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  • In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

    Nature Biotechnology - AOP - nature.com science feeds
    Lukasz Swiech
    18 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3055 Authors: Lukasz Swiech, Matthias Heidenreich, Abhishek Banerjee, Naomi Habib, Yinqing Li, John Trombetta, Mriganka Sur & Feng Zhang Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit single or multiple genes in replicating eukaryotic cells, resulting in frame-shifting insertion/deletion (indel) mutations and…
  • Cyborg Confidential

    Scientific American Mind
    Sandra Upson
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 30 (2014). doi:10.1038/scientificamericanmind1114-30 Author: Sandra Upson Hooking the brain up to a computer can do more than let the severely disabled move artificial limbs. It is also revealing the secrets of how we learn
  • Fungus from Asia threatens European salamanders

    NatureNews - Most recent articles - nature.com science feeds
    Emma Marris
    29 Oct 2014 | 5:00 pm
    North American salamanders and newts are safe for now, but epidemic could spread through pet trade.Nature News doi: 10.1038/nature.2014.16249
  • Pillars of reform

    Nature - Issue - nature.com science feeds
    28 Oct 2014 | 5:00 pm
    Pillars of reform Nature 514, 7524 (2014). doi:10.1038/514535a The Chinese government’s planned overhaul of its core research-funding system is vital if the country is to achieve its potential on the global scientific stage.
  • Plant science: Leaf veins share the time of day

    Nature - AOP - nature.com science feeds
    María C. Martí
    28 Oct 2014 | 5:00 pm
    Nature advance online publication 29 October 2014. doi:10.1038/nature13936 Authors: María C. Martí & Alex A. R. Webb Techniques for isolating and analysing leaf cell types have now been developed, leading to the discovery that circadian clocks in the plant vasculature communicate with and regulate clocks in neighbouring cells.
 
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    Nature - Issue - nature.com science feeds

  • Pillars of reform

    28 Oct 2014 | 5:00 pm
    Pillars of reform Nature 514, 7524 (2014). doi:10.1038/514535a The Chinese government’s planned overhaul of its core research-funding system is vital if the country is to achieve its potential on the global scientific stage.
  • Call to action

    28 Oct 2014 | 5:00 pm
    Call to action Nature 514, 7524 (2014). doi:10.1038/514535b Time to ramp up science’s contribution to controlling the Ebola outbreak.
  • Code share

    28 Oct 2014 | 5:00 pm
    Code share Nature 514, 7524 (2014). doi:10.1038/514536a Papers in Nature journals should make computer code accessible where possible.
  • Developed nations must not fear sending Ebola help

    Tim Inglis
    28 Oct 2014 | 5:00 pm
    Developed nations must not fear sending Ebola help Nature 514, 7524 (2014). http://www.nature.com/doifinder/10.1038/514537a Author: Tim Inglis The anxiety and stigma associated with Ebola are hampering Australia's willingness and ability to help with the control efforts in Africa, argues Tim Inglis.
  • Evolution: Lizards adapt quickly to invaders

    28 Oct 2014 | 5:00 pm
    Evolution: Lizards adapt quickly to invaders Nature 514, 7524 (2014). doi:10.1038/514538a Lizards in Florida have rapidly evolved traits that make them better tree-climbers, probably in response to an invasive competitor.Cuban brown anole lizards (Anolis sagrei) have spread over the past few decades across the southeastern United States, where they compete for territory and
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  • Plant science: Leaf veins share the time of day

    María C. Martí
    28 Oct 2014 | 5:00 pm
    Nature advance online publication 29 October 2014. doi:10.1038/nature13936 Authors: María C. Martí & Alex A. R. Webb Techniques for isolating and analysing leaf cell types have now been developed, leading to the discovery that circadian clocks in the plant vasculature communicate with and regulate clocks in neighbouring cells.
  • Origins of life: RNA made in its own mirror image

    Sandip A. Shelke
    28 Oct 2014 | 5:00 pm
    Nature advance online publication 29 October 2014. doi:10.1038/nature13935 Authors: Sandip A. Shelke & Joseph A. Piccirilli An RNA enzyme has been generated that can assemble a mirror-image version of itself. The finding helps to answer a long-standing conundrum about how RNA molecules could have proliferated on prebiotic Earth.
  • Promoterless gene targeting without nucleases ameliorates haemophilia B in mice

    A. Barzel
    28 Oct 2014 | 5:00 pm
    Nature advance online publication 29 October 2014. doi:10.1038/nature13864 Authors: A. Barzel, N. K. Paulk, Y. Shi, Y. Huang, K. Chu, F. Zhang, P. N. Valdmanis, L. P. Spector, M. H. Porteus, K. M. Gaensler & M. A. Kay Site-specific gene addition can allow stable transgene expression for gene therapy. When possible, this is preferred over the use of promiscuously integrating vectors, which are sometimes associated with clonal expansion and oncogenesis. Site-specific endonucleases that can induce high rates of targeted genome editing are finding increasing applications in biological…
  • Synaptic, transcriptional and chromatin genes disrupted in autism

    Silvia De Rubeis
    28 Oct 2014 | 5:00 pm
    Nature advance online publication 29 October 2014. doi:10.1038/nature13772 Authors: Silvia De Rubeis, Xin He, Arthur P. Goldberg, Christopher S. Poultney, Kaitlin Samocha, A. Ercument Cicek, Yan Kou, Li Liu, Menachem Fromer, Susan Walker, Tarjinder Singh, Lambertus Klei, Jack Kosmicki, Shih-Chen Fu, Branko Aleksic, Monica Biscaldi, Patrick F. Bolton, Jessica M. Brownfeld, Jinlu Cai, Nicholas G. Campbell, Angel Carracedo, Maria H. Chahrour, Andreas G. Chiocchetti, Hilary Coon, Emily L. Crawford, Lucy Crooks, Sarah R. Curran, Geraldine Dawson, Eftichia Duketis, Bridget A. Fernandez, Louise…
  • A cross-chiral RNA polymerase ribozyme

    Jonathan T. Sczepanski
    28 Oct 2014 | 5:00 pm
    Nature advance online publication 29 October 2014. doi:10.1038/nature13900 Authors: Jonathan T. Sczepanski & Gerald F. Joyce Thirty years ago it was shown that the non-enzymatic, template-directed polymerization of activated mononucleotides proceeds readily in a homochiral system, but is severely inhibited by the presence of the opposing enantiomer. This finding poses a severe challenge for the spontaneous emergence of RNA-based life, and has led to the suggestion that either RNA was preceded by some other genetic polymer that is not subject to chiral inhibition or chiral symmetry was…
 
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    Scientific American

  • Who Has the Best Fuel Economy?

    Mark Fischetti
    13 Oct 2014 | 5:00 pm
    Scientific American 311, 90 (2014). doi:10.1038/scientificamerican1114-90 Authors: Mark Fischetti & Kevin Schultz Contrary to claims, not everyone is No. 1
  • Letters

    13 Oct 2014 | 5:00 pm
    Scientific American 311, 8 (2014). doi:10.1038/scientificamerican1114-8
  • Catching Some Rays

    Debra Weiner
    13 Oct 2014 | 5:00 pm
    Scientific American 311, 32 (2014). doi:10.1038/scientificamerican1114-32 Author: Debra Weiner An embattled cosmic-ray telescope gets a lift
  • 50, 100 & 150 Years Ago

    Daniel C. Schlenoff
    13 Oct 2014 | 5:00 pm
    Scientific American 311, 89 (2014). doi:10.1038/scientificamerican1114-89 Author: Daniel C. Schlenoff
  • Quick Hits

    13 Oct 2014 | 5:00 pm
    Scientific American 311, 27 (2014). doi:10.1038/scientificamerican1114-27a
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    Scientific American Mind

  • Cyborg Confidential

    Sandra Upson
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 30 (2014). doi:10.1038/scientificamericanmind1114-30 Author: Sandra Upson Hooking the brain up to a computer can do more than let the severely disabled move artificial limbs. It is also revealing the secrets of how we learn
  • All-Purpose Antidepressants

    Julia Calderone
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 20 (2014). doi:10.1038/scientificamericanmind1114-20 Author: Julia Calderone Doctors are increasingly prescribing SSRIs to treat more than just depression
  • Happy Birthday to Us

    Sandra Upson
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 1 (2014). doi:10.1038/scientificamericanmind1114-1 Author: Sandra Upson
  • Hitting Just the Right Neurons

    Julia Calderone
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 8 (2014). doi:10.1038/scientificamericanmind1114-8b Author: Julia Calderone Noninvasive fields zap specific areas
  • Upgrading the Brain

    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 7 (2014). doi:10.1038/scientificamericanmind1114-7 Technology is shaping our thinking about mental abilities and their improvement
 
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    Nature Biotechnology - AOP - nature.com science feeds

  • Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads

    Valentí Moncunill
    25 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3027 Authors: Valentí Moncunill, Santi Gonzalez, Sílvia Beà, Lise O Andrieux, Itziar Salaverria, Cristina Royo, Laura Martinez, Montserrat Puiggròs, Maia Segura-Wang, Adrian M Stütz, Alba Navarro, Romina Royo, Josep L Gelpí, Ivo G Gut, Carlos López-Otín, Modesto Orozco, Jan O Korbel, Elias Campo, Xose S Puente & David Torrents
  • In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

    Lukasz Swiech
    18 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3055 Authors: Lukasz Swiech, Matthias Heidenreich, Abhishek Banerjee, Naomi Habib, Yinqing Li, John Trombetta, Mriganka Sur & Feng Zhang Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit single or multiple genes in replicating eukaryotic cells, resulting in frame-shifting insertion/deletion (indel) mutations and…
  • Comparative analyses of C4 and C3 photosynthesis in developing leaves of maize and rice

    Lin Wang
    11 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3019 Authors: Lin Wang, Angelika Czedik-Eysenberg, Rachel A Mertz, Yaqing Si, Takayuki Tohge, Adriano Nunes-Nesi, Stephanie Arrivault, Lauren K Dedow, Douglas W Bryant, Wen Zhou, Jiajia Xu, Sarit Weissmann, Anthony Studer, Pinghua Li, Cankui Zhang, Therese LaRue, Ying Shao, Zehong Ding, Qi Sun, Rohan V Patel, Robert Turgeon, Xinguang Zhu, Nicholas J Provart, Todd C Mockler, Alisdair R Fernie, Mark Stitt, Peng Liu & Thomas P Brutnell
  • Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells

    Nutan Prasain
    11 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3048 Authors: Nutan Prasain, Man Ryul Lee, Sasidhar Vemula, Jonathan Luke Meador, Momoko Yoshimoto, Michael J Ferkowicz, Alexa Fett, Manav Gupta, Brian M Rapp, Mohammad Reza Saadatzadeh, Michael Ginsberg, Olivier Elemento, Younghee Lee, Sherry L Voytik-Harbin, Hyung Min Chung, Ki Sung Hong, Emma Reid, Christina L O'Neill, Reinhold J Medina, Alan W Stitt, Michael P Murphy, Shahin Rafii, Hal E Broxmeyer & Mervin C Yoder The ability to differentiate human pluripotent stem cells into endothelial cells with properties of cord-blood endothelial…
  • A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

    Daniel C Leslie
    11 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3020 Authors: Daniel C Leslie, Anna Waterhouse, Julia B Berthet, Thomas M Valentin, Alexander L Watters, Abhishek Jain, Philseok Kim, Benjamin D Hatton, Arthur Nedder, Kathryn Donovan, Elana H Super, Caitlin Howell, Christopher P Johnson, Thy L Vu, Dana E Bolgen, Sami Rifai, Anne R Hansen, Michael Aizenberg, Michael Super, Joanna Aizenberg & Donald E Ingber
 
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    Nature Chemical Biology - Issue - nature.com science feeds

  • Cell cycle: Mitotic tag team

    Grant Miura
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 876 (2014). doi:10.1038/nchembio.1675 Author: Grant Miura
  • Protein turnover: Mitochondrial immaturity

    Grant Miura
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 877 (2014). doi:10.1038/nchembio.1679 Author: Grant Miura
  • Sculpting the proteome with small molecules

    Randall W King
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 870 (2014). doi:10.1038/nchembio.1671 Authors: Randall W King & Daniel Finley The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the principles that underlie the development of effective inhibitors or activators of the pathway. We emphasize insights from structural analysis and describe strategies for evaluating the…
  • Carbohydrates: Cutting out starch

    Catherine Goodman
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 877 (2014). doi:10.1038/nchembio.1677 Author: Catherine Goodman
  • Rick Morimoto

    Catherine Goodman
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 875 (2014). doi:10.1038/nchembio.1682 Author: Catherine Goodman A pioneer in proteostasis is changing the way we think about organismal biology and human disease.
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    Nature Chemistry

  • Light-harvesting materials: Soft support for energy conversion

    Ryan M. Stolley
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 949 (2014). doi:10.1038/nchem.2088 Authors: Ryan M. Stolley & Monte L. Helm To convert solar energy into viable fuels, coupling light-harvesting materials to catalysts is a crucial challenge. Now, the combination of an organic supramolecular hydrogel and a non-precious metal catalyst has been demonstrated to be effective for photocatalytic H2 production.
  • A spoonful of curiosity

    Catherine Goodman
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 945 (2014). doi:10.1038/nchem.2100 Author: Catherine Goodman
  • Blogroll: Hot and sweet

    Kat Day
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 947 (2014). doi:10.1038/nchem.2091 Author: Kat Day
  • Nucleic acids: An interfering delivery

    Russell Johnson
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 946 (2014). doi:10.1038/nchem.2103 Author: Russell Johnson
  • Asymmetric catalysis: Not so boring boron

    James Hennessy
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 946 (2014). doi:10.1038/nchem.2104 Author: James Hennessy
 
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    Nature Chemistry

  • Molecular motor-driven abrupt anisotropic shape change in a single crystal of a Ni complex

    Zi-Shuo Yao
    25 Oct 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2092 Authors: Zi-Shuo Yao, Masaki Mito, Takashi Kamachi, Yoshihito Shiota, Kazunari Yoshizawa, Nobuaki Azuma, Yuji Miyazaki, Kazuyuki Takahashi, Kuirun Zhang, Takumi Nakanishi, Soonchul Kang, Shinji Kanegawa & Osamu Sato Transferring molecular motion to macroscopic shape change of a crystal has potential application in actuators, or ‘artificial muscles’. Now, a single crystal of a Ni complex has been shown to exhibit a large, abrupt, temperature-induced crystal expansion/contraction near room temperature. The crystal deformation is induced by a…
  • Atom-efficient regioselective 1,2-dearomatization of functionalized pyridines by an earth-abundant organolanthanide catalyst

    Alexander S. Dudnik
    18 Oct 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2087 Authors: Alexander S. Dudnik, Victoria L. Weidner, Alessandro Motta, Massimiliano Delferro & Tobin J. Marks Selective pyridine dearomatization processes traditionally use precious metal catalysts with reagents in stoichiometric excess, and are not well-understood mechanistically. Now, efficient 1,2-regioselective pyridine dearomatization is achieved using equimolar pinacolborane and an earth-abundant lanthanide catalyst. Mechanistic and theoretical studies elucidate the reaction mechanism and explain observed reactivity trends.
  • 5-Hydroxymethylcytosine is a predominantly stable DNA modification

    Martin Bachman
    20 Sep 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2064 Authors: Martin Bachman, Santiago Uribe-Lewis, Xiaoping Yang, Michael Williams, Adele Murrell & Shankar Balasubramanian Reduction of 5-hydroxymethylcytosine (hmC) levels in DNA often occurs in cancers. Using isotope tracing experiments, this epigenetic DNA modification, which was thought to be an intermediate of demethylation, is now shown to be stable. A delay in the generation of hmC on newly synthesized DNA is responsible for the reduction of hmC levels in cancers.
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    Nature Genetics - Issue - nature.com science feeds

  • Kabuki syndrome and HDAC inhibitors

    Emily Niemitz
    28 Oct 2014 | 5:00 pm
    Nature Genetics 46, 1159 (2014). doi:10.1038/ng.3134 Author: Emily Niemitz
  • FANCM and breast cancer risk

    Kyle Vogan
    28 Oct 2014 | 5:00 pm
    Nature Genetics 46, 1159 (2014). doi:10.1038/ng.3132 Author: Kyle Vogan
  • PRC2 loss amplifies Ras signaling in cancer

    Annika Baude
    28 Oct 2014 | 5:00 pm
    Nature Genetics 46, 1154 (2014). doi:10.1038/ng.3124 Authors: Annika Baude, Anders M Lindroth & Christoph Plass The histone-modifying PRC2 complex has an ambiguous role in cancer, bearing both oncogenic and tumor-suppressive features depending on cell type. Studies of malignant peripheral nerve sheath tumors (MPNSTs) have now identified loss-of-function mutations altering PRC2 subunits, leading to the amplification of Ras-driven transcription and conferring vulnerability to BRD4 inhibitors.
  • GAPLINC and gastric cancer

    Brooke LaFlamme
    28 Oct 2014 | 5:00 pm
    Nature Genetics 46, 1159 (2014). doi:10.1038/ng.3136 Author: Brooke LaFlamme
  • SPRTN is a new player in an old story

    Kevin Hiom
    28 Oct 2014 | 5:00 pm
    Nature Genetics 46, 1155 (2014). doi:10.1038/ng.3125 Author: Kevin Hiom A new study identifies rare mutations in SPRTN that cause a novel progeroid syndrome. The results point to an unexpected function of SPRTN and bring insight to the mechanisms that link premature aging and cancer.
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  • Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

    Carol-Anne Martin
    25 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3122 Authors: Carol-Anne Martin, Ilyas Ahmad, Anna Klingseisen, Muhammad Sajid Hussain, Louise S Bicknell, Andrea Leitch, Gudrun Nürnberg, Mohammad Reza Toliat, Jennie E Murray, David Hunt, Fawad Khan, Zafar Ali, Sigrid Tinschert, James Ding, Charlotte Keith, Margaret E Harley, Patricia Heyn, Rolf Müller, Ingrid Hoffmann, Valérie Cormier Daire, Hélène Dollfus, Lucie Dupuis, Anu Bashamboo, Kenneth McElreavey, Ariana Kariminejad, Roberto Mendoza-Londono, Anthony T Moore, Anand Saggar, Catie Schlechter, Richard Weleber, Holger Thiele,…
  • Common variants associated with general and MMR vaccine–related febrile seizures

    Bjarke Feenstra
    25 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3129 Authors: Bjarke Feenstra, Björn Pasternak, Frank Geller, Lisbeth Carstensen, Tongfei Wang, Fen Huang, Jennifer L Eitson, Mads V Hollegaard, Henrik Svanström, Mogens Vestergaard, David M Hougaard, John W Schoggins, Lily Yeh Jan, Mads Melbye & Anders Hviid
  • RNF43 is frequently mutated in colorectal and endometrial cancers

    Marios Giannakis
    25 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3127 Authors: Marios Giannakis, Eran Hodis, Xinmeng Jasmine Mu, Mai Yamauchi, Joseph Rosenbluh, Kristian Cibulskis, Gordon Saksena, Michael S Lawrence, Zhi Rong Qian, Reiko Nishihara, Eliezer M Van Allen, William C Hahn, Stacey B Gabriel, Eric S Lander, Gad Getz, Shuji Ogino, Charles S Fuchs & Levi A Garraway We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in…
  • Comprehensive variation discovery in single human genomes

    Neil I Weisenfeld
    18 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3121 Authors: Neil I Weisenfeld, Shuangye Yin, Ted Sharpe, Bayo Lau, Ryan Hegarty, Laurie Holmes, Brian Sogoloff, Diana Tabbaa, Louise Williams, Carsten Russ, Chad Nusbaum, Eric S Lander, Iain MacCallum & David B Jaffe
  • Haplotype-resolved whole-genome sequencing by contiguity-preserving transposition and combinatorial indexing

    Sasan Amini
    18 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3119 Authors: Sasan Amini, Dmitry Pushkarev, Lena Christiansen, Emrah Kostem, Tom Royce, Casey Turk, Natasha Pignatelli, Andrew Adey, Jacob O Kitzman, Kandaswamy Vijayan, Mostafa Ronaghi, Jay Shendure, Kevin L Gunderson & Frank J Steemers
 
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    Nature Geoscience - Issue - nature.com science feeds

  • Towards transparency

    29 Oct 2014 | 5:00 pm
    Nature Geoscience 7, 777 (2014). doi:10.1038/ngeo2294 Sharing data is key for efficient scientific progress. More open code would be beneficial too.
  • Acquired risk

    29 Oct 2014 | 5:00 pm
    Nature Geoscience 7, 777 (2014). doi:10.1038/ngeo2295 Wealth in a country typically protects against earthquake damage. The same cannot always be said for wealth of individuals.
  • Addendum: Wave attenuation over coastal salt marshes under storm surge conditions

    Iris Möller
    29 Oct 2014 | 5:00 pm
    Nature Geoscience 7, 848 (2014). doi:10.1038/ngeo2287 Authors: Iris Möller, Matthias Kudella, Franziska Rupprecht, Tom Spencer, Maike Paul, Bregje K. van Wesenbeeck, Guido Wolters, Kai Jensen, Tjeerd J. Bouma, Martin Miranda-Lange & Stefan Schimmels
  • Of carrots and sticks

    Jens Kattge
    29 Oct 2014 | 5:00 pm
    Nature Geoscience 7, 778 (2014). doi:10.1038/ngeo2280 Authors: Jens Kattge, Sandra Díaz & Christian Wirth Journals and funders increasingly require public archiving of the data that support publications. We argue that this mandate is necessary, but not sufficient: more incentives for data sharing are needed.
  • Exhibition: Lens to the stars

    Tamara Goldin
    29 Oct 2014 | 5:00 pm
    Nature Geoscience 7, 782 (2014). doi:10.1038/ngeo2286 Author: Tamara Goldin
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  • Robust Arctic sea-ice influence on the frequent Eurasian cold winters in past decades

    Masato Mori
    25 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2277 Authors: Masato Mori, Masahiro Watanabe, Hideo Shiogama, Jun Inoue & Masahide Kimoto Over the past decade, severe winters occurred frequently in mid-latitude Eurasia, despite increasing global- and annual-mean surface air temperatures. Observations suggest that these cold Eurasian winters could have been instigated by Arctic sea-ice decline, through excitation of circulation anomalies similar to the Arctic Oscillation. In climate simulations, however, a robust atmospheric response to sea-ice decline has not been found, perhaps owing to energetic…
  • Orbital forcing of the East Antarctic ice sheet during the Pliocene and Early Pleistocene

    M. O. Patterson
    25 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2273 Authors: M. O. Patterson, R. McKay, T. Naish, C. Escutia, F. J. Jimenez-Espejo, M. E. Raymo, S. R. Meyers, L. Tauxe & H. Brinkhuis
  • Evidence for arsenic metabolism and cycling by microorganisms 2.7 billion years ago

    Marie Catherine Sforna
    25 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2276 Authors: Marie Catherine Sforna, Pascal Philippot, Andrea Somogyi, Mark A. van Zuilen, Kadda Medjoubi, Barbara Schoepp-Cothenet, Wolfgang Nitschke & Pieter T. Visscher The ability of microbes to metabolize arsenic may have emerged more than 3.4 billion years ago. Some of the modern environments in which prominent arsenic metabolism occurs are anoxic, as were the Precambrian oceans. Early oceans may also have had a relatively high abundance of arsenic. However, it is unclear whether arsenic cycling occurred in ancient environments. Here we assess the…
  • Early earth: Arsenic and primordial life

    Thomas R. Kulp
    25 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2275 Author: Thomas R. Kulp Some modern microorganisms derive energy from the oxidation and reduction of arsenic. The association of arsenic with organic cellular remains in 2.7-billion-year-old stromatolites hints at arsenic-based metabolisms at the dawn of life.
  • Plateau uplift in western Canada caused by lithospheric delamination along a craton edge

    Xuewei Bao
    18 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2270 Authors: Xuewei Bao, David W. Eaton & Bernard Guest Continental plateaux, such as the Tibetan Plateau in Asia and the Altiplano–Puna Plateau in South America, are thought to form partly because upwelling, hot asthenospheric mantle replaces some of the denser, lower lithosphere, making the region more buoyant. The spatial and temporal scales of this process are debated, with proposed mechanisms ranging from delamination of fragments to that of the entire lithosphere. The Canadian Cordillera is an exhumed ancient plateau that abuts the North…
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    Nature Immunology - Issue - nature.com science feeds

  • Tetherin signaling

    Laurie A Dempsey
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1008 (2014). doi:10.1038/ni.3018 Author: Laurie A Dempsey
  • Time to cast a larger net

    Matthew L Wheeler
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1000 (2014). doi:10.1038/ni.3013 Authors: Matthew L Wheeler & David M Underhill Neutrophils sense the size of microbial targets and respond via 'NETosis' when targets are too big to internalize and contain via phagocytosis.
  • Street smarts of science for students

    Michael M Chen
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 997 (2014). doi:10.1038/ni.2989 Authors: Michael M Chen, Anita Zahs, Sulie L Chang & Elizabeth J Kovacs A workshop organized by the Society for Leukocyte Biology offers advice to graduate students on how to navigate educational and professional waters to find success in academia.
  • TCR signaling fuels Treg cell suppressor function

    Jinfang Zhu
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1002 (2014). doi:10.1038/ni.3014 Authors: Jinfang Zhu & Ethan M Shevach Acute ablation of T cell antigen receptors (TCRs) in regulatory T cells (Treg cells) impairs the suppressive activity of these cells, even though they retain expression of Foxp3 and CD25. TCR signaling imparts a critical role in the suppressive function of Treg cells.
  • Isoketals drive hypertension

    Zoltan Fehervari
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1008 (2014). doi:10.1038/ni.3020 Author: Zoltan Fehervari
 
 
 
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    Nature Methods - AOP - nature.com science feeds

  • Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex

    Arnaud Muller
    25 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3151 Authors: Arnaud Muller, Victory Joseph, Paul A Slesinger & David Kleinfeld
  • Permanent genetic memory with >1-byte capacity

    Lei Yang
    25 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3147 Authors: Lei Yang, Alec A K Nielsen, Jesus Fernandez-Rodriguez, Conor J McClune, Michael T Laub, Timothy K Lu & Christopher A Voigt
  • Quantum dot–based multiphoton fluorescent pipettes for targeted neuronal electrophysiology

    Bertalan K Andrásfalvy
    18 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3146 Authors: Bertalan K Andrásfalvy, Gregorio L Galiñanes, Daniel Huber, Mladen Barbic, John J Macklin, Kimihiro Susumu, James B Delehanty, Alan L Huston, Judit K Makara & Igor L Medintz Targeting visually identified neurons for electrophysiological recording is a fundamental neuroscience technique; however, its potential is hampered by poor visualization of pipette tips in deep brain tissue. We describe quantum dot–coated glass pipettes that provide strong two-photon contrast at deeper penetration depths than those achievable with…
  • A DNA-based molecular probe for optically reporting cellular traction forces

    Brandon L Blakely
    11 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3145 Authors: Brandon L Blakely, Christoph E Dumelin, Britta Trappmann, Lynn M McGregor, Colin K Choi, Peter C Anthony, Van K Duesterberg, Brendon M Baker, Steven M Block, David R Liu & Christopher S Chen We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can in principle be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs consist of DNA hairpins conjugated to fluorophore-quencher pairs that unfold and fluoresce when subjected to specific…
  • An improved surface passivation method for single-molecule studies

    Boyang Hua
    11 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3143 Authors: Boyang Hua, Kyu Young Han, Ruobo Zhou, Hajin Kim, Xinghua Shi, Sanjaya C Abeysirigunawardena, Ankur Jain, Digvijay Singh, Vasudha Aggarwal, Sarah A Woodson & Taekjip Ha We report a surface passivation method based on dichlorodimethylsilane (DDS)–Tween-20 for in vitro single-molecule studies, which, under the conditions tested here, more efficiently prevented nonspecific binding of biomolecules than the standard poly(ethylene glycol) surface. The DDS–Tween-20 surface was simple and inexpensive to prepare and did not perturb the…
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    Nature Nanotechnology - Issue - nature.com science feeds

  • Bacterial nanowires: An extended membrane

    Ai Lin Chun
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 750 (2014). doi:10.1038/nnano.2014.230 Author: Ai Lin Chun
  • Graphene devices for life

    Kostas Kostarelos
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 744 (2014). doi:10.1038/nnano.2014.224 Authors: Kostas Kostarelos & Kostya S. Novoselov Kostas Kostarelos and Kostya S. Novoselov examine the potential of graphene in biomedical applications.
  • The global growth of graphene

    Wencai Ren
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 726 (2014). doi:10.1038/nnano.2014.229 Authors: Wencai Ren & Hui-Ming Cheng The large-scale production of graphene aimed at industrial applications has grown significantly in the past few years, especially since many companies in China have entered the market.
  • Graphene against corrosion

    Siva Böhm
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 741 (2014). doi:10.1038/nnano.2014.220 Author: Siva Böhm Siva Böhm discusses how graphene can be used to prevent corrosion of metals such as steel.
  • Challenges and opportunities in graphene commercialization

    Amaia Zurutuza
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 730 (2014). doi:10.1038/nnano.2014.225 Authors: Amaia Zurutuza & Claudio Marinelli As technical knowledge, manufacturing methods and the development of applications mature, key factors will affect the pace of commercialization of graphene.
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    Nature Neuroscience - Issue - nature.com science feeds

  • Putting big data to good use in neuroscience

    Terrence J Sejnowski
    27 Oct 2014 | 5:00 pm
    Nature Neuroscience 17, 1440 (2014). doi:10.1038/nn.3839 Authors: Terrence J Sejnowski, Patricia S Churchland & J Anthony Movshon
  • Decoding neural transcriptomes and epigenomes via high-throughput sequencing

    Jaehoon Shin
    27 Oct 2014 | 5:00 pm
    Nature Neuroscience 17, 1463 (2014). doi:10.1038/nn.3814 Authors: Jaehoon Shin, Guo-li Ming & Hongjun Song
  • Converting Drosophobia into Drosophila

    Meng-Fu Maxwell Shih
    27 Oct 2014 | 5:00 pm
    Nature Neuroscience 17, 1430 (2014). doi:10.1038/nn.3845 Authors: Meng-Fu Maxwell Shih & Josh Dubnau Fruit flies seek water, but only when they are thirsty. And imbibing is rewarding only to water-deprived individuals. The effects of thirst on water seeking and on formation of associative memories of drinking water each are mediated by distinct sets of dopamine neurons that innervate restricted zones of the mushroom bodies in the fly brain.
  • The big data challenges of connectomics

    Jeff W Lichtman
    27 Oct 2014 | 5:00 pm
    Nature Neuroscience 17, 1448 (2014). doi:10.1038/nn.3837 Authors: Jeff W Lichtman, Hanspeter Pfister & Nir Shavit
  • Bilingual neurons release glutamate and GABA

    Naoshige Uchida
    27 Oct 2014 | 5:00 pm
    Nature Neuroscience 17, 1432 (2014). doi:10.1038/nn.3840 Author: Naoshige Uchida A study finds evidence supporting co-release of glutamate and GABA, excitatory and inhibitory fast neurotransmitters, from a single axon terminal in neurons of the ventral tegmental area that project to the lateral habenula.
 
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    Nature Photonics - AOP - nature.com science feeds

  • Enhancement of laser power-efficiency by control of spatial hole burning interactions

    Li Ge
    25 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.244 Authors: Li Ge, Omer Malik & Hakan E. Türeci
  • Topological photonics

    Ling Lu
    25 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.248 Authors: Ling Lu, John D. Joannopoulos & Marin Soljačić
  • Network of time-multiplexed optical parametric oscillators as a coherent Ising machine

    Alireza Marandi
    25 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.249 Authors: Alireza Marandi, Zhe Wang, Kenta Takata, Robert L. Byer & Yoshihisa Yamamoto Finding the ground states of the Ising Hamiltonian maps to various combinatorial optimization problems in biology, medicine, wireless communications, artificial intelligence and social network. So far, no efficient classical and quantum algorithm is known for these problems and intensive research is focused on creating physical systems—Ising machines—capable of finding the absolute or approximate ground states of the Ising Hamiltonian. Here, we report an…
  • Ultra-high-density spatial division multiplexing with a few-mode multicore fibre

    R. G. H. van Uden
    25 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.243 Authors: R. G. H. van Uden, R. Amezcua Correa, E. Antonio Lopez, F. M. Huijskens, C. Xia, G. Li, A. Schülzgen, H. de Waardt, A. M. J. Koonen & C. M. Okonkwo
  • A long-range polarization-controlled optical tractor beam

    Vladlen Shvedov
    18 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.242 Authors: Vladlen Shvedov, Arthur R. Davoyan, Cyril Hnatovsky, Nader Engheta & Wieslaw Krolikowski The laser beam has become an indispensable tool for the controllable manipulation and transport of microscopic objects in biology, physical chemistry and condensed matter physics. In particular, ‘tractor’ laser beams can draw matter towards a laser source and perform, for instance, all-optical remote sampling. Recent advances in lightwave technology have already led to small-scale experimental demonstrations of tractor beams. However, the…
 
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    Nature Physics - AOP - nature.com science feeds

  • Coherent dipole–dipole coupling between two single Rydberg atoms at an electrically-tuned Förster resonance

    Sylvain Ravets
    25 Oct 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3119 Authors: Sylvain Ravets, Henning Labuhn, Daniel Barredo, Lucas Béguin, Thierry Lahaye & Antoine Browaeys Resonant energy transfers, the non-radiative redistribution of an electronic excitation between two particles coupled by the dipole–dipole interaction, lie at the heart of a variety of phenomena, notably photosynthesis. In 1948, Förster established the theory of fluorescence resonant energy transfer (FRET) between broadband, nearly-resonant donors and acceptors. The 1/R6 scaling of the energy transfer rate, where R is the…
  • Enhancement of long-range correlations in a 2D vortex lattice by an incommensurate 1D disorder potential

    I. Guillamón
    25 Oct 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3132 Authors: I. Guillamón, R. Córdoba, J. Sesé, J. M. De Teresa, M. R. Ibarra, S. Vieira & H. Suderow Long-range correlations in two-dimensional (2D) systems are significantly altered by disorder potentials. Theory has predicted the existence of disorder-induced phenomena, such as Anderson localization or the emergence of a Bose glass. More recently, it has been shown that when disorder breaks 2D continuous symmetry, long-range correlations can be enhanced. Experimentally, developments in quantum gases have allowed the observation of the…
  • Evidence of Andreev bound states as a hallmark of the FFLO phase in κ-(BEDT-TTF)2Cu(NCS)2

    H. Mayaffre
    25 Oct 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3121 Authors: H. Mayaffre, S. Krämer, M. Horvatić, C. Berthier, K. Miyagawa, K. Kanoda & V. F. Mitrović Superconductivity is a quantum phenomenon arising, in its simplest form, from the pairing of fermions with opposite spin into a state with zero net momentum. Whether superconductivity can occur in fermionic systems with an unequal number of two species distinguished by spin or flavour presents an important open question in condensed-matter physics or quantum chromodynamics. In condensed matter the imbalance between spin-up and spin-down…
  • Cooperative coupling of ultracold atoms and surface plasmons

    Christian Stehle
    25 Oct 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3129 Authors: Christian Stehle, Claus Zimmermann & Sebastian Slama
  • Rydberg atoms: Two to tango

    Robert Löw
    25 Oct 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3153 Author: Robert Löw The old adage that you can't tango alone is certainly true for humans. But recent experiments show that it may also be applicable to Rydberg atoms, which keep a beat through the coherent exchange of energy.
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Proteomics: Follow your heat

    M. Teresa Villanueva
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 706 (2014). doi:10.1038/nrc3853 Author: M. Teresa Villanueva Drug–target interactions can be assessed through a cellular thermal shift assay (CETSA) that assesses changes in protein thermal stability. Savitski et al. have combined CETSA with quantitative mass spectrometry to determine the affinity of a drug for all its potential targets. They measured how
  • Revisiting STAT3 signalling in cancer: new and unexpected biological functions

    Hua Yu
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 736 (2014). doi:10.1038/nrc3818 Authors: Hua Yu, Heehyoung Lee, Andreas Herrmann, Ralf Buettner & Richard Jove The Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) proteins, particularly STAT3, are among the most promising new targets for cancer therapy. In addition to interleukin-6 (IL-6) and its family members, multiple pathways, including G-protein-coupled receptors (GPCRs), Toll-like receptors (TLRs) and microRNAs
  • Therapeutics: Delivered in a tea bag

    M. Teresa Villanueva
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 706 (2014). doi:10.1038/nrc3851 Author: M. Teresa Villanueva Chung et al. havedesigned a therapeutic nanocarrier for drug delivery using compounds derived from epigallocatechin gallate (EGCG), an antioxidant found in green tea. The sequential self-assembly of the EGCG derivative with trastuzumab led to the formation of stable micellar nanocomplexes. The authors then added
  • Lymphoma: Release the B cell

    Gemma K. Alderton
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 707 (2014). doi:10.1038/nrc3856 Author: Gemma K. Alderton Germinal centre B cells (GCBs) are strictly localized to lymphoid organs, unlike those of GCB-like diffuse large B cell lymphoma (GCB-DLBCL). Muppidi et al. found that GCB-DLBCL-associated inactivating mutations in GNA13, which encodes the guanine nucleotide binding protein Gα13, allow AKT activation and
  • Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

    Simran S. Sabharwal
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 709 (2014). doi:10.1038/nrc3803 Authors: Simran S. Sabharwal & Paul T. Schumacker Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism, biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated by mitochondria participate in stress signalling in normal cells but also contribute to the initiation of nuclear or mitochondrial DNA mutations that
 
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • The driving role of consortia on the critical path to innovative therapies

    Janet Woodcock
    30 Oct 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 781 (2014). doi:10.1038/nrd4462 Authors: Janet Woodcock, Martha Brumfield, Dalvir Gill & Elias Zerhouni Launched a decade ago, the US Food and Drug Administration's Critical Path Initiative has helped catalyse the formation of many consortia focused on drug development challenges.
  • Paving the critical path of drug development: the CDER perspective

    Janet Woodcock
    30 Oct 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 783 (2014). doi:10.1038/nrd4435 Author: Janet Woodcock Improving the science of drug development and regulation is important in fulfilling the public health mission of the US Food and Drug Administration (FDA). A decade on from the launch of the Critical Path Initiative, the FDA's Center for Drug Evaluation and Research (CDER) is
  • NCI starts 'exceptional responder' hunt

    Asher Mullard
    30 Oct 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 803 (2014). doi:10.1038/nrd4482 Author: Asher Mullard Agency hopes that clinical trial 'subgroups' of one patient may open up new biology and rescue failed anticancer drugs.The lowdown: Even in failed oncology clinical trials, some patients may experience huge benefits from treatment. Using genomic analysis techniques that have only come online
  • The Critical Path Institute: transforming competitors into collaborators

    Martha Brumfield
    30 Oct 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 785 (2014). doi:10.1038/nrd4436 Author: Martha Brumfield The Critical Path Institute brings scientists from regulatory agencies, industry and academia together to improve drug development and regulatory processes.
  • Bispecific antibodies rise again

    Ken Garber
    30 Oct 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 799 (2014). doi:10.1038/nrd4478 Author: Ken Garber Amgen's blinatumomab is setting the stage for a bispecific-antibody revival, enabled by new formats that may solve the field's long-standing problems.
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Alternative splicing: Characterizing cell fate

    Isabel Lokody
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 706 (2014). doi:10.1038/nrg3847 Author: Isabel Lokody Chen et al. have identified and catalogued genes, transcripts and alternative splicing events that are specific to various human haematopoietic cell fates, providing insights into the transcriptional changes involved in the various haematopoeitic precursor populations.The authors used RNA sequencing to identify cell fate-specific
  • Alternative splicing: Retaining introns to sculpt gene expression

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 707 (2014). doi:10.1038/nrg3844 Author: Darren J. Burgess Intron retention is a common form of alternative splicing in plants and unicellular eukaryotes; however, its prevalence in mammals was unclear. Braunschweig et al. carried out high-throughput RNA sequencing from ∼40 human and mouse cell types and found evidence for intron retention in transcripts
  • Cancer: Up and down for DNA methylation inhibitors

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 707 (2014). doi:10.1038/nrg3845 Author: Darren J. Burgess Tumour suppressor genes in cancer cells are frequently silenced by promoter CpG methylation, which has led to the pursuit of DNA methylation inhibitors as potential cancer therapeutics to reactivate these genes. However, DNA methylation in gene bodies is associated with the opposite effect (that is,
  • Epigenetics: H3K27 methylation in transgenerational epigenetic memory

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 703 (2014). doi:10.1038/nrg3848 Author: Darren J. Burgess During reproduction, organisms must pass on genomes with suitable epigenetic states to the next generation. These states must be appropriate for gene expression programmes in the progeny and can be 'reset' to prevent the unwanted transgenerational inheritance of environmentally induced epigenetic states. Identifying the key
  • RNA: Dissecting circular RNA biogenesis

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 707 (2014). doi:10.1038/nrg3846 Author: Darren J. Burgess Circular RNAs are thought to arise from non-canonical splicing of linear pre-mRNAs, as they frequently harbour the 3′ end of one exon joined to an upstream (rather than downstream) 5′ end of an exon. Zhang et al. used bioinformatic analyses on human transcriptome data
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Microbiota: Support your friends to resist your enemies

    Kirsty Minton
    23 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 715 (2014). doi:10.1038/nri3765 Author: Kirsty Minton Fucosylation of intestinal epithelial cells in response to commensal or systemic bacterial stimulation promotes disease resistance and tolerance through the metabolic support of the gut microbiota.
  • Pattern recognition receptors: Picking LOX to find antibodies

    Yvonne Bordon
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 716 (2014). doi:10.1038/nri3764 Author: Yvonne Bordon LOX1 activates dendritic cells and B cells to boost humoral immune responses.
  • Regulated cell death and inflammation: an auto-amplification loop causes organ failure

    Andreas Linkermann
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 759 (2014). doi:10.1038/nri3743 Authors: Andreas Linkermann, Brent R. Stockwell, Stefan Krautwald & Hans-Joachim Anders Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in parenchymal cells may lead to the release of damage- associated molecular patterns that drive both tissue inflammation and the activation of further pathways of RCD. Following an initial event of regulated necrosis, RCD
  • Innate sensing of malaria parasites

    Ricardo T. Gazzinelli
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 744 (2014). doi:10.1038/nri3742 Authors: Ricardo T. Gazzinelli, Parisa Kalantari, Katherine A. Fitzgerald & Douglas T. Golenbock Innate immune receptors have a key role in immune surveillance by sensing microorganisms and initiating protective immune responses. However, the innate immune system is a classic 'double-edged sword' that can overreact to pathogens, which can have deleterious effects and lead to clinical manifestations. Recent studies
  • Tolerance: AIREs and graces

    Lucy Bird
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 714 (2014). doi:10.1038/nri3762 Author: Lucy Bird Distinct subsets of thymic antigen-presenting cells contribute to the generation of a diverse and self-tolerant T cell repertoire.
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Viral infection: Host and viral components of the influenza virion

    Andrea Du Toit
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 724 (2014). doi:10.1038/nrmicro3376 Author: Andrea Du Toit Influenza viruses produce pleomorphic virions, which has made it difficult to study their composition. Hutchinson et al. used a mass spectrometry approach to determine and quantify the protein composition of influenza virions. They show that the core architecture of virions is conserved despite variation
  • Bacterial pathogenesis: A pneumococcal heart-breaker

    Andrea Du Toit
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 724 (2014). doi:10.1038/nrmicro3374 Author: Andrea Du Toit Invasive pneumococcal disease is often associated with an increased incidence of adverse cardiac events. A new study now shows that Streptococcus pneumoniae, the main cause of community-acquired pneumonia, causes direct cardiotoxicity and induces the formation of microscopic lesions within the myocardium of experimentally infected
  • Bacterial genetics: Chromosomal position regulates gene expression

    Andrea Du Toit
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 724 (2014). doi:10.1038/nrmicro3375 Author: Andrea Du Toit The effect of chromosomal location on the expression of bacterial genes is understudied; here, Bryant et al. re-address how chromosomal position affects gene expression in Escherichia coli K-12. By inserting a reporter cassette composed of GFP under the control of the lac
  • Microbiome: Bacteria and the brain

    Christina Tobin Kåhrström
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 725 (2014). doi:10.1038/nrmicro3373 Author: Christina Tobin Kåhrström Accumulating evidence suggests that the gut microbiota influences host neurological activity and behaviour. Here, the authors find that the two gut Firmicutes, Clostridium sporogenes and Ruminococcus gnavus, produce and secrete two distinct tryptophan decarboxylases that catalyse the formation of the neurotransmitter tryptamine. Tryptamine
  • Marine microbiology: Exploring the unexplored

    Christina Tobin Kåhrström
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 725 (2014). doi:10.1038/nrmicro3371 Author: Christina Tobin Kåhrström Marine oxygen minimum zones (OMZs) are hot spots for microbial-driven matter and energy transformations, but the dynamics of virus–host interactions at these sites are poorly understood. In this study, Roux et al. used a combination of metagenomics and single-cell amplified genome (SAG) sequencing to
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Signalling dynamics in vertebrate segmentation

    Alexis Hubaud
    21 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 709 (2014). doi:10.1038/nrm3891 Authors: Alexis Hubaud & Olivier Pourquié Segmentation of the paraxial mesoderm is a major event of vertebrate development that establishes the metameric patterning of the body axis. This process involves the periodic formation of sequential units, termed somites, from the presomitic mesoderm. Somite formation relies on a molecular oscillator, the segmentation
  • Epigenetics: Enhancers under TET control

    Kim Baumann
    21 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 699 (2014). doi:10.1038/nrm3901 Author: Kim Baumann The ten-eleven-tanslocation (TET) family of proteins regulates enhancer methylation and activity in embryonic stem cells.
  • Technology: RNA targeting by Cas9

    Eytan Zlotorynski
    14 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 701 (2014). doi:10.1038/nrm3895 Author: Eytan Zlotorynski Cas9, a component of the genome editing tool CRISPR–Cas9, is a DNA endonuclease. It is targeted by guide RNAs (gRNAs), and its activity depends on recognizing a short sequence known as the protospacer adjacent motif (PAM). O'Connell et al. show that Cas9 also targets
  • Cell adhesion: Winning mechanism for angiogenesis

    Kirsty Minton
    14 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 702 (2014). doi:10.1038/nrm3893 Author: Kirsty Minton Angiogenic factors induce podosome rosettes in endothelial cells that mediate focal degradation of the basement membrane and blood vessel branching.
  • Protein quality control: Nuclear membrane proteins in check

    Kim Baumann
    14 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 700 (2014). doi:10.1038/nrm3898 Author: Kim Baumann The Asi complex defines an ERAD branch that is specific for inner nuclear membrane protein quality control in yeast.
 
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Perception: A decisive response

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3853 Author: Darran Yates Certain neurons in the medial temporal lobe (MTL) respond to different images and even the name of a given individual. Here, the authors assessed MTL neuron responses in a face adaptation task. Participants were shown the face of one of two well-known people (who were
  • Learning and memory: The left–right divide

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3851 Author: Darran Yates Several studies in mice have revealed that there are differences in the molecular make-up of and plasticity at CA3–CA1 pyramidal neuron synapses that depend on whether the presynaptic input comes from the left or right CA3. To detect any functional effects of this asymmetry, Shipton
  • Learning and memory: Actively compensating

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3854 Author: Darran Yates Alzheimer's disease is characterized by episodic memory impairments and brain deposition of the peptide amyloid-β (Aβ). However, not all older people with Aβ pathology exhibit memory deficits. Elman et al.examined whether brain hyperactivity, which has been observed in such individuals, might compensate for this
  • Neural circuits: Getting colder

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3852 Author: Darran Yates The neural circuitry that underlies the perception of skin cooling is unclear. To examine this, the authors trained mice to report temperature drops (delivered by a thermal probe applied to the forepaw skin) by licking a water dispenser. Cooling induced activity in the primary somatosensory
  • Neurotransmission: Transmission takes two

    Darran Yates
    14 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 700 (2014). doi:10.1038/nrn3848 Author: Darran Yates Two studies in rodents show that lateral habenula activity is regulated by neurons that co-release glutamate and GABA.
 
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    Nature Reviews Cardiology - Issue - nature.com science feeds

  • Celebrating the first 10 years of Nature Reviews Cardiology

    Gregory B. Lim
    16 Oct 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 617 (2014). doi:10.1038/nrcardio.2014.158 Author: Gregory B. Lim The inaugural issue of Nature Reviews Cardiology was published in November 2004 under the title of Nature Clinical Practice Cardiovascular Medicine. As reviewed in this 10-year anniversary issue, much has changed in cardiology over the past decade and, during this period, Nature Reviews
  • Decade in review—peripheral vascular disease: 10 Years of breakthroughs in peripheral vascular disease

    Mark A. Creager
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 635 (2014). doi:10.1038/nrcardio.2014.153 Author: Mark A. Creager Clinical trials published during the past decade have had substantial effects on the treatment of peripheral vascular diseases. In this article, I discuss ten important trials that have influenced treatment for common vascular disorders, including peripheral artery disease, abdominal aortic aneurysm, renal artery disease, extracranial carotid artery disease, and venous thromboembolism.
  • Top 10 cardiovascular therapies and interventions for the next decade

    Valentin Fuster
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 671 (2014). doi:10.1038/nrcardio.2014.137 Author: Valentin Fuster Cardiovascular disease (CVD) has become the most-common cause of death worldwide. The Western lifestyle does not promote healthy living, and the consequences are most devastating when social inequalities are combined with economic factors and population growth. The expansion of poor nutritional habits, obesity, and associated
  • Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation?

    Yutang Wang
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 638 (2014). doi:10.1038/nrcardio.2014.70-c1 Author: Yutang Wang I read with great interest the News & Views article by Schmieder (How should data from SYMPLICITY HTN-3 be interpreted? Nat. Rev. Cardiol.11, 375–376; 2014). Schmieder provided an excellent overview of the randomized, sham-controlled, single-blinded SYMPLICITY HTN-3 trial, and provided
  • Renal denervation—a valid treatment option despite SYMPLICITY HTN-3

    Roland E. Schmieder
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 638 (2014). doi:10.1038/nrcardio.2014.70-c2 Author: Roland E. Schmieder I thank Yutang Wang for his Correspondence (Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation? Nat. Rev. Cardiol. doi:10.1038/nrcardio.2014.70-c1) on my News & Views article (How should data from SYMPLICITY HTN-3 be interpreted? Nat. Rev. Cardiol.11
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    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • Celebrating 10 years since launch

    Lisa Hutchinson
    23 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 619 (2014). doi:10.1038/nrclinonc.2014.164 Author: Lisa Hutchinson It has been 10 years since the launch of Nature Reviews Clinical Oncology in November 2004, formerly branded Nature Clinical Practice Oncology. The journal's founding Editor-in-Chief, Vincent T. DeVita Jr, wrote an opening editorial, which stated “We live in the most exciting time
  • Breast cancer: Combining bevacizumab with chemotherapy—from maintenance to second-line treatment

    Alessia Errico
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 621 (2014). doi:10.1038/nrclinonc.2014.179 Author: Alessia Errico Bevacizumab is a VEGF-neutralizing antibody that blocks angiogenesis, a crucial process in the growth of both primary tumours and metastases. Bevacizumab has been used for the treatment of several cancer types, including colon and breast cancer.The combination of bevacizumab with chemotherapy, in the first-line
  • SLNB in melanoma—DFS a true and cost-effective benefit?

    Alexander C. J. van Akkooi
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 680 (2014). doi:10.1038/nrclinonc.2014.65-c3 Authors: Alexander C. J. van Akkooi & Alexander M. M. Eggermont With great interest have we noticed the correspondence of Faries et al. (
  • MSLT-I—response of clinical trial investigators

    Mark B. Faries
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 680 (2014). doi:10.1038/nrclinonc.2014.65-c1 Authors: Mark B. Faries, Alistair J. Cochran & John F. Thompson Three recent News & Views articles that were published back-to-back in the May 2014 issue of this journal commented on the final analysis of the first Multicenter Selective Lymphadenectomy Trial (MSLT-I). The authors of these articles recognized the size and quality of the
  • Decade in review—funding in cancer research: National Cancer Institute awards—a work in progress

    Tito Fojo
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 634 (2014). doi:10.1038/nrclinonc.2014.173 Authors: Tito Fojo & Paraskevi Giannakakou Over the past decade, funding for cancer research by the US government—and others—has stagnated, while the demand for investment has grown because of the increasing cancer incidence worldwide. We discuss how National Cancer Institute funding efforts have developed during this period, and the contemporary and future impact of these measures on cancer research in the USA.
 
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    Nature Reviews Gastroenterology and Hepatology - Issue - nature.com science feeds

  • Celebrating 10 years

    Katrina Ray
    29 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 639 (2014). doi:10.1038/nrgastro.2014.175 Author: Katrina Ray November 2014 is a special month for Nature Reviews Gastroenterology & Hepatology as it marks 10 years since the launch of the journal in 2004, originally as Nature Clinical Practice Gastroenterology & Hepatology. So get out the party poppers, take a slice of
  • Coeliac disease: Does age at introduction to gluten affect risk of coeliac disease?

    Claire Greenhill
    13 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 641 (2014). doi:10.1038/nrgastro.2014.176 Author: Claire Greenhill Two studies recently published in The New England Journal of Medicine have investigated whether the age at which an infant starts to eat gluten-containing foods affects their risk of developing coeliac disease. The findings of both studies suggest that the timing of when an
  • Decade in review—IBD: IBD—genes, bacteria and new therapeutic strategies

    Jean-Frederic Colombel
    13 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 652 (2014). doi:10.1038/nrgastro.2014.170 Author: Jean-Frederic Colombel IBD is known to be associated with an abnormal response to an unbalanced gut microbiota in genetically predisposed individuals. The therapeutic goal now is to control progression of the disease. Given the heterogeneity of IBD, the two universes of basic and clinical science must work in parallel to realize the hope of personalized therapy.
  • Hepatitis: HCV neutralizing antibodies eradicate HCV infection

    6 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 642 (2014). doi:10.1038/nrgastro.2014.173 Neutralizing antibodies are known to protect against HCV infection; however, their effect on existing infection is unclear. Jong et al. have shown that three broadly neutralizing antibodies (AR3A, AR3B and AR4A) can eradicate HCV infection in primary human hepatocytes and in a human
  • The past 10 years of gastroenterology and hepatology—reflections and predictions

    Scott L. Friedman
    6 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology 11, 692 (2014). doi:10.1038/nrgastro.2014.167 Authors: Scott L. Friedman, Eamonn M. M. Quigley, Keith A. Sharkey, Joseph J. Y. Sung & David C. Whitcomb In November 2004, the very first issue of this journal featured articles on the pathogenesis of ulcerative colitis, mechanisms leading to chronic pancreatitis, and treatment of recurrent Clostridium-difficile-associated diarrhoea. Although those topics might seem familiar, much has changed in the intervening years in our
 
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    Nature Reviews Gastroenterology and Hepatology - AOP

  • Liver cancer: Different effects of the Notch receptors in liver cancer revealed

    Claire Greenhill
    27 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.183 Author: Claire Greenhill
  • IBD: Global variations in environmental risk factors for IBD

    Gilaad G. Kaplan
    27 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.182 Author: Gilaad G. Kaplan IBD has emerged as a global disease. Ng and colleagues have identified that some environmental risk factors are shared across the world, whereas others are distinctly unique to individuals living in Asia. This work adds a new clue to the mystery of the environmental determinates of IBD.
  • Liver: The gut is a key target of therapy in hepatic encephalopathy

    Rohit Sawhney
    27 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.185 Authors: Rohit Sawhney & Rajiv Jalan Little progress has been made in the pharmacological management of patients with hepatic encephalopathy, partly because it is difficult to perform clinical trials in this group of patients. A new clinical trial now suggests that polyethylene glycol is more effective than the current standard first-line therapy in these patients.
  • IBD: Infliximab dose optimization in IBD—proactive or reactive?

    Alessandro Armuzzi
    20 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.180 Authors: Alessandro Armuzzi & Carla Felice Optimization of biologic therapies in IBD represents an important therapeutic strategy to improve clinical outcomes. Vaughn and colleagues have analysed the long-term benefits of proactive therapeutic concentration monitoring of infliximab in patients with IBD.
  • Hepatitis: Exosomal route of HCV transmission exists in patients

    Gillian Patman
    20 Oct 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.179 Author: Gillian Patman
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    Nature Reviews Nephrology - Issue - nature.com science feeds

  • Transplantation: Steroid-free immunosuppression reduces 5-year morbidity

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.188 A randomized, prospective study has compared the effects of corticosteroid use (≥6 months) versus no corticosteroid use, both in combination with standard immunosuppression in renal transplant recipients. A reduction in morbidity in the steroid-free group was detected after 5 years. Renal function at 5 years
  • Renal fibrosis: Renal interstitial fibrosis predicted by mathematical model

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.189 New research shows that the progression of renal fibrosis, as observed in patients with lupus nephritis, can be accurately simulated using mathematical modelling. The model was used to accurately predict the urinary concentrations of the putative biomarkers monocyte chemotactic protein-1 and transforming growth factor β
  • Renal artery stenosis: Routine renal revascularization after stenosis: no benefit

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.186 An update of a previous meta-analysis, in light of the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) trial, has revealed that routine renal revascularization following stenosis in patients with hypertension and/or chronic kidney disease has little effect on the risk of cardiovascular or renal outcomes
  • Risk factors: AKI after CABG increases risk of ESRD

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.187 New data from a study of 29,330 patients who received isolated coronary artery bypass grafting (CABG) surgery show that occurrence of postoperative acute kidney injury (AKI) results in an almost threefold increase in risk of end-stage renal disease (ESRD), after a mean follow-up of 4.3
  • Stones: Ultrasonography and computed tomography: performance in detection of kidney stones

    Susan J. Allison
    29 Sep 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 611 (2014). doi:10.1038/nrneph.2014.182 Author: Susan J. Allison The most appropriate imaging method for the diagnosis of kidney stones in patients with suspected nephrolithiasis is unclear. Computed tomography (CT) is the most commonly used imaging modality owing to its high sensitivity for the detection of stones, but this approach is more expensive than
 
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    Nature Reviews Rheumatology - Issue - nature.com science feeds

  • Spondyloarthropathies: Therapy influences herpes zoster risk in patients with PsA

    13 Oct 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 636 (2014). doi:10.1038/nrrheum.2014.177 The risk of herpes zoster in patients with psoriatic arthritis (PsA) is influenced by a number of factors, according to a retrospective cohort study of 3,128 patients. A total of 182 herpes zoster events were recorded in the database between 2002 and 2013. Grouping of
  • Connective tissue diseases: Primigravida is a risk factor for SLE flare

    13 Oct 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 636 (2014). doi:10.1038/nrrheum.2014.179 A retrospective analysis of 120 pregnant women with systemic lupus erythematosus (SLE) identified first pregnancy as a risk factor for flare of disease activity during pregnancy. The investigators identified 47 episodes of flare (relapse rate 37.9%), the most common manifestations of which were renal, joint,
  • Complementary and alternative therapy: No benefit from acupuncture for chronic knee pain

    13 Oct 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 636 (2014). doi:10.1038/nrrheum.2014.178 In a study in patients aged ≥50 years with moderate or severe chronic knee pain, neither laser acupuncture nor needle acupuncture was effective for improving pain or function. The trial allocated 282 community volunteers to treatment with needle acupuncture (n = 70), laser
  • Osteoarthritis: Animal data show VEGF blocker inhibits post-traumatic OA

    Caroline Barranco
    6 Oct 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 638 (2014). doi:10.1038/nrrheum.2014.173 Author: Caroline Barranco Early treatment with the anti-VEGF antibody bevacizumab retards the development of post-traumatic knee osteoarthritis (OA), according to new results published in Arthritis Research & Therapy.Masato Sato and colleagues' study shows that systemic bevacizumab treatment reduces synovitis, osteophyte formation and articular cartilage degradation in
  • Autoimmunity: Impaired mucosal immunity in patients with SLE

    João H. Duarte
    29 Sep 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 637 (2014). doi:10.1038/nrrheum.2014.171 Author: João H. Duarte A new study published this week in The Journal of Immunology identifies deficiencies in mucosal-associated invariant T (MAIT) cells from patients with systemic lupus erythematosus (SLE).MAIT cells have an important function in mucosal immunity by protecting against mycobacterial and enterobacterial infections. In turn,
 
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    Naturejobs - Search results

  • Senior Scientist Research & Development (LC MS)

    31 Oct 2014 | 12:14 am
    Expertise Scientific Research & Development Education Bachelors Job Type Full-time Location United States - Massachusetts - Franklin Job Level Experienced Posting date: October 27, 2014 Senior Scientist, Research & Development (LC-MS) Location: Franklin, MA Position Summary: Thermo Fisher Scientific is hiring a dynamic and self-motivated individual to support development of state-of-the-art LC-MS instrumentation. Come make a difference in the science and clinical research community t...
  • Product Support Engineer

    31 Oct 2014 | 12:14 am
    Expertise Scientific Research & Development Education Masters Job Type Full-time Location United States - California - San Jose Job Level Experienced Posting date: October 27, 2014 Position Summary: The LSMS Product Support team is looking for an engaged Product Support Engineer to add to our team. The ideal candidate has a strong background in LC/MS with an emphasis on Triple Quadrupole technologies with a solid technical understanding of the hardware and technology. Experience in L...
  • Shared Services Representative

    31 Oct 2014 | 12:14 am
    The role: •Reconciling ERP uploads•Dealing with queries in an efficient and timely manner•Working as part of a large team that has responsibility for accurate and timely input of information (this is essential to the company’s payment processes -vendor invoices, and to the monthly reporting of results to the Corporation.)•Timely checking and accurate processing of invoices and payments •Interfacing with various internal departments and external suppliers to resolve any queries. ••Adhoc Project W...
  • Site Technician South San Francisco CA

    31 Oct 2014 | 12:14 am
    Expertise Field Services Education High School/GED Job Type Full-time Location United States - California - San Francisco Job Level Experienced Posting date: October 29, 2014 Position Summary: This position is focused on service delivery excellence for UnityTM Lab Services. Specific activities relative to the job function could include: inventory management. This position will utilize the basic functionality of systems and applications relevant to the job function, such as: RIMS, e...
  • Senior Tax Analyst

    31 Oct 2014 | 12:14 am
    Expertise Finance Job Type Full-time Location United States - California - Carlsbad Job Level Experienced Posting date: October 6, 2014 Position Summary: The Senior Tax Analyst is responsible for various aspects of federal, state, and local income and franchise tax compliance, reporting, income tax accounting, and research and planning for Thermo Fisher Scientific and its affiliated companies. Thermo Fisher Scientific is a large multi-national corporation with over 700 domestic and fore...
 
 
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    British Journal of Pharmacology

  • Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11

    David F Tough, Huw D Lewis, Inmaculada Rioja, Matthew J Lindon, Rab K Prinjha
    27 Oct 2014 | 9:10 am
    The properties of a cell are determined both genetically by the DNA sequence of its genes and epigenetically through processes that regulate the pattern, timing and magnitude of expression of its genes. While the genetic basis of disease has been a topic of intense study for decades, recent years have seen a dramatic increase in the understanding of epigenetic regulatory mechanisms and a growing appreciation that epigenetic misregulation makes a significant contribution to human disease. Several large protein families have been identified that act in different ways to control the expression…
  • 1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription

    Tatyana Ammosova, Maxim Platonov, Andrei Ivanov, Yasemin Saygideğer Kont, Namita Kumari, Kylene Kehn-Hall, Marina Jerebtsova, Amol A Kulkarni, Aykut Üren, Dmytro Kovalskyy, Sergei Nekhai
    27 Oct 2014 | 9:10 am
    Background and PurposeHIV-1 transcription is activated by the Tat protein which recruits the cyclin-dependent kinase CDK9/cyclin T1 to TAR RNA. Tat binds to protein phosphatase-1 (PP1) through the Q35VCF38 sequence and translocates PP1 to the nucleus. PP1 dephosphorylates CDK9 and activates HIV-1 transcription. We have synthesized a low MW compound 1H4, that targets PP1 and prevents HIV-1 Tat interaction with PP1 and inhibits HIV-1 gene transcription. Here, we report our further work with the 1H4-derived compounds and analysis of their mechanism of action. Experimental ApproachUsing the…
  • Issue Information

    27 Oct 2014 | 9:10 am
  • Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays

    A Gilchrist, T D Gauntner, A Fazzini, K M Alley, D S Pyen, J Ahn, S J Ha, A Willett, S E Sansom, J L Yarfi, K A Bachovchin, M R Mazzoni, J R Merritt
    27 Oct 2014 | 9:10 am
    Background and PurposeInvestigators have suggested that the chemokine receptor CCR1 plays a role in multiple myeloma. Studies using antisense and neutralizing antibodies to CCR1 showed that down-regulation of the receptor altered disease progression in a mouse model. More recently, experiments utilizing scid mice injected with human myeloma cells demonstrated that the CCR1 antagonist BX471 reduced osteolytic lesions, while the CCR1 antagonist MLN-3897 prevented myeloma cell adhesion to osteoclasts. However, information is limited regarding the pharmacology of CCR1 antagonists in myeloma…
  • Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors

    Martyn Wood, Vanessa Dubois, Dieter Scheller, Michel Gillard
    22 Oct 2014 | 9:00 pm
    BACKGROUND AND PURPOSERotigotine acts as a dopamine receptor agonist with high affinity for the dopamine D2, D3, D4 and D5 receptors but with a low affinity for the dopamine D1 receptor. We have investigated this further in radioligand binding and functional studies and compared the profile of rotigotine with that of other drugs used in the treatment of PD. EXPERIMENTAL APPROACHThe binding interaction of rotigotine with human dopamine D1, D2, D3, D4 and D5 receptors was determined in radioligand binding studies using [3H]rotigotine and compared with that of standard antagonist radioligands.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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    Molecular Psychiatry - AOP - nature.com science feeds

  • Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass

    J Davis
    27 Oct 2014 | 5:00 pm
    Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass Molecular Psychiatry advance online publication, October 28 2014. doi:10.1038/mp.2014.139 Authors: J Davis, M Maes, A Andreazza, J J McGrath, S J Tye & M Berk
  • ADAR2-dependent GluA2 editing regulates cocaine seeking

    H D Schmidt
    27 Oct 2014 | 5:00 pm
    ADAR2-dependent GluA2 editing regulates cocaine seeking Molecular Psychiatry advance online publication, October 28 2014. doi:10.1038/mp.2014.134 Authors: H D Schmidt, K N McFarland, S B Darnell, M N Huizenga, G R Sangrey, J-H J Cha, R C Pierce & G Sadri-Vakili
  • Molecular psychiatry of zebrafish

    A M Stewart
    27 Oct 2014 | 5:00 pm
    Molecular psychiatry of zebrafish Molecular Psychiatry advance online publication, October 28 2014. doi:10.1038/mp.2014.128 Authors: A M Stewart, J F P Ullmann, W H J Norton, M O Parker, C H Brennan, R Gerlai & A V Kalueff
  • Calcyon stimulates neuregulin 1 maturation and signaling

    D-M Yin
    27 Oct 2014 | 5:00 pm
    Calcyon stimulates neuregulin 1 maturation and signaling Molecular Psychiatry advance online publication, October 28 2014. doi:10.1038/mp.2014.131 Authors: D-M Yin, Y-J Chen, S Liu, H Jiao, C Shen, A Sathyamurthy, T W Lin, W-C Xiong, B-M Li, L Mei & C Bergson
  • Genetic background of extreme violent behavior

    J Tiihonen
    27 Oct 2014 | 5:00 pm
    Genetic background of extreme violent behavior Molecular Psychiatry advance online publication, October 28 2014. doi:10.1038/mp.2014.130 Authors: J Tiihonen, M-R Rautiainen, H M Ollila, E Repo-Tiihonen, M Virkkunen, A Palotie, O Pietiläinen, K Kristiansson, M Joukamaa, H Lauerma, J Saarela, S Tyni, H Vartiainen, J Paananen, D Goldman & T Paunio
 
 
 
 
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    PSI-Nature Structural Biology Knowledgebase

  • Microbiome: Artificial Sweeteners Induce Unhealthy Metabolism

    Anita M. Engh
    15 Oct 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.228 Author: Anita M. Engh Artificial sweeteners alter metabolism through shifts in the distribution of gut microbiota species.
  • Microbiome: When Form Doesn't Equal Function

    Catherine Goodman
    15 Oct 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.229 Author: Catherine Goodman The characterization of three proteins from the human microbiome extends our understanding of PLP-dependent enzymes.
  • Commensally sourced antibiotics

    Cláudio Nunes-Alves
    21 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology , (2014). doi:10.1038/nrmicro3363 Author: Cláudio Nunes-Alves A study analyzes the distribution of biosynthetic gene clusters in the human microbiome.
  • First aid kit for cholera

    Andrea Du Toit
    28 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology , (2014). doi:10.1038/nrmicro3366 Author: Andrea Du Toit The role of the human gut microbiota in Vibrio cholerae infection is investigated.
  • Microbiome: Expanding the Gut Gene Catalog

    Tal Nawy
    15 Oct 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.230 Author: Tal Nawy An international effort has identified nearly ten million genes belonging to microbes hosted by diverse human guts.
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