Nature.com

 
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    Nature - Issue - nature.com science feeds

  • Trading places

    25 May 2015 | 5:00 pm
    Trading places Nature 521, 7553 (2015). doi:10.1038/521393a Scientists have a valuable part to play in clarifying the impacts of a proposed trade treaty between the United States and Europe.
  • Wakey wakey

    25 May 2015 | 5:00 pm
    Wakey wakey Nature 521, 7553 (2015). doi:10.1038/521394a Sleeping-beauty papers offer hope that authors of uncited works are in good company.
  • Silicon smarts

    26 May 2015 | 5:00 pm
    Silicon smarts Nature 521, 7553 (2015). doi:10.1038/521394b A package of articles in Nature assesses the state of artificial-intelligence research.
  • Eat insects for fun, not to help the environment

    Ophelia Deroy
    26 May 2015 | 5:00 pm
    Eat insects for fun, not to help the environment Nature 521, 7553 (2015). http://www.nature.com/doifinder/10.1038/521395a Author: Ophelia Deroy Insects are an excellent source of sustainable protein, but people will only be persuaded to eat them if they seem appealing, says Ophelia Deroy.
  • Marine ecology: Ocean survey finds huge diversity

    26 May 2015 | 5:00 pm
    Marine ecology: Ocean survey finds huge diversity Nature 521, 7553 (2015). doi:10.1038/521396a After a 3.5-year voyage at sea, scientists have discovered more than 100,000 new eukaryotic organisms, many existing in symbiotic relationships with each other.Scientists aboard the research schooner Tara collected some 35,000 ocean samples at 210 locations around the world, from as deep as
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  • Interaction and signalling between a cosmopolitan phytoplankton and associated bacteria

    S. A. Amin
    26 May 2015 | 5:00 pm
    Nature advance online publication 27 May 2015. doi:10.1038/nature14488 Authors: S. A. Amin, L. R. Hmelo, H. M. van Tol, B. P. Durham, L. T. Carlson, K. R. Heal, R. L. Morales, C. T. Berthiaume, M. S. Parker, B. Djunaedi, A. E. Ingalls, M. R. Parsek, M. A. Moran & E. V. Armbrust Interactions between primary producers and bacteria impact the physiology of both partners, alter the chemistry of their environment, and shape ecosystem diversity. In marine ecosystems, these interactions are difficult to study partly because the major photosynthetic organisms are microscopic, unicellular…
  • A prefrontal–thalamo–hippocampal circuit for goal-directed spatial navigation

    Hiroshi T. Ito
    26 May 2015 | 5:00 pm
    Nature advance online publication 27 May 2015. doi:10.1038/nature14396 Authors: Hiroshi T. Ito, Sheng-Jia Zhang, Menno P. Witter, Edvard I. Moser & May-Britt Moser
  • Cell biology: The micronucleus gets its big break

    Kristin A. Knouse
    26 May 2015 | 5:00 pm
    Nature advance online publication 27 May 2015. doi:10.1038/nature14528 Authors: Kristin A. Knouse & Angelika Amon Extensive chromosomal rearrangement – chromothripsis – is seen in several cancers. Imaging and sequencing of single cells shows that this phenomenon can occur inside cellular anomalies known as micronuclei.
  • Cancer: Precise control of localized signals

    Vuk Stambolic
    26 May 2015 | 5:00 pm
    Nature advance online publication 27 May 2015. doi:10.1038/nature14531 Author: Vuk Stambolic The tumour-suppressor protein PTEN is mostly found in the cell cytoplasm, tethered to endosome vesicles. This localization regulates the enzyme's activity towards specific lipids and influences its control of cell growth.
  • Microbiology: Exclusive networks in the sea

    Alexander J. Limardo
    26 May 2015 | 5:00 pm
    Nature advance online publication 27 May 2015. doi:10.1038/nature14530 Authors: Alexander J. Limardo & Alexandra Z. Worden The identification of an exchange of nutrients and signalling molecules between a planktonic alga and a bacterium demonstrates that targeted mutualistic interactions occur across domains of life in the oceans.
 
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    Scientific American

  • Gold Flush

    Steve Mirsky
    18 May 2015 | 5:00 pm
    Scientific American 312, 81 (2015). doi:10.1038/scientificamerican0615-81 Author: Steve Mirsky A cloud with a silver lining pales next to solid waste laced with gold
  • An Apocalypse Think Tank

    Erin Biba
    18 May 2015 | 5:00 pm
    Scientific American 312, 26 (2015). doi:10.1038/scientificamerican0615-26 Author: Erin Biba
  • Letters

    18 May 2015 | 5:00 pm
    Scientific American 312, 6 (2015). doi:10.1038/scientificamerican0615-6
  • Our Personal Vaccine Helpers

    Katherine Harmon Courage
    18 May 2015 | 5:00 pm
    Scientific American 312, 22 (2015). doi:10.1038/scientificamerican0615-22 Author: Katherine Harmon Courage A fact of early childhood the world over, vaccines are a mainstay of global public health. But not all prove equally effective in all kids. Why? Gut microbes may be a big reason
  • 50, 100 & 150 Years Ago

    Daniel C. Schlenoff
    18 May 2015 | 5:00 pm
    Scientific American 312, 82 (2015). doi:10.1038/scientificamerican0615-82 Author: Daniel C. Schlenoff
 
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    Nature Biotechnology - AOP - nature.com science feeds

  • COMPASS identifies T-cell subsets correlated with clinical outcomes

    Lin Lin
    24 May 2015 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3187 Authors: Lin Lin, Greg Finak, Kevin Ushey, Chetan Seshadri, Thomas R Hawn, Nicole Frahm, Thomas J Scriba, Hassan Mahomed, Willem Hanekom, Pierre-Alexandre Bart, Giuseppe Pantaleo, Georgia D Tomaras, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Nelson L Michael, Jerome H Kim, Merlin L Robb, Robert J O'Connell, Nicos Karasavvas, Peter Gilbert, Stephen C De Rosa, M Juliana McElrath & Raphael Gottardo
  • De novo assembly of a haplotype-resolved human genome

    Hongzhi Cao
    24 May 2015 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3200 Authors: Hongzhi Cao, Honglong Wu, Ruibang Luo, Shujia Huang, Yuhui Sun, Xin Tong, Yinlong Xie, Binghang Liu, Hailong Yang, Hancheng Zheng, Jian Li, Bo Li, Yu Wang, Fang Yang, Peng Sun, Siyang Liu, Peng Gao, Haodong Huang, Jing Sun, Dan Chen, Guangzhu He, Weihua Huang, Zheng Huang, Yue Li, Laurent C A M Tellier, Xiao Liu, Qiang Feng, Xun Xu, Xiuqing Zhang, Lars Bolund, Anders Krogh, Karsten Kristiansen, Radoje Drmanac, Snezana Drmanac, Rasmus Nielsen, Songgang Li, Jian Wang, Huanming Yang, Yingrui Li, Gane Ka-Shu Wong & Jun Wang
  • Assembling large genomes with single-molecule sequencing and locality-sensitive hashing

    Konstantin Berlin
    24 May 2015 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3238 Authors: Konstantin Berlin, Sergey Koren, Chen-Shan Chin, James P Drake, Jane M Landolin & Adam M Phillippy
  • Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

    Huanhuan Joyce Chen
    24 May 2015 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3239 Authors: Huanhuan Joyce Chen, Jian Sun, Zhiliang Huang, Harry Hou, Myra Arcilla, Nikolai Rakhilin, Daniel J Joe, Jiahn Choi, Poornima Gadamsetty, Jeff Milsom, Govind Nandakumar, Randy Longman, Xi Kathy Zhou, Robert Edwards, Jonlin Chen, Kai Yuan Chen, Pengcheng Bu, Lihua Wang, Yitian Xu, Robert Munroe, Christian Abratte, Andrew D Miller, Zeynep H Gümüş, Michael Shuler, Nozomi Nishimura, Winfried Edelmann, Xiling Shen & Steven M Lipkin Current orthotopic xenograft models of human colorectal cancer (CRC) require surgery and do not…
  • In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

    Azita J Mahiny
    17 May 2015 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3241 Authors: Azita J Mahiny, Alexander Dewerth, Lauren E Mays, Mohammed Alkhaled, Benedikt Mothes, Emad Malaeksefat, Brigitta Loretz, Jennifer Rottenberger, Darina M Brosch, Philipp Reautschnig, Pacharapan Surapolchai, Franziska Zeyer, Andrea Schams, Melanie Carevic, Martina Bakele, Matthias Griese, Matthias Schwab, Bernd Nürnberg, Sandra Beer-Hammer, Rupert Handgretinger, Dominik Hartl, Claus-Michael Lehr & Michael S D Kormann
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    Nature Chemical Biology - Issue - nature.com science feeds

  • Archaeochemistry: Raising a glass

    Terry L. Sheppard
    14 May 2015 | 5:00 pm
    Nature Chemical Biology 11, 380 (2015). doi:10.1038/nchembio.1827 Author: Terry L. Sheppard
  • What's in a name?

    14 May 2015 | 5:00 pm
    Nature Chemical Biology 11, 363 (2015). doi:10.1038/nchembio.1832 Chemical biology may elude simple definitions, but there remains no question that chemical biologists have crafted a compelling interdisciplinary narrative that advances science and benefits society.
  • Greatest hits

    14 May 2015 | 5:00 pm
    Nature Chemical Biology 11, 364 (2015). doi:10.1038/nchembio.1815 We present a selection of papers published in Nature Chemical Biology over the past decade that reflect the diversity and excitement of chemical biology research.
  • Brain cancer: Staying alive

    Grant Miura
    14 May 2015 | 5:00 pm
    Nature Chemical Biology 11, 381 (2015). doi:10.1038/nchembio.1824 Author: Grant Miura
  • Know your target, know your molecule

    Mark E Bunnage
    14 May 2015 | 5:00 pm
    Nature Chemical Biology 11, 368 (2015). doi:10.1038/nchembio.1813 Authors: Mark E Bunnage, Adam M Gilbert, Lyn H Jones & Erik C Hett The pharmaceutical industry continues to experience significant attrition of drug candidates during phase 2 proof-of-concept clinical studies. We describe some questions about the characteristics of protein targets and small-molecule drugs that may be important to consider in drug-discovery projects and could improve prospects for future clinical success.
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  • Prolonged and tunable residence time using reversible covalent kinase inhibitors

    J Michael Bradshaw
    24 Jun 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1817 Authors: J Michael Bradshaw, Jesse M McFarland, Ville O Paavilainen, Angelina Bisconte, Danny Tam, Vernon T Phan, Sergei Romanov, David Finkle, Jin Shu, Vaishali Patel, Tony Ton, Xiaoyan Li, David G Loughhead, Philip A Nunn, Dane E Karr, Mary E Gerritsen, Jens Oliver Funk, Timothy D Owens, Erik Verner, Ken A Brameld, Ronald J Hill, David M Goldstein & Jack Taunton
  • Drug-target interactions: Stay tuned

    Robert A Copeland
    24 May 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1831 Author: Robert A Copeland The ability to vary a drug's residence time on a target is important for drug optimization. A series of reversible covalent inhibitors of select kinases demonstrates the feasibility of tuning residence time from minutes to days through modification of noncovalent features of the molecules.
  • Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride

    Dario A Vitturi
    24 May 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1814 Authors: Dario A Vitturi, Lucia Minarrieta, Sonia R Salvatore, Edward M Postlethwait, Marco Fazzari, Gerardo Ferrer-Sueta, Jack R Lancaster, Bruce A Freeman & Francisco J Schopfer
  • Metabolic engineering: Biosensor keeps DOPA on track

    Pamela Peralta-Yahya
    17 May 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1830 Author: Pamela Peralta-Yahya Biosensors are emerging as an important tool to evolutionarily engineer metabolic pathway enzymes for the microbial production of chemicals. A colorimetric biosensor used to increase dopamine levels in yeast now enables the production of benzylisoquinoline alkaloids from glucose.
  • An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

    William C DeLoache
    17 May 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1816 Authors: William C DeLoache, Zachary N Russ, Lauren Narcross, Andrew M Gonzales, Vincent J J Martin & John E Dueber
 
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    Nature Chemistry

  • Proteomics: Profiling lipidated proteins

    Russell Johnson
    19 May 2015 | 5:00 pm
    Nature Chemistry 7, 465 (2015). doi:10.1038/nchem.2276 Author: Russell Johnson
  • Molecular sensors: Spoiler alert

    Thomas Faust
    19 May 2015 | 5:00 pm
    Nature Chemistry 7, 466 (2015). doi:10.1038/nchem.2273 Author: Thomas Faust
  • Oxygen-evolving complex: The state of manganese

    Anne Pichon
    19 May 2015 | 5:00 pm
    Nature Chemistry 7, 465 (2015). doi:10.1038/nchem.2275 Author: Anne Pichon
  • Blogroll: Those who left

    Brandon Findlay
    19 May 2015 | 5:00 pm
    Nature Chemistry 7, 466 (2015). doi:10.1038/nchem.2263 Author: Brandon Findlay
  • Computational chemistry: Making a bad calculation

    Arthur Winter
    19 May 2015 | 5:00 pm
    Nature Chemistry 7, 473 (2015). doi:10.1038/nchem.2267 Author: Arthur Winter Computations of the energetics and mechanism of the Morita–Baylis–Hillman reaction are “not even wrong” when compared with experiments. While computational abstinence may be the purest way to calculate challenging reaction mechanisms, taking prophylactic measures to avoid regrettable outcomes may be more realistic.
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    Nature Chemistry

  • Simulation-guided DNA probe design for consistently ultraspecific hybridization

    Juexiao Sherry Wang
    24 May 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2266 Authors: Juexiao Sherry Wang & David Yu Zhang The use of kinetic simulations to guide the design of competitive hybridization probe systems is shown to enable high selectivity for single-nucleotide variants. Using this approach across 44 cancer mutation/wild-type sequence pairs showed between a 200- and 3,000-fold higher binding affinity than the corresponding wild-type sequence. In combination with PCR amplification this method enabled the detection a 1% concentration of variant alleles in human genomic DNA.
  • Selective, rapid and optically switchable regulation of protein function in live mammalian cells

    Yu-Hsuan Tsai
    17 May 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2253 Authors: Yu-Hsuan Tsai, Sebastian Essig, John R. James, Kathrin Lang & Jason W. Chin The rapid and selective regulation of a target protein within living cells containing closely related family members is a longstanding challenge. Here we introduce genetically directed bio-orthogonal ligand tethering (BOLT) and demonstrate selective inhibition (iBOLT), and optical switching (photo-BOLT), of protein function in live mammalian cells to address this challenge.
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    Nature Genetics - Issue - nature.com science feeds

  • Modeling NOTCH1 haploinsufficiency

    Emily Niemitz
    26 May 2015 | 5:00 pm
    Nature Genetics 47, 568 (2015). doi:10.1038/ng.3328 Author: Emily Niemitz
  • Hypertension linked to PDE3A activation

    Miles Houslay
    26 May 2015 | 5:00 pm
    Nature Genetics 47, 562 (2015). doi:10.1038/ng.3316 Author: Miles Houslay A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.
  • Fibrogenic lineage identified

    Kyle Vogan
    26 May 2015 | 5:00 pm
    Nature Genetics 47, 568 (2015). doi:10.1038/ng.3326 Author: Kyle Vogan
  • Transposon mutagenesis disentangles osteosarcoma genetic drivers

    Kevin B Jones
    26 May 2015 | 5:00 pm
    Nature Genetics 47, 564 (2015). doi:10.1038/ng.3317 Author: Kevin B Jones The genetic drivers of osteosarcoma have been difficult to identify because of the genomic complexity consistently encountered in cancer cells at diagnosis. A new study uses Sleeping Beauty transposon mutagenesis to drive osteosarcomagenesis in the mouse and identify likely drivers of the disease in humans.
  • Corrigendum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

    James J Crowley
    26 May 2015 | 5:00 pm
    Nature Genetics 47, 690 (2015). doi:10.1038/ng0615-690a Author: James J Crowley, Vasyl Zhabotynsky, Wei Sun, Shunping Huang, Isa Kemal Pakatci, Yunjung Kim, Jeremy R Wang, Andrew P Morgan, John D Calaway, David L Aylor, Zaining Yun, Timothy A Bell, Ryan J Buus, Mark E Calaway, John P Didion, Terry J Gooch, Stephanie D Hansen, Nashiya N Robinson, Ginger D Shaw, Jason S Spence, Corey R Quackenbush, Cordelia J Barrick, Randal J Nonneman, Kyungsu Kim, James Xenakis, Yuying Xie, William Valdar, Alan B Lenarcic, Wei Wang, Catherine E Welsh, Chen-Ping Fu, Zhaojun Zhang, James Holt, Zhishan Guo,…
 
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  • A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

    Vafa Alakbarzade
    24 May 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3313 Authors: Vafa Alakbarzade, Abdul Hameed, Debra Q Y Quek, Barry A Chioza, Emma L Baple, Amaury Cazenave-Gassiot, Long N Nguyen, Markus R Wenk, Arshia Q Ahmad, Ajith Sreekantan-Nair, Michael N Weedon, Phil Rich, Michael A Patton, Thomas T Warner, David L Silver & Andrew H Crosby The major pathway by which the brain obtains essential omega-3 fatty acids from the circulation is through a sodium-dependent lysophosphatidylcholine (LPC) transporter (MFSD2A), expressed in the endothelium of the blood-brain barrier. Here we show that a homozygous mutation…
  • Transcriptional regulator PRDM12 is essential for human pain perception

    Ya-Chun Chen
    24 May 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3308 Authors: Ya-Chun Chen, Michaela Auer-Grumbach, Shinya Matsukawa, Manuela Zitzelsberger, Andreas C Themistocleous, Tim M Strom, Chrysanthi Samara, Adrian W Moore, Lily Ting-Yin Cho, Gareth T Young, Caecilia Weiss, Maria Schabhüttl, Rolf Stucka, Annina B Schmid, Yesim Parman, Luitgard Graul-Neumann, Wolfram Heinritz, Eberhard Passarge, Rosemarie M Watson, Jens Michael Hertz, Ute Moog, Manuela Baumgartner, Enza Maria Valente, Diego Pereira, Carlos M Restrepo, Istvan Katona, Marina Dusl, Claudia Stendel, Thomas Wieland, Fay Stafford, Frank Reimann, Katja…
  • Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

    Alicia Guemez-Gamboa
    24 May 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3311 Authors: Alicia Guemez-Gamboa, Long N Nguyen, Hongbo Yang, Maha S Zaki, Majdi Kara, Tawfeg Ben-Omran, Naiara Akizu, Rasim Ozgur Rosti, Basak Rosti, Eric Scott, Jana Schroth, Brett Copeland, Keith K Vaux, Amaury Cazenave-Gassiot, Debra Q Y Quek, Bernice H Wong, Bryan C Tan, Markus R Wenk, Murat Gunel, Stacey Gabriel, Neil C Chi, David L Silver & Joseph G Gleeson Docosahexanoic acid (DHA) is the most abundant omega-3 fatty acid in brain, and, although it is considered essential, deficiency has not been linked to disease. Despite the large mass of DHA in…
  • Spatial genomic heterogeneity within localized, multifocal prostate cancer

    Paul C Boutros
    24 May 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3315 Authors: Paul C Boutros, Michael Fraser, Nicholas J Harding, Richard de Borja, Dominique Trudel, Emilie Lalonde, Alice Meng, Pablo H Hennings-Yeomans, Andrew McPherson, Veronica Y Sabelnykova, Amin Zia, Natalie S Fox, Julie Livingstone, Yu-Jia Shiah, Jianxin Wang, Timothy A Beck, Cherry L Have, Taryne Chong, Michelle Sam, Jeremy Johns, Lee Timms, Nicholas Buchner, Ada Wong, John D Watson, Trent T Simmons, Christine P'ng, Gaetano Zafarana, Francis Nguyen, Xuemei Luo, Kenneth C Chu, Stephenie D Prokopec, Jenna Sykes, Alan Dal Pra, Alejandro Berlin, Andrew…
  • A cascade of arabinosyltransferases controls shoot meristem size in tomato

    Cao Xu
    24 May 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3309 Authors: Cao Xu, Katie L Liberatore, Cora A MacAlister, Zejun Huang, Yi-Hsuan Chu, Ke Jiang, Christopher Brooks, Mari Ogawa-Ohnishi, Guangyan Xiong, Markus Pauly, Joyce Van Eck, Yoshikatsu Matsubayashi, Esther van der Knaap & Zachary B Lippman
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    Nature Geoscience - Issue - nature.com science feeds

  • Pliocene warmth and gradients

    Chris Brierley
    27 May 2015 | 5:00 pm
    Nature Geoscience 8, 419 (2015). doi:10.1038/ngeo2444 Authors: Chris Brierley, Natalie Burls, Christina Ravelo & Alexey Fedorov
  • Biogeochemistry: Silica cycling over geologic time

    Daniel J. Conley
    27 May 2015 | 5:00 pm
    Nature Geoscience 8, 431 (2015). doi:10.1038/ngeo2454 Authors: Daniel J. Conley & Joanna C. Carey The Earth's long-term silica cycle is intimately linked to weathering rates and biogenic uptake. Changes in weathering rates and the retention of silica on land have altered silica availability in the oceans for hundreds of millions of years.
  • More space for methods

    27 May 2015 | 5:00 pm
    Nature Geoscience 8, 417 (2015). doi:10.1038/ngeo2461 Nature Geoscience introduces 3,000-word Methods sections that are integrated with the online paper.
  • Reply to 'Pliocene warmth and gradients'

    Charlotte L. O'Brien
    27 May 2015 | 5:00 pm
    Nature Geoscience 8, 420 (2015). doi:10.1038/ngeo2445 Authors: Charlotte L. O'Brien, Gavin L. Foster, James W. B. Rae & Richard D. Pancost
  • The catastrophic nature of humans

    Richard Guthrie
    27 May 2015 | 5:00 pm
    Nature Geoscience 8, 421 (2015). doi:10.1038/ngeo2455 Author: Richard Guthrie Natural landscapes are shaped by frequent moderate-sized events, except for the rare catastrophe. Human modifications to the Earth's surface are, compared with natural processes, increasingly catastrophic.
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  • Persistence of dissolved organic matter in lakes related to its molecular characteristics

    Anne M. Kellerman
    24 May 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2440 Authors: Anne M. Kellerman, Dolly N. Kothawala, Thorsten Dittmar & Lars J. Tranvik Whether intrinsic molecular properties or extrinsic factors such as environmental conditions control the decomposition of natural organic matter across soil, marine and freshwater systems has been subject to debate. Comprehensive evaluations of the controls that molecular structure exerts on organic matter’s persistence in the environment have been precluded by organic matter’s extreme complexity. Here we examine dissolved organic matter from 109 Swedish…
  • Landscape biogeochemistry reflected in shifting distributions of chemical traits in the Amazon forest canopy

    Gregory P. Asner
    24 May 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2443 Authors: Gregory P. Asner, Christopher B. Anderson, Roberta E. Martin, Raul Tupayachi, David E. Knapp & Felipe Sinca
  • Long-term interaction between mid-ocean ridges and mantle plumes

    J. M. Whittaker
    24 May 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2437 Authors: J. M. Whittaker, J. C. Afonso, S. Masterton, R. D. Müller, P. Wessel, S. E. Williams & M. Seton Plate tectonic motions are commonly considered to be driven by slab pull at subduction zones and ridge push at mid-ocean ridges, with motion punctuated by plumes of hot material rising from the lower mantle. Within this model, the geometry and location of mid-ocean ridges are considered to be independent of lower-mantle dynamics, such as deeply sourced plumes that produce voluminous lava eruptions—termed large igneous provinces. Here…
  • Pacific origin of the abrupt increase in Indian Ocean heat content during the warming hiatus

    Sang-Ki Lee
    17 May 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2438 Authors: Sang-Ki Lee, Wonsun Park, Molly O. Baringer, Arnold L. Gordon, Bruce Huber & Yanyun Liu Global mean surface warming has stalled since the end of the twentieth century, but the net radiation imbalance at the top of the atmosphere continues to suggest an increasingly warming planet. This apparent contradiction has been reconciled by an anomalous heat flux into the ocean, induced by a shift towards a La Niña-like state with cold sea surface temperatures in the eastern tropical Pacific over the past decade or so. A significant portion of…
  • Stratospheric influence on tropospheric jet streams, storm tracks and surface weather

    Joseph Kidston
    17 May 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2424 Authors: Joseph Kidston, Adam A. Scaife, Steven C. Hardiman, Daniel M. Mitchell, Neal Butchart, Mark P. Baldwin & Lesley J. Gray
 
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    Nature Materials - Issue - nature.com science feeds

  • Quantum physics: Indistinguishable atoms

    Maria Maragkou
    19 May 2015 | 5:00 pm
    Nature Materials 14, 556 (2015). doi:10.1038/nmat4315 Author: Maria Maragkou
  • New horizons for glass formation and stability

    A. Lindsay Greer
    19 May 2015 | 5:00 pm
    Nature Materials 14, 542 (2015). doi:10.1038/nmat4292 Author: A. Lindsay Greer It has long been thought impossible for pure metals to form stable glasses. Recent work supports earlier evidence of glass formation in pure metals, shows the potential for devices based on rapid glass–crystal phase change, and highlights the lack of an adequate theory for fast crystal growth.
  • Metallic glasses: Tunable nanostructures

    John Plummer
    19 May 2015 | 5:00 pm
    Nature Materials 14, 556 (2015). doi:10.1038/nmat4313 Author: John Plummer
  • Tuning order in disorder

    Evan Ma
    19 May 2015 | 5:00 pm
    Nature Materials 14, 547 (2015). doi:10.1038/nmat4300 Author: Evan Ma Recent research has revealed considerable diversity in the short-range ordering of metallic glass, identifying favoured and unfavoured local atomic configurations coexisting in an inhomogeneous amorphous structure. Tailoring the population of these local motifs may selectively enhance a desired property.
  • Organic–inorganic perovskites: Lower threshold for nanowire lasers

    Anthony Fu
    19 May 2015 | 5:00 pm
    Nature Materials 14, 557 (2015). doi:10.1038/nmat4291 Authors: Anthony Fu & Peidong Yang Hybrid perovskite is introduced as a new material for nanowire lasers. One-dimensional nanostructures of these perovskites can be optically pumped to lase with tunable wavelength at relatively low threshold, which marks a step towards their use in integrated photonics.
 
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    Nature Medicine - AOP - nature.com science feeds

  • Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

    Ivan D Mascanfroni
    24 May 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3868 Authors: Ivan D Mascanfroni, Maisa C Takenaka, Ada Yeste, Bonny Patel, Yan Wu, Jessica E Kenison, Shafiuddin Siddiqui, Alexandre S Basso, Leo E Otterbein, Drew M Pardoll, Fan Pan, Avner Priel, Clary B Clish, Simon C Robson & Francisco J Quintana
  • The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells

    Di Zhu
    24 May 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3867 Authors: Di Zhu, Zhongqiu Wang, Jian-Jun Zhao, Teresa Calimeri, Jiang Meng, Teru Hideshima, Mariateresa Fulciniti, Yue Kang, Scott B Ficarro, Yu-Tzu Tai, Zachary Hunter, Douglas McMilin, Haoxuan Tong, Constantine S Mitsiades, Catherine J Wu, Steven P Treon, David M Dorfman, Geraldine Pinkus, Nikhil C Munshi, Pierfrancesco Tassone, Jarrod A Marto, Kenneth C Anderson & Ruben D Carrasco
  • KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

    Laura S Shankman
    17 May 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3866 Authors: Laura S Shankman, Delphine Gomez, Olga A Cherepanova, Morgan Salmon, Gabriel F Alencar, Ryan M Haskins, Pamela Swiatlowska, Alexandra A C Newman, Elizabeth S Greene, Adam C Straub, Brant Isakson, Gwendalyn J Randolph & Gary K Owens
  • The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

    Bengt-Frederik Belgardt
    17 May 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3862 Authors: Bengt-Frederik Belgardt, Kashan Ahmed, Martina Spranger, Mathieu Latreille, Remy Denzler, Nadiia Kondratiuk, Ferdinand von Meyenn, Felipe Nunez Villena, Karolin Herrmanns, Domenico Bosco, Julie Kerr-Conte, Francois Pattou, Thomas Rülicke & Markus Stoffel
  • Common clonal origin of central and resident memory T cells following skin immunization

    Olivier Gaide
    10 May 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3860 Authors: Olivier Gaide, Ryan O Emerson, Xiaodong Jiang, Nicholas Gulati, Suzanne Nizza, Cindy Desmarais, Harlan Robins, James G Krueger, Rachael A Clark & Thomas S Kupper Central memory T (TCM) cells in lymph nodes (LNs) and resident memory T (TRM) cells in peripheral tissues have distinct roles in protective immunity. Both are generated after primary infections, but their clonal origins have been unclear. To address this question, we immunized mice through the skin with a protein antigen, a chemical hapten, or a non-replicating poxvirus. We then…
 
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    Nature Methods - AOP - nature.com science feeds

  • Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

    Anca M Paşca
    24 May 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3415 Authors: Anca M Paşca, Steven A Sloan, Laura E Clarke, Yuan Tian, Christopher D Makinson, Nina Huber, Chul Hoon Kim, Jin-Young Park, Nancy A O'Rourke, Khoa D Nguyen, Stephen J Smith, John R Huguenard, Daniel H Geschwind, Ben A Barres & Sergiu P Paşca
  • Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation

    Joan Savall
    24 May 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3410 Authors: Joan Savall, Eric Tatt Wei Ho, Cheng Huang, Jessica R Maxey & Mark J Schnitzer We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking; translations and rotations; characterizations of fly phenotypes and behaviors; microdissection; or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform…
  • Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR

    Mohammed Kaplan
    17 May 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3406 Authors: Mohammed Kaplan, Abhishek Cukkemane, Gydo C P van Zundert, Siddarth Narasimhan, Mark Daniëls, Deni Mance, Gabriel Waksman, Alexandre M J J Bonvin, Rémi Fronzes, Gert E Folkers & Marc Baldus Studying biomolecules at atomic resolution in their native environment is the ultimate aim of structural biology. We investigated the bacterial type IV secretion system core complex (T4SScc) by cellular dynamic nuclear polarization–based solid-state nuclear magnetic resonance spectroscopy to validate a structural model previously generated…
  • A microfluidic device for label-free, physical capture of circulating tumor cell clusters

    A Fatih Sarioglu
    17 May 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3404 Authors: A Fatih Sarioglu, Nicola Aceto, Nikola Kojic, Maria C Donaldson, Mahnaz Zeinali, Bashar Hamza, Amanda Engstrom, Huili Zhu, Tilak K Sundaresan, David T Miyamoto, Xi Luo, Aditya Bardia, Ben S Wittner, Sridhar Ramaswamy, Toshi Shioda, David T Ting, Shannon L Stott, Ravi Kapur, Shyamala Maheswaran, Daniel A Haber & Mehmet Toner
  • Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection

    Adam D Ewing
    17 May 2015 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3407 Authors: Adam D Ewing, Kathleen E Houlahan, Yin Hu, Kyle Ellrott, Cristian Caloian, Takafumi N Yamaguchi, J Christopher Bare, Christine P'ng, Daryl Waggott, Veronica Y Sabelnykova, Michael R Kellen, Thea C Norman, David Haussler, Stephen H Friend, Gustavo Stolovitzky, Adam A Margolin, Joshua M Stuart & Paul C Boutros
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    Nature Nanotechnology - Issue - nature.com science feeds

  • Graphene opens up to new applications

    6 May 2015 | 5:00 pm
    Nature Nanotechnology 10, 381 (2015). doi:10.1038/nnano.2015.110 Effective separation membranes could be created by etching nanometre-sized pores in two-dimensional materials.
  • Our choice from the recent literature

    6 May 2015 | 5:00 pm
    Nature Nanotechnology 10, 383 (2015). doi:10.1038/nnano.2015.99
  • Nanoporous graphene: Membranes at the limit

    Dong-Yeun Koh
    6 May 2015 | 5:00 pm
    Nature Nanotechnology 10, 385 (2015). doi:10.1038/nnano.2015.77 Authors: Dong-Yeun Koh & Ryan P. Lively Water desalination membranes can be created by etching nanometre-sized pores in a single layer of graphene.
  • Creativity unleashed

    François Grey
    6 May 2015 | 5:00 pm
    Nature Nanotechnology 10, 480 (2015). doi:10.1038/nnano.2015.95 Author: François Grey Hands-on challenges such as building a low-cost atomic force microscope for schools can teach more than standard lessons, says François Grey.
  • 2D materials: Memristor goes two-dimensional

    Jiangtan Yuan
    6 May 2015 | 5:00 pm
    Nature Nanotechnology 10, 389 (2015). doi:10.1038/nnano.2015.94 Authors: Jiangtan Yuan & Jun Lou A single layer of MoS2 can be used to fabricate a memristor by exploiting structural defects in the crystal.
 
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    Nature Neuroscience - Issue - nature.com science feeds

  • Social nudges: utility conferred from others

    David V Smith
    25 May 2015 | 5:00 pm
    Nature Neuroscience 18, 791 (2015). doi:10.1038/nn.4031 Authors: David V Smith & Mauricio R Delgado Observing the choices of others adds utility to the chosen option. The additional utility conferred by others' choices is encoded by the ventromedial prefrontal cortex and explains the idiosyncratic effects of social influence.
  • Once upon a spine: setting striatal dopamine

    Christoph Kellendonk
    25 May 2015 | 5:00 pm
    Nature Neuroscience 18, 788 (2015). doi:10.1038/nn.4029 Authors: Christoph Kellendonk & Joshua A Gordon The prefrontal cortex is known to influence dopamine release in the striatum–but how? New data in mice suggest that cortical spine density affects striatal dopamine release via monosynaptic control of dopamine neurons, tracing a chain of events from spine loss to antipsychotic-responsive psychomotor agitation.
  • The case for rejecting the amyloid cascade hypothesis

    Karl Herrup
    25 May 2015 | 5:00 pm
    Nature Neuroscience 18, 794 (2015). doi:10.1038/nn.4017 Author: Karl Herrup
  • Hunger logic

    Richard Palmiter
    25 May 2015 | 5:00 pm
    Nature Neuroscience 18, 789 (2015). doi:10.1038/nn.4032 Author: Richard Palmiter Activation of AgRP-expressing 'hunger' neurons promotes robust feeding. Recent studies reveal the valence, dynamics and neural circuits engaged by AgRP neurons.
  • Lysosomes to combat Parkinson's disease

    Ole Isacson
    25 May 2015 | 5:00 pm
    Nature Neuroscience 18, 792 (2015). doi:10.1038/nn.4027 Author: Ole Isacson A study finds the transcription factor Lmx1b to be necessary in adults for preventing degeneration of midbrain dopamine neurons and implicates it in lysosomal function and regulation in these neurons.
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    Nature Photonics - Issue - nature.com science feeds

  • Cathodoluminescence: Nanoscale tomography

    Oliver Graydon
    27 May 2015 | 5:00 pm
    Nature Photonics 9, 352 (2015). doi:10.1038/nphoton.2015.99 Author: Oliver Graydon
  • Memories of Charles Townes

    Elsa Garmire
    27 May 2015 | 5:00 pm
    Nature Photonics 9, 347 (2015). doi:10.1038/nphoton.2015.91 Author: Elsa Garmire Charles Townes, the Nobel laureate acclaimed for his pioneering work on lasers and nonlinear optics, sadly passed away in January this year. Here I offer personal reflections of working with him as one of his graduate students.
  • Master of electrons and photons

    27 May 2015 | 5:00 pm
    Nature Photonics 9, 345 (2015). doi:10.1038/nphoton.2015.100 Nikola Tesla is known for his work on alternating current power systems, induction motors and wireless transmission but he is also an unsung hero of research into X-rays and light sources.
  • New titles at a glance

    27 May 2015 | 5:00 pm
    Nature Photonics 9, 351 (2015). doi:10.1038/nphoton.2015.90
  • Photovoltaics: Non-cubic solar cell materials

    Vera Steinmann
    27 May 2015 | 5:00 pm
    Nature Photonics 9, 355 (2015). doi:10.1038/nphoton.2015.85 Authors: Vera Steinmann, Riley E. Brandt & Tonio Buonassisi Controlled growth of non-cubic, anisotropic solar cell materials, such as antimony selenide, is bringing new opportunities for efficient thin-film photovoltaics.
 
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    Nature Photonics - AOP - nature.com science feeds

  • Efficient inverted polymer solar cells employing favourable molecular orientation

    Varun Vohra
    24 May 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.84 Authors: Varun Vohra, Kazuaki Kawashima, Takeshi Kakara, Tomoyuki Koganezawa, Itaru Osaka, Kazuo Takimiya & Hideyuki Murata
  • High-rate measurement-device-independent quantum cryptography

    Stefano Pirandola
    24 May 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.83 Authors: Stefano Pirandola, Carlo Ottaviani, Gaetana Spedalieri, Christian Weedbrook, Samuel L. Braunstein, Seth Lloyd, Tobias Gehring, Christian S. Jacobsen & Ulrik L. Andersen
  • Detection of X-ray photons by solution-processed lead halide perovskites

    Sergii Yakunin
    24 May 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.82 Authors: Sergii Yakunin, Mykhailo Sytnyk, Dominik Kriegner, Shreetu Shrestha, Moses Richter, Gebhard J. Matt, Hamed Azimi, Christoph J. Brabec, Julian Stangl, Maksym V. Kovalenko & Wolfgang Heiss
  • High-speed detection at two micrometres with monolithic silicon photodiodes

    Jason J. Ackert
    24 May 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.81 Authors: Jason J. Ackert, David J. Thomson, Li Shen, Anna C. Peacock, Paul E. Jessop, Graham T. Reed, Goran Z. Mashanovich & Andrew P. Knights With continued steep growth in the volume of data transmitted over optical networks there is a widely recognized need for more sophisticated photonics technologies to forestall a ‘capacity crunch’. A promising solution is to open new spectral regions at wavelengths near 2 μm and to exploit the long-wavelength transmission and amplification capabilities of hollow-core photonic-bandgap fibres and…
  • An integrated-nanophotonics polarization beamsplitter with 2.4 × 2.4 μm2 footprint

    Bing Shen
    17 May 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.80 Authors: Bing Shen, Peng Wang, Randy Polson & Rajesh Menon We have designed, fabricated and characterized an integrated-nanophotonics polarization beamsplitter with a footprint of 2.4 × 2.4 μm2, which is the smallest polarization beamsplitter ever demonstrated. A nonlinear optimization algorithm was used to design the device for λ0 = 1,550 nm. The polarization beamsplitter and the input/output waveguides can be fabricated in a single lithography step. Here, we experimentally show an average transmission efficiency of greater…
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    Nature Physics - AOP - nature.com science feeds

  • Wheeler’s delayed-choice gedanken experiment with a single atom

    A. G. Manning
    24 May 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3343 Authors: A. G. Manning, R. I. Khakimov, R. G. Dall & A. G. Truscott The wave–particle dual nature of light and matter and the fact that the choice of measurement determines which one of these two seemingly incompatible behaviours we observe are examples of the counterintuitive features of quantum mechanics. They are illustrated by Wheeler’s famous ‘delayed-choice’ experiment, recently demonstrated in a single-photon experiment. Here, we use a single ultracold metastable helium atom in a Mach–Zehnder interferometer to…
  • One minute parity lifetime of a NbTiN Cooper-pair transistor

    David J. van Woerkom
    24 May 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3342 Authors: David J. van Woerkom, Attila Geresdi & Leo P. Kouwenhoven The parity modulation of the ground state of a superconducting island is a direct consequence of the presence of the Cooper-pair condensate preferring an even number of charge carriers. The addition energy of an odd, unpaired quasiparticle equals the superconducting gap, Δ, suppressing single-electron hopping in the low-temperature limit, kBT ≪ Δ. Controlling the quasiparticle occupation is of fundamental importance for superconducting qubits as single-electron…
  • Interpreting attoclock measurements of tunnelling times

    Lisa Torlina
    24 May 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3340 Authors: Lisa Torlina, Felipe Morales, Jivesh Kaushal, Igor Ivanov, Anatoli Kheifets, Alejandro Zielinski, Armin Scrinzi, Harm Geert Muller, Suren Sukiasyan, Misha Ivanov & Olga Smirnova
  • Optically reconfigurable magnetic materials

    Marc Vogel
    17 May 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3325 Authors: Marc Vogel, Andrii V. Chumak, Erik H. Waller, Thomas Langner, Vitaliy I. Vasyuchka, Burkard Hillebrands & Georg von Freymann Structuring of materials is the most general approach for controlling waves in solids. As spin waves—eigen-excitations of the electrons’ spin system—are free from Joule heating, they are of interest for a range of applications, such as processing, filtering and short-time data storage. Whereas all these applications rely on predefined constant structures, a dynamic variation of the structures would…
  • Rotational state-changing cold collisions of hydroxyl ions with helium

    Daniel Hauser
    17 May 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3326 Authors: Daniel Hauser, Seunghyun Lee, Fabio Carelli, Steffen Spieler, Olga Lakhmanskaya, Eric S. Endres, Sunil S. Kumar, Franco Gianturco & Roland Wester Cold molecules are important for many applications, from fundamental precision measurements, quantum information processing, quantum-controlled chemistry, to understanding the cold interstellar medium. Molecular ions are known to be cooled efficiently in sympathetic collisions with cold atoms or ions. However, little knowledge is available on the elementary cooling steps, because the determination…
 
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Tumour immunology: Eosinophils — T cells' little helpers

    M. Teresa Villanueva
    21 May 2015 | 5:00 pm
    Nature Reviews Cancer 15, 320 (2015). doi:10.1038/nrc3969 Author: M. Teresa Villanueva Eosinophilia is frequently observed in cancer and eosinophils are attracted to tumours but it is still unknown whether they play an active part in tumour rejection. Carretero et al. have shown that, in the presence of tumour-specific CD8+ T cells, eosinophils secreted
  • Immunotherapy: Put your coat on!

    Nicola McCarthy
    21 May 2015 | 5:00 pm
    Nature Reviews Cancer 15, 319 (2015). doi:10.1038/nrc3964 Author: Nicola McCarthy Tumour cells coated with immunoglobulin G are able to induce an immune response in mice that causes tumour regression.
  • Immunotherapy: Killer combo

    M. Teresa Villanueva
    21 May 2015 | 5:00 pm
    Nature Reviews Cancer 15, 320 (2015). doi:10.1038/nrc3968 Author: M. Teresa Villanueva Cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death 1 (PD1) receptor inhibit antitumour immunity through complementary and non-redundant mechanisms. A new trial assessed the combination of ipilimumab (a CTLA4-specific monoclonal antibody) and nivolumab (a PD1-specific monoclonal antibody) in 142 patients with metastatic melanoma
  • Therapeutic resistance: Fibroblasts restrain drug sensitivity

    Gemma K. Alderton
    21 May 2015 | 5:00 pm
    Nature Reviews Cancer 15, 318 (2015). doi:10.1038/nrc3965 Author: Gemma K. Alderton Hirata et al. used intravital imaging to characterize a surprising form of BRAF-V600E inhibitor resistance in melanoma.
  • Non-coding RNA: Stressed to bits

    Sarah Seton-Rogers
    21 May 2015 | 5:00 pm
    Nature Reviews Cancer 15, 320 (2015). doi:10.1038/nrc3966 Author: Sarah Seton-Rogers Goodarzi et al. find that small non-coding RNAs derived from the cleavage of tRNAs under hypoxic conditions can suppress metastatic progression.
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Non-coding RNA: X chromosome inactivation unravelled

    Eytan Zlotorynski
    17 May 2015 | 5:00 pm
    Nature Reviews Genetics 16, 315 (2015). doi:10.1038/nrg3955 Author: Eytan Zlotorynski The long non-coding RNA (lncRNA) Xist (X inactive-specific transcript) is required for the transcriptional silencing of one X chromosome in each cell, in a process known as X chromosome inactivation (XCI) that occurs during mammalian female development. Owing to technical limitations, little is known
  • Ageing: Heterochromatin disorganization associated with premature ageing

    Bryony Jones
    17 May 2015 | 5:00 pm
    Nature Reviews Genetics 16, 318 (2015). doi:10.1038/nrg3958 Author: Bryony Jones Werner syndrome (also known as adult progeria) is a premature ageing disorder with phenotypes such as grey hair, osteoporosis and diabetes, which are linked to defects in mesodermal tissue. Werner syndrome is caused by mutations in the WRN gene, which is involved in several
  • In the news

    Orli G. Bahcall
    17 May 2015 | 5:00 pm
    Nature Reviews Genetics 16, 318 (2015). doi:10.1038/nrg3959 Author: Orli G. Bahcall Rudolf Jaenisch Awarded March of Dimes PrizeThe 2015 March of Dimes Prize in Developmental Biology has been awarded to Rudolf Jaenisch for work that provided the foundation for the development of induced pluripotent stem (iPS) cells and applications used to treat a range of
  • Disease genetics: Network effects of disease mutations

    Darren J. Burgess
    17 May 2015 | 5:00 pm
    Nature Reviews Genetics 16, 317 (2015). doi:10.1038/nrg3957 Author: Darren J. Burgess Of the >100,000 genetic variants that have been statistically associated with human disease, a major challenge is to identify and characterize the subset that have functional consequences. Such information helps to pinpoint variants that causally contribute to diseases (thus refining disease risk estimates for individuals
  • The diverse origins of the human gene pool

    Svante Pääbo
    17 May 2015 | 5:00 pm
    Nature Reviews Genetics 16, 313 (2015). doi:10.1038/nrg3954 Author: Svante Pääbo Analyses of the genomes of Neanderthals and Denisovans, the closest evolutionary relatives of present-day humans, suggest that our ancestors were part of a web of now-extinct populations linked by limited, but intermittent or sometimes perhaps even persistent, gene flow.
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Gene regulation: Seasonal genes explain the winter blues

    Lucy Bird
    25 May 2015 | 5:00 pm
    Nature Reviews Immunology 15, 334 (2015). doi:10.1038/nri3869 Author: Lucy Bird New research may explain why some inflammatory diseases are more common in the winter. According to Todd and colleagues, the activity of ∼23% of human genes varies with the seasons. Genome-wide analyses of mRNA levels in peripheral blood mononuclear cells from European cohorts revealed a
  • T cell memory: New insight on old-timers

    Yvonne Bordon
    25 May 2015 | 5:00 pm
    Nature Reviews Immunology 15, 331 (2015). doi:10.1038/nri3866 Author: Yvonne Bordon Interleukin-7 supports metabolic activity in memory CD8+ T cells, and should our paradigms of memory subsets be revised?
  • T cells: LEM keeps the wheels turning

    Olive Leavy
    25 May 2015 | 5:00 pm
    Nature Reviews Immunology 15, 334 (2015). doi:10.1038/nri3870 Author: Olive Leavy A newly identified protein, LEM, promotes CD8+ T cell proliferation and memory formation.
  • Regulation of tumour necrosis factor signalling: live or let die

    Dirk Brenner
    25 May 2015 | 5:00 pm
    Nature Reviews Immunology 15, 362 (2015). doi:10.1038/nri3834 Authors: Dirk Brenner, Heiko Blaser & Tak W. Mak Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an
  • Inflammation: Interferon-λ2 limits neutrophil migration

    Elisabeth Kugelberg
    25 May 2015 | 5:00 pm
    Nature Reviews Immunology 15, 334 (2015). doi:10.1038/nri3867 Author: Elisabeth Kugelberg The type III interferon (IFN) family comprises IFNλ1, IFNλ2 and IFNλ3, which are mainly known for their role in antiviral immunity. Now, Blazek et al. show that IFNλ2 has anti-inflammatory functions, and treatment with IFNλ2 halts and reverses the development of collagen-induced arthritis (CIA)
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Secretion systems in Gram-negative bacteria: structural and mechanistic insights

    Tiago R. D. Costa
    14 May 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 343 (2015). doi:10.1038/nrmicro3456 Authors: Tiago R. D. Costa, Catarina Felisberto-Rodrigues, Amit Meir, Marie S. Prevost, Adam Redzej, Martina Trokter & Gabriel Waksman Bacteria have evolved a remarkable array of sophisticated nanomachines to export various virulence factors across the bacterial cell envelope. In recent years, considerable progress has been made towards elucidating the structural and molecular mechanisms of the six secretion systems (types I–VI) of Gram-negative bacteria, the
  • Bacterial physiology: Alternative ways to flip out

    Claudio Nunes-Alves
    14 May 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 328 (2015). doi:10.1038/nrmicro3500 Author: Claudio Nunes-Alves Previous work in Escherichia coli has provided evidence that MurJ is the flippase responsible for transport of the cell wall precursor lipid II across the cytoplasmic membrane. However, deletion of MurJ paralogues in Bacillus subtilis does not affect cell viability, which suggests that
  • There's no place like home

    Alison E. Mather
    14 May 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 331 (2015). doi:10.1038/nrmicro3497 Author: Alison E. Mather This month's Genome Watch looks at how the combination of household contact sampling and whole-genome sequencing has provided insight into the sources and transmission patterns of methicillin-resistant Staphylococcus aureus clone USA300.
  • Archaeal evolution: Bridging the gap

    Naomi Attar
    14 May 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 328 (2015). doi:10.1038/nrmicro3501 Author: Naomi Attar Eukaryotes are thought to have arisen via the engulfment of a proto-mitochondrion by an archaeon, suggesting that many features of the eukaryotic cell were present in the archaeal ancestor. However, known archaea lack certain eukaryotic hallmarks of cellular complexity, such as an endomembrane system and
  • Advances in molecular genetic systems in malaria

    Tania F. de Koning-Ward
    14 May 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 373 (2015). doi:10.1038/nrmicro3450 Authors: Tania F. de Koning-Ward, Paul R. Gilson & Brendan S. Crabb Robust tools for analysing gene function in Plasmodium parasites, which are the causative agents of malaria, are being developed at an accelerating rate. Two decades after genetic technologies for use in Plasmodium spp. were first described, a range of genetic tools are now
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Nuclear envelope: Curving out a nuclear pore

    Kirsty Minton
    21 May 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 328 (2015). doi:10.1038/nrm4006 Author: Kirsty Minton The basket nucleoproteins Nup1 and Nup60 contribute to nuclear pore complex formation by inducing membrane curvature.
  • DNA replication origin activation in space and time

    Michalis Fragkos
    21 May 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 360 (2015). doi:10.1038/nrm4002 Authors: Michalis Fragkos, Olivier Ganier, Philippe Coulombe & Marcel Méchali DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding
  • Protein folding: Drugs for protein misfolding diseases

    Katharine H. Wrighton
    19 May 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 328 (2015). doi:10.1038/nrm4004 Author: Katharine H. Wrighton Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) helps to prevent the accumulation of misfolded proteins in the endoplasmic reticulum by decreasing protein synthesis; this phosphorylation is removed by a complex composed of the phosphatase PP1c and its regulatory subunit PPP1R15A. Although the compound guanabenz
  • A giant molecular proton pump: structure and mechanism of respiratory complex I

    Leonid A. Sazanov
    19 May 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 375 (2015). doi:10.1038/nrm3997 Author: Leonid A. Sazanov The mitochondrial respiratory chain, also known as the electron transport chain (ETC), is crucial to life, and energy production in the form of ATP is the main mitochondrial function. Three proton-translocating enzymes of the ETC, namely complexes I, III and IV, generate proton motive force,
  • Live to die another way: modes of programmed cell death and the signals emanating from dying cells

    Yaron Fuchs
    19 May 2015 | 5:00 pm
    Nature Reviews Molecular Cell Biology 16, 329 (2015). doi:10.1038/nrm3999 Authors: Yaron Fuchs & Hermann Steller All life ends in death, but perhaps one of life's grander ironies is that it also depends on death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for animal development, tissue homeostasis and pathogenesis. Originally, PCD was almost synonymous with apoptosis; recently, however,
 
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Immune attack: the role of inflammation in Alzheimer disease

    Frank L. Heppner
    19 May 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 358 (2015). doi:10.1038/nrn3880 Authors: Frank L. Heppner, Richard M. Ransohoff & Burkhard Becher The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with AD has been assumed to be merely a response to pathophysiological events. However, new data from preclinical and
  • Compromised autophagy and neurodegenerative diseases

    Fiona M. Menzies
    19 May 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 345 (2015). doi:10.1038/nrn3961 Authors: Fiona M. Menzies, Angeleen Fleming & David C. Rubinsztein Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial dysfunction. Autophagy is a powerful process for removing such proteins and for maintaining mitochondrial homeostasis. Over recent years, evidence has accumulated to demonstrate that upregulation
  • Neural circuits: Pain or pleasure?

    Katherine Whalley
    19 May 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 316 (2015). doi:10.1038/nrn3975 Author: Katherine Whalley A study uses optogenetics to dissect the circuits involved in associating environmental stimuli with positive or negative outcomes.
  • Neuronal circuits for fear and anxiety

    Philip Tovote
    19 May 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 317 (2015). doi:10.1038/nrn3945 Authors: Philip Tovote, Jonathan Paul Fadok & Andreas Lüthi Decades of research has identified the brain areas that are involved in fear, fear extinction, anxiety and related defensive behaviours. Newly developed genetic and viral tools, optogenetics and advanced in vivo imaging techniques have now made it possible to characterize the activity, connectivity and
  • Neurodegeneration: Neurodegeneration takes its TOLL

    Sian Lewis
    12 May 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 316 (2015). doi:10.1038/nrn3971 Author: Sian Lewis Sterile-α and TIR motif-containing protein 1 (SARM1) is an essential mediator of axon degeneration, and increased levels of NAD+ are neuroprotective, but the link between the two remains unclear. A recent paper showed that, in mice, dimerization of the Toll–interleukin receptor (TIR) domain
 
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    Nature Reviews Cardiology - Issue - nature.com science feeds

  • Cardiac resuscitation: No benefit of therapeutic hypothermia after cardiac arrest in children

    Gregory B. Lim
    11 May 2015 | 5:00 pm
    Nature Reviews Cardiology 12, 318 (2015). doi:10.1038/nrcardio.2015.73 Author: Gregory B. Lim Therapeutic hypothermia (controlled cooling of core body temperature) is recommended in guidelines for comatose adults after witnessed out-of-hospital cardiac arrest. However, new data from the Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital (THAPCA-OH) trial, published in the New England Journal of Medicine, indicate that
  • Risk factors: More data to encourage current cigarette smokers to quit

    Bryony M. Mearns
    4 May 2015 | 5:00 pm
    Nature Reviews Cardiology 12, 320 (2015). doi:10.1038/nrcardio.2015.70 Author: Bryony M. Mearns A link between smoking and coronary heart disease was noted >50 years ago, and much evidence for a causal role for smoking has accrued since then. A large meta-analysis of individual data from 25 cohort studies has now been performed to assess the association between
  • ACE2–angiotensin-(1-7)–Mas axis might be a promising therapeutic target for pulmonary arterial hypertension

    Hailong Dai
    4 May 2015 | 5:00 pm
    Nature Reviews Cardiology 12, 374 (2015). doi:10.1038/nrcardio.2015.6-c1 Authors: Hailong Dai, Lihong Jiang, Zhicheng Xiao & Xuefeng Guang We read with great interest the Review by Latus et al. (Treatment of pulmonary arterial hypertension in children. Nat. Rev. Cardiol.12, 244–254; 2015), in which the authors thoroughly summarize the latest developments in drug therapy for patients with pulmonary
  • Transplantation: Ex vivo perfusion of human hearts—implications for donor organ availability

    Gregory B. Lim
    4 May 2015 | 5:00 pm
    Nature Reviews Cardiology 12, 317 (2015). doi:10.1038/nrcardio.2015.69 Author: Gregory B. Lim Preservation of hearts between harvesting from a donor and implantation into a recipient is a limitation to transplantation. Currently, hearts are temporarily kept in cold ischaemic storage, which leads to time-dependent ischaemic and reperfusion injuries, and can impair cardiac function after transplantation. A possible solution
  • Genetics: Alzheimer disease and dyslipidaemia

    João H. Duarte
    27 Apr 2015 | 5:00 pm
    Nature Reviews Cardiology 12, 318 (2015). doi:10.1038/nrcardio.2015.67 Author: João H. Duarte Inflammation and dyslipidaemia have been associated with risk of developing Alzheimer disease (AD) and dementia, but the reasons for this link are not well understood. In a new analysis of existing AD genome-wide association studies (GWAS), Desikan et al. identified genetic polymorphisms associated
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    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • Gastrointestinal cancer: Rationale for metronomic chemotherapy in phase III trials

    Robert S. Kerbel
    11 May 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 313 (2015). doi:10.1038/nrclinonc.2015.89 Authors: Robert S. Kerbel & Axel Grothey Investigational metronomic chemotherapy involves frequent, regularly spaced, long-term administration of a sub-maximum tolerated dose. The phase III CAIRO3 trial evaluated continuous metronomic oral capecitabine, with bevacizumab, as a maintenance treatment in patients with metastatic colorectal cancer; a benefit in progression-free survival compared with observation only was observed, highlighting that metronomic chemotherapy could be a less toxic and convenient…
  • Gastrointestinal cancer: Effect of lymphadenectomy on survival in oesophageal cancer

    Bo Jan Noordman
    11 May 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 315 (2015). doi:10.1038/nrclinonc.2015.91 Authors: Bo Jan Noordman & J. Jan B. van Lanschot In patients with oesophageal cancer, the effect of lymphadenectomy on survival remains unclear. A recent retrospective cohort study suggests that extensive lymphadenectomy does not improve survival and might even hamper it in patients with early T-stage tumours. The available data show conflicting results and the introduction of neoadjuvant chemoradiotherapy might decrease any positive effect of extensive lymphadenectomy on survival.
  • The need for post-mastectomy radiotherapy in patients with IBC

    Konstantinos Tryfonidis
    27 Apr 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 370 (2015). doi:10.1038/nrclinonc.2015.13-c2 Authors: Konstantinos Tryfonidis, Elzbieta Senkus, Maria J. Cardoso & Fatima Cardoso We have read with interest the comment from Gustavo Ruis Ares et al. (
  • Urological cancer: Is docetaxel the 'black widow' of mCRPC drugs?

    Bobby C. Liaw
    27 Apr 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 316 (2015). doi:10.1038/nrclinonc.2015.79 Authors: Bobby C. Liaw & William K. Oh In the recent MAINSAIL trial, addition of lenalidomide to docetaxel for metastatic castration-resistant prostate cancer (mCRPC) was associated with inferior overall survival and more toxicity; thus, lenalidomide joins a long line of agents that failed to improve the efficacy of docetaxel. The process by which new therapies are advanced to phase III studies, particularly in combination with docetaxel, should be re-examined.
  • The need for post-mastectomy radiotherapy in patients with IBC

    Gustavo Ruiz Ares
    27 Apr 2015 | 5:00 pm
    Nature Reviews Clinical Oncology 12, 370 (2015). doi:10.1038/nrclinonc.2015.13-c1 Authors: Gustavo Ruiz Ares, Eva Ciruelos & Luis Manso We have read with great interest the Review by Tryfonidis et al. (Management of locally advanced breast cancer—perspectives and future directions. Nat. Rev. Clin. Oncol.12, 147–162, 2015), which discussed the management of locally advanced
 
 
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    Nature Reviews Nephrology - Issue - nature.com science feeds

  • Microbiota—implications for immunity and transplantation

    Jonathan S. Bromberg
    11 May 2015 | 5:00 pm
    Nature Reviews Nephrology 11, 342 (2015). doi:10.1038/nrneph.2015.70 Authors: Jonathan S. Bromberg, W. Florian Fricke, C. Colin Brinkman, Thomas Simon & Emmanuel F. Mongodin Each individual harbours a unique set of commensal microorganisms, collectively referred to as the microbiota. Notably, these microorganisms exceed the number of cells in the human body by 10-fold. This finding has accelerated a shift in our understanding of human physiology, with the realization that
  • Genetics: Increased prevalence of large genomic imbalances among children with chronic kidney disease

    Ellen F. Carney
    4 May 2015 | 5:00 pm
    Nature Reviews Nephrology 11, 315 (2015). doi:10.1038/nrneph.2015.73 Author: Ellen F. Carney Children with chronic kidney disease (CKD) have an excess burden of large genomic imbalances that are not suspected based on standard clinical examinations, according to a new study. Researchers Ali Gharavi, Miguel Verbitsky and colleagues suggest that these findings have important implications for the diagnosis
  • Hypertension: Vascular type 1A angiotensin II receptors regulate renal blood flow and natriuresis

    Ellen F. Carney
    27 Apr 2015 | 5:00 pm
    Nature Reviews Nephrology 11, 318 (2015). doi:10.1038/nrneph.2015.69 Author: Ellen F. Carney Angiotensin II (Ang II)-dependent renal vasoconstriction contributes to blood pressure control, sodium balance and the pathogenesis of hypertension, according to new findings. Matthew Sparks, Thomas Coffman and colleagues suggest that activation of Ang II type 1A (AT1A) receptors expressed on vascular smooth muscle
  • Genetics: Hidden intronic mutations in DGKE are causative of aHUS

    Jessica K. Edwards
    27 Apr 2015 | 5:00 pm
    Nature Reviews Nephrology 11, 316 (2015). doi:10.1038/nrneph.2015.68 Author: Jessica K. Edwards Recessive mutations in diacylglycerol kinase ɛ (DGKE) can cause atypical haemolytic uraemic syndrome (aHUS)—a common cause of acquired acute renal failure in children. New research by Giuseppe Remuzzi and colleagues extends this association, with the identification of a novel aHUS-causative intronic mutation in
  • Primary disease recurrence—effects on paediatric renal transplantation outcomes

    Justine Bacchetta
    27 Apr 2015 | 5:00 pm
    Nature Reviews Nephrology 11, 371 (2015). doi:10.1038/nrneph.2015.54 Authors: Justine Bacchetta & Pierre Cochat Primary disease recurrence after renal transplantation is mainly diagnosed by examination of biopsy samples, but can also be associated with clinical symptoms. In some patients, recurrence can lead to graft loss (7–8% of all graft losses). Primary disease recurrence is generally associated with a high
 
 
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    Naturejobs - Search results

  • Clinical Scientist - Virology

    28 May 2015 | 8:58 pm
    Canterbury Health Laboratories (CHL) is the leading medical diagnostic reference laboratory in New Zealand with links and collaborative partners both nationally and internationally. We have an exciting opportunity for a mid-career Scientist with a high degree of experience in the field of virology and human infectious disease diagnostics, and who has hands on experience with traditional virological methods as well as current molecular technologies. Our laboratories are modern, state of the…
  • Postdoc: Protein Engineering - Artificial Enzyme Evolution – In Vitro Selection

    28 May 2015 | 3:33 pm
    We are looking for candidates who are highly motivated to employ in vitro selection and directed evolution to create de novo proteins, or tailor existing enzymes to a variety of useful applications. We have established a general method to create enzymes from scratch – enzymes that have not been found in nature. Our approach enables us to search for enzymes in libraries of trillions of proteins variants in a single experiment. • One objective of our research is to create enzymes as ‘design…
  • Assay Development Scientist PhD

    28 May 2015 | 2:57 pm
    Intermountain Precision Genomics (IPG) uses genetic mapping to develop personalized treatment options for cancer patients. Headquartered in St. George, Utah, we are able to analyze a patient's tumor DNA and identify mutations to determine why and how the tumor is growing, and most importantly, what can be done to treat it. We are seeking a full-time Assay Development-Scientist to be responsible for supporting ongoing development and optimization of clinical genomics assays at Intermounta…
  • Postdoctoral Fellow – Molecular Imaging/Tissue Engineering

    28 May 2015 | 2:15 pm
    Postdoctoral Fellow – Molecular Imaging/Tissue Engineering: University of Michigan, Center for Molecular Imaging, Ann Arbor, MI 48109 United States Description: Applications are invited for a postdoctoral position for molecular imaging and tissue engineering research led by Drs. Gary Luker, M.D. and Kathryn Luker, Ph.D. in the University of Michigan Center for Molecular Imaging. The candidate will develop novel optical molecular imaging tools and multi-scale models of breast cancer to underst…
  • Postdoc Position in Adipocyte Biology

    28 May 2015 | 1:32 pm
    A postdoctoral position is available to study molecular mechanisms underlying brown and beige adipocyte development and their impacts on metabolic diseases. Our research particularly focuses on transcriptional control, epigenetics, and non-coding RNAs. Candidates should have a Ph.D. and/or M.D degree and possess research experience in molecular and cellular biology. Experience in animal physiology is preferred but not required. Please forward your CV to: Dr. Yong-Xu Wang Department of Mo…
 
 
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    British Journal of Pharmacology

  • Issue Information

    28 May 2015 | 4:07 am
  • Validating the GTP cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

    D Hussein, A Starr, L Heikal, E McNeill, K M Channon, P R Brown, B J Sutton, J M McDonnell, M Nandi
    25 May 2015 | 3:25 am
    Abstract Background and purposeTetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients. Unfortunately, oral BH4 has limited efficacy. Therefore, orally bioavailable pharmacological activators of endogenous BH4 biosynthesis hold significant therapeutic potential. GTP-cyclohydrolase-1 (GCH1), the rate limiting enzyme in BH4 synthesis, forms a protein complex with GCH1 feedback regulatory protein (GFRP). This complex is subject to allosteric feed-forward activation by…
  • New selective inhibitors of calcium-activated chloride channels—T16Ainh-A01, CaCCinh-A01, and MONNA—what do they inhibit?

    D M B Boedtkjer, S Kim, A B Jensen, V M Matchkov, KE Andersson
    25 May 2015 | 3:25 am
    Abstract Background and purposeT16Ainh-A01, CaCCinh-A01, and MONNA are identified as selective inhibitors of the TMEM16A calcium-activated chloride channel (CaCC). The aim of this study was to examine the chloride-specificity of these compounds on isolated resistance arteries in the presence and absence (±) of extracellular chloride. Experimental approachIsolated resistance arteries were maintained in a myograph and tension recording in some instances combined with microelectrode impalement for membrane potential measurements or intracellular calcium monitoring using fura-2.
  • Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells

    J A Reihill, B Malcomson, A Bertelsen, S Cheung, A Czerwiec, R Barsden, J S Elborn, H Dürkop, B Hirsch, M Ennis, C Kelly, B C Schock
    25 May 2015 | 3:24 am
    Abstract Background and purposeNF-κB driven inflammation is negatively regulated by the zinc finger protein, A20. Gibberellic acid (GA3) is a plant-derived diterpenoid with documented anti-inflammatory activity, which is reported to induce A20-like zinc finger proteins in plants. Here, we sought to investigate the anti-inflammatory effect of GA3 in airway epithelial cells and determine if the anti-inflammatory action relates to A20 induction. Experimental approachPrimary nasal epithelial cells (n=7), and a human bronchial epithelial cell line (16HBE14o-) were used. Cells were pre-incubated…
  • Endothelin ETA receptor/lipid peroxides/COX-2/TGF-β1 signaling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats

    Maged W. Helmy, Hanan M. El-Gowelli, Rabab M. Ali, Mahmoud M. El-Mas
    25 May 2015 | 3:24 am
    Summary Background and PurposeCyclosporine (CSA) and nonsteroidal antiinflammatory drugs (NSAIDs) are co-prescribed for some arthritic conditions. We tested the hypothesis that this combined regimen elicits exaggerated nephrotoxicity in rats via the upregulation of endothelin (ET) receptor signaling. Experimental approachThe effect of 10-day treatment with CSA (20 mg.kg-1.day-1), indomethacin (5 mg.kg-1.day-1), or their combination on renal biochemical, inflammatory, oxidative and structural profiles were assessed. The roles of ETA receptor and cyclooxygenase-2 (COX-2) pathways in the…
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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