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  • Uniform, optimal signal processing of mapped deep-sequencing data

    Nature Biotechnology - AOP - nature.com science feeds
    Vibhor Kumar
    15 Jun 2013 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2596 Authors: Vibhor Kumar, Masafumi Muratani, Nirmala Arul Rayan, Petra Kraus, Thomas Lufkin, Huck Hui Ng & Shyam Prabhakar

  • How has the human brain evolved over the years?

    Scientific American Mind
    5 Jun 2013 | 5:00 pm
    Scientific American Mind 24, 76 (2013). doi:10.1038/scientificamericanmind0713-76b

  • A panoramic view of acute myeloid leukemia

    Nature Genetics - Issue - nature.com science feeds
    Sai-Juan Chen
    28 May 2013 | 5:00 pm
    Nature Genetics 45, 586 (2013). doi:10.1038/ng.2651 Authors: Sai-Juan Chen, Yang Shen & Zhu Chen A recent study in the New England Journal of Medicine reports the genomic and epigenomic changes in adult acute myeloid leukemia (AML). The patterns of somatic mutation suggest biologically relevant connections between the functional categories of genes driving AML.

  • Bimodal expression of PHO84 is modulated by early termination of antisense transcription

    Nature Structural & Molecular Biology - AOP - nature.com science feeds
    Manuele Castelnuovo
    15 Jun 2013 | 5:00 pm
    Nature Structural & Molecular Biology. doi:10.1038/nsmb.2598 Authors: Manuele Castelnuovo, Samir Rahman, Elisa Guffanti, Valentina Infantino, Françoise Stutz & Daniel Zenklusen

  • Ready for Anything

    Scientific American Mind
    Steven M. Southwick
    5 Jun 2013 | 5:00 pm
    Scientific American Mind 24, 32 (2013). doi:10.1038/scientificamericanmind0713-32 Authors: Steven M. Southwick & Dennis S. Charney Scientists have compiled evidence-based tactics for building resilience. Among them: rethink adversity, forge close friendships and tackle novel challenges
 
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    Nature - Issue - nature.com science feeds

  • No dishonour in depression

    11 Jun 2013 | 5:00 pm
    No dishonour in depression Nature 498, 7453 (2013). doi:10.1038/498137a The stigma associated with mental illness discourages investment in finding cures — even though the burden of the disorders on society is immense.

  • Track the trackers

    11 Jun 2013 | 5:00 pm
    Track the trackers Nature 498, 7453 (2013). doi:10.1038/498137b Oversight and public debate about access to personal data are crucial to preserving privacy.

  • Young upstarts

    11 Jun 2013 | 5:00 pm
    Young upstarts Nature 498, 7453 (2013). doi:10.1038/498138a Lucrative prizes emulating the Nobels bring welcome money and publicity for science.

  • Be prepared for the big genome leak

    Steven E. Brenner
    11 Jun 2013 | 5:00 pm
    Be prepared for the big genome leak Nature 498, 7453 (2013). http://www.nature.com/doifinder/10.1038/498139a Author: Steven E. Brenner It is only a matter of time until idealism sees the release of confidential genetic data on study participants, says Steven E. Brenner.

  • Climate science: Reindeer keep the ground cool

    11 Jun 2013 | 5:00 pm
    Climate science: Reindeer keep the ground cool Nature 498, 7453 (2013). doi:10.1038/498140a Reindeer herding practices and their effect on vegetation in northern Scandinavia may influence when snow melts in spring.Tall, dense shrubs can hasten snow melt in the tundra. As more branches protrude over packed snow, less sunlight is reflected off the bright surface and more
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  • Mutational heterogeneity in cancer and the search for new cancer-associated genes

    Michael S. Lawrence
    15 Jun 2013 | 5:00 pm
    Nature advance online publication 16 June 2013. doi:10.1038/nature12213 Authors: Michael S. Lawrence, Petar Stojanov, Paz Polak, Gregory V. Kryukov, Kristian Cibulskis, Andrey Sivachenko, Scott L. Carter, Chip Stewart, Craig H. Mermel, Steven A. Roberts, Adam Kiezun, Peter S. Hammerman, Aaron McKenna, Yotam Drier, Lihua Zou, Alex H. Ramos, Trevor J. Pugh, Nicolas Stransky, Elena Helman, Jaegil Kim, Carrie Sougnez, Lauren Ambrogio, Elizabeth Nickerson, Erica Shefler, Maria L. Cortés, Daniel Auclair, Gordon Saksena, Douglas Voet, Michael Noble, Daniel DiCara, Pei Lin, Lee Lichtenstein,…

  • Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography

    Shanshuang Chen
    15 Jun 2013 | 5:00 pm
    Nature advance online publication 16 June 2013. doi:10.1038/nature12232 Authors: Shanshuang Chen, Michael L. Oldham, Amy L. Davidson & Jue Chen Efficient carbon utilization is critical to the survival of microorganisms in competitive environments. To optimize energy usage, bacteria have developed an integrated control system to preferentially uptake carbohydrates that support rapid growth. The availability of a preferred carbon source, such as glucose, represses the synthesis and activities of proteins necessary for the transport and metabolism of secondary carbon sources. This regulatory…

  • Pan genome of the phytoplankton Emiliania underpins its global distribution

    Betsy A. Read
    11 Jun 2013 | 5:00 pm
    Nature advance online publication 12 June 2013. doi:10.1038/nature12221 Authors: Betsy A. Read, Jessica Kegel, Mary J. Klute, Alan Kuo, Stephane C. Lefebvre, Florian Maumus, Christoph Mayer, John Miller, Adam Monier, Asaf Salamov, Jeremy Young, Maria Aguilar, Jean-Michel Claverie, Stephan Frickenhaus, Karina Gonzalez, Emily K. Herman, Yao-Cheng Lin, Jonathan Napier, Hiroyuki Ogata, Analissa F. Sarno, Jeremy Shmutz, Declan Schroeder, Colomban de Vargas, Frederic Verret, Peter von Dassow, Klaus Valentin, Yves Van de Peer, Glen Wheeler, Joel B. Dacks, Charles F. Delwiche, Sonya T. Dyhrman,…

  • Corrigendum: Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

    Jia Zhu
    11 Jun 2013 | 5:00 pm
    Nature advance online publication 12 June 2013. doi:10.1038/nature12324 Authors: Jia Zhu, Tao Peng, Christine Johnston, Khamsone Phasouk, Angela S. Kask, Alexis Klock, Lei Jin, Kurt Diem, David M. Koelle, Anna Wald, Harlan Robins & Lawrence Corey

  • Erratum: Integrated genomic characterization of endometrial carcinoma

    11 Jun 2013 | 5:00 pm
    Nature advance online publication 12 June 2013. doi:10.1038/nature12325 Author:
 
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    Nature China - nature.com science feeds

  • Infectious diseases: More on avian influenza

    Felix Cheung
    4 Jun 2013 | 5:00 pm
    Nature China(2013). doi:10.1038/nchina.2013.47 Author: Felix Cheung Researchers in Hong Kong and Mainland China have gathered more data on the H7N9 virus

  • Condensed matter physics: Quantum resistance

    Felix Cheung
    4 Jun 2013 | 5:00 pm
    Nature China(2013). doi:10.1038/nchina.2013.51 Author: Felix Cheung The Hall resistance of chromium-doped topological insulator thin films exhibit a distinct plateau with the quantized value h/e2

  • Cancer biology: A new player in senescence

    Felix Cheung
    4 Jun 2013 | 5:00 pm
    Nature China(2013). doi:10.1038/nchina.2013.42 Author: Felix Cheung Yes-associated protein regulates cellular senescence through TEAD transcription factors and CDK6

  • Polymers: Hold your breath

    Felix Cheung
    4 Jun 2013 | 5:00 pm
    Nature China(2013). doi:10.1038/nchina.2013.49 Author: Felix Cheung Because the carbon dioxide you exhale can open up the pores of breathing polymersomes

  • Cell biology: Calling for help

    Edward Duca
    4 Jun 2013 | 5:00 pm
    Nature China(2013). doi:10.1038/nchina.2013.43 Author: Edward Duca A specific protein is needed to recruit immune T-helper cells to germinal centres where antibodies mature
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    Scientific American Mind

  • How has the human brain evolved over the years?

    5 Jun 2013 | 5:00 pm
    Scientific American Mind 24, 76 (2013). doi:10.1038/scientificamericanmind0713-76b

  • Nanotechnology That Detects and Treats Alzheimer's

    Stephani Sutherland
    5 Jun 2013 | 5:00 pm
    Scientific American Mind 24, 9 (2013). doi:10.1038/scientificamericanmind0713-9 Author: Stephani Sutherland

  • Can Herbs Ease Anxiety and Depression?

    Hal Arkowitz
    5 Jun 2013 | 5:00 pm
    Scientific American Mind 24, 72 (2013). doi:10.1038/scientificamericanmind0713-72 Authors: Hal Arkowitz & Scott O. Lilienfeld Some plant-based remedies may stand in for conventional ones, but most lack scientific support as treatments for psychological problems

  • Ready for Anything

    Steven M. Southwick
    5 Jun 2013 | 5:00 pm
    Scientific American Mind 24, 32 (2013). doi:10.1038/scientificamericanmind0713-32 Authors: Steven M. Southwick & Dennis S. Charney Scientists have compiled evidence-based tactics for building resilience. Among them: rethink adversity, forge close friendships and tackle novel challenges

  • OCD in New Moms

    Carrie Arnold
    5 Jun 2013 | 5:00 pm
    Scientific American Mind 24, 16 (2013). doi:10.1038/scientificamericanmind0713-16b Author: Carrie Arnold
 
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    Nature Cell Biology - Issue - nature.com science feeds

  • Preventing lysosomal fat indigestion

    Ana Maria Cuervo
    2 Jun 2013 | 5:00 pm
    Nature Cell Biology 15, 565 (2013). doi:10.1038/ncb2778 Author: Ana Maria Cuervo Autophagy contributes to lipid catabolism through direct mobilization and breakdown of cellular lipid stores. Two recent studies reveal the regulatory mechanisms activated by cells during starvation to ensure that the cellular compartments involved in autophagic lipid catabolism are ready to receive, process and use these lipids. The regulators represent attractive therapeutic targets to help fight lipid-excess-associated diseases.

  • Control of metastatic progression by microRNA regulatory networks

    Nora Pencheva
    2 Jun 2013 | 5:00 pm
    Nature Cell Biology 15, 546 (2013). doi:10.1038/ncb2769 Authors: Nora Pencheva & Sohail F. Tavazoie

  • YAP forces fibroblasts to feel the tension

    Ori Maller
    2 Jun 2013 | 5:00 pm
    Nature Cell Biology 15, 570 (2013). doi:10.1038/ncb2777 Authors: Ori Maller, Christopher C. DuFort & Valerie M. Weaver Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and remodelling. However, how CAFs become activated and their roles in tumour mechanics have remained unclear. YAP is now identified as a tension-stimulated CAF activator that promotes malignancy through a mechanically reinforced feed-forward loop.

  • Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

    Christian C. Dibble
    2 Jun 2013 | 5:00 pm
    Nature Cell Biology 15, 555 (2013). doi:10.1038/ncb2763 Authors: Christian C. Dibble & Brendan D. Manning

  • White to brite adipocyte transition and back again

    Youn-Kyoung Lee
    2 Jun 2013 | 5:00 pm
    Nature Cell Biology 15, 568 (2013). doi:10.1038/ncb2776 Authors: Youn-Kyoung Lee & Chad A. Cowan Identification and characterization of a third type of adipocyte known as brite (brown-in-white) adipocytes has drawn considerable attention, as these cells are thought to regulate energy expenditure and may help combat obesity. Remarkably, white adipocytes can adopt the characteristics of brite adipocytes following cold stimulation, and this process is reversible in vivo.
 
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    Nature Chemistry

  • Alkene synthesis: Activating iodoniums

    Stephen Davey
    21 May 2013 | 5:00 pm
    Nature Chemistry 5, 443 (2013). doi:10.1038/nchem.1674 Author: Stephen Davey

  • Self-assembly: A SAGE design

    Russell Johnson
    21 May 2013 | 5:00 pm
    Nature Chemistry 5, 442 (2013). doi:10.1038/nchem.1673 Author: Russell Johnson

  • Detective work

    Paul Bonvallet
    21 May 2013 | 5:00 pm
    Nature Chemistry 5, 441 (2013). doi:10.1038/nchem.1665 Author: Paul Bonvallet

  • Li–O2 batteries: An agent for change

    Yonggang Wang
    21 May 2013 | 5:00 pm
    Nature Chemistry 5, 445 (2013). doi:10.1038/nchem.1658 Authors: Yonggang Wang & Yongyao Xia The rechargeable Li–O2 battery has low energy efficiency, which is mainly due to kinetic difficulties in the electrochemical oxidation of the insulating discharge product, Li2O2. Now a redox mediator, acting as an electron–hole transfer agent, has been used to promote this oxidation reaction.

  • Interlocked molecules: Tangled tetrahedra

    Stuart Cantrill
    21 May 2013 | 5:00 pm
    Nature Chemistry 5, 442 (2013). doi:10.1038/nchem.1671 Author: Stuart Cantrill
 
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    Nature Chemistry

  • The Janus-faced role of external forces in mechanochemical disulfide bond cleavage

    Przemyslaw Dopieralski
    15 Jun 2013 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1676 Authors: Przemyslaw Dopieralski, Jordi Ribas-Arino, Padmesh Anjukandi, Martin Krupicka, Janos Kiss & Dominik Marx Using ab initio simulations external mechanical forces are shown to trigger structural changes to disulfide bridges that result in conformations that are less susceptible to nucleophilic attack. This finding is crucial for the interpretation of recent force microscopy experiments, and could be important for understanding protein regulation.

  • A pentagonal cyanostar macrocycle with cyanostilbene CH donors binds anions and forms dialkylphosphate [3]rotaxanes

    Semin Lee
    15 Jun 2013 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1668 Authors: Semin Lee, Chun-Hsing Chen & Amar H. Flood Macrocycles are key compounds in supramolecular chemistry, yet their efficient preparation is an ever present challenge. Now, it has been shown that a C5-symmetric macrocycle, termed ‘cyanostar’, can be formed in high yields on multigram scales in one pot. Cyanostars form unusually strong sandwich complexes with large and weakly coordinating anions and can template the formation of a dialkylphosphate [3]rotaxane.

  • Entangled quantum electronic wavefunctions of the Mn4CaO5 cluster in photosystem II

    Yuki Kurashige
    8 Jun 2013 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1677 Authors: Yuki Kurashige, Garnet Kin-Lic Chan & Takeshi Yanai Many-electron quantum modelling of the metal clusters in metalloenzymes is a long-standing ambition for theoreticians. Here, using the density matrix renormalization group, the many-electron wavefunctions of the Mn4CaO5 cluster of photosystem II are computed, providing new insights into the electronic structure and reactivity at the level of many-particle quantum mechanics and entanglement.

  • Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates

    Gregor Fuhrmann
    8 Jun 2013 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1675 Authors: Gregor Fuhrmann, Andrea Grotzky, Ružica Lukić, Simon Matoori, Paola Luciani, Hao Yu, Baozhong Zhang, Peter Walde, A. Dieter Schlüter, Marc A. Gauthier & Jean-Christophe Leroux Methods for stabilizing enzymatic activity in the gastrointestinal tract are rarely investigated because of the difficulty in protecting proteins from an environment that promotes their digestion. Now, functionally diverse polymers have been conjugated to therapeutic enzymes, which lead to a substantial enhancement of their in vivo activity in the gastrointestinal…

  • A robustness screen for the rapid assessment of chemical reactions

    Karl D. Collins
    8 Jun 2013 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1669 Authors: Karl D. Collins & Frank Glorius For researchers to rapidly adopt new synthetic methodology, they need to gauge whether the reaction will work for their substrate — a point not easily conveyed by traditional screens of reaction scope. Here, a simple method is described to assess the likely scope and limitations of a chemical reaction beyond the idealized conditions initially reported.
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    Nature Genetics - Issue - nature.com science feeds

  • SETD2 and mismatch repair

    Emily Niemitz
    28 May 2013 | 5:00 pm
    Nature Genetics 45, 591 (2013). doi:10.1038/ng.2660 Author: Emily Niemitz

  • The Genotype-Tissue Expression (GTEx) project

    John Lonsdale
    28 May 2013 | 5:00 pm
    Nature Genetics 45, 580 (2013). doi:10.1038/ng.2653 Authors: John Lonsdale, Jeffrey Thomas, Mike Salvatore, Rebecca Phillips, Edmund Lo, Saboor Shad, Richard Hasz, Gary Walters, Fernando Garcia, Nancy Young, Barbara Foster, Mike Moser, Ellen Karasik, Bryan Gillard, Kimberley Ramsey, Susan Sullivan, Jason Bridge, Harold Magazine, John Syron, Johnelle Fleming, Laura Siminoff, Heather Traino, Maghboeba Mosavel, Laura Barker, Scott Jewell, Dan Rohrer, Dan Maxim, Dana Filkins, Philip Harbach, Eddie Cortadillo, Bree Berghuis, Lisa Turner, Eric Hudson, Kristin Feenstra, Leslie Sobin, James Robb,…

  • Malaria gene allows infection

    Pamela Feliciano
    28 May 2013 | 5:00 pm
    Nature Genetics 45, 591 (2013). doi:10.1038/ng.2662 Author: Pamela Feliciano

  • A panoramic view of acute myeloid leukemia

    Sai-Juan Chen
    28 May 2013 | 5:00 pm
    Nature Genetics 45, 586 (2013). doi:10.1038/ng.2651 Authors: Sai-Juan Chen, Yang Shen & Zhu Chen A recent study in the New England Journal of Medicine reports the genomic and epigenomic changes in adult acute myeloid leukemia (AML). The patterns of somatic mutation suggest biologically relevant connections between the functional categories of genes driving AML.

  • Stimulating β cell proliferation

    Kyle Vogan
    28 May 2013 | 5:00 pm
    Nature Genetics 45, 591 (2013). doi:10.1038/ng.2659 Author: Kyle Vogan
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    Nature Genetics - AOP - nature.com science feeds

  • Oocyte differentiation is genetically dissociable from meiosis in mice

    Gregoriy A Dokshin
    15 Jun 2013 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2672 Authors: Gregoriy A Dokshin, Andrew E Baltus, John J Eppig & David C Page

  • An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy

    Michael N Weedon
    15 Jun 2013 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2670 Authors: Michael N Weedon, Sian Ellard, Marc J Prindle, Richard Caswell, Hana Lango Allen, Richard Oram, Koumudi Godbole, Chittaranjan S Yajnik, Paolo Sbraccia, Giuseppe Novelli, Peter Turnpenny, Emma McCann, Kim Jee Goh, Yukai Wang, Jonathan Fulford, Laura J McCulloch, David B Savage, Stephen O'Rahilly, Katarina Kos, Lawrence A Loeb, Robert K Semple & Andrew T Hattersley DNA polymerase δ, whose catalytic subunit is encoded by POLD1, is responsible for lagging-strand DNA synthesis during DNA replication. It carries out this synthesis with high…

  • Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

    Sonja I Berndt
    15 Jun 2013 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2652 Authors: Sonja I Berndt, Christine F Skibola, Vijai Joseph, Nicola J Camp, Alexandra Nieters, Zhaoming Wang, Wendy Cozen, Alain Monnereau, Sophia S Wang, Rachel S Kelly, Qing Lan, Lauren R Teras, Nilanjan Chatterjee, Charles C Chung, Meredith Yeager, Angela R Brooks-Wilson, Patricia Hartge, Mark P Purdue, Brenda M Birmann, Bruce K Armstrong, Pierluigi Cocco, Yawei Zhang, Gianluca Severi, Anne Zeleniuch-Jacquotte, Charles Lawrence, Laurie Burdette, Jeffrey Yuenger, Amy Hutchinson, Kevin B Jacobs, Timothy G Call, Tait D Shanafelt, Anne J Novak, Neil E Kay,…

  • Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma

    Patrick S Tarpey
    15 Jun 2013 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2668 Authors: Patrick S Tarpey, Sam Behjati, Susanna L Cooke, Peter Van Loo, David C Wedge, Nischalan Pillay, John Marshall, Sarah O'Meara, Helen Davies, Serena Nik-Zainal, David Beare, Adam Butler, John Gamble, Claire Hardy, Jonathon Hinton, Ming Ming Jia, Alagu Jayakumar, David Jones, Calli Latimer, Mark Maddison, Sancha Martin, Stuart McLaren, Andrew Menzies, Laura Mudie, Keiran Raine, Jon W Teague, Jose M C Tubio, Dina Halai, Roberto Tirabosco, Fernanda Amary, Peter J Campbell, Michael R Stratton, Adrienne M Flanagan & P Andrew Futreal Chondrosarcoma is…

  • Whole-genome sequence–based analysis of high-density lipoprotein cholesterol

    15 Jun 2013 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2671 Authors: We describe initial steps for interrogating whole-genome sequence data to characterize the genetic architecture of a complex trait, levels of high-density lipoprotein cholesterol (HDL-C). We report whole-genome sequencing and analysis of 962 individuals from the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) studies. From this analysis, we estimate that common variation contributes more to heritability of HDL-C levels than rare variation, and screening for mendelian variants for dyslipidemia identified individuals with…
 
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    Nature Geoscience - AOP - nature.com science feeds

  • Strong inheritance of texture between perovskite and post-perovskite in the D′′ layer

    David P. Dobson
    15 Jun 2013 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo1844 Authors: David P. Dobson, Nobuyosihi Miyajima, Fabrizio Nestola, Matteo Alvaro, Nicola Casati, Christian Liebske, Ian G. Wood & Andrew M. Walker About 200 km above the core–mantle boundary, the D′′seismic discontinuity marks the depth where magnesium silicate perovskite—the main mantle mineral—is transformed into its high-pressure phase of post-perovskite. Observations of seismic anisotropy within the D′′ region are inferred to arise from textures within post-perovskite that are created by flow in the…

  • Noble gas transport into the mantle facilitated by high solubility in amphibole

    Colin R. M. Jackson
    15 Jun 2013 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo1851 Authors: Colin R. M. Jackson, Stephen W. Parman, Simon P. Kelley & Reid F. Cooper The chemical evolution of both the Earth’s atmosphere and mantle can be traced using noble gases. Their abundance in mantle and atmosphere reflects a balance between the flux of noble gases from the Earth’s interior through magmatism, and the recycling of noble gases from the atmosphere back into the mantle at subduction zones. The flux of noble gases back into the mantle has long been thought to be negligible. However, analyses of samples from the mantle…

  • Atlantic cooling associated with a marine biotic crisis during the mid-Cretaceous period

    A. McAnena
    15 Jun 2013 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo1850 Authors: A. McAnena, S. Flögel, P. Hofmann, J. O. Herrle, A. Griesand, J. Pross, H. M. Talbot, J. Rethemeyer, K. Wallmann & T. Wagner Most of the marine biotic crises that occurred during the hot Mesozoic era have been linked to episodes of extreme warmth. Others, however, may have occurred during cooler intervals that interrupted Cretaceous greenhouse warmth. There are some indications of cooling in the late Aptian (116–114 Myr ago), but it has not been definitively linked to biotic crisis. Here we assess the timing and magnitude…

  • Anthropogenic perturbation of the carbon fluxes from land to ocean

    Pierre Regnier
    8 Jun 2013 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo1830 Authors: Pierre Regnier, Pierre Friedlingstein, Philippe Ciais, Fred T. Mackenzie, Nicolas Gruber, Ivan A. Janssens, Goulven G. Laruelle, Ronny Lauerwald, Sebastiaan Luyssaert, Andreas J. Andersson, Sandra Arndt, Carol Arnosti, Alberto V. Borges, Andrew W. Dale, Angela Gallego-Sala, Yves Goddéris, Nicolas Goossens, Jens Hartmann, Christoph Heinze, Tatiana Ilyina, Fortunat Joos, Douglas E. LaRowe, Jens Leifeld, Filip J. R. Meysman, Guy Munhoven, Peter A. Raymond, Renato Spahni, Parvadha Suntharalingam & Martin Thullner

  • Intensification of open-ocean oxygen depletion by vertically migrating animals

    Daniele Bianchi
    8 Jun 2013 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo1837 Authors: Daniele Bianchi, Eric D. Galbraith, David A. Carozza, K. A. S. Mislan & Charles A. Stock Throughout the ocean, countless small animals swim to depth in the daytime, presumably to seek refuge from large predators. These animals return to the surface at night to feed. This substantial diel vertical migration can result in the transfer of significant amounts of carbon and nutrients from the surface to depth. However, its consequences on ocean chemistry at the global scale have remained uncertain. Here, we determine the depths of these diel…
 
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    Nature Materials - Issue - nature.com science feeds

  • Join the dots

    21 May 2013 | 5:00 pm
    Nature Materials 12, 467 (2013). doi:10.1038/nmat3681 The properties of semiconductor quantum dots can now be controlled down to the level of single electrons and spins. These solid-state 'artificial atoms' have inspired scientists to look at them as possible building blocks for realizations of quantum computers, with unexpected consequences.

  • Stem cell isolation: Differential stickiness

    Oscar J. Abilez
    21 May 2013 | 5:00 pm
    Nature Materials 12, 474 (2013). doi:10.1038/nmat3664 Authors: Oscar J. Abilez & Joseph C. Wu Technologies to isolate colonies of human pluripotent stem cells from other cell types in a high-throughput manner are lacking. A microfluidic-based approach that exploits differences in the adhesion strength between these cells and a substrate may soon fill the gap.

  • Negative friction coefficients

    Esben Thormann
    21 May 2013 | 5:00 pm
    Nature Materials 12, 468 (2013). doi:10.1038/nmat3656 Author: Esben Thormann

  • Coiled-coil balls

    Pep Pàmies
    21 May 2013 | 5:00 pm
    Nature Materials 12, 472 (2013). doi:10.1038/nmat3680 Author: Pep Pàmies

  • Nuclear spins keep coming back

    Hugo Ribeiro
    21 May 2013 | 5:00 pm
    Nature Materials 12, 469 (2013). doi:10.1038/nmat3671 Authors: Hugo Ribeiro & Guido Burkard Semiconducting quantum dots have been extensively investigated with the idea of using single spins for quantum computing. Whereas access to single electrons and their spins has become routine, the challenges posed by nuclear spins remain ever present.
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  • Imaging currents in HgTe quantum wells in the quantum spin Hall regime

    Katja C. Nowack
    15 Jun 2013 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3682 Authors: Katja C. Nowack, Eric M. Spanton, Matthias Baenninger, Markus König, John R. Kirtley, Beena Kalisky, C. Ames, Philipp Leubner, Christoph Brüne, Hartmut Buhmann, Laurens W. Molenkamp, David Goldhaber-Gordon & Kathryn A. Moler The quantum spin Hall (QSH) state is a state of matter characterized by a non-trivial topology of its band structure, and associated conducting edge channels. The QSH state was predicted and experimentally demonstrated to be realized in HgTe quantum wells. The existence of the edge channels has been inferred from local…

  • Compositional segregation in shaped Pt alloy nanoparticles and their structural behaviour during electrocatalysis

    Chunhua Cui
    15 Jun 2013 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3668 Authors: Chunhua Cui, Lin Gan, Marc Heggen, Stefan Rudi & Peter Strasser

  • Current-driven dynamics of chiral ferromagnetic domain walls

    Satoru Emori
    15 Jun 2013 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3675 Authors: Satoru Emori, Uwe Bauer, Sung-Min Ahn, Eduardo Martinez & Geoffrey S. D. Beach In most ferromagnets the magnetization rotates from one domain to the next with no preferred handedness. However, broken inversion symmetry can lift the chiral degeneracy, leading to topologically rich spin textures such as spin spirals and skyrmions through the Dzyaloshinskii–Moriya interaction (DMI). Here we show that in ultrathin metallic ferromagnets sandwiched between a heavy metal and an oxide, the DMI stabilizes chiral domain walls (DWs) whose spin…

  • A family of binary magnetic icosahedral quasicrystals based on rare earths and cadmium

    Alan I. Goldman
    8 Jun 2013 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3672 Authors: Alan I. Goldman, Tai Kong, Andreas Kreyssig, Anton Jesche, Mehmet Ramazanoglu, Kevin W. Dennis, Sergey L. Bud’ko & Paul C. Canfield Examples of stable binary icosahedral quasicrystals are relatively rare, and at present there are no known examples featuring localized magnetic moments. These would represent an ideal model system for attaining a deeper understanding of the nature of magnetic interactions in aperiodic lattices. Here we report the discovery of a family of at least seven rare earth icosahedral binary quasicrystals, i-R–Cd…

  • Piezoelectric control of the mobility of a domain wall driven by adiabatic and non-adiabatic torques

    E. De Ranieri
    8 Jun 2013 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3657 Authors: E. De Ranieri, P. E. Roy, D. Fang, E. K. Vehsthedt, A. C. Irvine, D. Heiss, A. Casiraghi, R. P. Campion, B. L. Gallagher, T. Jungwirth & J. Wunderlich
 
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    Nature Medicine - AOP - nature.com science feeds

  • A largely random AAV integration profile after LPLD gene therapy

    Christine Kaeppel
    15 Jun 2013 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3230 Authors: Christine Kaeppel, Stuart G Beattie, Raffaele Fronza, Richard van Logtenstein, Florence Salmon, Sabine Schmidt, Stephan Wolf, Ali Nowrouzi, Hanno Glimm, Christof von Kalle, Harald Petry, Daniel Gaudet & Manfred Schmidt The clinical application of adeno-associated virus vectors (AAVs) is limited because of concerns about AAV integration–mediated tumorigenicity. We performed integration-site analysis after AAV1-LPLS447X intramuscular injection in five lipoprotein lipase–deficient subjects, revealing random nuclear integration and…

  • Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

    Erich Gulbins
    15 Jun 2013 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3214 Authors: Erich Gulbins, Monica Palmada, Martin Reichel, Anja Lüth, Christoph Böhmer, Davide Amato, Christian P Müller, Carsten H Tischbirek, Teja W Groemer, Ghazaleh Tabatabai, Katrin A Becker, Philipp Tripal, Sven Staedtler, Teresa F Ackermann, Johannes van Brederode, Christian Alzheimer, Michael Weller, Undine E Lang, Burkhard Kleuser, Heike Grassmé & Johannes Kornhuber Major depression is a highly prevalent severe mood disorder that is treated with antidepressants. The molecular targets of antidepressants require definition. We…

  • Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling

    Wei Chin Chou
    8 Jun 2013 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3194 Authors: Wei Chin Chou, Makoto Takeo, Piul Rabbani, Hai Hu, Wendy Lee, Young Rock Chung, John Carucci, Paul Overbeek & Mayumi Ito During wound healing, stem cells provide functional mature cells to meet acute demands for tissue regeneration. Simultaneously, the tissue must maintain a pool of stem cells to sustain its future regeneration capability. However, how these requirements are balanced in response to injury is unknown. Here we demonstrate that after wounding or ultraviolet type B irradiation, melanocyte stem cells (McSCs) in the hair follicle…

  • Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

    Djalma S Lima-Junior
    8 Jun 2013 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3221 Authors: Djalma S Lima-Junior, Diego L Costa, Vanessa Carregaro, Larissa D Cunha, Alexandre L N Silva, Tiago W P Mineo, Fredy R S Gutierrez, Maria Bellio, Karina R Bortoluci, Richard A Flavell, Marcelo T Bozza, João S Silva & Dario S Zamboni

  • MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion

    James Soh
    8 Jun 2013 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3200 Authors: James Soh, Jahangir Iqbal, Joyce Queiroz, Carlos Fernandez-Hernando & M Mahmood Hussain
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    Nature Methods - Issue - nature.com science feeds

  • Points of view: Plotting symbols

    Martin Krzywinski
    29 May 2013 | 5:00 pm
    Nature Methods 10, 451 (2013). doi:10.1038/nmeth.2490 Authors: Martin Krzywinski & Bang Wong Choose distinct symbols that overlap without ambiguity and communicate relationships in data.

  • The author file: Joshua Sanes

    Vivien Marx
    29 May 2013 | 5:00 pm
    Nature Methods 10, 449 (2013). doi:10.1038/nmeth.2487 Author: Vivien Marx New features are added to a neuron-painting toolbox that could contribute to the recently announced US brain-mapping initiative.

  • Sensors and probes: Magnetic field imaging and more

    Daniel Evanko
    29 May 2013 | 5:00 pm
    Nature Methods 10, 468 (2013). doi:10.1038/nmeth.2511 Author: Daniel Evanko Two reports demonstrate further advances in the use of nitrogen vacancies for very different imaging applications.

  • Epigenetics: Dynamics of DNA demethylation

    Tal Nawy
    29 May 2013 | 5:00 pm
    Nature Methods 10, 466 (2013). doi:10.1038/nmeth.2506 Author: Tal Nawy Locating the final oxidation products of methylated cytosine by enrichment and sequencing reveals that DNA demethylation is common across the genome.

  • Endrov: an integrated platform for image analysis

    Johan Henriksson
    29 May 2013 | 5:00 pm
    Nature Methods 10, 454 (2013). doi:10.1038/nmeth.2478 Authors: Johan Henriksson, Jürgen Hench, Yong Guang Tong, Arvid Johansson, David Johansson & Thomas R Bürglin
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  • Genome-wide profiling of human cap-independent translation-enhancing elements

    Brian P Wellensiek
    15 Jun 2013 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2522 Authors: Brian P Wellensiek, Andrew C Larsen, Bret Stephens, Kim Kukurba, Karl Waern, Natalia Briones, Li Liu, Michael Snyder, Bertram L Jacobs, Sudhir Kumar & John C Chaput We report an in vitro selection strategy to identify RNA sequences that mediate cap-independent initiation of translation. This method entails mRNA display of trillions of genomic fragments, selection for initiation of translation and high-throughput deep sequencing. We identified >12,000 translation-enhancing elements (TEEs) in the human genome, generated a high-resolution…

  • Near-infrared fluorescent proteins for multicolor in vivo imaging

    Daria M Shcherbakova
    15 Jun 2013 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2521 Authors: Daria M Shcherbakova & Vladislav V Verkhusha Near-infrared fluorescent proteins (FPs) are in high demand for in vivo imaging. We developed four spectrally distinct near-infrared FPs—iRFP670, iRFP682, iRFP702 and iRFP720—from bacterial phytochromes. iRFPs exhibit high brightness in mammalian cells and tissues and are suitable for long-term studies. iRFP670 and iRFP720 enable two-color imaging with standard approaches in living cells and mice. The four new iRFPs and the previously engineered iRFP713 allow multicolor imaging with…

  • OpenSPIM: an open-access light-sheet microscopy platform

    Peter G Pitrone
    8 Jun 2013 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2507 Authors: Peter G Pitrone, Johannes Schindelin, Luke Stuyvenberg, Stephan Preibisch, Michael Weber, Kevin W Eliceiri, Jan Huisken & Pavel Tomancak

  • OpenSpinMicroscopy: an open-source integrated microscopy platform

    Emilio J Gualda
    8 Jun 2013 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2508 Authors: Emilio J Gualda, Tiago Vale, Pedro Almada, José A Feijó, Gabriel G Martins & Nuno Moreno

  • Integrated proteomic analysis of post-translational modifications by serial enrichment

    Philipp Mertins
    8 Jun 2013 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2518 Authors: Philipp Mertins, Jana W Qiao, Jinal Patel, Namrata D Udeshi, Karl R Clauser, D R Mani, Michael W Burgess, Michael A Gillette, Jacob D Jaffe & Steven A Carr We report a mass spectrometry–based method for the integrated analysis of protein expression, phosphorylation, ubiquitination and acetylation by serial enrichments of different post-translational modifications (SEPTM) from the same biological sample. This technology enabled quantitative analysis of nearly 8,000 proteins and more than 20,000 phosphorylation, 15,000 ubiquitination and…
 
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    Nature Nanotechnology - Issue - nature.com science feeds

  • Thermal transport: Naturally glassy crystals

    Austin J. Minnich
    4 Jun 2013 | 5:00 pm
    Nature Nanotechnology 8, 392 (2013). doi:10.1038/nnano.2013.106 Author: Austin J. Minnich Spontaneously formed natural nanostructures are responsible for a glass-like thermal conductivity in a perfectly crystalline semiconductor.

  • Single-molecule junctions beyond electronic transport

    Sriharsha V. Aradhya
    4 Jun 2013 | 5:00 pm
    Nature Nanotechnology 8, 399 (2013). doi:10.1038/nnano.2013.91 Authors: Sriharsha V. Aradhya & Latha Venkataraman

  • A brief history of molecular electronics

    Mark Ratner
    4 Jun 2013 | 5:00 pm
    Nature Nanotechnology 8, 378 (2013). doi:10.1038/nnano.2013.110 Author: Mark Ratner The field of molecular electronics has been around for more than 40 years, but only recently have some fundamental problems been overcome. It is now time for researchers to move beyond simple descriptions of charge transport and explore the numerous intrinsic features of molecules.

  • Quantum dots: And then there were three

    David J. Reilly
    4 Jun 2013 | 5:00 pm
    Nature Nanotechnology 8, 395 (2013). doi:10.1038/nnano.2013.103 Author: David J. Reilly Experiments with triple quantum dot devices show that distant qubits can be directly coupled and suggest a potential route to the development of fast, complex quantum circuits.

  • Wiring molecules into circuits

    Emanuel Lörtscher
    4 Jun 2013 | 5:00 pm
    Nature Nanotechnology 8, 381 (2013). doi:10.1038/nnano.2013.105 Author: Emanuel Lörtscher Inexpensive, functional and atomically precise molecules could be the basis of future electronic devices, but integrating them into circuits will require the development of new ways to control the interface between molecules and electrodes.
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    Nature Neuroscience - Issue - nature.com science feeds

  • Learning to deal with life's ups and downs

    Mitra Heshmati
    27 May 2013 | 5:00 pm
    Nature Neuroscience 16, 658 (2013). doi:10.1038/nn.3400 Authors: Mitra Heshmati & Scott J Russo A study shows that circadian glucocorticoid oscillations have dual roles in dendritic spine plasticity, controlling spine formation and elimination through distinct mechanisms important for motor learning.

  • Sneaky politics

    27 May 2013 | 5:00 pm
    Nature Neuroscience 16, 655 (2013). doi:10.1038/nn.3421 Scientists need to mobilize to combat changing tactics by animal rights activists.

  • Ganglionic eminence graft pre-eminence in epilepsy

    Jack M Parent
    27 May 2013 | 5:00 pm
    Nature Neuroscience 16, 656 (2013). doi:10.1038/nn.3406 Authors: Jack M Parent & Geoffrey G Murphy Intrahippocampal transplantation of inhibitory interneuron progenitors derived from the medial ganglionic eminence markedly ameliorates the seizure activity and neurobehavioral deficits typically observed in the pilocarpine mouse model of mesial temporal lobe epilepsy, even if the cells are engrafted after the onset of spontaneous seizures.

  • The uncertainty of it all

    Adam Kepecs
    27 May 2013 | 5:00 pm
    Nature Neuroscience 16, 660 (2013). doi:10.1038/nn.3416 Author: Adam Kepecs Two studies in this issue report the discovery of different types of uncertainty signals in little-studied, but critical, regions of the forebrain: decision confidence in the pulvinar and reward risk in the anterodorsal septum.

  • Fixate and stabilize: shall the twain meet?

    Guillaume S Masson
    27 May 2013 | 5:00 pm
    Nature Neuroscience 16, 663 (2013). doi:10.1038/nn.3411 Authors: Guillaume S Masson & Laurent Goffart A study reports that fixation and optomotor responses in Drosophila rely on parallel neural processing of position and motion information, but interact at the behavioral level.
 
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    Nature Physics - Issue - nature.com science feeds

  • Shear drop

    May Chiao
    2 Jun 2013 | 5:00 pm
    Nature Physics 9, 320 (2013). doi:10.1038/nphys2657 Author: May Chiao

  • Organic materials: Graphene gets molecules into order

    Friedrich Reinert
    2 Jun 2013 | 5:00 pm
    Nature Physics 9, 321 (2013). doi:10.1038/nphys2643 Author: Friedrich Reinert Small metal-free organic molecules on an epitaxial graphene monolayer are shown to receive a local magnetic moment from the substrate. This magnetic moment survives when many molecules combine to form a layer, with some indication of long-range ferromagnetic order.

  • What has econophysics ever done for us?

    Mark Buchanan
    2 Jun 2013 | 5:00 pm
    Nature Physics 9, 317 (2013). doi:10.1038/nphys2648 Author: Mark Buchanan

  • Camera insecta obscura

    David Gevaux
    2 Jun 2013 | 5:00 pm
    Nature Physics 9, 320 (2013). doi:10.1038/nphys2659 Author: David Gevaux

  • Correction

    2 Jun 2013 | 5:00 pm
    Nature Physics 9, 317 (2013). doi:10.1038/nphys2651
 
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    Nature Physics - AOP - nature.com science feeds

  • A sudden collapse in the transport lifetime across the topological phase transition in (Bi1−xInx)2Se3

    Liang Wu
    15 Jun 2013 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2647 Authors: Liang Wu, M. Brahlek, R. Valdés Aguilar, A. V. Stier, C. M. Morris, Y. Lubashevsky, L. S. Bilbro, N. Bansal, S. Oh & N. P. Armitage Topological insulators are newly discovered states of matter with robust metallic surface states protected by the topological properties of the bulk wavefunctions. A quantum phase transition from a topological insulator to a conventional insulator and a change in topological class can occur only when the bulk bandgap closes. In this work, we have used time-domain terahertz spectroscopy to investigate the…

  • Fractional spinon excitations in the quantum Heisenberg antiferromagnetic chain

    Martin Mourigal
    15 Jun 2013 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2652 Authors: Martin Mourigal, Mechthild Enderle, Axel Klöpperpieper, Jean-Sébastien Caux, Anne Stunault & Henrik M. Rønnow

  • Neutron stars: A taste of pasta?

    William G. Newton
    8 Jun 2013 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2663 Author: William G. Newton Comparing quantitative calculations of the magnetic field decay of neutron stars and their corresponding spin evolution with observations suggests a high degree of disorder in the inner crust, which might provide evidence for nuclear 'pasta'.

  • Charge-cluster glass in an organic conductor

    F. Kagawa
    8 Jun 2013 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2642 Authors: F. Kagawa, T. Sato, K. Miyagawa, K. Kanoda, Y. Tokura, K. Kobayashi, R. Kumai & Y. Murakami Geometrically frustrated spin systems often do not exhibit long-range magnetic ordering, resulting in either quantum-mechanically disordered states, such as quantum spin liquids, or classically disordered states, such as spin ices or spin glasses. Geometric frustration may play a similar role in charge ordering, potentially leading to unconventional electronic states without long-range order; however, there are no previous experimental demonstrations…

  • A highly resistive layer within the crust of X-ray pulsars limits their spin periods

    José A. Pons
    8 Jun 2013 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2640 Authors: José A. Pons, Daniele Viganò & Nanda Rea
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Apoptosis: Direct action

    Nicola McCarthy
    23 May 2013 | 5:00 pm
    Nature Reviews Cancer 13, 379 (2013). doi:10.1038/nrc3544 Author: Nicola McCarthy RB1, the gene that encodes the retinoblastoma tumour suppressor protein (RB), is mutated in one-third of human cancers. Although widely appreciated as a transcriptional coregulator, Jacqueline Lees and colleagues have found that RB also functions outside of the nucleus at the mitochondrial membrane. Recombinant

  • Cancer genomics: Coming in waves

    Sarah Seton-Rogers
    23 May 2013 | 5:00 pm
    Nature Reviews Cancer 13, 379 (2013). doi:10.1038/nrc3541 Author: Sarah Seton-Rogers Genome sequencing of 57 prostate tumours has revealed the frequent occurrence of complex, chained genomic rearrangements (termed 'chromoplexy') that result in deletions or rearrangements of cancer genes. Furthermore, prostate cancers may undergo multiple rounds of chromoplexy throughout tumour evolution.

  • Not as sunny as advertised

    Nicola McCarthy
    23 May 2013 | 5:00 pm
    Nature Reviews Cancer 13, 378 (2013). doi:10.1038/nrc3540 Author: Nicola McCarthy Several recent reports in the popular press have indicated that the benefits of exposure to sunlight might outweigh the risks of developing skin cancer.

  • Epigenetics: Histone modification

    Nicola McCarthy
    23 May 2013 | 5:00 pm
    Nature Reviews Cancer 13, 379 (2013). doi:10.1038/nrc3542 Author: Nicola McCarthy This paper is one of several recent publications to examine the mechanisms through which mutations of genes that encode histone 3 (H3) variants contribute to glioma development in young children, including in those with diffuse intrinsic pontine glioma (DIPG). A mutation in H3F3A that

  • Tumour suppressors: Restoring function

    Nicola McCarthy
    23 May 2013 | 5:00 pm
    Nature Reviews Cancer 13, 379 (2013). doi:10.1038/nrc3543 Author: Nicola McCarthy A high proportion of malignant melanomas express wild-type p53 that is often inactive. Xin Lu and colleagues have found that most malignant melanoma cell lines with wild-type p53 have high levels of phosphorylated iASPP in the nucleus. iASPP interacts with p53 and inhibits apoptosis, and
 
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • Anticancer drugs: Blocking RAS effects

    Darren J. Burgess
    30 May 2013 | 5:00 pm
    Nature Reviews Drug Discovery 12, 422 (2013). doi:10.1038/nrd4033 Author: Darren J. Burgess Owing to their driver status in many cancers, members of the RAS family of oncoproteins have been strongly pursued as drug targets. However, inhibitors of proteins that farnesylate RAS proteins have shown limited clinical efficacy, hence alternative routes to RAS inhibition are required. A recent

  • Menelas Pangalos

    AsherMullard
    30 May 2013 | 5:00 pm
    Nature Reviews Drug Discovery 12, 418 (2013). doi:10.1038/nrd4044 Author: Asher Mullard AstraZeneca, along with many of its big pharma peers, has struggled to deliver new drugs in recent years. In the hopes of turning the company around, its Chief Executive Officer Pascal Soriot recently shuffled the scientific management and promoted Menelas Pangalos to head up the discovery and early-stage development of small molecules. Pangalos has been with AstraZeneca since 2010 and has previously worked at Pfizer as head of neuroscience research and development (R&D), as well as at Wyeth and…

  • LifeTrain: towards a European framework for continuing professional development in biomedical sciences

    Mike Hardman
    30 May 2013 | 5:00 pm
    Nature Reviews Drug Discovery 12, 407 (2013). doi:10.1038/nrd4026 Authors: Mike Hardman, Cath Brooksbank, Claire Johnson, Christa Janko, Wolf See, Pierre Lafolie, Heinrich Klech, Patrice Verpillat & Hans Lindén Successful biomedical scientists learn throughout their careers. The LifeTrain project aims to optimize investments in learning to support the development of medicines in Europe and to encourage stronger interactions between industry and academia.

  • Trial watch: Opioid receptor blocker shows promise in Phase II depression trial

    Charlotte Harrison
    30 May 2013 | 5:00 pm
    Nature Reviews Drug Discovery 12, 415 (2013). doi:10.1038/nrd4028 Author: Charlotte Harrison Preliminary results from a Phase II trial of Alkermes's ALKS 5461, a therapeutic that acts as a κ-opioid receptor antagonist, indicate that it improves symptoms in patients with major depressive disorder who do not respond to current therapies.Current antidepressants — selective serotonin reuptake inhibitors,

  • All-oral HCV therapies near approval

    Man Tsuey Tse
    30 May 2013 | 5:00 pm
    Nature Reviews Drug Discovery 12, 409 (2013). doi:10.1038/nrd4036 Author: Man Tsuey Tse Gilead has filed the first interferon-free hepatitis C virus regimen for approval in the United States, but drug developers are making strides with better combinations.
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    Nature Reviews Drug Discovery - AOP - nature.com science feeds

  • David Haslam

    MullardAsher
    13 Jun 2013 | 5:00 pm
    Nature Reviews Drug Discovery. doi:10.1038/nrd4053 Author: Mullard Asher When the UK's National Institute for Clinical Excellence (NICE) was launched on April Fools' Day in 1999, some of its architects had doubts it would survive. Fourteen years on NICE is going strong, providing treatment guidance and drug cost–benefit analyses. Because many markets use UK drug pricing as a reference point, NICE's decisions also have a footprint far beyond the country. Now, the rebranded National Institute for Health and Care Excellence has its first new Chairman. David Haslam, a family doctor who was…

  • New anti-inflammatory targets for chronic obstructive pulmonary disease

    Peter J. Barnes
    13 Jun 2013 | 5:00 pm
    Nature Reviews Drug Discovery. doi:10.1038/nrd4025 Author: Peter J. Barnes
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Immunology of age-related macular degeneration

    Jayakrishna Ambati
    23 May 2013 | 5:00 pm
    Nature Reviews Immunology 13, 438 (2013). doi:10.1038/nri3459 Authors: Jayakrishna Ambati, John P. Atkinson & Bradley D. Gelfand Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD

  • Macrophages: Metabolites mangle microbes

    Yvonne Bordon
    23 May 2013 | 5:00 pm
    Nature Reviews Immunology 13, 393 (2013). doi:10.1038/nri3475 Author: Yvonne Bordon Macrophages express high levels of immunoresponsive gene 1 (IRG1) under inflammatory conditions but the function of this gene has been unknown. This study now identifies IRG1 as an enzyme that catalyses the production of itaconic acid by decarboxylating the Krebs cycle intermediate cis-aconitate.

  • Activation and regulation of the inflammasomes

    Eicke Latz
    23 May 2013 | 5:00 pm
    Nature Reviews Immunology 13, 397 (2013). doi:10.1038/nri3452 Authors: Eicke Latz, T. Sam Xiao & Andrea Stutz Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the

  • Mast cells: Distal signalling in mast cell degranulation

    Maria Papatriantafyllou
    23 May 2013 | 5:00 pm
    Nature Reviews Immunology 13, 393 (2013). doi:10.1038/nri3473 Author: Maria Papatriantafyllou Ligation of the high-affinity Fc receptor for IgE (FcɛRI) promotes mast cell activation. Now, a role for a truncated splice variant of the FcɛRI β-subunit (tFcɛRIβ) in mast cell degranulation has been identified. Findings by Cruse et al. suggest that full-length FcɛRIβ might inhibit

  • Technique: A genetically encoded T cell calcium indicator

    Kirsty Minton
    23 May 2013 | 5:00 pm
    Nature Reviews Immunology 13, 393 (2013). doi:10.1038/nri3474 Author: Kirsty Minton For the first time, the genetically encoded calcium indicator TN-XXL has been used for in vivo imaging of T cell activation. As TN-XXL is self-replenishing, it should enable longer-term in vivo work to be carried out than the synthetic calcium indicator dyes that
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Bacterial genomics: Learning about rare bacteria

    Rachel David
    13 Jun 2013 | 5:00 pm
    Nature Reviews Microbiology 11, 431 (2013). doi:10.1038/nrmicro3062 Author: Rachel David A key limitation in our understanding of microbial ecology and evolution is the fact that a large proportion of microorganisms remains unculturable. One method used to bypass this bottleneck is metagenomics — shotgun sequencing of DNA directly extracted from environmental samples — followed by genome

  • An arms race with H7N9

    Ursula Hofer
    13 Jun 2013 | 5:00 pm
    Nature Reviews Microbiology 11, 430 (2013). doi:10.1038/nrmicro3059 Author: Ursula Hofer The first cases of drug-resistant H7N9 influenza virus infection were recently reported in a hospital in Shanghai, China. Isolates were obtained from three patients who failed to clear the infection after antiviral treatment, and genetic testing revealed that the viruses carried a neuraminidase mutation that

  • A prime example for an HIV vaccine

    Ursula Hofer
    13 Jun 2013 | 5:00 pm
    Nature Reviews Microbiology 11, 430 (2013). doi:10.1038/nrmicro3057 Author: Ursula Hofer HIV vaccines have had limited success in human trials, and protective CD8+ T cell responses are rarely observed. In a previous vaccine trial for simian immunodeficiency virus (SIV), SIV protein-expressing rhesus cytomegalovirus strain 68-1 vectors proved successful for the generation and maintenance of

  • Coronavirus controversy

    Ursula Hofer
    13 Jun 2013 | 5:00 pm
    Nature Reviews Microbiology 11, 430 (2013). doi:10.1038/nrmicro3058 Author: Ursula Hofer The novel coronavirus, Middle East respiratory syndrome coronavirus (MERS-CoV), continues to cause new infections, with the report of the first death in France and a new hospital cluster in Saudi Arabia. The viral reservoir of infection is unknown, but human-to-human transmission is suspected to occur.

  • It's microbiology, citizens

    13 Jun 2013 | 5:00 pm
    Nature Reviews Microbiology 11, 427 (2013). doi:10.1038/nrmicro3065 The rise of the 'citizen science' movement in microbiology provides an opportunity for public engagement and the chance to gather essential data on a large scale.
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Heterogeneity of sister cell fates

    Timm Schroeder
    22 May 2013 | 5:00 pm
    Nature Reviews Molecular Cell Biology 14, 327 (2013). doi:10.1038/nrm3594 Author: Timm Schroeder Multipotent stem and progenitor cells are heterogeneous in lineage choice and timing of commitment to differentiation.

  • Organization of the ER–Golgi interface for membrane traffic control

    Federica Brandizzi
    22 May 2013 | 5:00 pm
    Nature Reviews Molecular Cell Biology 14, 382 (2013). doi:10.1038/nrm3588 Authors: Federica Brandizzi & Charles Barlowe Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries and other transport factors are highly conserved across species, high-resolution imaging studies indicate that the organization of the ER–Golgi

  • DNA repair: A histone signal for mismatch repair

    Rachel David
    22 May 2013 | 5:00 pm
    Nature Reviews Molecular Cell Biology 14, 328 (2013). doi:10.1038/nrm3596 Author: Rachel David Errors that arise during DNA replication are corrected by the mismatch repair pathway (MMR), which detects base–base mismatches and insertion–deletion loops primarily via MutSα (comprising MutS homologue 2 (MSH2) and MSH6). Previous work had indicated that additional factors to the core MMR machinery, such as

  • Tying replication to cell identity

    Dieter Egli
    22 May 2013 | 5:00 pm
    Nature Reviews Molecular Cell Biology 14, 326 (2013). doi:10.1038/nrm3593 Authors: Dieter Egli & Gloryn Chia Le Bin The timing of DNA replication might have a role in establishing cell identity during development.

  • RNA: DIS3L2, the final player in let-7 degradation

    Rachel David
    22 May 2013 | 5:00 pm
    Nature Reviews Molecular Cell Biology 14, 328 (2013). doi:10.1038/nrm3595 Author: Rachel David The pluripotency factor LIN28 maintains stem cells in an undifferentiated state by blocking the expression of let-7 microRNAs (miRNAs). LIN28 achieves this by recruiting 3′ terminal uridylyl transferases, which add a terminal oligouridine tail to pre-let-7 that inhibits its processing and promotes miRNA decay. This
 
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    Nature Reviews Cardiology - Issue - nature.com science feeds

  • The importance of the endothelium in atherothrombosis and coronary stenting

    Fumiyuki Otsuka
    22 May 2013 | 5:00 pm
    Nature Reviews Cardiology 10, 300 (2013). doi:10.1038/nrcardio.2013.58 Author: Fumiyuki Otsuka, Aloke V. Finn, Saami K. Yazdani, Masataka Nakano, Frank D. Kolodgie & Renu Virmani Nat. Rev. Cardiol.9, 439–453 (2012); doi:10.1038/nrcardio.2012.64In the version of this article originally published online and in print, the following sentence should have been included in the Figure 3 legend: Parts c, e, and h were previously

  • Surgery: Translating trials to clinical practice in cardiac surgery

    John H. Alexander
    6 May 2013 | 5:00 pm
    Nature Reviews Cardiology 10, 306 (2013). doi:10.1038/nrcardio.2013.67 Authors: John H. Alexander & Eric D. Peterson Three randomized clinical trials have added data to the debate about whether off-pump CABG surgery has any advantages over the on-pump approach. A growing consensus is emerging; however, understanding the conflicting results of these trials, and how they might apply to clinical practice, requires careful attention to trial design.

  • Prevention: Low adoption of healthy lifestyles

    Alexandra King
    6 May 2013 | 5:00 pm
    Nature Reviews Cardiology 10, 299 (2013). doi:10.1038/nrcardio.2013.71 Author: Alexandra King Less than 5% of patients who have experienced a cardiovascular event subsequently adopt three healthy lifestyle behaviours (smoking cessation, physical acitivy, healthy diet), according to data from the PURE study. This investigation, the first of its kind to be undertaken on such a wide scale,

  • Interventional cardiology: PCI without surgical backup—evidence-based, but wise?

    Thomas M. Maddox
    6 May 2013 | 5:00 pm
    Nature Reviews Cardiology 10, 301 (2013). doi:10.1038/nrcardio.2013.68 Authors: Thomas M. Maddox & John S. Rumsfeld The results of MASS COMM support the safety of performing percutaneous coronary intervention at centres without on-site cardiothoracic surgery services. To translate these findings into clinical practice, robust quality oversight programmes, with direct measurement of procedural outcomes and complications, are needed. The VA CART programme provides a model for such a strategy.

  • Age-independent telomere shortening and ion-channel defects in SCD

    Birendranath Banerjee
    29 Apr 2013 | 5:00 pm
    Nature Reviews Cardiology 10, 362 (2013). doi:10.1038/nrcardio.2013.30-c1 Authors: Birendranath Banerjee & M. Prakash Hande In the Review article by Fyhrquist et al. (The roles of senescence and telomere shortening in cardiovascular disease. Nat. Rev. Cardiol.doi:10.1038/nrcardio.2013.30), the authors extensively appraise the role in cardiovascular diseases of telomere length homeostasis in response to senescence, oxidative stress,
 
 
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    Nature Reviews Neurology - Issue - nature.com science feeds

  • Stroke: Could PTEN nuclear translocation be a target for therapy after stroke?

    27 May 2013 | 5:00 pm
    Nature Reviews Neurology 9, 299 (2013). doi:10.1038/nrneurol.2013.102 Nuclear translocation of the phosphatase PTEN increases the susceptibility of neurons to excitotoxic and ischaemic injury, new research reveals. Zhang et al. found that excitotoxic stimulation of cultured neurons caused PTEN to accumulate in the nucleus. In a rat model of stroke, a

  • Movement disorders: SCA37—a new subtype of spinocerebellar ataxia

    27 May 2013 | 5:00 pm
    Nature Reviews Neurology 9, 299 (2013). doi:10.1038/nrneurol.2013.101 A distinct spinocerebellar ataxia (SCA) phenotype that includes impaired vertical eye movements has recently been identified in a family from Spain. This new SCA subtype, designated SCA37 by the Human Genome Nomenclature Committee, maps to an 11-Mb region of chromosome 1p32. The altered eye movements

  • Sleep: Obstructive sleep apnoea raises the risk of cerebral white matter change

    27 May 2013 | 5:00 pm
    Nature Reviews Neurology 9, 299 (2013). doi:10.1038/nrneurol.2013.100 Research from Korea indicates that obstructive sleep apnoea (OSA) is a risk factor for cerebral white matter change (WMC) in middle-aged and older populations. Among 503 individuals with an average age of 59.63 years, moderate to severe OSA increased the odds of cerebral WMC approximately

  • Dementia: A link between microbial infection and cognition?

    Walter Swardfager
    27 May 2013 | 5:00 pm
    Nature Reviews Neurology 9, 301 (2013). doi:10.1038/nrneurol.2013.93 Authors: Walter Swardfager & Sandra E. Black A recent study of a large multi-ethnic cohort has shown that cumulative serum titres of antibodies against five common microbial pathogens are associated with an increased risk of cognitive impairment. Further studies are needed to better understand this risk and enable translation of the findings into effective preventative strategies.

  • Multiple sclerosis: On the TRAIL of IFN-β response

    27 May 2013 | 5:00 pm
    Nature Reviews Neurology 9, 299 (2013). doi:10.1038/nrneurol.2013.99 A single nucleotide polymorphism (SNP) in the TRAILR-1 gene is associated with the clinical response to IFN-β therapy in patients with multiple sclerosis (MS), according to a study conducted in a Spanish cohort. TRAILR-1 encodes a receptor for TRAIL, a proapoptotic cytokine that
 
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    Naturejobs - Search results

  • GFS Strategy & Policy Manager

    17 Jun 2013 | 9:02 am
    Global Food Security: Strategy & Policy Manager The Global Food Security (GFS) programme aims to help meet the challenge of providing the world’s growing population with a sustainable and secure supply of safe, nutritious and affordable food. Our vision is to raise the profile of the food security challenge and provide leadership in this area. We aim to inform, influence and shape the research and policy landscape around global food security, identifying and responding to current and …

  • GFS Strategy & Policy Officer

    17 Jun 2013 | 8:56 am
    Global Food Security: Strategy & Policy Officer The Global Food Security (GFS) programme aims to help meet the challenge of providing the world’s growing population with a sustainable and secure supply of safe, nutritious and affordable food. Our vision is to raise the profile of the food security challenge and provide leadership in this area. We aim to inform, influence and shape the research and policy landscape around global food security, identifying and responding to current and f…

  • Clinical Development Physician

    17 Jun 2013 | 8:02 am
    Leading the Clinical Development Strategy for a large maternal global immunisation program, this is an integral position within the company’s vaccines franchises. In this role you will: • Be the medical lead in strategising the clinical development of one of a number of programs related to pediatric infectious diseases • Coordinate a matrix team of clinical colleagues to author all clinical documents and address medical and scientific issues related to the projects within the assigne…

  • PhD Position in Zebrafish Development

    17 Jun 2013 | 7:43 am
    The Developmental Biology group at the University of Bayreuth, Germany, is looking for aPhD student in Zebrafish Development We welcome applications from highly motivated students who wish to join our group and contribute to our ongoing research on limb development and regeneration in the zebrafish. The aim of the project is to examine the molecular and genetic differences between the development of the fore- and hindlimbs in a genetically accessible system, the zebrafish. This will be ac…

  • Scientific Programmer

    17 Jun 2013 | 7:34 am
    Closing Date of vacancy: 18 July 2013 Division: Breakthrough Breast Cancer Research Unit, King’s College London Type of Contract: Fixed Term Length of Contract: 2 years Salary Range: £31,331 – £37,382 per annum plus £2323 London Allowance per annum Work Location: Guy’s Hospital Campus Hours per week: 35 hours per week The Breakthrough Breast Cancer Research Unit sits within the section of Research Oncology in the Division of Cancer Studies at the Guy’s Hospital Campus o…
 
 
 
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    British Journal of Pharmacology

  • Impact of biological sex on the pathophysiology of the heart

    Loubina Fazal, Feriel Azibani, Nicolas Vodovar, Alain Cohen Solal, Claude Delcayre, Jane-Lise Samuel
    14 Jun 2013 | 4:12 am
    Abstract The cardiovascular diseases are the leading causes of death in men and women in industrialised countries. While the impact of biological sex on cardiovascular pathophysiology has long been known, the sex-specific mechanisms mediating these processes have progressed during the last years. This review aims at analysing the sex-based differences in cardiac structure and function in adult mammals, and the sex-based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex-based difference is a…

  • Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition

    Mara Ferrandi, Paolo Barassi, Francesco Tadini-Buoninsegni, Gianluca Bartolommei, Isabella Molinari, Maria Grazia Tripodi, Cristina Reina, Maria Rosa Moncelli, Giuseppe Bianchi, Patrizia Ferrari
    13 Jun 2013 | 9:55 pm
    Summary Background and purposeCalcium handling is known to be deranged in heart failure. Interventions aimed at improving cell Ca2+ cycling may represent a promising approach to heart failure therapy. Istaroxime is a new luso-inotropic compound that stimulates cardiac contractility and relaxation in healthy and failing animal models and in patients with acute heart failure (AHF) syndrome. Istaroxime is a Na-K ATPase inhibitor with the unique property of increasing sarcoplasmic reticulum (SR) SERCA2a activity as shown in heart microsomes from humans and guinea pigs. The present study addressed…

  • Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental amyotrophic lateral sclerosis models

    Takata M, Tanaka H, Kimura M, Nagahara Y, Tanaka K, Kawasaki K, Seto M, Tsuruma K, Shimazawa M, Hara H
    13 Jun 2013 | 9:55 pm
    Background and purposeAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with no effective treatments. Fasudil hydrochloride (fasudil), a potent rho kinase (ROCK) inhibitor, is useful for the treatment of ischemic diseases. In previous report, fasudil improved pathology in mouse models of Alzheimer's disease and spinal muscular atrophy, but there is no evidence in ALS. We therefore investigated its effects on experimental ALS models. Experimental approachIn NSC34 cells, the neuroprotective effect of hydroxyfasudil (M3), an active metabolite of fasudil, and its mechanism…

  • Opposite effects of genistein on regulation of insulin-mediated glucose homeostasis in adipose tissue

    M Wang, XJ Gao, WW Zhao, WJ Zhao, S Jiang, F Huang, JP Kou, BL Liu, K Liu
    13 Jun 2013 | 9:54 pm
    Background And PurposeThis study aims to evaluate the effect of genistein on glucose homeostasis and underlying mechanisms under normal and insulin resistant conditions. Experimental ApproachTo induced insulin resistance, mice or differentiated 3T3-L1 adipocytes were treated with macrophage-derived conditioned medium. Glucose tolerance test was used to investigate the effect of genistein. Insulin signaling activation, glucose transporter-4 (GLUT4) translocation and AMP-activated protein kinase (AMPK) activation were detected by Western blot analysis or ELISA method. Key ResultsGenistein…

  • Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase

    Barbara Lies, Dieter Groneberg, Stepan Gambaryan, Andreas Friebe
    13 Jun 2013 | 9:54 pm
    Summary Background and purposeNitric oxide (NO) is known to activate NO-sensitive guanylyl cyclase (NO-GC) and to elicit cGMP production. However, NO has also been proposed to induce cGMP-independent effects. It is accepted practice to use specific NO-GC inhibitors, such as ODQ or NS2028, to assess cGMP-dependent NO effects. Consequently, NO-induced reactions seen in the presence of these inhibitors commonly serve as an affirmation of cGMP independence. Experimental approachWe evaluated the use of ODQ to discriminate between cGMP-dependent and cGMP-independent NO effects. NO-GC-expressing HEK…
 
 
 
 
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    EMBO reports - Issue - nature.com science feeds

  • Howyland

    Howy Jacobs
    2 Jun 2013 | 5:00 pm
    EMBO Reports 14, 481 (2013). doi:10.1038/embor.2013.57 Author: Howy Jacobs In the world of academic science, an enormous amount of time and money is wasted on the compilation, evaluation and administration of research grants. An even greater waste is that of scientists who fail to get onto the funding ladder in the first place, or

  • MicroRNA and autophagy—C. elegans joins the crew

    Olivier Voinnet
    16 May 2013 | 5:00 pm
    EMBO Reports 14, 485 (2013). doi:10.1038/embor.2013.65 Author: Olivier Voinnet C. elegans

  • Homo artefaciens

    Ladislav Kováč
    16 May 2013 | 5:00 pm
    EMBO Reports 14, 482 (2013). doi:10.1038/embor.2013.66 Author: Ladislav Kováč It has been fashionable to regard science as an ‘unending quest’, which involves the formulation of a hypothesis, its submission to empirical testing and, if ‘falsified’, its replacement with a new one and repetition of the procedure [1]. This doctrine of the “logic

  • One world, one health

    Paul D van Helden
    16 May 2013 | 5:00 pm
    EMBO Reports 14, 497 (2013). doi:10.1038/embor.2013.61 Authors: Paul D van Helden, Lesley S van Helden & Eileen G Hoal The notion that humans, animals and the environment are tightly linked and that their respective well-beings are interdependent has been recognized for centuries. However, the sophistication of these interactions has only begun to be revealed. Even by the late nineteenth century, it was established knowledge

  • Your decisions are what you eat

    Philip Hunter
    16 May 2013 | 5:00 pm
    EMBO Reports 14, 505 (2013). doi:10.1038/embor.2013.69 Author: Philip Hunter The old suspicion that wars are caused by a leader's indigestion does not seem so far-fetched in the light of accumulating evidence that our metabolic state can influence rational decision-making and our approach to risk. For decades, scientists have demonstrated links between the availability and
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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    Neuropsychopharmacology - Issue - nature.com science feeds

  • Treatment for Tobacco Dependence: Effect on Brain Nicotinic Acetylcholine Receptor Density

    Arthur L Brody
    12 Jun 2013 | 5:00 pm
    Treatment for Tobacco Dependence: Effect on Brain Nicotinic Acetylcholine Receptor Density Neuropsychopharmacology 38, 1548 (July 2013). doi:10.1038/npp.2013.53 Authors: Arthur L Brody, Alexey G Mukhin, Stephanie Shulenberger, Michael S Mamoun, Maggie Kozman, Jonathan Phuong, Meaghan Neary, Trinh Luu & Mark A Mandelkern Keywords: Addiction & Substance Abuse; Biological Psychiatry; Bupropion; Cognitive-Behavioral Therapy; Imaging; Clinical or Preclinical; Nicotine; Nicotinic Acetylcholine Receptor; Psychiatry & Behavioral Sciences; Tobacco Dependence

  • Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood

    Lin Suo
    12 Jun 2013 | 5:00 pm
    Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood Neuropsychopharmacology 38, 1387 (July 2013). doi:10.1038/npp.2013.67 Authors: Lin Suo, Liyan Zhao, Jijian Si, Jianfeng Liu, Weili Zhu, Baisheng Chai, Yan Zhang, Jiajia Feng, Zengbo Ding, Yixiao Luo, Haishui Shi, Jie Shi & Lin Lu Keywords: adolescence; behavioral science; depression; development/developmental disorders; molecular & cellular neurobiology; mood/anxiety/stress disorders; mTOR; predictable chronic mild stress; resilience

  • Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

    Yair J Ben-Efraim
    12 Jun 2013 | 5:00 pm
    Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts Neuropsychopharmacology 38, 1504 (July 2013). doi:10.1038/npp.2013.49 Authors: Yair J Ben-Efraim, Danuta Wasserman, Jerzy Wasserman & Marcus Sokolowski Keywords: neuroendocrinology; neuropharmacology; depression; unipolar/bipolar; epidemiology; suicidality; gene-environment interactions; depression; HPA axis; current depressive symptoms

  • Craving in Alcohol-Dependent Patients After Detoxification Is Related to Glutamatergic Dysfunction in the Nucleus Accumbens and the Anterior Cingulate Cortex

    Jochen Bauer
    12 Jun 2013 | 5:00 pm
    Craving in Alcohol-Dependent Patients After Detoxification Is Related to Glutamatergic Dysfunction in the Nucleus Accumbens and the Anterior Cingulate Cortex Neuropsychopharmacology 38, 1401 (July 2013). doi:10.1038/npp.2013.45 Authors: Jochen Bauer, Anya Pedersen, Norbert Scherbaum, Johanna Bening, Johanna Patschke, Harald Kugel, Walter Heindel, Volker Arolt & Patricia Ohrmann Keywords: alcohol & alcoholism; biological psychiatry; craving; glutamate; neurochemistry; nucleus accumbens; spectroscopy

  • Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity

    Ashlee Van't Veer
    12 Jun 2013 | 5:00 pm
    Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity Neuropsychopharmacology 38, 1585 (July 2013). doi:10.1038/npp.2013.58 Authors: Ashlee Van't Veer, Anita J Bechtholt, Sara Onvani, David Potter, Yujun Wang, Lee-Yuan Liu-Chen, Günther Schütz, Elena H Chartoff, Uwe Rudolph, Bruce M Cohen & William A Carlezon Keywords: animal models; cocaine; dopamine; kappa-opioid receptor; mice; mood/anxiety/stress disorders; mutation; opioids
 
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    Neuropsychopharmacology - AOP - nature.com science feeds

  • Cocaine-Induced Membrane Adaptation in the Central Nucleus of Amygdala

    Bo Chen
    11 Jun 2013 | 5:00 pm
    Cocaine-Induced Membrane Adaptation in the Central Nucleus of Amygdala Neuropsychopharmacology advance online publication, June 12 2013. doi:10.1038/npp.2013.124 Authors: Bo Chen, Yao-Ying Ma, Yao Wang, Xiusong Wang, Oliver M Schlüter, Yan Dong & Yanhua H Huang Keywords: addiction & substance abuse; amygdala; central nucleus; CRF; depression; unipolar / bipolar; low-threshold bursting; membrane excitability; neurophysiology; psychostimulants; regular spiking

  • Hippocampal Network Connectivity and Activation Differentiates Post-Traumatic Stress Disorder From Generalized Anxiety Disorder

    Ashley C Chen
    11 Jun 2013 | 5:00 pm
    Hippocampal Network Connectivity and Activation Differentiates Post-Traumatic Stress Disorder From Generalized Anxiety Disorder Neuropsychopharmacology advance online publication, June 12 2013. doi:10.1038/npp.2013.122 Authors: Ashley C Chen & Amit Etkin Keywords: anxiety; biological psychiatry; connectivity; default-mode network; hippocampus; imaging; clinical or preclinical; mood/anxiety/stress disorders; Neuroanatomy; PTSD; resting state

  • A Novel Translational Assay of Response Inhibition and Impulsivity: Effects of Prefrontal Cortex Lesions, Drugs Used in ADHD, and Serotonin 2C Receptor Antagonism

    Trevor Humby
    11 Jun 2013 | 5:00 pm
    A Novel Translational Assay of Response Inhibition and Impulsivity: Effects of Prefrontal Cortex Lesions, Drugs Used in ADHD, and Serotonin 2C Receptor Antagonism Neuropsychopharmacology advance online publication, June 12 2013. doi:10.1038/npp.2013.112 Authors: Trevor Humby, Jessica B Eddy, Mark A Good, Amy C Reichelt & Lawrence S Wilkinson Keywords: 5-HT2C receptor antagonism; ADHD; animal models; biological psychiatry; impulsivity; neuropharmacology; serotonin; stop-signal reaction time; translation

  • Neuroplasticity in Depressed Individuals Compared with Healthy Controls

    Michael J Player
    11 Jun 2013 | 5:00 pm
    Neuroplasticity in Depressed Individuals Compared with Healthy Controls Neuropsychopharmacology advance online publication, June 12 2013. doi:10.1038/npp.2013.126 Authors: Michael J Player, Janet L Taylor, Cynthia Shannon Weickert, Angelo Alonzo, Perminder Sachdev, Donel Martin, Philip B Mitchell & Colleen K Loo Keywords: Depression; Unipolar/Bipolar; Learning & Memory; major depressive disorder; motor cortex; Neurophysiology; neuroplasticity; paired associative stimulation; Plasticity; transcranial magnetic stimulation

  • Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter

    Anat Maoz
    11 Jun 2013 | 5:00 pm
    Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter Neuropsychopharmacology advance online publication, June 12 2013. doi:10.1038/npp.2013.114 Authors: Anat Maoz, Martin J Hicks, Shankar Vallabhjosula, Michael Synan, Paresh J Kothari, Jonathan P Dyke, Douglas J Ballon, Stephen M Kaminsky, Bishnu P De, Jonathan B Rosenberg, Diana Martinez, George F Koob, Kim D Janda & Ronald G Crystal Keywords: animal models; behavioral science; cocaine vaccine; imaging; clinical or preclinical; neuropharmacology
 
 
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    Cell Migration Gateway - Update - nature.com science feeds

  • With the flick of a switch…

    Nikki Watson
    31 May 2013 | 5:00 pm
    With the flick of a switch… Cell Migration Gateway (2013). http://www.cellmigration.org/cmcnews/cmcnews13.shtml#jun13a Author: Nikki Watson Dagliyan et al. have overcome the challenges of designing a broadly applicable artificial regulatory domain to create a single chain protein, uniRapR, that can be regulated by a small molecule, offering the potential for precise, specific and temporal control of signalling molecules. Only in the presence of rapamycin does subdomain-A, containing a modified version of FK506-binding protein 12 (FKBP12), interact with subdomain-B, which includes the…

  • ILK stability promotes motility

    Katrin Legg
    31 May 2013 | 5:00 pm
    ILK stability promotes motility Cell Migration Gateway (2013). http://www.cellmigration.org/cmg_update/2013/130601/full/cmg180.shtml Author: Katrin Legg The presence of the Hsp90 chaperone stabilizes integrin-linked kinase to establish and maintain the integrin–actin linkage, thereby facilitating cell migration.

  • Collagen-induced SNAIL1 stabilization sustains the pace of invasion

    Katrin Legg
    31 May 2013 | 5:00 pm
    Collagen-induced SNAIL1 stabilization sustains the pace of invasion Cell Migration Gateway (2013). http://www.cellmigration.org/cmg_update/2013/130601/full/cmg179.shtml Author: Katrin Legg Activation of the collagen receptor DDR2 and subsequent downstream signalling increases the stability of SNAIL1 to promote tumour cell invasion.

  • Other CMC Publications

    Nikki Watson
    31 May 2013 | 5:00 pm
    Other CMC Publications Cell Migration Gateway (2013). http://www.cellmigration.org/cmcnews/cmcnews13.shtml#jun13b Author: Nikki Watson Bravo-Cordero JJ, Sharma VP, Roh-Johnson M, Chen X, Eddy R, Condeelis J, Hodgson L. Spatial regulation of RhoC activity defines protrusion formation in migrating cells. J Cell Sci 2013; May 23. [Epub ahead of print] - Trepat X, Chen Z, Jacobson K. Cell Migration.Compr Physiol. 2012 Oct 1;2(4):2369-2392.
 
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