atherosclerosis. Consequently, antagonists of CXCR3 are of therapeutic interest. In this study, we set out to characterize binding sites of the specific small molecule CXCR3 antagonist VUF10085 and the broad spectrum antagonist TAK-779 which has activity at CXCR3 and also the receptors CCR2 and CCR5. Experimental approachMolecular modeling of CXCR3, followed by virtual ligand docking highlighted several CXCR3 residues likely to contact either…
  • Δ9Tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells

    R Rao, P S Nagarkatti, M Nagarkatti
    26 Nov 2014 | 2:51 am
    Summary Background And PurposeThe superantigen Staphylococcal enterotoxin B (SEB) is a potent activator of Vβ8+T-cells which results in the clonal expansion of ∼30% of the T-cell pool. Consequently, this leads to the substantial release of inflammatory cytokines, induction of toxic shock, and eventually death. In the current study, we investigated if Δ9Tetrahydrocannabinol (THC), a cannabinoid known for its anti-inflammatory properties, could prevent SEB-induced mortality and alleviate symptoms of toxic shock. Experimental ApproachWe investigated the therapeutic efficacy of THC against…
  • The melatonin-sulforaphane hybrid ITH12674 affords neuroprotection in oxidative stress conditions by a “Drug – Prodrug” mechanism of action

    Javier Egea, Izaskun Buendia, Esther Parada, Elisa Navarro, Patricia Rada, Antonio Cuadrado, Manuela G. López, Antonio G. García, Rafael León
    26 Nov 2014 | 2:51 am
    Abstract Background and purposeNeurodegenerative diseases are a major problem afflicting aging populations; however, there are no effective treatments to stop their progression. Oxidative stress and neuroinflammation are common factors in their pathogenesis. Nrf2 is the master regulator to control oxidative stress and melatonin is an endogenous hormone with antioxidative properties that reduces its levels with aging. We have designed a new compound that combines melatonin with Nrf2 induction properties with the idea of achieving improved neuroprotective properties. Experimental…
  • Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ9-tetrahydrocannabinol in Sprague-Dawley rats

    M A Taffe, K M Creehan, S A Vandewater
    26 Nov 2014 | 2:51 am
    Abstract Background and PurposeGrowing evidence shows cannabidiol (CBD) modulates some effects of Δ9-tetrahydrocannabinol (THC). CBD is a constituent of some strains of recreational cannabis but content is highly variable. High CBD strains may be less memory impairing than low-CBD strains and CBD can reverse behavioral effects of THC in monkeys. CBD/THC interactions in rodents are more complicated as it can attenuate or exacerbate the effects of THC. This study was undertaken to determine if CBD could reverse hypothermia or hypolocomotor effects caused by THC in rats. Experimental…
  • TRPV4 and KCa functionally couple as osmosensors in the PVN

    C. H. Feetham, N. Nunn, R. Lewis, C. Dart, R. Barrett-Jolley
    24 Nov 2014 | 8:20 pm
    Summary Background and purposeTransient receptor potential vanilloid type 4 (TRPV4) and calcium-activated potassium channels (KCa) are reported to mediate osmosensing in a range of tissues. Both TRPV4 and KCa have been identified in the paraventricular nucleus of the hypothalamus (PVN); an area critical for sympathetic control of cardiovascular and renal function. In this study we investigate whether TRPV4 channels functionally couple to KCa channels to mediate osmosensing in PVN parvocellular neurones and pharmacologically characterize the subtype of KCa involved. Experimental approachWe…
 
 
 
 
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    European Journal of Human Genetics - AOP - nature.com science feeds

  • Further delineation of the KAT6B molecular and phenotypic spectrum

    Tamsin Gannon
    25 Nov 2014 | 4:00 pm
    Further delineation of the KAT6B molecular and phenotypic spectrum European Journal of Human Genetics advance online publication, November 26 2014. doi:10.1038/ejhg.2014.248 Authors: Tamsin Gannon, Rahat Perveen, Hélene Schlecht, Simon Ramsden, Beverley Anderson, Bronwyn Kerr, Ruth Day, Siddharth Banka, Mohnish Suri, Siren Berland, Michael Gabbett, Alan Ma, Stan Lyonnet, Valerie Cormier-Daire, Rüstem Yilmaz, Guntram Borck, Dagmar Wieczorek, Britt-Marie Anderlid, Sarah Smithson, Julie Vogt, Heather Moore-Barton, Pelin Ozlem Simsek-Kiper, Isabelle Maystadt, Anne Destrée, Jessica…
  • Further delineation of the KBG syndrome phenotype caused by ANKRD11 aberrations

    Charlotte W Ockeloen
    25 Nov 2014 | 4:00 pm
    Further delineation of the KBG syndrome phenotype caused by ANKRD11 aberrations European Journal of Human Genetics advance online publication, November 26 2014. doi:10.1038/ejhg.2014.253 Authors: Charlotte W Ockeloen, Marjolein H Willemsen, Sonja de Munnik, Bregje WM van Bon, Nicole de Leeuw, Aad Verrips, Sarina G Kant, Elizabeth A Jones, Han G Brunner, Rosa LE van Loon, Eric EJ Smeets, Mieke M van Haelst, Gijs van Haaften, Ann Nordgren, Helena Malmgren, Giedre Grigelioniene, Sascha Vermeer, Pedro Louro, Lina Ramos, Thomas JJ Maal, Celeste C van Heumen, Helger G Yntema, Carine EL Carels &…
  • Genome-wide inbreeding estimation within Lebanese communities using SNP arrays

    Nadine Jalkh
    25 Nov 2014 | 4:00 pm
    Genome-wide inbreeding estimation within Lebanese communities using SNP arrays European Journal of Human Genetics advance online publication, November 26 2014. doi:10.1038/ejhg.2014.246 Authors: Nadine Jalkh, Mourad Sahbatou, Eliane Chouery, André Megarbane, Anne-Louise Leutennegger & Jean-Louis Serre
  • Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype

    Sarah L Williamson
    25 Nov 2014 | 4:00 pm
    Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype European Journal of Human Genetics advance online publication, November 26 2014. doi:10.1038/ejhg.2014.249 Authors: Sarah L Williamson, Carolyn J Ellaway, Greg B Peters, Gregory J Pelka, Patrick PL Tam & John Christodoulou
  • Heritability of liver enzyme levels estimated from genome-wide SNP data

    Jenny H D A van Beek
    25 Nov 2014 | 4:00 pm
    Heritability of liver enzyme levels estimated from genome-wide SNP data European Journal of Human Genetics advance online publication, November 26 2014. doi:10.1038/ejhg.2014.259 Authors: Jenny H D A van Beek, Gitta H Lubke, Marleen H M de Moor, Gonneke Willemsen, Eco J C de Geus, Jouke Jan Hottenga, LivGen consortium, Raymond K Walters, Jan H Smit, Brenda W J H Penninx & Dorret I Boomsma
 
 
 
 
 
 
 
 
 
 
 
 
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    Modern Pathology - AOP - nature.com science feeds

  • Update for the practicing pathologist: The International Consultation On Urologic Disease-European association of urology consultation on bladder cancer

    Mahul B Amin
    20 Nov 2014 | 4:00 pm
    Update for the practicing pathologist: The International Consultation On Urologic Disease-European association of urology consultation on bladder cancer Modern Pathology advance online publication, November 21 2014. doi:10.1038/modpathol.2014.158 Authors: Mahul B Amin, Steven C Smith, Victor E Reuter, Jonathan I Epstein, David J Grignon, Donna E Hansel, Oscar Lin, Jesse K McKenney, Rodolfo Montironi, Gladell P Paner, Hikmat A Al-Ahmadie, Ferran Algaba, Syed Ali, Isabel Alvarado-Cabrero, Lukas Bubendorf, Liang Cheng, John C Cheville, Glen Kristiansen, Richard J Cote, Brett Delahunt, John N…
  • Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation

    Ulrike Protzer
    20 Nov 2014 | 4:00 pm
    Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation Modern Pathology advance online publication, November 21 2014. doi:10.1038/modpathol.2014.147 Authors: Ulrike Protzer, Friederike Böhm, Thomas Longerich, Judith Seebach, Mojdeh Heidary Navid, Juliane Friemel, Ewerton Marques-Maggio, Marion Bawohl, Mathias Heikenwalder, Peter Schirmacher, Philipp Dutkowski, Pierre-Alain Clavien, Peter Schemmer, Paul Schnitzler, Daniel Gotthardt, Beat Müllhaupt & Achim Weber
  • Calculation of the Ki67 index in pancreatic neuroendocrine tumors: a comparative analysis of four counting methodologies

    Michelle D Reid
    20 Nov 2014 | 4:00 pm
    Calculation of the Ki67 index in pancreatic neuroendocrine tumors: a comparative analysis of four counting methodologies Modern Pathology advance online publication, November 21 2014. doi:10.1038/modpathol.2014.156 Authors: Michelle D Reid, Pelin Bagci, Nobuyuki Ohike, Burcu Saka, Ipek Erbarut Seven, Nevra Dursun, Serdar Balci, Hasan Gucer, Kee-Taek Jang, Takuma Tajiri, Olca Basturk, So Yeon Kong, Michael Goodman, Gizem Akkas & Volkan Adsay
  • Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia

    Robert T Jones
    20 Nov 2014 | 4:00 pm
    Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia Modern Pathology advance online publication, November 21 2014. doi:10.1038/modpathol.2014.150 Authors: Robert T Jones, Malak S Abedalthagafi, Mohan Brahmandam, Edward A Greenfield, Mai P Hoang, David N Louis, Jason L Hornick & Sandro Santagata
  • NY-ESO-1 (CTAG1B) expression in mesenchymal tumors

    Makoto Endo
    20 Nov 2014 | 4:00 pm
    NY-ESO-1 (CTAG1B) expression in mesenchymal tumors Modern Pathology advance online publication, November 21 2014. doi:10.1038/modpathol.2014.155 Authors: Makoto Endo, Marieke A de Graaff, Davis R Ingram, Simin Lim, Dina C Lev, Inge H Briaire-de Bruijn, Neeta Somaiah, Judith VMG Bovée, Alexander J Lazar & Torsten O Nielsen
 
 
 
 
 
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    PSI-Nature Structural Biology Knowledgebase

  • Mitochondrion: Flipping for UCP2

    Jennifer Cable
    19 Nov 2014 | 4:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.233 Author: Jennifer Cable NMR studies reveal how UCP2 facilitates translocation of protons across the mitochondrial membrane via fatty acids.
  • Mitochondrion: Setting a New TRAP1

    Catherine Goodman
    19 Nov 2014 | 4:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.234 Author: Catherine Goodman An asymmetric Hsp90 structure supports a new mechanism for coupling ATP hydrolysis with substrate turnover.
  • Structure–function analysis of KDM2A

    Eytan Zlotorynski
    27 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 630 (2014). doi:10.1038/nrm3870 Author: Eytan Zlotorynski The substrate specificity of the histone Lys demethylase KDM2A was elucidated by solving its crystal structure in complex with methylated peptides.
  • Streptomyces teams up with c-di-GMP

    Christina Tobin Kåhrström
    21 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 724 (2014). doi:10.1038/nrmicro3361 Author: Christina Tobin Kåhrström A unique tetrameric form of c-di-GMP controls bacterial development by mediating dimerization of a transcription factor.
  • Transmembrane Spans

    Irene Kaganman
    19 Nov 2014 | 4:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.235 Author: Irene Kaganman Analyses of nine topology prediction programs identify those with the greatest prediction accuracy for specific transmembrane transport protein families, and lead the authors to propose several distinguishable evolutionary pathways for these proteins.
 
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