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  • Encoding and decoding in parietal cortex during sensorimotor decision-making

    Nature Neuroscience - AOP - nature.com science feeds
    Il Memming Park
    30 Aug 2014 | 5:00 pm
    Nature Neuroscience. doi:10.1038/nn.3800 Authors: Il Memming Park, Miriam L R Meister, Alexander C Huk & Jonathan W Pillow
  • Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer

    Nature Medicine - AOP - nature.com science feeds
    Christine M Lovly
    30 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3667 Authors: Christine M Lovly, Nerina T McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C Heukamp, Yingjun Yan, Alexandra Florin, Luka Ozretić, Diana Lim, Lu Wang, Zhao Chen, Xi Chen, Pengcheng Lu, Paul K Paik, Ronglai Shen, Hailing Jin, Reinhard Buettner, Sascha Ansén, Sven Perner, Michael Brockmann, Marc Bos, Jürgen Wolf, Masyar Gardizi, Gavin M Wright, Benjamin Solomon, Prudence A Russell, Toni-Maree Rogers, Yoshiyuki Suehara, Monica Red-Brewer, Rudy Tieu, Elisa de Stanchina, Qingguo Wang, Zhongming Zhao, David H Johnson, Leora Horn,…
  • Seven days: 22–28 August 2014

    Nature - Issue - nature.com science feeds
    26 Aug 2014 | 5:00 pm
    Seven days: 22–28 August 2014 Nature 512, 7515 (2014). http://www.nature.com/doifinder/10.1038/512352a The week in science: Botched launch for Europe’s GPS satellites; Iran’s science minister dismissed; and marmosets judged best model for MERS virus.
  • Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

    Nature Chemistry
    Shiyu Chen
    30 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2043 Authors: Shiyu Chen, Ranganath Gopalakrishnan, Tifany Schaer, Fabrice Marger, Ruud Hovius, Daniel Bertrand, Florence Pojer & Christian Heinis Disulfide bonds formed between two cysteine residues are important in the folding and stability of proteins. Now, unnatural amino acids with side-chains that contain two thiol groups are described. Incorporation of these dithiol amino acids into a serine protease inhibitor and a nicotinic acetyl choline receptor antagonist is shown to increase their inhibitory activity.
  • TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release

    Nature Structural & Molecular Biology - AOP - nature.com science feeds
    Heeyoun Bunch
    30 Aug 2014 | 5:00 pm
    Nature Structural & Molecular Biology. doi:10.1038/nsmb.2878 Authors: Heeyoun Bunch, Xiaofeng Zheng, Adam Burkholder, Simon T Dillon, Shmulik Motola, Gabriel Birrane, Christopher C Ebmeier, Stuart Levine, David Fargo, Guang Hu, Dylan J Taatjes & Stuart K Calderwood
 
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  • People power

    26 Aug 2014 | 5:00 pm
    People power Nature 512, 7515 (2014). doi:10.1038/512347b Climate models must consider how humans are responding to a warming world.
  • Bold moves

    Peter Fiske
    26 Aug 2014 | 5:00 pm
    Bold moves Nature 512, 7515 (2014). doi:10.1038/nj7515-457a Author: Peter Fiske People seeking non-academic jobs may need to try something unexpected to be noticed, says Peter Fiske.
  • Virology: Polio killed the vaccinated

    26 Aug 2014 | 5:00 pm
    Virology: Polio killed the vaccinated Nature 512, 7515 (2014). doi:10.1038/512351c The poliovirus strain that caused an outbreak in the Republic of the Congo in 2010 is able to resist the immune responses generated by a commonly used vaccine. The finding could explain why the outbreak, which killed nearly half of the 445 people infected, was
  • Marine ecology: Sick reefs repel young coral

    26 Aug 2014 | 5:00 pm
    Marine ecology: Sick reefs repel young coral Nature 512, 7515 (2014). doi:10.1038/512350a Coral larvae actively avoid the smell of degraded marine ecosystems — potentially impeding efforts to rebuild damaged reefs.Mark Hay at the Georgia Institute of Technology in Atlanta and his team studied coral reefs near Fiji (pictured). They focused on the behaviour of coral larvae
  • Seven days: 22–28 August 2014

    26 Aug 2014 | 5:00 pm
    Seven days: 22–28 August 2014 Nature 512, 7515 (2014). http://www.nature.com/doifinder/10.1038/512352a The week in science: Botched launch for Europe’s GPS satellites; Iran’s science minister dismissed; and marmosets judged best model for MERS virus.
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  • Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

    Gregory W. Goldberg
    30 Aug 2014 | 5:00 pm
    Nature advance online publication 31 August 2014. doi:10.1038/nature13637 Authors: Gregory W. Goldberg, Wenyan Jiang, David Bikard & Luciano A. Marraffini A fundamental feature of immune systems is the ability to distinguish pathogenic from self and commensal elements, and to attack the former but tolerate the latter. Prokaryotic CRISPR-Cas immune systems defend against phage infection by using Cas nucleases and small RNA guides that specify one or more target sites for cleavage of the viral genome. Temperate phages include viruses that can integrate into the bacterial chromosome, and…
  • Sensory-evoked LTP driven by dendritic plateau potentials in vivo

    Frédéric Gambino
    30 Aug 2014 | 5:00 pm
    Nature advance online publication 31 August 2014. doi:10.1038/nature13664 Authors: Frédéric Gambino, Stéphane Pagès, Vassilis Kehayas, Daniela Baptista, Roberta Tatti, Alan Carleton & Anthony Holtmaat Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites. However, local dendritic depolarization has been shown to mediate these…
  • High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

    Manon D. Schulz
    30 Aug 2014 | 5:00 pm
    Nature advance online publication 31 August 2014. doi:10.1038/nature13398 Authors: Manon D. Schulz, Çiğdem Atay, Jessica Heringer, Franziska K. Romrig, Sarah Schwitalla, Begüm Aydin, Paul K. Ziegler, Julia Varga, Wolfgang Reindl, Claudia Pommerenke, Gabriela Salinas-Riester, Andreas Böck, Carl Alpert, Michael Blaut, Sara C. Polson, Lydia Brandl, Thomas Kirchner, Florian R. Greten, Shawn W. Polson & Melek C. Arkan Several features common to a Western lifestyle, including obesity and low levels of physical activity, are known risk factors for gastrointestinal cancers.
  • Early turbulent mixing as the origin of chemical homogeneity in open star clusters

    Yi Feng
    30 Aug 2014 | 5:00 pm
    Nature advance online publication 31 August 2014. doi:10.1038/nature13662 Authors: Yi Feng & Mark R. Krumholz The abundances of elements in stars are critical clues to stars’ origins. Observed star-to-star variations in logarithmic abundance within an open star cluster—a gravitationally bound ensemble of stars in the Galactic plane—are typically only about 0.01 to 0.05 over many elements, which is noticeably smaller than the variation of about 0.06 to 0.3 seen in the interstellar medium from which the stars form. It is unknown why star clusters are so homogenous, and…
  • Neuroscience: Shedding light on a change of mind

    Tomonori Takeuchi
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13745 Authors: Tomonori Takeuchi & Richard G. M. Morris Sophisticated genetic tools that make brain cells responsive to light have now been used in mice to trigger a memory connected with a particular place, and to switch its association from negative to positive, or vice versa.
 
 
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    Nature Cell Biology - Issue - nature.com science feeds

  • Following your interests: The importance of good mentors

    Daniel J. Klionsky
    31 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 823 (2014). doi:10.1038/ncb3033 Author: Daniel J. Klionsky
  • Hi-TEC reprogramming for organ regeneration

    Bruno Di Stefano
    31 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 824 (2014). doi:10.1038/ncb3032 Authors: Bruno Di Stefano & Thomas Graf The induction of cell reprogramming by transcription factors into alternative cell fates opens new avenues for regenerative medicine. Thymic epithelial cells that were obtained from fibroblasts by Foxn1 overexpression support the formation of an ectopic thymus following transplantation.
  • An ABC of ciliogenesis

    Pascal Barbry
    31 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 826 (2014). doi:10.1038/ncb3034 Authors: Pascal Barbry & Laure-Emmanuelle Zaragosi ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.
  • Reconstitution of the augmin complex provides insights into its architecture and function

    Kuo-Chiang Hsia
    30 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 852 (2014). doi:10.1038/ncb3030 Authors: Kuo-Chiang Hsia, Elizabeth M. Wilson-Kubalek, Alejandro Dottore, Qi Hao, Kuang-Lei Tsai, Scott Forth, Yuta Shimamoto, Ronald A. Milligan & Tarun M. Kapoor
  • Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

    Daqing Jin
    30 Aug 2014 | 5:00 pm
    Nature Cell Biology 16, 841 (2014). doi:10.1038/ncb3029 Authors: Daqing Jin, Terri T. Ni, Jianjian Sun, Haiyan Wan, Jeffrey D. Amack, Guangju Yu, Jonathan Fleming, Chin Chiang, Wenyan Li, Anna Papierniak, Satish Cheepala, Gwenaëlle Conseil, Susan P. C. Cole, Bin Zhou, Iain A. Drummond, John D. Schuetz, Jarema Malicki & Tao P. Zhong
 
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    Nature Chemistry

  • Blogroll: Life in the lab

    Matthew Hartings
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 755 (2014). doi:10.1038/nchem.2036 Author: Matthew Hartings
  • Carboboration: Addition to alkynoates

    Stephen Davey
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 754 (2014). doi:10.1038/nchem.2051 Author: Stephen Davey
  • An ode to the atomic weights

    Juris Meija
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 749 (2014). doi:10.1038/nchem.2047 Author: Juris Meija They might not be fundamental constants of nature, but atomic weights are one of the foundations on which modern chemistry is built, explains Juris Meija.
  • Enzyme catalysis: Evolution made easy

    Eugene J. H. Wee
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 756 (2014). doi:10.1038/nchem.2046 Authors: Eugene J. H. Wee & Matt Trau Directed evolution is a powerful tool for the development of improved enzyme catalysts. Now, a method that enables an enzyme, its encoding DNA and a fluorescent reaction product to be encapsulated in a gel bead enables the application of directed evolution in an ultra-high-throughput format.
  • The chemists behind the crystals

    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 751 (2014). doi:10.1038/nchem.2033 Benjamin King and Dieter Schlüter, the corresponding authors of two Articles in this issue that describe single-crystal characterization of two-dimensional polymers, talk to Nature Chemistry about the background, challenges and prospects of their work.
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    Nature Chemistry

  • Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

    Shiyu Chen
    30 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2043 Authors: Shiyu Chen, Ranganath Gopalakrishnan, Tifany Schaer, Fabrice Marger, Ruud Hovius, Daniel Bertrand, Florence Pojer & Christian Heinis Disulfide bonds formed between two cysteine residues are important in the folding and stability of proteins. Now, unnatural amino acids with side-chains that contain two thiol groups are described. Incorporation of these dithiol amino acids into a serine protease inhibitor and a nicotinic acetyl choline receptor antagonist is shown to increase their inhibitory activity.
  • Chiral self-sorting and amplification in isotropic liquids of achiral molecules

    Christian Dressel
    30 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2039 Authors: Christian Dressel, Tino Reppe, Marko Prehm, Marcel Brautzsch & Carsten Tschierske The spontaneous resolution of racemic mixtures can occur when the molecules are confined in a crystal lattice, on surfaces or in other well-ordered assemblies. Now, mirror symmetry breaking within an isotropic liquid of achiral molecules has been observed. These liquids show strong chiral amplification and provide a possible mode of emergence of chirality in prebiotic fluids.
  • In situ X-ray snapshot analysis of transient molecular adsorption in a crystalline channel

    Ryou Kubota
    30 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2044 Authors: Ryou Kubota, Shohei Tashiro, Motoo Shiro & Mitsuhiko Shionoya Analysing the dynamic adsorption of small molecules in porous materials is a significant challenge. Now, in situ single-crystal X-ray diffraction has shown that molecular adsorption in a crystalline nanochannel occurs through multiple steps. Transient states during the process were also visualized, demonstrating the potential of X-ray analysis for probing non-covalent adsorption processes.
  • Low-energy spectrum of iron–sulfur clusters directly from many-particle quantum mechanics

    Sandeep Sharma
    30 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2041 Authors: Sandeep Sharma, Kantharuban Sivalingam, Frank Neese & Garnet Kin-Lic Chan FeS clusters are a universal motif in organisms and are central to many processes, including nitrogen fixation and respiration. By carrying out the first many-electron calculation of the [2Fe-2S] and [4Fe-4S] clusters, they are shown to have an unusual set of closely packed energy levels, which are key to understanding their reactivity.
  • Efficient discovery of bioactive scaffolds by activity-directed synthesis

    George Karageorgis
    23 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2034 Authors: George Karageorgis, Stuart Warriner & Adam Nelson A discovery approach termed activity-directed synthesis is described; it exploits arrays of reactions whose outcome is critically dependent on the conditions used, and prioritizes reactions that yield bioactive product mixtures. The discovery of both bioactive small molecules and associated synthetic routes thus occurs in parallel.
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    Nature Genetics - Issue - nature.com science feeds

  • Corrigendum: Genome-wide genetic changes during modern breeding of maize

    Yinping Jiao
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 1039 (2014). doi:10.1038/ng0914-1039 Author: Yinping Jiao, Hainan Zhao, Longhui Ren, Weibin Song, Biao Zeng, Jinjie Guo, Baobao Wang, Zhipeng Liu, Jing Chen, Wei Li, Mei Zhang, Shaojun Xie & Jingsheng Lai
  • Cancer gene discovery goes mobile

    Louise van der Weyden
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 928 (2014). doi:10.1038/ng.3072 Authors: Louise van der Weyden, Marco Ranzani & David J Adams A new study describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this system in combination with cancer genome data to define new genes and pathways involved in sarcoma development. Gene discovery in this way suggests that we are far from a complete catalog of cancer drivers.
  • Corrigendum: Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions

    Chen Wu
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 1040 (2014). doi:10.1038/ng0914-1040b Author: Chen Wu, Peter Kraft, Kan Zhai, Jiang Chang, Zhaoming Wang, Yun Li, Zhibin Hu, Zhonghu He, Weihua Jia, Christian C Abnet, Liming Liang, Nan Hu, Xiaoping Miao, Yifeng Zhou, Zhihua Liu, Qimin Zhan, Yu Liu, Yan Qiao, Yuling Zhou, Guangfu Jin, Chuanhai Guo, Changdong Lu, Haijun Yang, Jianhua Fu, Dianke Yu, Neal D Freedman, Ti Ding, Wen Tan, Alisa M Goldstein, Tangchun Wu, Hongbing Shen, Yang Ke, Yixin Zeng, Stephen J Chanock, Philip R Taylor & Dongxin Lin
  • RNA switch at enhancers

    Jeffrey J Quinn
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 929 (2014). doi:10.1038/ng.3074 Authors: Jeffrey J Quinn & Howard Y Chang Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.
  • Data use under the NIH GWAS Data Sharing Policy and future directions

    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 934 (2014). doi:10.1038/ng.3062 Authors:
 
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  • The Scc2–Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions

    Lidia Lopez-Serra
    30 Aug 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3080 Authors: Lidia Lopez-Serra, Gavin Kelly, Harshil Patel, Aengus Stewart & Frank Uhlmann The cohesin complex is at the heart of many chromosomal activities, including sister chromatid cohesion and transcriptional regulation. Cohesin loading onto chromosomes depends on the Scc2–Scc4 cohesin loader complex, but the chromatin features that form cohesin loading sites remain poorly understood. Here we show that the RSC chromatin remodeling complex recruits budding yeast Scc2–Scc4 to broad nucleosome-free regions, which the cohesin loader helps to…
  • Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma

    Puya Gharahkhani
    30 Aug 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3079 Authors: Puya Gharahkhani, Kathryn P Burdon, Rhys Fogarty, Shiwani Sharma, Alex W Hewitt, Sarah Martin, Matthew H Law, Katie Cremin, Jessica N Cooke Bailey, Stephanie J Loomis, Louis R Pasquale, Jonathan L Haines, Michael A Hauser, Ananth C Viswanathan, Peter McGuffin, Fotis Topouzis, Paul J Foster, Stuart L Graham, Robert J Casson, Mark Chehade, Andrew J White, Tiger Zhou, Emmanuelle Souzeau, John Landers, Jude T Fitzgerald, Sonja Klebe, Jonathan B Ruddle, Ivan Goldberg & Paul R Healey Primary open-angle glaucoma (POAG) is a major cause of…
  • Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma

    Yuhong Chen
    30 Aug 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3078 Authors: Yuhong Chen, Ying Lin, Eranga N Vithana, Liyun Jia, Xianbo Zuo, Tien Yin Wong, Li Jia Chen, Xianjun Zhu, Pancy O S Tam, Bo Gong, Shaohong Qian, Zheng Li, Xiaoqi Liu, Baskaran Mani, Qian Luo, Celeste Guzman, Christopher K S Leung, Xiaobo Li, Wenjun Cao, Quanyao Yang, Clement C Y Tham, Yilian Cheng, Xuejun Zhang, Ningli Wang, Tin Aung, Chiea Chuen Khor, Chi Pui Pang, Xinghuai Sun & Zhenglin Yang We performed a genome-wide association study for primary open-angle glaucoma (POAG) in 1,007 cases with high-pressure glaucoma (HPG) and 1,009 controls…
  • Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

    Pirro G Hysi
    30 Aug 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3087 Authors: Pirro G Hysi, Ching-Yu Cheng, Henriët Springelkamp, Stuart Macgregor, Jessica N Cooke Bailey, Robert Wojciechowski, Veronique Vitart, Abhishek Nag, Alex W Hewitt, René Höhn, Cristina Venturini, Alireza Mirshahi, Wishal D Ramdas, Gudmar Thorleifsson, Eranga Vithana, Chiea-Chuen Khor, Arni B Stefansson, Jiemin Liao, Jonathan L Haines, Najaf Amin, Ya Xing Wang, Philipp S Wild, Ayse B Ozel, Jun Z Li, Brian W Fleck, Tanja Zeller, Sandra E Staffieri, Yik-Ying Teo, Gabriel Cuellar-Partida, Xiaoyan Luo, R Rand Allingham, Julia E Richards,…
  • A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera

    Andreas Wallberg
    23 Aug 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3077 Authors: Andreas Wallberg, Fan Han, Gustaf Wellhagen, Bjørn Dahle, Masakado Kawata, Nizar Haddad, Zilá Luz Paulino Simões, Mike H Allsopp, Irfan Kandemir, Pilar De la Rúa, Christian W Pirk & Matthew T Webster
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    Nature Geoscience - Issue - nature.com science feeds

  • Journal-to-journal shortcuts

    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 613 (2014). doi:10.1038/ngeo2246 At Nature Publishing Group we offer a transfer system that allows authors to move papers between our journals at the click of a button if their first-choice journal declined. We encourage authors to use that service.
  • Wedge approach to water stress

    Yoshihide Wada
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 615 (2014). doi:10.1038/ngeo2241 Authors: Yoshihide Wada, Tom Gleeson & Laurent Esnault Water availability and use are inherently regional concerns. However, a global-scale approach to evaluating strategies to reduce water stress can help maximize mitigation.
  • Carbon sequestration: Tiny potential

    Amy Whitchurch
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 623 (2014). doi:10.1038/ngeo2242 Author: Amy Whitchurch
  • Corrigendum: Lusi mud eruption triggered by geometric focusing of seismic waves

    M. Lupi
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 687 (2014). doi:10.1038/ngeo2239 Authors: M. Lupi, E. H. Saenger, F. Fuchs & S. A. Miller
  • Deep earth: Post-perovskite at ten

    Sang-Heon Shim
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 621 (2014). doi:10.1038/ngeo2237 Authors: Sang-Heon Shim & Thorne Lay In 2004, a phase transition was discovered in the most abundant lower-mantle mineral. A decade of focused experiments, computations and seismic imaging stimulated by this discovery has revealed previously unknown complexities in Earth's deep mantle.
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  • Microbial shaping of sedimentary wrinkle structures

    G. Mariotti
    30 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2229 Authors: G. Mariotti, S. B. Pruss, J. T. Perron & T. Bosak Wrinkle structures on sandy bed surfaces were present in some of the earliest sedimentary environments, but are rare in modern environments. These enigmatic millimetre- to centimetre-scale ridges or pits are particularly common in sediments that harbour trace fossils and imprints of early animals, and appeared in the aftermath of some large mass extinctions. Wrinkle structures have been interpreted as possible remnants of microbial mats, but the formation mechanism and associated…
  • Vertical structure of stratospheric water vapour trends derived from merged satellite data

    M. I. Hegglin
    30 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2236 Authors: M. I. Hegglin, D. A. Plummer, T. G. Shepherd, J. F. Scinocca, J. Anderson, L. Froidevaux, B. Funke, D. Hurst, A. Rozanov, J. Urban, T. von Clarmann, K. A. Walker, H. J. Wang, S. Tegtmeier & K. Weigel
  • Rapid sea-level rise along the Antarctic margins in response to increased glacial discharge

    Craig D. Rye
    30 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2230 Authors: Craig D. Rye, Alberto C. Naveira Garabato, Paul R. Holland, Michael P. Meredith, A. J. George Nurser, Chris W. Hughes, Andrew C. Coward & David J. Webb The Antarctic shelf seas are a climatically and ecologically important region, and are at present receiving increasing amounts of freshwater from the melting of the Antarctic Ice Sheet and its fringing ice shelves, primarily around the Antarctic Peninsula and the Amudsen Sea. In response, the surface ocean salinity in this region has declined in past decades. Here, we assess the effects of…
  • Resilience of Pacific pelagic fish across the Cretaceous/Palaeogene mass extinction

    Elizabeth C. Sibert
    23 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2227 Authors: Elizabeth C. Sibert, Pincelli M. Hull & Richard D. Norris Open-ocean ecosystems experienced profound disruptions to biodiversity and ecological structure during the Cretaceous/Palaeogene mass extinction about 66 million years ago. It has been suggested that during this mass extinction, a collapse of phytoplankton production rippled up the food chain, causing the wholesale loss of consumers and top predators. Pelagic fish represent a key trophic link between primary producers and top predators, and changes in their abundance provide a means…
  • Seafloor methane: Atlantic bubble bath

    John Kessler
    23 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2238 Author: John Kessler The release of large quantities of methane from ocean sediments might affect global climate change. The discovery of expansive methane seeps along the US Atlantic margin provides an ideal test bed for such a marine methane–climate connection.
 
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    Nature Materials - Issue - nature.com science feeds

  • Mapping in-cell topology

    Pep Pàmies
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 843 (2014). doi:10.1038/nmat4078 Author: Pep Pàmies
  • Acoustic metamaterials: Nearly perfect sound absorbers

    Mathias Fink
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 848 (2014). doi:10.1038/nmat4067 Author: Mathias Fink Membrane-based acoustic resonators of subwavelength dimensions achieve nearly perfect acoustic absorption.
  • The light and shade of perovskite solar cells

    Michael Grätzel
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 838 (2014). doi:10.1038/nmat4065 Author: Michael Grätzel The rise of metal halide perovskites as light harvesters has stunned the photovoltaic community. As the efficiency race continues, questions on the control of the performance of perovskite solar cells and on its characterization are being addressed.
  • Perovskite solar cells: Continuing to soar

    Michael D. McGehee
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 845 (2014). doi:10.1038/nmat4050 Author: Michael D. McGehee The dream of printing highly efficient solar cells is closer than ever to being realized. Solvent engineering has enabled the deposition of uniform perovskite semiconductor films that yield greater than 15% power-conversion efficiency.
  • Boron clusters

    Alison Stoddart
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 843 (2014). doi:10.1038/nmat4074 Author: Alison Stoddart
 
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  • Phase-engineered low-resistance contacts for ultrathin MoS2 transistors

    Rajesh Kappera
    30 Aug 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4080 Authors: Rajesh Kappera, Damien Voiry, Sibel Ebru Yalcin, Brittany Branch, Gautam Gupta, Aditya D. Mohite & Manish Chhowalla
  • Entropy-driven formation of large icosahedral colloidal clusters by spherical confinement

    Bart de Nijs
    30 Aug 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4072 Authors: Bart de Nijs, Simone Dussi, Frank Smallenburg, Johannes D. Meeldijk, Dirk J. Groenendijk, Laura Filion, Arnout Imhof, Alfons van Blaaderen & Marjolein Dijkstra Icosahedral symmetry, which is not compatible with truly long-range order, can be found in many systems, such as liquids, glasses, atomic clusters, quasicrystals and virus-capsids. To obtain arrangements with a high degree of icosahedral order from tens of particles or more, interparticle attractive interactions are considered to be essential. Here, we report that entropy and…
  • Giant bandgap renormalization and excitonic effects in a monolayer transition metal dichalcogenide semiconductor

    Miguel M. Ugeda
    30 Aug 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4061 Authors: Miguel M. Ugeda, Aaron J. Bradley, Su-Fei Shi, Felipe H. da Jornada, Yi Zhang, Diana Y. Qiu, Wei Ruan, Sung-Kwan Mo, Zahid Hussain, Zhi-Xun Shen, Feng Wang, Steven G. Louie & Michael F. Crommie Two-dimensional (2D) transition metal dichalcogenides (TMDs) are emerging as a new platform for exploring 2D semiconductor physics. Reduced screening in two dimensions results in markedly enhanced electron–electron interactions, which have been predicted to generate giant bandgap renormalization and excitonic effects. Here we present a rigorous…
  • Lateral heterojunctions within monolayer MoSe2–WSe2 semiconductors

    Chunming Huang
    23 Aug 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4064 Authors: Chunming Huang, Sanfeng Wu, Ana M. Sanchez, Jonathan J. P. Peters, Richard Beanland, Jason S. Ross, Pasqual Rivera, Wang Yao, David H. Cobden & Xiaodong Xu Heterojunctions between three-dimensional (3D) semiconductors with different bandgaps are the basis of modern light-emitting diodes, diode lasers and high-speed transistors. Creating analogous heterojunctions between different 2D semiconductors would enable band engineering within the 2D plane and open up new realms in materials science, device physics and engineering. Here we demonstrate…
  • Direct observation of ferroelectric field effect and vacancy-controlled screening at the BiFeO3/LaxSr1 − xMnO3 interface

    Young-Min Kim
    16 Aug 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4058 Authors: Young-Min Kim, Anna Morozovska, Eugene Eliseev, Mark P. Oxley, Rohan Mishra, Sverre M. Selbach, Tor Grande, S. T. Pantelides, Sergei V. Kalinin & Albina Y. Borisevich
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    Nature Medicine - AOP - nature.com science feeds

  • Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer

    Christine M Lovly
    30 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3667 Authors: Christine M Lovly, Nerina T McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C Heukamp, Yingjun Yan, Alexandra Florin, Luka Ozretić, Diana Lim, Lu Wang, Zhao Chen, Xi Chen, Pengcheng Lu, Paul K Paik, Ronglai Shen, Hailing Jin, Reinhard Buettner, Sascha Ansén, Sven Perner, Michael Brockmann, Marc Bos, Jürgen Wolf, Masyar Gardizi, Gavin M Wright, Benjamin Solomon, Prudence A Russell, Toni-Maree Rogers, Yoshiyuki Suehara, Monica Red-Brewer, Rudy Tieu, Elisa de Stanchina, Qingguo Wang, Zhongming Zhao, David H Johnson, Leora Horn,…
  • Micromagnetic resonance relaxometry for rapid label-free malaria diagnosis

    Weng Kung Peng
    30 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3622 Authors: Weng Kung Peng, Tian Fook Kong, Chee Sheng Ng, Lan Chen, Yongxue Huang, Ali Asgar S Bhagat, Nam-Trung Nguyen, Peter Rainer Preiser & Jongyoon Han
  • The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

    Xuelian He
    23 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3666 Authors: Xuelian He, Liguo Zhang, Ying Chen, Marc Remke, David Shih, Fanghui Lu, Haibo Wang, Yaqi Deng, Yang Yu, Yong Xia, Xiaochong Wu, Vijay Ramaswamy, Tom Hu, Fan Wang, Wenhao Zhou, Dennis K Burns, Se Hoon Kim, Marcel Kool, Stefan M Pfister, Lee S Weinstein, Scott L Pomeroy, Richard J Gilbertson, Joshua B Rubin, Yiping Hou, Robert Wechsler-Reya, Michael D Taylor & Q Richard Lu
  • An implantable microfluidic device for self-monitoring of intraocular pressure

    Ismail E Araci
    23 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3621 Authors: Ismail E Araci, Baolong Su, Stephen R Quake & Yossi Mandel
  • Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

    Robert Fledrich
    23 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3664 Authors: Robert Fledrich, Ruth M Stassart, Axel Klink, Lennart M Rasch, Thomas Prukop, Lauren Haag, Dirk Czesnik, Theresa Kungl, Tamer A M Abdelaal, Naureen Keric, Christine Stadelmann, Wolfgang Brück, Klaus-Armin Nave & Michael W Sereda Duplication of the gene encoding the peripheral myelin protein of 22 kDa (PMP22) underlies the most common inherited neuropathy, Charcot-Marie-Tooth 1A (CMT1A), a disease without a known cure. Although demyelination represents a characteristic feature, the clinical phenotype of CMT1A is determined by the degree of…
 
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    Nature Methods - Issue - nature.com science feeds

  • Points of Significance: Replication

    Paul Blainey
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 879 (2014). doi:10.1038/nmeth.3091 Authors: Paul Blainey, Martin Krzywinski & Naomi Altman Quality is often more important than quantity.
  • Change at Nature Methods

    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 875 (2014). doi:10.1038/nmeth.3097 We announce a change in leadership at Nature Methods and wish Daniel Evanko, our departing chief editor and the new head of editorial services at Nature Publishing Group, every success.
  • The Author File: Richard Neutze

    Vivien Marx
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 877 (2014). doi:10.1038/nmeth.3074 Author: Vivien Marx Proteins 'breathe' in an ultrafast way that can be captured with XFELs.
  • A critique of methods for temperature imaging in single cells

    Guillaume Baffou
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 899 (2014). doi:10.1038/nmeth.3073 Authors: Guillaume Baffou, Hervé Rigneault, Didier Marguet & Ludovic Jullien We argue that standard thermodynamic considerations and scaling laws show that a single cell cannot substantially raise its temperature by endogenous thermogenesis. This statement seriously questions the interpretations of recent work reporting temperature heterogeneities measured in single living cells.
  • Improved reproducibility by assuring confidence in measurements in biomedical research

    Anne L Plant
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 895 (2014). doi:10.1038/nmeth.3076 Authors: Anne L Plant, Laurie E Locascio, Willie E May & Patrick D Gallagher 'Irreproducibility' is symptomatic of a broader challenge in measurement in biomedical research. From the US National Institute of Standards and Technology (NIST) perspective of rigorous metrology, reproducibility is only one aspect of establishing confidence in measurements. Appropriate controls, reference materials, statistics and informatics are required for a robust measurement process. Research is required to establish these tools for biological…
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  • Multiplexed aberration measurement for deep tissue imaging in vivo

    Chen Wang
    16 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3068 Authors: Chen Wang, Rui Liu, Daniel E Milkie, Wenzhi Sun, Zhongchao Tan, Aaron Kerlin, Tsai-Wen Chen, Douglas S Kim & Na Ji We describe an adaptive optics method that modulates the intensity or phase of light rays at multiple pupil segments in parallel to determine the sample-induced aberration. Applicable to fluorescent protein–labeled structures of arbitrary complexity, it allowed us to obtain diffraction-limited resolution in various samples in vivo. For the strongly scattering mouse brain, a single aberration correction improved structural…
  • Accurate de novo and transmitted indel detection in exome-capture data using microassembly

    Giuseppe Narzisi
    16 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3069 Authors: Giuseppe Narzisi, Jason A O'Rawe, Ivan Iossifov, Han Fang, Yoon-ha Lee, Zihua Wang, Yiyang Wu, Gholson J Lyon, Michael Wigler & Michael C Schatz We present an open-source algorithm, Scalpel (http://scalpel.sourceforge.net/), which combines mapping and assembly for sensitive and specific discovery of insertions and deletions (indels) in exome-capture data. A detailed repeat analysis coupled with a self-tuning k-mer strategy allows Scalpel to outperform other state-of-the-art approaches for indel discovery, particularly in regions containing…
  • Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

    David Arnlund
    9 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3067 Authors: David Arnlund, Linda C Johansson, Cecilia Wickstrand, Anton Barty, Garth J Williams, Erik Malmerberg, Jan Davidsson, Despina Milathianaki, Daniel P DePonte, Robert L Shoeman, Dingjie Wang, Daniel James, Gergely Katona, Sebastian Westenhoff, Thomas A White, Andrew Aquila, Sadia Bari, Peter Berntsen, Mike Bogan, Tim Brandt van Driel, R Bruce Doak, Kasper Skov Kjær, Matthias Frank, Raimund Fromme, Ingo Grotjohann, Robert Henning, Mark S Hunter, Richard A Kirian, Irina Kosheleva, Christopher Kupitz, Mengning Liang, Andrew V Martin, Martin…
  • Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum

    Jeffrey C Wagner
    9 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3063 Authors: Jeffrey C Wagner, Randall J Platt, Stephen J Goldfless, Feng Zhang & Jacquin C Niles Malaria is a major cause of global morbidity and mortality, and new strategies for treating and preventing this disease are needed. Here we show that the Streptococcus pyogenes Cas9 DNA endonuclease and single guide RNAs (sgRNAs) produced using T7 RNA polymerase (T7 RNAP) efficiently edit the Plasmodium falciparum genome. Targeting the genes encoding native knob-associated histidine-rich protein (kahrp) and erythrocyte binding antigen 175 (eba-175), we…
  • Epiviz: interactive visual analytics for functional genomics data

    Florin Chelaru
    2 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3038 Authors: Florin Chelaru, Llewellyn Smith, Naomi Goldstein & Héctor Corrada Bravo Visualization is an integral aspect of genomics data analysis. Algorithmic-statistical analysis and interactive visualization are most effective when used iteratively. Epiviz (http://epiviz.cbcb.umd.edu/), a web-based genome browser, and the Epivizr Bioconductor package allow interactive, extensible and reproducible visualization within a state-of-the-art data-analysis platform.
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    Nature Neuroscience - Issue - nature.com science feeds

  • All that glitters is not reward signal

    Benjamin Y Hayden
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1142 (2014). doi:10.1038/nn.3795 Authors: Benjamin Y Hayden & Sarah R Heilbronner In this issue, Shenhav et al. critically evaluate the idea that neural correlates of value actually represent value. They describe how, in many situations, value correlates can reflect other cognitive factors, such as decisional difficulty.
  • The epigenetic landscape of Alzheimer's disease

    Jenny Lord
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1138 (2014). doi:10.1038/nn.3792 Authors: Jenny Lord & Carlos Cruchaga Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.
  • Reward processing by the lateral habenula in normal and depressive behaviors

    Christophe D Proulx
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1146 (2014). doi:10.1038/nn.3779 Authors: Christophe D Proulx, Okihide Hikosaka & Roberto Malinow
  • CLEARance wars: PolyQ strikes back

    X William Yang
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1140 (2014). doi:10.1038/nn.3793 Authors: X William Yang & Ai Yamamoto Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.
  • Scenting Waldo: analyzing olfactory scenes

    Timothy E Holy
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1144 (2014). doi:10.1038/nn.3796 Author: Timothy E Holy Olfaction has often been described as a 'synthetic' sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects.
 
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  • Damage to dorsolateral prefrontal cortex affects tradeoffs between honesty and self-interest

    Lusha Zhu
    30 Aug 2014 | 5:00 pm
    Nature Neuroscience. doi:10.1038/nn.3798 Authors: Lusha Zhu, Adrianna C Jenkins, Eric Set, Donatella Scabini, Robert T Knight, Pearl H Chiu, Brooks King-Casas & Ming Hsu Substantial correlational evidence suggests that prefrontal regions are critical to honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. We found that lesions of the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions when…
  • Edge-orientation processing in first-order tactile neurons

    J Andrew Pruszynski
    30 Aug 2014 | 5:00 pm
    Nature Neuroscience. doi:10.1038/nn.3804 Authors: J Andrew Pruszynski & Roland S Johansson
  • Reversal of theta rhythm flow through intact hippocampal circuits

    Jesse Jackson
    30 Aug 2014 | 5:00 pm
    Nature Neuroscience. doi:10.1038/nn.3803 Authors: Jesse Jackson, Bénédicte Amilhon, Romain Goutagny, Jean-Bastien Bott, Frédéric Manseau, Christian Kortleven, Steven L Bressler & Sylvain Williams
  • Encoding and decoding in parietal cortex during sensorimotor decision-making

    Il Memming Park
    30 Aug 2014 | 5:00 pm
    Nature Neuroscience. doi:10.1038/nn.3800 Authors: Il Memming Park, Miriam L R Meister, Alexander C Huk & Jonathan W Pillow
  • Genetic variability in the regulation of gene expression in ten regions of the human brain

    Adaikalavan Ramasamy
    30 Aug 2014 | 5:00 pm
    Nature Neuroscience. doi:10.1038/nn.3801 Authors: Adaikalavan Ramasamy, Daniah Trabzuni, Sebastian Guelfi, Vibin Varghese, Colin Smith, Robert Walker, Tisham De, John Hardy, Mina Ryten, Daniah Trabzuni, Sebastian Guelfi, Michael E Weale, Adaikalavan Ramasamy, Paola Forabosco, Colin Smith, Robert Walker, Sampath Arepalli, Mark R Cookson, Allissa Dillman, J Raphael Gibbs, Dena G Hernandez, Michael A Nalls, Andrew B Singleton, Bryan Traynor, Marcel van der Brug, Luigi Ferrucci, Robert Johnson, Ronald Zielke, Dan L Longo, Juan Troncoso, Alan Zonderman, Lachlan Coin, Rohan de Silva, Mark R…
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    Nature Photonics - Issue - nature.com science feeds

  • Solar cell woes

    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 665 (2014). doi:10.1038/nphoton.2014.212 The pressure to publish results claiming organic solar cells with high efficiencies is leading to pervasive problems of false reporting within the community.
  • Optomechanics: Vibrating VCSELs

    David Pile
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 675 (2014). doi:10.1038/nphoton.2014.196 Author: David Pile
  • Hot photoluminescence or Raman scattering?

    Kasey J. Russell
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 666 (2014). doi:10.1038/nphoton.2014.190 Authors: Kasey J. Russell & Evelyn L. Hu
  • View from... CLEO 2014: High-performance optics

    David Pile
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 682 (2014). doi:10.1038/nphoton.2014.211 Author: David Pile Developments in optical materials and components for extreme applications such as the James Webb Space Telescope and petawatt laser systems were showcased at CLEO 2014.
  • Reply to 'Hot photoluminescence or Raman scattering?'

    Carlos O. Aspetti
    31 Aug 2014 | 5:00 pm
    Nature Photonics 8, 667 (2014). doi:10.1038/nphoton.2014.191 Authors: Carlos O. Aspetti, Chang-Hee Cho, Joohee Park & Ritesh Agarwal
 
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    Nature Physics - Issue - nature.com science feeds

  • Cheap trick

    Federico Levi
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 620 (2014). doi:10.1038/nphys3091 Author: Federico Levi
  • In with the new

    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 615 (2014). doi:10.1038/nphys3100 As the ninth year of Nature Physics draws to a close, we say goodbye to our launching Chief Editor, Alison Wright, and welcome her successor, Andrea Taroni, to the team.
  • Waste knot, want knot

    Alvaro Zinos-Amaro
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 698 (2014). doi:10.1038/nphys3102 Author: Alvaro Zinos-Amaro A trip to the shops.
  • Benefits of diversity

    Abraham Loeb
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 616 (2014). doi:10.1038/nphys3089 Author: Abraham Loeb Discoveries in astronomy — or, in fact, any branch of science — can only happen when people are open-minded and willing to take risks.
  • Stacks of potential

    Bart Verberck
    31 Aug 2014 | 5:00 pm
    Nature Physics 10, 620 (2014). doi:10.1038/nphys3093 Author: Bart Verberck
 
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Tumorigenesis: FBP1 is suppressed in kidney tumours

    Gemma K. Alderton
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 575 (2014). doi:10.1038/nrc3810 Author: Gemma K. Alderton Li et al. find that fructose-1,6-bisphosphatase 1 (FBP1) levels are uniformly reduced in clear cell renal cell carcinoma (ccRCC), identifying a new mechanism of metabolic reprogramming in this cancer type.
  • The impact of the endoplasmic reticulum protein-folding environment on cancer development

    Miao Wang
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 581 (2014). doi:10.1038/nrc3800 Authors: Miao Wang & Randal J. Kaufman The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage and regulated release of calcium and as the entrance to the secretory pathway. Protein misfolding in the ER causes accumulation of misfolded proteins (ER stress) and activation of the unfolded protein
  • Tumour suppressors: p53 and cellular plasticity

    Sarah Seton-Rogers
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 577 (2014). doi:10.1038/nrc3814 Author: Sarah Seton-Rogers Suppression of the liver cancers hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) by p53 was investigated by Tschaharganeh et al. p53 loss promoted dedifferentiation of mature hepatocytes by indirectly promoting the expression of nestin, a protein associated with stem and progenitor cells. The resulting progenitor-like
  • RNA dynamics: Destabilizing mRNAs promotes metastasis

    Isabel Lokody
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 578 (2014). doi:10.1038/nrc3809 Author: Isabel Lokody Goodarzi et al. highlight the regulation of RNA stability as a crucial mechanism in breast cancer metastasis.
  • Metastasis: Regulating brain metastasis

    Isabel Lokody
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 577 (2014). doi:10.1038/nrc3813 Author: Isabel Lokody Sevenich et al. have shown that the protease cathepsin S regulates breast cancer metastasis to the brain in mice by cleaving junctional adhesion protein B (JAM-B) in cells that form the blood–brain barrier (BBB) to facilitate extravasation of breast cancer cells across the BBB.
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • Market watch: A framework for biomedical innovation in emerging markets

    Ajay Gautam
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 646 (2014). doi:10.1038/nrd4413 Authors: Ajay Gautam & Steve Yang Recent studies have investigated public and venture-capital funding for life sciences in emerging markets to understand government policy and investment strategy (Nature Biotech.31, 195–201; 2013; N. Engl. J. Med.370, 3–6; 2014). This article describes a framework to help
  • Harnessing the informatics revolution for neuroscience drug R&D

    Husseini K. Manji
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 709 (2014). doi:10.1038/nrd4431 Author: Husseini K. Manji, Thomas R. Insel & Vaibhav A. Narayan Nature Reviews Drug Discovery13, 561–562 (2014)The middle initial of the second author was incorrect; it should be Thomas R. Insel, as above. The online versions have been corrected accordingly.
  • FDA approves second transgenic milk drug

    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 644 (2014). doi:10.1038/nrd4426 Despite regulatory success for Pharming's conestat alfa, 'farmaceuticals' continue to face an uphill battle.The lowdown: The US Food and Drug Administration (FDA) approved Pharming's conestat alfa for the treatment of hereditary angioedema, providing a second complete case study for developers of drugs from
  • Bank tests drug development waters

    Asher Mullard
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 643 (2014). doi:10.1038/nrd4412 Author: Asher Mullard The European Investment Bank has invested [euro]75 million in a risk-sharing drug development deal with the pharmaceutical company UCB, potentially opening up a new source of research and development (R&D) funding.
  • Cancer: PLK4 inhibitor shows potent antitumour activity

    Alexandra Flemming
    31 Aug 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 654 (2014). doi:10.1038/nrd4430 Author: Alexandra Flemming Polo-like kinase 4 (PLK4) was identified as an anticancer target in an RNA interference (RNAi) screen in human breast cancers and cell lines, and the small molecule CFI-400945 was found to be a potent, selective and orally available PLK4 inhibitor. In vitro studies showed
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Evolutionary genetics: Homing in on anthropoid evolution

    Bryony Jones
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 575 (2014). doi:10.1038/nrg3812 Author: Bryony Jones To investigate the genetic factors that drove anthropoid primate evolution, researchers have identified 23,949 anthropoid-specific constrained (ASC) regions in the genome. ASC regions are enriched in loci previously associated with brain development, vision and neurotransmission; notably, almost all of these regions are non-coding. In addition,
  • Non-coding RNA: MicroRNA stimulates mitochondrial translation

    Linda Koch
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 572 (2014). doi:10.1038/nrg3806 Author: Linda Koch The muscle-specific microRNA miR-1 stimulates translation of various transcripts encoded by mitochondrial DNA, while repressing its nuclear DNA-encoded targets in the cytoplasm, report Zhang and colleagues. The observed effect is dependent on specific base-pairing between miR-1 and its target transcripts, as well as on the
  • Model organisms: Sexual conflict in nematodes

    Isabel Lokody
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 575 (2014). doi:10.1038/nrg3811 Author: Isabel Lokody A new study in Caenorhabditis nematodes has shown that the species barrier is maintained by highly aggressive sperm. Rather than producing infertile offspring as a result of interspecific mating, as observed in other species, interspecific mating in Caenorhabditis spp. results in maternal infertility
  • Technology: Using DNA repair to detect modified bases

    Darren J. Burgess
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 572 (2014). doi:10.1038/nrg3805 Author: Darren J. Burgess There is great interest in characterizing the locations and functions of chemically modified bases in genomes. Bryan et al. report their Excision-seq method, in which DNA repair enzymes are used to cut genomic DNA at sites of the particular damaged bases they recognize, followed
  • Therapeutics: Targeting huntingtin through morpholino oligomers

    Darren J. Burgess
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 572 (2014). doi:10.1038/nrg3804 Author: Darren J. Burgess Huntington's disease is caused by a mutant huntingtin (HTT) gene that contains an expanded tract of poly(CAG) repeats. Sun et al. designed phosphorodiamidate morpholino oligomers (PMOs, which are stable nucleic acid mimics) as antisense reagents to target the CAG tract in HTT
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Inflammasomes: New LPS receptors discovered

    Cláudio Nunes-Alves
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 582 (2014). doi:10.1038/nri3736 Author: Cláudio Nunes-Alves A new study identifies inflammatory caspases as the cytoplasmic LPS receptors that trigger non-canonical inflammasome activation.
  • The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

    Sarah L. Gaffen
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 585 (2014). doi:10.1038/nri3707 Authors: Sarah L. Gaffen, Renu Jain, Abhishek V. Garg & Daniel J. Cua Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In
  • Phenotypic models of T cell activation

    Melissa Lever
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 619 (2014). doi:10.1038/nri3728 Authors: Melissa Lever, Philip K. Maini, P. Anton van der Merwe & Omer Dushek T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors (TCRs) and peptide–MHC complexes (pMHC complexes). Despite extensive experimental studies, the relationship between the TCR–pMHC binding parameters and T
  • A long-awaited merger of the pathways mediating host defence and programmed cell death

    J. Magarian Blander
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 601 (2014). doi:10.1038/nri3720 Author: J. Magarian Blander Historically, cell death and inflammation have been closely linked, but the necessary divergence of the fields in the past few decades has enriched our molecular understanding of the signalling pathways that mediate various programmes of cell death and multiple types of inflammatory responses. The fields
  • Regulatory T cells: Alarmin(g) control

    Elisabeth Kugelberg
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 579 (2014). doi:10.1038/nri3733 Author: Elisabeth Kugelberg In response to intestinal tissue damage, the alarmin interleukin-33 enhances local regulatory T cell responses.
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Bacterial pathogenesis: More to CRISPR than adaptive immunity

    Christina Tobin Kåhrström
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 596 (2014). doi:10.1038/nrmicro3338 Author: Christina Tobin Kåhrström A new study shows that the type II CRISPR–Cas (clustered, regularly interspaced short palindromic repeats–CRISPR-associated proteins) system of the intracellular pathogen Francisella novicida downregulates the expression of an immunostimulatory bacterial lipoprotein (BLP), which increases the integrity of the cell envelope, resulting in antibiotic resistance
  • Uniting the classification of cultured and uncultured bacteria and archaea using 16S rRNA gene sequences

    Pablo Yarza
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 635 (2014). doi:10.1038/nrmicro3330 Authors: Pablo Yarza, Pelin Yilmaz, Elmar Pruesse, Frank Oliver Glöckner, Wolfgang Ludwig, Karl-Heinz Schleifer, William B. Whitman, Jean Euzéby, Rudolf Amann & Ramon Rosselló-Móra Publicly available sequence databases of the small subunit ribosomal RNA gene, also known as 16S rRNA in bacteria and archaea, are growing rapidly, and the number of entries currently exceeds 4 million. However, a unified classification and nomenclature framework for all bacteria and archaea does
  • RAB11-mediated trafficking in host–pathogen interactions

    Annabel Guichard
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 624 (2014). doi:10.1038/nrmicro3325 Authors: Annabel Guichard, Victor Nizet & Ethan Bier Many bacterial and viral pathogens block or subvert host cellular processes to promote successful infection. One host protein that is targeted by invading pathogens is the small GTPase RAB11, which functions in vesicular trafficking. RAB11 functions in conjunction with a protein complex known as the
  • Voyage to the bottom of the 'seaquence'

    Rachael Wash
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 597 (2014). doi:10.1038/nrmicro3341 Authors: Rachael Wash & Carmen Diaz Soria This month's Genome Watch highlights the use of deep sequencing metagenomics to identify bacteriophages that carry sulphur-oxidizing genes in deep-sea hydrothermal vent plumes.
  • Viral infection: Seeding the HIV-1 reservoir

    Cláudio Nunes-Alves
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 594 (2014). doi:10.1038/nrmicro3342 Author: Cláudio Nunes-Alves A new study shows that the HIV viral reservoir is seeded rapidly, even before the establishment of viraemia.
 
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • RNA localization: Promoters of mRNA fate

    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 563 (2014). doi:10.1038/nrm3865 Cells respond to stress by transcribing survival genes. Zid and O'shea found that, in response to glucose starvation in budding yeast, the translation of a subset of transcriptionally activated mRNAs was increased, and that of another subset was decreased. Transcripts of the first subset were
  • Endocytosis: Unlocking AP2 activity

    Katharine H. Wrighton
    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 560 (2014). doi:10.1038/nrm3863 Author: Katharine H. Wrighton The clathrin adaptor assembly polypeptide 2 (AP2) cannot bind to clathrin in the cytoplasm owing to an autoinhibitory mechanism.
  • Nuclear envelope: ATR senses mechanical stress

    Kim Baumann
    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 559 (2014). doi:10.1038/nrm3864 Author: Kim Baumann Mechanical stress activates an ATR pathway at the nuclear envelope that is important for chromatin condensation and nuclear envelope breakdown.
  • Cell migration: The forces that close wounds

    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 563 (2014). doi:10.1038/nrm3866 Epithelial tissues repair wounds through the collective movement of epithelial cells into the damaged area. This involves extension of the leading edge of cells, which exerts traction on the substrate to propel the cells forward, and the contraction of a supracellular actomyosin ring around the
  • Stem cells: A role for nuclear p120 catenin in differentiation

    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 563 (2014). doi:10.1038/nrm3867 p120 catenin interacts with E-cadherin and functions at adherens junctions; it can also modulate gene expression in the nucleus. Lee et al. reveal that nuclear p120 catenin binds to REST and Co-REST, components of a transcriptional repressor complex. Depleting mouse embryonic stem (ES) cells
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Oscillations: A dynamic role for astrocytes

    Katherine Whalley
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3810 Author: Katherine Whalley Astrocytes contribute to the maintenance of fast synchronous activity in the hippocampus and have a role in recognition memory.
  • Sensory processing: Mixed-up mitral cells

    Sian Lewis
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3813 Author: Sian Lewis In this study, whole-cell recordings of mitral/tufted cells (M/TCs) in the olfactory bulb of awake mice revealed greater hetereogeneity of activity compared with that in mice in an anaesthetized state, including in a subpopulation of cells with high spontaneous baseline activity and a subpopulation with
  • Pain: Finding motivation in pain

    Sian Lewis
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3814 Author: Sian Lewis People with chronic pain can experience reduced motivation to complete goal-directed tasks, but the mechanism is poorly understood. In this study, the decreased motivation that occurred in two mouse models of chronic pain was associated with reduced activity in medium spiny neurons of the nucleus
  • Decision making: Off the hook

    Sian Lewis
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3816 Author: Sian Lewis It has been suggested that the state of mind of the perpetrator of a crime plays a strong part in people's judgement of what constitutes an appropriate punishment. This functional MRI study showed that when people are shown an intentionally harmful act, activity in their
  • Metabolism: Sugar on the brain

    Leonie Welberg
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 563 (2014). doi:10.1038/nrn3812 Author: Leonie Welberg High levels of central transforming growth factor-β1 induce hypothalamic inflammation and lead to hyperglycaemia and glucose intolerance.
 
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    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • Drug therapy: Keeping rats in the dark sheds light on tamoxifen resistance

    David Killock
    11 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 500 (2014). doi:10.1038/nrclinonc.2014.139 Author: David Killock New data from a rat model of oestrogen receptor (ER)-positive human breast cancer indicate that exposure to light at night might underlie intrinsic resistance to tamoxifen, which is a common cause of treatment failure in patients with this disease.Circadian melatonin has been implicated as
  • Genetics: New molecular classification of gastric adenocarcinoma proposed by The Cancer Genome Atlas

    Mina Razzak
    11 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 499 (2014). doi:10.1038/nrclinonc.2014.138 Author: Mina Razzak Currently, two histological classification systems are available to characterize gastric adenocarcinomas, which represents the majority of gastric tumours. The Lauren classification system comprises two subtypes (intestinal and diffuse) and the WHO classification has four subtypes (papillary, tubular, mucinous and poorly cohesive). Neither system is particularly
  • Skin cancer: Less is as good as more in refractory melanoma

    Lisa Hutchinson
    4 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 502 (2014). doi:10.1038/nrclinonc.2014.132 Author: Lisa Hutchinson Although great strides have been made in the treatment of advanced-stage melanoma, resistance to new protein kinase pathway inhibitors—such as vemurafenib, dabrafenib and trametinib—ultimately results in patient relapse or disease progression. Even patients who initially respond to the use of combination therapies with BRAF and
  • CNS cancer: It takes two to tango

    M. Teresa Villanueva
    4 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 502 (2014). doi:10.1038/nrclinonc.2014.133 Author: M. Teresa Villanueva One of the main characteristics of malignant glioblastoma is the rapid formation of new, leaky blood vessels, which are responsible for the oedema that contributes to the numerous neurological symptoms associated with this disease. Hence, multiple studies have assessed targeting the VEGF pathway in patients
  • Targeted therapies: Redefining the primary objective of phase I oncology trials

    Mark J. Ratain
    4 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 503 (2014). doi:10.1038/nrclinonc.2014.135 Author: Mark J. Ratain Cytotoxic agents are conventionally dosed on the basis of the maximum tolerated dose defined in phase I trials. A study assessing adverse events in over 2,000 patients treated with molecularly targeted agents suggests a need to redefine criteria for dosing of molecularly targeted agents, which should be based on randomized, dose-ranging phase II trials.
 
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    Nature Reviews Gastroenterology and Hepatology - AOP

  • Diagnosis and management of solid benign liver lesions

    Jacques Belghiti
    1 Sep 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.151 Authors: Jacques Belghiti, François Cauchy, Valérie Paradis & Valérie Vilgrain
  • Radiation enteropathy—pathogenesis, treatment and prevention

    Martin Hauer-Jensen
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.158 Author: Martin Hauer-Jensen, James W. Denham & H. Jervoise N. Andreyev
  • Gut microbiota: Ordered development of gut microbiota observed in premature infants

    Isobel Leake
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.152 Author: Isobel Leake
  • Imaging: Dynamic imaging of gut function—allowing the blind to see

    Bishnu P. Joshi
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.149 Authors: Bishnu P. Joshi & Thomas D. Wang Improved methods are needed to dynamically image gut behaviour to assess whether neuromuscular degenerative disease is present. So-called nanonaps (soluble nanoformulated naphthalocyanines) have been developed for oral administration to pass through the intestines and provide high contrast for visualizing bowel motion on photoacoustic imaging. Moreover, radiotracer labelling of these nanoparticles facilitates multimodal detection using PET.
  • Screening: Colorectal cancer screening—insights and challenges

    Stephen P. Halloran
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.150 Author: Stephen P. Halloran Colorectal cancer (CRC) screening, the decade's most promising cancer-related public health development, is evolving. Faecal immunochemical tests (FIT) will be the primary population-based CRC screening biomarker for the next 10–15 years. Will the international community exploit the full potential of FIT and other CRC risk indicators to enable a revolution in the effectiveness of screening?
 
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    Nature Reviews Nephrology - Issue - nature.com science feeds

  • Reply: Nephrons are generated via a series of committed progenitors

    Paola Romagnani
    11 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 491 (2014). doi:10.1038/nrneph.2012.290-c2 Authors: Paola Romagnani, Laura Lasagni & Giuseppe Remuzzi We thank Fujian Zhang and colleagues for their interesting comment (The Drosophila nephrocyte has a glomerular filtration system. Nat. Rev. Nephrol., 12 August 2014; doi:10.1038/nrneph.2012.290-c1) on our Review (Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat. Rev. Nephrol
  • The Drosophila nephrocyte has a glomerular filtration system

    Fujian Zhang
    11 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 491 (2014). doi:10.1038/nrneph.2012.290-c1 Authors: Fujian Zhang & Xiangmei Chen We read with interest the Review by Paola Romagnani and colleagues (Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat Rev Nephrol.9, 137–146; 2013), which discusses the importance of the evolutionarily conserved nephron structure in kidney regeneration. Nephrology students
  • Anaemia: FIND-CKD: intravenous iron in predialysis CKD

    Steven Fishbane
    4 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 488 (2014). doi:10.1038/nrneph.2014.139 Authors: Steven Fishbane & Azzour D. Hazzan A new study has advanced our understanding of iron management in chronic kidney disease (CKD) by comparing oral iron to high-dose and low-dose intravenous ferric carboxymaltose (FCM) in patients with predialysis CKD. Intravenous FCM treatment to achieve a higher serum ferritin target improved patient haemoglobin levels and reduced initiation of other anaemia treatments.
  • Polycystic kidney disease: Kidney volume—a crystal ball for ADPKD prognosis?

    Emilie Cornec-Le Gall
    4 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 485 (2014). doi:10.1038/nrneph.2014.132 Authors: Emilie Cornec-Le Gall & Yannick Le Meur A new study has addressed a key question in autosomal dominant polycystic kidney disease (ADPKD): can we predict renal outcome at an early disease stage? Indeed, this information is useful for any patient with ADPKD. Moreover, while targeted therapies continue to emerge, optimal selection of patients for clinical trials remains a challenge.
  • Diabetes: Intensive glucose-lowering: long-lasting benefits on albuminuria in patients with type 1 diabetes

    Susan J. Allison
    4 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 481 (2014). doi:10.1038/nrneph.2014.140 Author: Susan J. Allison Studies have shown that intensive regimens to lower blood glucose levels in patients with diabetes mellitus provide microvascular protection that lasts beyond the duration of treatment; however, the extent to which these effects persist is unknown. A new report published in The Lancet Diabetes &
 
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    Nature Reviews Rheumatology - Issue - nature.com science feeds

  • Connective tissue diseases: A mechanism of B cell hyperactivity in SLE

    Nicholas J. Bernard
    11 Aug 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 513 (2014). doi:10.1038/nrrheum.2014.141 Author: Nicholas J. Bernard Researchers have identified a mechanism for B cell hyperactivity in patients with systemic lupus erythematosus (SLE). Published in Science Translational Medicine, the data show that microRNAs (miRNAs) miR-7, miR-21 and miR-22 enhance B-cell receptor signalling by suppressing the expression of PTEN, a process
  • Autoinflammation: A new STING-associated monogenic autoinflammatory disease

    Sarah Onuora
    4 Aug 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 512 (2014). doi:10.1038/nrrheum.2014.126 Author: Sarah Onuora Studies involving a series of children with a distinct vascular and pulmonary syndrome has led to the discovery of an autoinflammatory disease caused by mutations in the gene encoding stimulator of interferon genes protein (STING), a major regulator of interferon signalling. The syndrome, now referred
  • Vasculitis disorders: Re-treat relapses of AAV with rituximab

    4 Aug 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 512 (2014). doi:10.1038/nrrheum.2014.133 As part of the RAVE (rituximab in antineutrophil cytoplasmic antibody–associated vasculitis [AAV]) trial, patients who experienced a severe relapse of disease after achieving remission were eligible for open-label treatment with rituximab and prednisone, regardless of whether remission induction was accomplished with rituximab or with cyclophosphamide
  • Pain: Reconsidering paracetamol for low back pain

    4 Aug 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 512 (2014). doi:10.1038/nrrheum.2014.130 The results of a double-blind, randomized, controlled trial of paracetamol for acute low back pain question the efficacy of this universally recommended therapeutic approach. Analysis of patients assigned to receive placebo (n = 547) or paracetamol, administered either at regular doses (total 3,990
  • Therapy: Hitting the target: delivering IL-10 to treat experimental arthritis

    Katrina Ray
    4 Aug 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 511 (2014). doi:10.1038/nrrheum.2014.135 Author: Katrina Ray Targeting therapeutic agents specifically to the diseased joint during active disease has been an area of much research in recent years. Now, two new studies demonstrate that the anti-inflammatory cytokine IL-10 can be delivered as a therapeutic agent—either via local gene therapy or via a
 
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    Naturejobs - Search results

  • Faculty Position in Biophysics

    1 Sep 2014 | 10:11 am
    The Department of Biophysics at the University of Texas Southwestern Medical Center invites applications for tenure-track faculty positions at the level of assistant professor. We seek outstanding candidates who study molecular mechanisms of biological processes, in vitro or in vivo, using physical and quantitative approaches. We particularly encourage applications from those with backgrounds in single-molecule spectroscopy or quantitative imaging, but are interested in all excellent candidate…
  • Tenure Track Faculty Positions

    1 Sep 2014 | 9:46 am
    As part of a major expansion, the Department of Genetics is now recruiting investigators at all academic levels. Individuals with expertise in high-throughput functional genomics, including single-cell analysis; computational and systems biology; development of cellular and animal models of human disease; stem cell biology; genome engineering; epigenomics and analysis of gene-environment interactions; or novel strategies to evaluate the role of genetic variants in disease etiology, are encourage…
  • Tenure Track Faculty Positions

    1 Sep 2014 | 9:46 am
    As part of a major expansion, the Department of Genetics is now recruiting investigators at all academic levels. Individuals with expertise in high-throughput functional genomics, including single-cell analysis; computational and systems biology; development of cellular and animal models of human disease; stem cell biology; genome engineering; epigenomics and analysis of gene-environment interactions; or novel strategies to evaluate the role of genetic variants in disease etiology, are encourage…
  • Senior Mass Spectrometrist / Head of Core Facility Proteomics

    1 Sep 2014 | 6:37 am
    The „Zentrum für Biosystemanalyse ZBSA“(Centre for Systems Biology) is an interdisciplinary research centre at the Albert-Ludwigs-University Freiburg (Germany). Together with several large collaborative research projects, the ZBSA has established a research focus in systems biology. TheZBSA now advertises the following position: Senior Mass Spectrometrist/Head of the Core Facility Proteomics Fulltime position, start date: immediately Suitable candidates are expected to have expert…
  • PhD/Graduate Student Positions

    1 Sep 2014 | 5:47 am
    The Vienna Biocenter (VBC) PhD Programme in Life Sciences has been successfully running since 1993, providing students from all over the world with excellent training. As a student at the VBC PhD Programme you will be supervised by a top scientist and have full access to state-of-the-art facilities, thus giving you the opportunity to start a fruitful scientific career. The Campus is highly multidisciplinary with research areas ranging from molecules to populations: RNA biology, gene regulati…
 
 
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    British Journal of Pharmacology

  • Structure-function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control

    Chiuan Yee Leow, Charlene Willis, Andreas Hofmann, Malcolm K. Jones
    1 Sep 2014 | 1:11 am
    Neglected tropical diseases are a group of some 17 diseases that afflict poor and predominantly rural people in developing nations. One significant disease that contributes to substantial morbidity in endemic areas is schistosomiasis, caused by infection with one of 5 species of blood fluke belonging to the trematode genus Schistosoma. Although there is one drug available for treatment of affected individuals in clinics, or for mass administration in endemic regions, there is a need for new therapies. A prominent target organ of schistosomes, either for drug or vaccine development, is the…
  • Oxidized LDL-induced angiogenesis involves sphingosine-1-phosphate. Prevention by anti-S1P antibody

    Caroline Camaré, Magali Trayssac, Barbara Garmy-Susini, Elodie Mucher, Roger Sabbadini, Robert Salvayre, Anne Negre-Salvayre
    1 Sep 2014 | 1:11 am
    Abstract Background and purposeNeovascularization occurring in atherosclerotic lesions may promote plaque expansion, intraplaque haemorrhage and rupture. Oxidized LDL (oxLDL) are atherogenic, but their angiogenic effect is controversial because both angiogenic and anti-angiogenic effects were reported. The angiogenic mechanism of oxLDL is partly understood, but the role of the angiogenic sphingolipid mediator sphingosine-1-phosphate (S1P) in this proces is not known. Thus, we aimed to investigate whether S1P is implicated in the oxLDL-induced angiogenesis and whether an anti-S1P monoclonal…
  • Auto-Inhibition at a Ligand-Gated Ion Channel: A Cross-Talk Between Orthosteric and Allosteric Sites

    Xiang-Qun Hu
    1 Sep 2014 | 1:10 am
    Summary Background and purposeA ligand is believed to produce either positive or negative efficacies, or to block both of them. However, an indole compound was found to promote both positive and negative efficacies at the 5-HT3AB receptor that displays low level of spontaneous activity. The present study attempted to delineate mechanisms underlying this phenomenon. Experimental approachThe spontaneously active V291S 5-HT3A receptor was used to explore behaviors of 5-hydroxyindole (5-HoI) and 5-methoxyindole (5-MoI), structural analogs of 5-HT, either alone or in combination with orthosteric…
  • Nonpeptidic GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia

    Hui Fan, Nian Gong, Teng-Fei Li, Ai-Niu Ma, Xiao-Yan Wu, Ming-Wei Wang, Yong-Xiang Wang
    1 Sep 2014 | 1:10 am
    Summary Background and PurposeWe recently reported that the glucagon-like peptide-1 receptor (GLP-1R) peptidic agonists exenatide and GLP-1 produced anti-hypersensitive effects in neuropathic, cancer and diabetic pain. In this study, we investigated the anti-allodynic and anti-hyperalgesic effects of the nonpeptidic agonist WB4-24 in inflammatory nociception and possible involvements of microglial β-endorphin and pro-inflammatory cytokines. Experimental ApproachRat formalin-, carrageenan- and complete Freund's adjuvant (CFA)-induced inflammatory nociceptive models were employed and…
  • Side-Effect Profile of Serotoninergic Treatments for Parkinson's Disease and L-DOPA-induced Dyskinesia in Rats

    D. Lindenbach, N. Palumbo, C. Y. Ostock, N. Vilceus, M. M. Conti, C. Bishop
    1 Sep 2014 | 1:10 am
    Summary Background and PurposeTreatment of Parkinson's disease (PD) with L-DOPA eventually causes abnormal involuntary movements known as dyskinesias in most patients. Dyskinesia can be reduced using compounds that act as direct or indirect agonists of the serotonin (5-HT)1A receptor, but these drugs have been reported to worsen PD features and are known to produce “5-HT syndrome”, symptoms of which include tremor, myoclonus, rigidity and hyperreflexia. Experimental ApproachSprague-Dawley rats were given unilateral nigrostriatal dopamine lesions with 6-hydroxydopamine. Each of the…
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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    PSI-Nature Structural Biology Knowledgebase

  • Drug Targets: Bile Acids in Motion

    Claudia Lupp
    20 Aug 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.218 Author: Claudia Lupp Crystal structures of sodium-dependent bile acid transporters provide insight into transport mechanism.
  • Drug Targets: S1R's Ligands and Partners

    Anita M. Engh
    20 Aug 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.219 Author: Anita M. Engh Stabilization of oligomers by small-molecule ligands suggests a mechanism for regulating a membrane protein chaperone.
  • Structural insight into autophagy initiation

    Katharine H. Wrighton
    22 May 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 367 (2014). doi:10.1038/nrm3815 Author: Katharine H. Wrighton Structural work offers insight into starvation-induced assembly of the autophagy initiation complex.
  • Displaying membrane proteins for cryo-EM

    26 Jun 2014 | 5:00 pm
    Nature Methods 11, 714 (2014). doi:10.1038/nmeth.3012
  • Complex Search

    Irene Kaganman
    20 Aug 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.220 Author: Irene Kaganman A search engine identifies assemblies with structural similarities, providing biologically relevant insights not accessible by comparison of individual proteins.
 
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