Nature.com

  • Most Topular Stories

  • Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone

    Molecular Psychiatry - AOP - nature.com science feeds
    Y Cheng
    20 Oct 2014 | 5:00 pm
    Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone Molecular Psychiatry advance online publication, October 21 2014. doi:10.1038/mp.2014.136 Authors: Y Cheng, R M Rodriguiz, S R K Murthy, V Senatorov, E Thouennon, N X Cawley, D K Aryal, S Ahn, B Lecka-Czernik, W C Wetsel & Y P Loh
  • A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

    Nature Chemical Biology - AOP - nature.com science feeds
    Baptiste Ronan
    18 Oct 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1681 Authors: Baptiste Ronan, Odile Flamand, Lionel Vescovi, Christine Dureuil, Laurence Durand, Florence Fassy, Marie-France Bachelot, Annabelle Lamberton, Magali Mathieu, Thomas Bertrand, Jean-Pierre Marquette, Youssef El-Ahmad, Bruno Filoche-Romme, Laurent Schio, Carlos Garcia-Echeverria, Hélène Goulaouic & Benoit Pasquier
  • A quantum world arising from many ordinary ones

    NatureNews - Most recent articles - nature.com science feeds
    Alexandra Witze
    23 Oct 2014 | 5:00 pm
    Radical theory proposes that interactions between classical worlds can explain some quantum phenomena.Nature News doi: 10.1038/nature.2014.16213
  • A ripe time for gaining ground

    Nature - Issue - nature.com science feeds
    21 Oct 2014 | 5:00 pm
    A ripe time for gaining ground Nature 514, 7523 (2014). doi:10.1038/514403a After three years of heated debate, the advocates and critics of gain-of-function research must work to agree on how best to regulate the work.
  • Luminal signalling links cell communication to tissue architecture during organogenesis

    Nature - AOP - nature.com science feeds
    Sevi Durdu
    21 Oct 2014 | 5:00 pm
    Nature advance online publication 22 October 2014. doi:10.1038/nature13852 Authors: Sevi Durdu, Murat Iskar, Celine Revenu, Nicole Schieber, Andreas Kunze, Peer Bork, Yannick Schwab & Darren Gilmour Morphogenesis is the process whereby cell collectives are shaped into differentiated tissues and organs. The self-organizing nature of morphogenesis has been recently demonstrated by studies showing that stem cells in three-dimensional culture can generate complex organoids, such as mini-guts, optic-cups and even mini-brains. To achieve this, cell collectives must regulate the activity of…
 
  • add this feed to my.Alltop

    Nature - Issue - nature.com science feeds

  • A ripe time for gaining ground

    21 Oct 2014 | 5:00 pm
    A ripe time for gaining ground Nature 514, 7523 (2014). doi:10.1038/514403a After three years of heated debate, the advocates and critics of gain-of-function research must work to agree on how best to regulate the work.
  • The ice bucket

    21 Oct 2014 | 5:00 pm
    The ice bucket Nature 514, 7523 (2014). doi:10.1038/514403b Social-media fun for medical research bypasses animal sensitivities.
  • Toxic influence

    20 Oct 2014 | 5:00 pm
    Toxic influence Nature 514, 7523 (2014). doi:10.1038/514404a Europe must act to stop livestock drugs from wiping out its vulture populations.
  • Stormy outlook for long-term ecology studies

    Tim Birkhead
    20 Oct 2014 | 5:00 pm
    Stormy outlook for long-term ecology studies Nature 514, 7523 (2014). http://www.nature.com/doifinder/10.1038/514405a Author: Tim Birkhead The closure of a 40-year project to understand and protect seabirds shows the false priorities of funders, warns Tim Birkhead.
  • Solar physics: Solar atmosphere is a hotbed of activity

    21 Oct 2014 | 5:00 pm
    Solar physics: Solar atmosphere is a hotbed of activity Nature 514, 7523 (2014). doi:10.1038/514406a Explosions of plasma in the Sun's atmosphere can reach temperatures of nearly 100,000 °C, much hotter than scientists had expected.The finding is one of several about the region between the solar surface and the uppermost edge of the Sun's atmosphere, or corona, revealed by
  • add this feed to my.Alltop

    Nature - AOP - nature.com science feeds

  • Luminal signalling links cell communication to tissue architecture during organogenesis

    Sevi Durdu
    21 Oct 2014 | 5:00 pm
    Nature advance online publication 22 October 2014. doi:10.1038/nature13852 Authors: Sevi Durdu, Murat Iskar, Celine Revenu, Nicole Schieber, Andreas Kunze, Peer Bork, Yannick Schwab & Darren Gilmour Morphogenesis is the process whereby cell collectives are shaped into differentiated tissues and organs. The self-organizing nature of morphogenesis has been recently demonstrated by studies showing that stem cells in three-dimensional culture can generate complex organoids, such as mini-guts, optic-cups and even mini-brains. To achieve this, cell collectives must regulate the activity of…
  • Astrophysics: Secret ingredient exposed

    Christopher M. Johns-Krull
    21 Oct 2014 | 5:00 pm
    Nature advance online publication 22 October 2014. doi:10.1038/nature13932 Author: Christopher M. Johns-Krull Astronomers have suspected for some time that magnetic fields are a key ingredient in the accretion of material that surrounds young stars. New observations have just begun to reveal these fields in action.
  • Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

    Laura Bonapace
    21 Oct 2014 | 5:00 pm
    Nature advance online publication 22 October 2014. doi:10.1038/nature13862 Authors: Laura Bonapace, Marie-May Coissieux, Jeffrey Wyckoff, Kirsten D. Mertz, Zsuzsanna Varga, Tobias Junt & Mohamed Bentires-Alj Secretion of C–C chemokine ligand 2 (CCL2) by mammary tumours recruits CCR2-expressing inflammatory monocytes to primary tumours and metastatic sites, and CCL2 neutralization in mice inhibits metastasis by retaining monocytes in the bone marrow. Here we report a paradoxical effect of CCL2 in four syngeneic mouse models of metastatic breast cancer. Surprisingly, interruption of…
  • Cancer: Metastasis risk after anti-macrophage therapy

    Ioanna Keklikoglou
    21 Oct 2014 | 5:00 pm
    Nature advance online publication 22 October 2014. doi:10.1038/nature13931 Authors: Ioanna Keklikoglou & Michele De Palma Blocking the activity of macrophages may delay the spread of cancer. But new findings show that these immune cells can rapidly rebound to tumours after therapy withdrawal, accelerating lethal metastasis in mice.
  • Structure and insights into the function of a Ca2+-activated Cl− channel

    Veronica Kane Dickson
    21 Oct 2014 | 5:00 pm
    Nature advance online publication 22 October 2014. doi:10.1038/nature13913 Authors: Veronica Kane Dickson, Leanne Pedi & Stephen B. Long
 
  • add this feed to my.Alltop

    Scientific American

  • Who Has the Best Fuel Economy?

    Mark Fischetti
    13 Oct 2014 | 5:00 pm
    Scientific American 311, 90 (2014). doi:10.1038/scientificamerican1114-90 Authors: Mark Fischetti & Kevin Schultz Contrary to claims, not everyone is No. 1
  • Letters

    13 Oct 2014 | 5:00 pm
    Scientific American 311, 8 (2014). doi:10.1038/scientificamerican1114-8
  • Catching Some Rays

    Debra Weiner
    13 Oct 2014 | 5:00 pm
    Scientific American 311, 32 (2014). doi:10.1038/scientificamerican1114-32 Author: Debra Weiner An embattled cosmic-ray telescope gets a lift
  • 50, 100 & 150 Years Ago

    Daniel C. Schlenoff
    13 Oct 2014 | 5:00 pm
    Scientific American 311, 89 (2014). doi:10.1038/scientificamerican1114-89 Author: Daniel C. Schlenoff
  • Quick Hits

    13 Oct 2014 | 5:00 pm
    Scientific American 311, 27 (2014). doi:10.1038/scientificamerican1114-27a
  • add this feed to my.Alltop

    Scientific American Mind

  • Cyborg Confidential

    Sandra Upson
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 30 (2014). doi:10.1038/scientificamericanmind1114-30 Author: Sandra Upson Hooking the brain up to a computer can do more than let the severely disabled move artificial limbs. It is also revealing the secrets of how we learn
  • All-Purpose Antidepressants

    Julia Calderone
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 20 (2014). doi:10.1038/scientificamericanmind1114-20 Author: Julia Calderone Doctors are increasingly prescribing SSRIs to treat more than just depression
  • Happy Birthday to Us

    Sandra Upson
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 1 (2014). doi:10.1038/scientificamericanmind1114-1 Author: Sandra Upson
  • Hitting Just the Right Neurons

    Julia Calderone
    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 8 (2014). doi:10.1038/scientificamericanmind1114-8b Author: Julia Calderone Noninvasive fields zap specific areas
  • Upgrading the Brain

    15 Oct 2014 | 5:00 pm
    Scientific American Mind 25, 7 (2014). doi:10.1038/scientificamericanmind1114-7 Technology is shaping our thinking about mental abilities and their improvement
 
  • add this feed to my.Alltop

    Nature Biotechnology - AOP - nature.com science feeds

  • In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

    Lukasz Swiech
    18 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3055 Authors: Lukasz Swiech, Matthias Heidenreich, Abhishek Banerjee, Naomi Habib, Yinqing Li, John Trombetta, Mriganka Sur & Feng Zhang Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit single or multiple genes in replicating eukaryotic cells, resulting in frame-shifting insertion/deletion (indel) mutations and…
  • Comparative analyses of C4 and C3 photosynthesis in developing leaves of maize and rice

    Lin Wang
    11 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3019 Authors: Lin Wang, Angelika Czedik-Eysenberg, Rachel A Mertz, Yaqing Si, Takayuki Tohge, Adriano Nunes-Nesi, Stephanie Arrivault, Lauren K Dedow, Douglas W Bryant, Wen Zhou, Jiajia Xu, Sarit Weissmann, Anthony Studer, Pinghua Li, Cankui Zhang, Therese LaRue, Ying Shao, Zehong Ding, Qi Sun, Rohan V Patel, Robert Turgeon, Xinguang Zhu, Nicholas J Provart, Todd C Mockler, Alisdair R Fernie, Mark Stitt, Peng Liu & Thomas P Brutnell
  • Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells

    Nutan Prasain
    11 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3048 Authors: Nutan Prasain, Man Ryul Lee, Sasidhar Vemula, Jonathan Luke Meador, Momoko Yoshimoto, Michael J Ferkowicz, Alexa Fett, Manav Gupta, Brian M Rapp, Mohammad Reza Saadatzadeh, Michael Ginsberg, Olivier Elemento, Younghee Lee, Sherry L Voytik-Harbin, Hyung Min Chung, Ki Sung Hong, Emma Reid, Christina L O'Neill, Reinhold J Medina, Alan W Stitt, Michael P Murphy, Shahin Rafii, Hal E Broxmeyer & Mervin C Yoder The ability to differentiate human pluripotent stem cells into endothelial cells with properties of cord-blood endothelial…
  • A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

    Daniel C Leslie
    11 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3020 Authors: Daniel C Leslie, Anna Waterhouse, Julia B Berthet, Thomas M Valentin, Alexander L Watters, Abhishek Jain, Philseok Kim, Benjamin D Hatton, Arthur Nedder, Kathryn Donovan, Elana H Super, Caitlin Howell, Christopher P Johnson, Thy L Vu, Dana E Bolgen, Sami Rifai, Anne R Hansen, Michael Aizenberg, Michael Super, Joanna Aizenberg & Donald E Ingber
  • Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

    David Bikard
    4 Oct 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.3043 Authors: David Bikard, Chad W Euler, Wenyan Jiang, Philip M Nussenzweig, Gregory W Goldberg, Xavier Duportet, Vincent A Fischetti & Luciano A Marraffini Antibiotics target conserved bacterial cellular pathways or growth functions and therefore cannot selectively kill specific members of a complex microbial population. Here, we develop programmable, sequence-specific antimicrobials using the RNA-guided nuclease Cas9 (refs.1,2) delivered by a bacteriophage. We show that Cas9, reprogrammed to target virulence genes, kills virulent, but not…
 
  • add this feed to my.Alltop

    Nature Chemical Biology - Issue - nature.com science feeds

  • Cell cycle: Mitotic tag team

    Grant Miura
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 876 (2014). doi:10.1038/nchembio.1675 Author: Grant Miura
  • Protein turnover: Mitochondrial immaturity

    Grant Miura
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 877 (2014). doi:10.1038/nchembio.1679 Author: Grant Miura
  • Sculpting the proteome with small molecules

    Randall W King
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 870 (2014). doi:10.1038/nchembio.1671 Authors: Randall W King & Daniel Finley The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the principles that underlie the development of effective inhibitors or activators of the pathway. We emphasize insights from structural analysis and describe strategies for evaluating the…
  • Carbohydrates: Cutting out starch

    Catherine Goodman
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 877 (2014). doi:10.1038/nchembio.1677 Author: Catherine Goodman
  • Rick Morimoto

    Catherine Goodman
    16 Oct 2014 | 5:00 pm
    Nature Chemical Biology 10, 875 (2014). doi:10.1038/nchembio.1682 Author: Catherine Goodman A pioneer in proteostasis is changing the way we think about organismal biology and human disease.
  • add this feed to my.Alltop

    Nature Chemistry

  • Light-harvesting materials: Soft support for energy conversion

    Ryan M. Stolley
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 949 (2014). doi:10.1038/nchem.2088 Authors: Ryan M. Stolley & Monte L. Helm To convert solar energy into viable fuels, coupling light-harvesting materials to catalysts is a crucial challenge. Now, the combination of an organic supramolecular hydrogel and a non-precious metal catalyst has been demonstrated to be effective for photocatalytic H2 production.
  • A spoonful of curiosity

    Catherine Goodman
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 945 (2014). doi:10.1038/nchem.2100 Author: Catherine Goodman
  • Blogroll: Hot and sweet

    Kat Day
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 947 (2014). doi:10.1038/nchem.2091 Author: Kat Day
  • Nucleic acids: An interfering delivery

    Russell Johnson
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 946 (2014). doi:10.1038/nchem.2103 Author: Russell Johnson
  • Asymmetric catalysis: Not so boring boron

    James Hennessy
    23 Oct 2014 | 5:00 pm
    Nature Chemistry 6, 946 (2014). doi:10.1038/nchem.2104 Author: James Hennessy
 
  • add this feed to my.Alltop

    Nature Chemistry

  • Atom-efficient regioselective 1,2-dearomatization of functionalized pyridines by an earth-abundant organolanthanide catalyst

    Alexander S. Dudnik
    18 Oct 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2087 Authors: Alexander S. Dudnik, Victoria L. Weidner, Alessandro Motta, Massimiliano Delferro & Tobin J. Marks Selective pyridine dearomatization processes traditionally use precious metal catalysts with reagents in stoichiometric excess, and are not well-understood mechanistically. Now, efficient 1,2-regioselective pyridine dearomatization is achieved using equimolar pinacolborane and an earth-abundant lanthanide catalyst. Mechanistic and theoretical studies elucidate the reaction mechanism and explain observed reactivity trends.
  • DNA brick crystals with prescribed depths

    Yonggang Ke
    18 Oct 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2083 Authors: Yonggang Ke, Luvena L. Ong, Wei Sun, Jie Song, Mingdong Dong, William M. Shih & Peng Yin The programmed assembly of single DNA strands into bricks and ultimately micrometre-sized two-dimensional crystals with prescribed depths up to 80 nm is described. These crystals display intricate three-dimensional features including continuous or discontinuous cavities and channels with nanometre precision, and can pack DNA helices in parallel or perpendicularly to the plane of the crystals.
  • Switching on the fluorescence of 2-aminopurine by site-selective microhydration

    Simon Lobsiger
    18 Oct 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2086 Authors: Simon Lobsiger, Susan Blaser, Rajeev K. Sinha, Hans-Martin Frey & Samuel Leutwyler The adenine analogue 2-aminopurine has been considered as intrinsically fluorescent and is widely used in biochemical assays to probe DNA and RNA structure. It is now shown that the molecule alone is nearly non-fluorescent, however, its fluorescence is increased by up to 95 times through hydrogen bonding to a single water molecule.
  • Self-assembling hydrogel scaffolds for photocatalytic hydrogen production

    Adam S. Weingarten
    4 Oct 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2075 Authors: Adam S. Weingarten, Roman V. Kazantsev, Liam C. Palmer, Mark McClendon, Andrew R. Koltonow, Amanda P. S. Samuel, Derek J. Kiebala, Michael R. Wasielewski & Samuel I. Stupp Self-assembled ribbons of perylene amphiphiles have been shown to crystallize in the presence of a nickel-based hydrogen production catalyst, allowing efficient electronic coupling between the perylene chromophores. This hydrogel material photocatalyses the production of H2, and can be shaped and placed on surfaces for incorporation into devices.
  • Direct observation of a borane–silane complex involved in frustrated Lewis-pair-mediated hydrosilylations

    Adrian Y. Houghton
    27 Sep 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2063 Authors: Adrian Y. Houghton, Juha Hurmalainen, Akseli Mansikkamäki, Warren E. Piers & Heikki M. Tuononen Comprehensive solution and solid-state characterization of an adduct between a Lewis acidic perfluoroaryl borane and an electron-rich silane is demonstrated. This has long been proposed as an intermediate in the ‘frustrated’ Lewis-pair hydrosilylation of C=C, C=O and C=N double bonds, but its existence has, so far, only been inferred from indirect experimental evidence.
  • add this feed to my.Alltop

    Nature Genetics - AOP - nature.com science feeds

  • Haplotype-resolved whole-genome sequencing by contiguity-preserving transposition and combinatorial indexing

    Sasan Amini
    18 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3119 Authors: Sasan Amini, Dmitry Pushkarev, Lena Christiansen, Emrah Kostem, Tom Royce, Casey Turk, Natasha Pignatelli, Andrew Adey, Jacob O Kitzman, Kandaswamy Vijayan, Mostafa Ronaghi, Jay Shendure, Kevin L Gunderson & Frank J Steemers
  • Comprehensive variation discovery in single human genomes

    Neil I Weisenfeld
    18 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3121 Authors: Neil I Weisenfeld, Shuangye Yin, Ted Sharpe, Bayo Lau, Ryan Hegarty, Laurie Holmes, Brian Sogoloff, Diana Tabbaa, Louise Williams, Carsten Russ, Chad Nusbaum, Eric S Lander, Iain MacCallum & David B Jaffe
  • Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability

    Francesca Antonacci
    18 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3120 Authors: Francesca Antonacci, Megan Y Dennis, John Huddleston, Peter H Sudmant, Karyn Meltz Steinberg, Jill A Rosenfeld, Mattia Miroballo, Tina A Graves, Laura Vives, Maika Malig, Laura Denman, Archana Raja, Andrew Stuart, Joyce Tang, Brenton Munson, Lisa G Shaffer, Chris T Amemiya, Richard K Wilson & Evan E Eichler
  • Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

    Ming Zhang
    11 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3116 Authors: Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin McMahon, Rajni Sharma, Qing Wang, Allan J Belzberg, Kaisorn Chaichana, Gary L Gallia, Ziya L Gokaslan, Greg J Riggins, Jean-Paul Wolinksy, Laura D Wood, Elizabeth A Montgomery, Ralph H Hruban, Kenneth W Kinzler, Nickolas Papadopoulos, Bert Vogelstein & Chetan Bettegowda Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand…
  • Genomic analyses provide insights into the history of tomato breeding

    Tao Lin
    11 Oct 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3117 Authors: Tao Lin, Guangtao Zhu, Junhong Zhang, Xiangyang Xu, Qinghui Yu, Zheng Zheng, Zhonghua Zhang, Yaoyao Lun, Shuai Li, Xiaoxuan Wang, Zejun Huang, Junming Li, Chunzhi Zhang, Taotao Wang, Yuyang Zhang, Aoxue Wang, Yancong Zhang, Kui Lin, Chuanyou Li, Guosheng Xiong, Yongbiao Xue, Andrea Mazzucato, Mathilde Causse, Zhangjun Fei, James J Giovannoni, Roger T Chetelat, Dani Zamir, Thomas Städler, Jingfu Li, Zhibiao Ye, Yongchen Du & Sanwen Huang
  • add this feed to my.Alltop

    Nature Geoscience - Issue - nature.com science feeds

  • Steps for success of OCO-2

    John B. Miller
    28 Sep 2014 | 5:00 pm
    Nature Geoscience 7, 691 (2014). doi:10.1038/ngeo2255 Authors: John B. Miller, Pieter P. Tans & Manuel Gloor
  • Biological impact on Greenland's albedo

    Liane G. Benning
    28 Sep 2014 | 5:00 pm
    Nature Geoscience 7, 691 (2014). doi:10.1038/ngeo2260 Authors: Liane G. Benning, Alexandre M. Anesio, Stefanie Lutz & Martyn Tranter
  • Coastal processes: Storm-proofing with marshes

    Sergio Fagherazzi
    28 Sep 2014 | 5:00 pm
    Nature Geoscience 7, 701 (2014). doi:10.1038/ngeo2262 Author: Sergio Fagherazzi Shorelines are vulnerable to the destructive waves and water levels of increasingly frequent extreme storm events. Wave tank experiments demonstrate that salt marsh vegetation dissipates wave energy and withstands extreme storm conditions.
  • Wave attenuation over coastal salt marshes under storm surge conditions

    Iris Möller
    28 Sep 2014 | 5:00 pm
    Nature Geoscience 7, 727 (2014). doi:10.1038/ngeo2251 Authors: Iris Möller, Matthias Kudella, Franziska Rupprecht, Tom Spencer, Maike Paul, Bregje K. van Wesenbeeck, Guido Wolters, Kai Jensen, Tjeerd J. Bouma, Martin Miranda-Lange & Stefan Schimmels Coastal communities around the world face an increasing risk from flooding as a result of rising sea level, increasing storminess and land subsidence. Salt marshes can act as natural buffer zones, providing protection from waves during storms. However, the effectiveness of marshes in protecting the coastline during extreme events when…
  • Biogeochemistry: Microbial flexibility

    Alicia Newton
    28 Sep 2014 | 5:00 pm
    Nature Geoscience 7, 696 (2014). doi:10.1038/ngeo2265 Author: Alicia Newton
 
  • add this feed to my.Alltop

    Nature Geoscience - AOP - nature.com science feeds

  • Plateau uplift in western Canada caused by lithospheric delamination along a craton edge

    Xuewei Bao
    18 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2270 Authors: Xuewei Bao, David W. Eaton & Bernard Guest Continental plateaux, such as the Tibetan Plateau in Asia and the Altiplano–Puna Plateau in South America, are thought to form partly because upwelling, hot asthenospheric mantle replaces some of the denser, lower lithosphere, making the region more buoyant. The spatial and temporal scales of this process are debated, with proposed mechanisms ranging from delamination of fragments to that of the entire lithosphere. The Canadian Cordillera is an exhumed ancient plateau that abuts the North…
  • A multi-sill magma plumbing system beneath the axis of the East Pacific Rise

    Milena Marjanović
    18 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2272 Authors: Milena Marjanović, Suzanne M. Carbotte, Helene Carton, Mladen R. Nedimović, John C. Mutter & Juan Pablo Canales Upper oceanic crust at fast- to intermediate-spreading mid-ocean ridges is thought to form from the intrusion and eruption of magma accumulated within a mid-crustal reservoir present beneath the ridge axis. However, the mechanisms for formation of the lower crust are debated. Observations from pieces of ancient oceanic crust exposed on land — ophiolites — imply that multiple small magma lenses exist…
  • Nitrogen speciation in upper mantle fluids and the origin of Earth's nitrogen-rich atmosphere

    Sami Mikhail
    18 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2271 Authors: Sami Mikhail & Dimitri A. Sverjensky Volatile elements stored in the mantles of terrestrial planets escape through volcanic degassing, and thereby influence planetary atmospheric evolution and habitability. Compared with the atmospheres of Venus and Mars, Earth's atmosphere is nitrogen-rich relative to primordial noble gas concentrations. The compatibility of volatile elements in mantle minerals versus melts and fluids controls how readily these elements are degassed. However, the speciation of nitrogen in mantle fluids is not well…
  • Evidence for basaltic volcanism on the Moon within the past 100 million years

    S. E. Braden
    11 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2252 Authors: S. E. Braden, J. D. Stopar, M. S. Robinson, S. J. Lawrence, C. H. van der Bogert & H. Hiesinger The bulk of basaltic magmatism on the Moon occurred from 3.9 to 3.1 billion years ago on the ancient lunar mare plains. There is evidence for basaltic volcanism as recently as 2.9 billion years ago from crystallization ages and a billion years ago from stratigraphy. An enigmatic surface formation named Ina (18.65° N, 5.30° E) may represent much younger mare volcanism, but age estimates are poorly constrained. Here we investigate 70…
  • Subtropical iceberg scours and meltwater routing in the deglacial western North Atlantic

    Jenna C. Hill
    11 Oct 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2267 Authors: Jenna C. Hill & Alan Condron Abrupt centennial-to-millennial shifts in Northern Hemisphere climate during the last deglaciation are thought to have been triggered by the discharge of large volumes of meltwater and icebergs to the subpolar North Atlantic. Here we show that meltwater and icebergs were also transported directly from the Laurentide ice margin to the subtropical North Atlantic in a narrow coastal current. We present high-resolution bathymetric data from south of Cape Hatteras showing numerous scours that we interpret as relict…
  • add this feed to my.Alltop

    Nature Immunology - Issue - nature.com science feeds

  • Tetherin signaling

    Laurie A Dempsey
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1008 (2014). doi:10.1038/ni.3018 Author: Laurie A Dempsey
  • Time to cast a larger net

    Matthew L Wheeler
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1000 (2014). doi:10.1038/ni.3013 Authors: Matthew L Wheeler & David M Underhill Neutrophils sense the size of microbial targets and respond via 'NETosis' when targets are too big to internalize and contain via phagocytosis.
  • Street smarts of science for students

    Michael M Chen
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 997 (2014). doi:10.1038/ni.2989 Authors: Michael M Chen, Anita Zahs, Sulie L Chang & Elizabeth J Kovacs A workshop organized by the Society for Leukocyte Biology offers advice to graduate students on how to navigate educational and professional waters to find success in academia.
  • TCR signaling fuels Treg cell suppressor function

    Jinfang Zhu
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1002 (2014). doi:10.1038/ni.3014 Authors: Jinfang Zhu & Ethan M Shevach Acute ablation of T cell antigen receptors (TCRs) in regulatory T cells (Treg cells) impairs the suppressive activity of these cells, even though they retain expression of Foxp3 and CD25. TCR signaling imparts a critical role in the suppressive function of Treg cells.
  • Isoketals drive hypertension

    Zoltan Fehervari
    19 Oct 2014 | 5:00 pm
    Nature Immunology 15, 1008 (2014). doi:10.1038/ni.3020 Author: Zoltan Fehervari
 
  • add this feed to my.Alltop

    Nature Materials - AOP - nature.com science feeds

  • Self-similar mesostructure evolution of the growing mollusc shell reminiscent of thermodynamically driven grain growth

    Bernd Bayerlein
    18 Oct 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4110 Authors: Bernd Bayerlein, Paul Zaslansky, Yannicke Dauphin, Alexander Rack, Peter Fratzl & Igor Zlotnikov Significant progress has been made in understanding the interaction between mineral precursors and organic components leading to material formation and structuring in biomineralizing systems. The mesostructure of biological materials, such as the outer calcitic shell of molluscs, is characterized by many parameters and the question arises as to what extent they all are, or need to be, controlled biologically. Here, we analyse the…
  • Re-entrant solidification in polymer–colloid mixtures as a consequence of competing entropic and enthalpic attractions

    Lang Feng
    18 Oct 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4109 Authors: Lang Feng, Bezia Laderman, Stefano Sacanna & Paul Chaikin In polymer–colloid mixtures, non-adsorbing polymers dispersed with much larger colloids provide a universal yet specific entropic attraction between the colloids. Such so-called depletion interaction arises from an osmotic-pressure imbalance caused by the polymers and is considered to be independent of temperature. Here we show that, for the most commonly used polymer–colloid depletion systems, the polymer undergoes a crossover from non-adsorbing to adsorbing and that,…
  • Liquid-like pseudoelasticity of sub-10-nm crystalline silver particles

    Jun Sun
    11 Oct 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4105 Authors: Jun Sun, Longbing He, Yu-Chieh Lo, Tao Xu, Hengchang Bi, Litao Sun, Ze Zhang, Scott X. Mao & Ju Li In nanotechnology, small-volume metals with large surface area are used as electrodes, catalysts, interconnects and antennae. Their shape stability at room temperature has, however, been questioned. Using in situ high-resolution transmission electron microscopy, we find that Ag nanoparticles can be deformed like a liquid droplet but remain highly crystalline in the interior, with no sign of dislocation activity during deformation.
  • Giant spin splitting of the two-dimensional electron gas at the surface of SrTiO3

    A. F. Santander-Syro
    11 Oct 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4107 Authors: A. F. Santander-Syro, F. Fortuna, C. Bareille, T. C. Rödel, G. Landolt, N. C. Plumb, J. H. Dil & M. Radović Two-dimensional electron gases (2DEGs) forming at the interfaces of transition metal oxides exhibit a range of properties, including tunable insulator–superconductor–metal transitions, large magnetoresistance, coexisting ferromagnetism and superconductivity, and a spin splitting of a few meV (refs , ). Strontium titanate (SrTiO3), the cornerstone of such oxide-based electronics, is a transparent, non-magnetic, wide-bandgap…
  • Oligopeptide complex for targeted non-viral gene delivery to adipocytes

    Young-Wook Won
    4 Oct 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4092 Authors: Young-Wook Won, Partho Protim Adhikary, Kwang Suk Lim, Hyung Jin Kim, Jang Kyoung Kim & Yong-Hee Kim
  • add this feed to my.Alltop

    Nature Medicine - AOP - nature.com science feeds

  • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

    Desirée Schubert
    19 Oct 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3746 Authors: Desirée Schubert, Claudia Bode, Rupert Kenefeck, Tie Zheng Hou, James B Wing, Alan Kennedy, Alla Bulashevska, Britt-Sabina Petersen, Alejandro A Schäffer, Björn A Grüning, Susanne Unger, Natalie Frede, Ulrich Baumann, Torsten Witte, Reinhold E Schmidt, Gregor Dueckers, Tim Niehues, Suranjith Seneviratne, Maria Kanariou, Carsten Speckmann, Stephan Ehl, Anne Rensing-Ehl, Klaus Warnatz, Mirzokhid Rakhmanov, Robert Thimme, Peter Hasselblatt, Florian Emmerich, Toni Cathomen, Rolf Backofen, Paul Fisch, Maximilian Seidl, Annette May,…
  • Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

    Zhentao Zhang
    18 Oct 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3700 Authors: Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Il-Sun Kwon, Duc M Duong, Nicholas T Seyfried, William T Hu, Zhixue Liu, Jian-Zhi Wang, Liming Cheng, Yi E Sun, Shan Ping Yu, Allan I Levey & Keqiang Ye
  • Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

    Ingmar Bruns
    18 Oct 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3707 Authors: Ingmar Bruns, Daniel Lucas, Sandra Pinho, Jalal Ahmed, Michele P Lambert, Yuya Kunisaki, Christoph Scheiermann, Lauren Schiff, Mortimer Poncz, Aviv Bergman & Paul S Frenette In the bone marrow, hematopoietic stem cells (HSCs) lodge in specialized microenvironments that tightly control the proliferative state of HSCs to adapt to the varying needs for replenishment of blood cells while also preventing HSC exhaustion. All putative niche cells suggested thus far have a nonhematopoietic origin. Thus, it remains unclear how feedback from mature…
  • Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production

    Elizabeth C Rosser
    18 Oct 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3680 Authors: Elizabeth C Rosser, Kristine Oleinika, Silvia Tonon, Ronan Doyle, Anneleen Bosma, Natalie A Carter, Kathryn A Harris, Simon A Jones, Nigel Klein & Claudia Mauri Regulatory B cells (Breg cells) differentiate in response to inflammation and subsequently restrain excessive immune responses via the release of interleukin-10 (IL-10). However, the precise inflammatory signals governing their differentiation remain to be elucidated. Here we show that the gut microbiota promotes the differentiation of Breg cells in the spleen as well as in the…
  • An in vivo model of human small intestine using pluripotent stem cells

    Carey L Watson
    18 Oct 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3737 Authors: Carey L Watson, Maxime M Mahe, Jorge Múnera, Jonathan C Howell, Nambirajan Sundaram, Holly M Poling, Jamie I Schweitzer, Jefferson E Vallance, Christopher N Mayhew, Ying Sun, Gregory Grabowski, Stacy R Finkbeiner, Jason R Spence, Noah F Shroyer, James M Wells & Michael A Helmrath Differentiation of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers an exciting avenue for the study of embryonic development and disease processes, for pharmacologic studies and as a potential resource for therapeutic transplant. To date,…
 
  • add this feed to my.Alltop

    Nature Methods - Issue - nature.com science feeds

  • Structural biology: The structural basis of Spinach

    28 Sep 2014 | 5:00 pm
    Nature Methods 11, 992 (2014). doi:10.1038/nmeth.3119
  • The Author File: Paola Picotti

    Vivien Marx
    28 Sep 2014 | 5:00 pm
    Nature Methods 11, 975 (2014). doi:10.1038/nmeth.3116 Author: Vivien Marx Cells brim with activity that a special set of protein assays can help track.
  • Genome engineering: the next genomic revolution

    Charles A Gersbach
    28 Sep 2014 | 5:00 pm
    Nature Methods 11, 1009 (2014). doi:10.1038/nmeth.3113 Author: Charles A Gersbach A decade of advances in genome engineering technologies has enabled the editing of genome sequences much like one edits computer code; many more applications for precisely manipulating genome structure and function are on the horizon.
  • Points of Significance: Nested designs

    Martin Krzywinski
    28 Sep 2014 | 5:00 pm
    Nature Methods 11, 977 (2014). doi:10.1038/nmeth.3137 Authors: Martin Krzywinski, Naomi Altman & Paul Blainey For studies with hierarchical noise sources, use a nested analysis of variance approach.
  • Biophysics: A stir in the cytoplasm

    Irene Kaganman
    28 Sep 2014 | 5:00 pm
    Nature Methods 11, 996 (2014). doi:10.1038/nmeth.3132 Author: Irene Kaganman A combination of techniques reveals that aggregate forces from all enzymes active in the cytoplasm result in randomly fluctuating forces throughout the cell.
  • add this feed to my.Alltop

    Nature Methods - AOP - nature.com science feeds

  • A DNA-based molecular probe for optically reporting cellular traction forces

    Brandon L Blakely
    11 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3145 Authors: Brandon L Blakely, Christoph E Dumelin, Britta Trappmann, Lynn M McGregor, Colin K Choi, Peter C Anthony, Van K Duesterberg, Brendon M Baker, Steven M Block, David R Liu & Christopher S Chen We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can in principle be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs consist of DNA hairpins conjugated to fluorophore-quencher pairs that unfold and fluoresce when subjected to specific…
  • An improved surface passivation method for single-molecule studies

    Boyang Hua
    11 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3143 Authors: Boyang Hua, Kyu Young Han, Ruobo Zhou, Hajin Kim, Xinghua Shi, Sanjaya C Abeysirigunawardena, Ankur Jain, Digvijay Singh, Vasudha Aggarwal, Sarah A Woodson & Taekjip Ha We report a surface passivation method based on dichlorodimethylsilane (DDS)–Tween-20 for in vitro single-molecule studies, which, under the conditions tested here, more efficiently prevented nonspecific binding of biomolecules than the standard poly(ethylene glycol) surface. The DDS–Tween-20 surface was simple and inexpensive to prepare and did not perturb the…
  • A general design strategy for protein-responsive riboswitches in mammalian cells

    Simon Ausländer
    4 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3136 Authors: Simon Ausländer, Pascal Stücheli, Charlotte Rehm, David Ausländer, Jörg S Hartig & Martin Fussenegger
  • Time-resolved crystallography using the Hadamard transform

    Briony A Yorke
    4 Oct 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3139 Authors: Briony A Yorke, Godfrey S Beddard, Robin L Owen & Arwen R Pearson We describe a method for performing time-resolved X-ray crystallographic experiments based on the Hadamard transform, in which time resolution is defined by the underlying periodicity of the probe pulse sequence, and signal/noise is greatly improved over that for the fastest pump-probe experiments depending on a single pulse. This approach should be applicable on standard synchrotron beamlines and will enable high-resolution measurements of protein and small-molecule…
  • Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

    Irene Miranda-Lorenzo
    27 Sep 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3112 Authors: Irene Miranda-Lorenzo, Jorge Dorado, Enza Lonardo, Sonia Alcala, Alicia G Serrano, Jenifer Clausell-Tormos, Michele Cioffi, Diego Megias, Sladjana Zagorac, Anamaria Balic, Manuel Hidalgo, Mert Erkan, Joerg Kleeff, Aldo Scarpa, Bruno Sainz & Christopher Heeschen
  • add this feed to my.Alltop

    Nature Nanotechnology - Issue - nature.com science feeds

  • Bacterial nanowires: An extended membrane

    Ai Lin Chun
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 750 (2014). doi:10.1038/nnano.2014.230 Author: Ai Lin Chun
  • Graphene devices for life

    Kostas Kostarelos
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 744 (2014). doi:10.1038/nnano.2014.224 Authors: Kostas Kostarelos & Kostya S. Novoselov Kostas Kostarelos and Kostya S. Novoselov examine the potential of graphene in biomedical applications.
  • The global growth of graphene

    Wencai Ren
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 726 (2014). doi:10.1038/nnano.2014.229 Authors: Wencai Ren & Hui-Ming Cheng The large-scale production of graphene aimed at industrial applications has grown significantly in the past few years, especially since many companies in China have entered the market.
  • Graphene against corrosion

    Siva Böhm
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 741 (2014). doi:10.1038/nnano.2014.220 Author: Siva Böhm Siva Böhm discusses how graphene can be used to prevent corrosion of metals such as steel.
  • Challenges and opportunities in graphene commercialization

    Amaia Zurutuza
    5 Oct 2014 | 5:00 pm
    Nature Nanotechnology 9, 730 (2014). doi:10.1038/nnano.2014.225 Authors: Amaia Zurutuza & Claudio Marinelli As technical knowledge, manufacturing methods and the development of applications mature, key factors will affect the pace of commercialization of graphene.
 
  • add this feed to my.Alltop

    Nature Photonics - AOP - nature.com science feeds

  • A long-range polarization-controlled optical tractor beam

    Vladlen Shvedov
    18 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.242 Authors: Vladlen Shvedov, Arthur R. Davoyan, Cyril Hnatovsky, Nader Engheta & Wieslaw Krolikowski The laser beam has become an indispensable tool for the controllable manipulation and transport of microscopic objects in biology, physical chemistry and condensed matter physics. In particular, ‘tractor’ laser beams can draw matter towards a laser source and perform, for instance, all-optical remote sampling. Recent advances in lightwave technology have already led to small-scale experimental demonstrations of tractor beams. However, the…
  • Probing the mechanisms of large Purcell enhancement in plasmonic nanoantennas

    Gleb M. Akselrod
    11 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.228 Authors: Gleb M. Akselrod, Christos Argyropoulos, Thang B. Hoang, Cristian Ciracì, Chao Fang, Jiani Huang, David R. Smith & Maiken H. Mikkelsen To move nanophotonic devices such as lasers and single-photon sources into the practical realm, a challenging list of requirements must be met, including directional emission, room-temperature and broadband operation, high radiative quantum efficiency and a large spontaneous emission rate. To achieve these features simultaneously, a platform is needed for which the various decay channels of embedded…
  • Ultrafast multi-terahertz nano-spectroscopy with sub-cycle temporal resolution

    M. Eisele
    4 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.225 Authors: M. Eisele, T. L. Cocker, M. A. Huber, M. Plankl, L. Viti, D. Ercolani, L. Sorba, M. S. Vitiello & R. Huber Phase-locked ultrashort pulses in the rich terahertz spectral range have provided key insights into phenomena as diverse as quantum confinement, first-order phase transitions, high-temperature superconductivity and carrier transport in nanomaterials. Ultrabroadband electro-optic sampling of few-cycle field transients can even reveal novel dynamics that occur faster than a single oscillation cycle of light. However, conventional…
  • All-optical coherent control of vacuum Rabi oscillations

    Ranojoy Bose
    4 Oct 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.224 Authors: Ranojoy Bose, Tao Cai, Kaushik Roy Choudhury, Glenn S. Solomon & Edo Waks
  • Access to long-term optical memories using photon echoes retrieved from semiconductor spins

    L. Langer
    27 Sep 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.219 Authors: L. Langer, S. V. Poltavtsev, I. A. Yugova, M. Salewski, D. R. Yakovlev, G. Karczewski, T. Wojtowicz, I. A. Akimov & M. Bayer
 
  • add this feed to my.Alltop

    Nature Physics - Issue - nature.com science feeds

  • Shine a light

    Andrea Taroni
    29 Sep 2014 | 5:00 pm
    Nature Physics 10, 704 (2014). doi:10.1038/nphys3126 Author: Andrea Taroni
  • Together we stand

    Ioannis Pavlidis
    29 Sep 2014 | 5:00 pm
    Nature Physics 10, 700 (2014). doi:10.1038/nphys3110 Authors: Ioannis Pavlidis, Alexander M. Petersen & Ioanna Semendeferi University culture stands at a critical crossroads: the era of team science is upon us functionally, but not yet structurally. Solutions to the problems this mismatch creates involve rethinking education — and giving credit where credit is due.
  • Two-star show

    Abigail Klopper
    29 Sep 2014 | 5:00 pm
    Nature Physics 10, 704 (2014). doi:10.1038/nphys3124 Author: Abigail Klopper
  • Clear as a Bell

    Mark Buchanan
    29 Sep 2014 | 5:00 pm
    Nature Physics 10, 703 (2014). doi:10.1038/nphys3118 Author: Mark Buchanan
  • Drive for a spin

    Luke Fleet
    29 Sep 2014 | 5:00 pm
    Nature Physics 10, 704 (2014). doi:10.1038/nphys3123 Author: Luke Fleet
 
  • add this feed to my.Alltop

    Nature Reviews Cancer - Issue - nature.com science feeds

  • Proteomics: Follow your heat

    M. Teresa Villanueva
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 706 (2014). doi:10.1038/nrc3853 Author: M. Teresa Villanueva Drug–target interactions can be assessed through a cellular thermal shift assay (CETSA) that assesses changes in protein thermal stability. Savitski et al. have combined CETSA with quantitative mass spectrometry to determine the affinity of a drug for all its potential targets. They measured how
  • Revisiting STAT3 signalling in cancer: new and unexpected biological functions

    Hua Yu
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 736 (2014). doi:10.1038/nrc3818 Authors: Hua Yu, Heehyoung Lee, Andreas Herrmann, Ralf Buettner & Richard Jove The Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) proteins, particularly STAT3, are among the most promising new targets for cancer therapy. In addition to interleukin-6 (IL-6) and its family members, multiple pathways, including G-protein-coupled receptors (GPCRs), Toll-like receptors (TLRs) and microRNAs
  • Therapeutics: Delivered in a tea bag

    M. Teresa Villanueva
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 706 (2014). doi:10.1038/nrc3851 Author: M. Teresa Villanueva Chung et al. havedesigned a therapeutic nanocarrier for drug delivery using compounds derived from epigallocatechin gallate (EGCG), an antioxidant found in green tea. The sequential self-assembly of the EGCG derivative with trastuzumab led to the formation of stable micellar nanocomplexes. The authors then added
  • Lymphoma: Release the B cell

    Gemma K. Alderton
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 707 (2014). doi:10.1038/nrc3856 Author: Gemma K. Alderton Germinal centre B cells (GCBs) are strictly localized to lymphoid organs, unlike those of GCB-like diffuse large B cell lymphoma (GCB-DLBCL). Muppidi et al. found that GCB-DLBCL-associated inactivating mutations in GNA13, which encodes the guanine nucleotide binding protein Gα13, allow AKT activation and
  • Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

    Simran S. Sabharwal
    23 Oct 2014 | 5:00 pm
    Nature Reviews Cancer 14, 709 (2014). doi:10.1038/nrc3803 Authors: Simran S. Sabharwal & Paul T. Schumacker Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism, biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated by mitochondria participate in stress signalling in normal cells but also contribute to the initiation of nuclear or mitochondrial DNA mutations that
  • add this feed to my.Alltop

    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • Merck wins first PD1 sprint in US

    30 Sep 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 715 (2014). doi:10.1038/nrd4458 US regulators approved Merck & Co.'s breakthrough cancer immunotherapy pembrolizumab, just over 3 years after it entered the clinic.The lowdown: After a brief but bright surge through the clinic, the first of the much hyped and hoped-for programmed cell death protein 1 (PD1)
  • Momentum builds around new antibiotic business models

    Asher Mullard
    30 Sep 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 711 (2014). doi:10.1038/nrd4455 Author: Asher Mullard The Innovative Medicines Initiative's DRIVE-AB project joins the fray of task forces working to reinvigorate interest in antibiotics by developing reimbursement models that delink revenue from sales volume.
  • Reanalyse this

    30 Sep 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 715 (2014). doi:10.1038/nrd4460 Re-evaluations of clinical trial results are rare, but they often point to new conclusions.The lowdown: With industry and academic institutions continuing to negotiate the terms of increased clinical trial result transparency, John Ioannidis of Stanford University and his colleagues scoured the literature to
  • False dawn for cystic fibrosis disease modifiers?

    David Holmes
    30 Sep 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 713 (2014). doi:10.1038/nrd4456 Author: David Holmes Recent results have cast doubt over how effective a breakthrough class of cystic fibrosis drugs can be in patients with the most common form of the disease.
  • Illuminating interleukin-5 data

    30 Sep 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 715 (2014). doi:10.1038/nrd4459 GlaxoSmithKline's mepolizumab succeeded in two Phase III asthma trials, whereas AstraZeneca's benralizumab failed in a Phase II chronic obstructive pulmonary disease trial.The lowdown: In 2000, GlaxoSmithKline (GSK) hit a wall when its interleukin-5 (IL-5)-specific antibody mepolizumab failed in its first Phase II trial.
 
  • add this feed to my.Alltop

    Nature Reviews Genetics - Issue - nature.com science feeds

  • Alternative splicing: Characterizing cell fate

    Isabel Lokody
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 706 (2014). doi:10.1038/nrg3847 Author: Isabel Lokody Chen et al. have identified and catalogued genes, transcripts and alternative splicing events that are specific to various human haematopoietic cell fates, providing insights into the transcriptional changes involved in the various haematopoeitic precursor populations.The authors used RNA sequencing to identify cell fate-specific
  • Alternative splicing: Retaining introns to sculpt gene expression

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 707 (2014). doi:10.1038/nrg3844 Author: Darren J. Burgess Intron retention is a common form of alternative splicing in plants and unicellular eukaryotes; however, its prevalence in mammals was unclear. Braunschweig et al. carried out high-throughput RNA sequencing from ∼40 human and mouse cell types and found evidence for intron retention in transcripts
  • Cancer: Up and down for DNA methylation inhibitors

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 707 (2014). doi:10.1038/nrg3845 Author: Darren J. Burgess Tumour suppressor genes in cancer cells are frequently silenced by promoter CpG methylation, which has led to the pursuit of DNA methylation inhibitors as potential cancer therapeutics to reactivate these genes. However, DNA methylation in gene bodies is associated with the opposite effect (that is,
  • Epigenetics: H3K27 methylation in transgenerational epigenetic memory

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 703 (2014). doi:10.1038/nrg3848 Author: Darren J. Burgess During reproduction, organisms must pass on genomes with suitable epigenetic states to the next generation. These states must be appropriate for gene expression programmes in the progeny and can be 'reset' to prevent the unwanted transgenerational inheritance of environmentally induced epigenetic states. Identifying the key
  • RNA: Dissecting circular RNA biogenesis

    Darren J. Burgess
    16 Oct 2014 | 5:00 pm
    Nature Reviews Genetics 15, 707 (2014). doi:10.1038/nrg3846 Author: Darren J. Burgess Circular RNAs are thought to arise from non-canonical splicing of linear pre-mRNAs, as they frequently harbour the 3′ end of one exon joined to an upstream (rather than downstream) 5′ end of an exon. Zhang et al. used bioinformatic analyses on human transcriptome data
 
  • add this feed to my.Alltop

    Nature Reviews Immunology - Issue - nature.com science feeds

  • Microbiota: Support your friends to resist your enemies

    Kirsty Minton
    23 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 715 (2014). doi:10.1038/nri3765 Author: Kirsty Minton Fucosylation of intestinal epithelial cells in response to commensal or systemic bacterial stimulation promotes disease resistance and tolerance through the metabolic support of the gut microbiota.
  • Pattern recognition receptors: Picking LOX to find antibodies

    Yvonne Bordon
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 716 (2014). doi:10.1038/nri3764 Author: Yvonne Bordon LOX1 activates dendritic cells and B cells to boost humoral immune responses.
  • Regulated cell death and inflammation: an auto-amplification loop causes organ failure

    Andreas Linkermann
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 759 (2014). doi:10.1038/nri3743 Authors: Andreas Linkermann, Brent R. Stockwell, Stefan Krautwald & Hans-Joachim Anders Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in parenchymal cells may lead to the release of damage- associated molecular patterns that drive both tissue inflammation and the activation of further pathways of RCD. Following an initial event of regulated necrosis, RCD
  • Innate sensing of malaria parasites

    Ricardo T. Gazzinelli
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 744 (2014). doi:10.1038/nri3742 Authors: Ricardo T. Gazzinelli, Parisa Kalantari, Katherine A. Fitzgerald & Douglas T. Golenbock Innate immune receptors have a key role in immune surveillance by sensing microorganisms and initiating protective immune responses. However, the innate immune system is a classic 'double-edged sword' that can overreact to pathogens, which can have deleterious effects and lead to clinical manifestations. Recent studies
  • Tolerance: AIREs and graces

    Lucy Bird
    16 Oct 2014 | 5:00 pm
    Nature Reviews Immunology 14, 714 (2014). doi:10.1038/nri3762 Author: Lucy Bird Distinct subsets of thymic antigen-presenting cells contribute to the generation of a diverse and self-tolerant T cell repertoire.
  • add this feed to my.Alltop

    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Viral infection: Host and viral components of the influenza virion

    Andrea Du Toit
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 724 (2014). doi:10.1038/nrmicro3376 Author: Andrea Du Toit Influenza viruses produce pleomorphic virions, which has made it difficult to study their composition. Hutchinson et al. used a mass spectrometry approach to determine and quantify the protein composition of influenza virions. They show that the core architecture of virions is conserved despite variation
  • Bacterial pathogenesis: A pneumococcal heart-breaker

    Andrea Du Toit
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 724 (2014). doi:10.1038/nrmicro3374 Author: Andrea Du Toit Invasive pneumococcal disease is often associated with an increased incidence of adverse cardiac events. A new study now shows that Streptococcus pneumoniae, the main cause of community-acquired pneumonia, causes direct cardiotoxicity and induces the formation of microscopic lesions within the myocardium of experimentally infected
  • Bacterial genetics: Chromosomal position regulates gene expression

    Andrea Du Toit
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 724 (2014). doi:10.1038/nrmicro3375 Author: Andrea Du Toit The effect of chromosomal location on the expression of bacterial genes is understudied; here, Bryant et al. re-address how chromosomal position affects gene expression in Escherichia coli K-12. By inserting a reporter cassette composed of GFP under the control of the lac
  • Microbiome: Bacteria and the brain

    Christina Tobin Kåhrström
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 725 (2014). doi:10.1038/nrmicro3373 Author: Christina Tobin Kåhrström Accumulating evidence suggests that the gut microbiota influences host neurological activity and behaviour. Here, the authors find that the two gut Firmicutes, Clostridium sporogenes and Ruminococcus gnavus, produce and secrete two distinct tryptophan decarboxylases that catalyse the formation of the neurotransmitter tryptamine. Tryptamine
  • Marine microbiology: Exploring the unexplored

    Christina Tobin Kåhrström
    15 Oct 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 725 (2014). doi:10.1038/nrmicro3371 Author: Christina Tobin Kåhrström Marine oxygen minimum zones (OMZs) are hot spots for microbial-driven matter and energy transformations, but the dynamics of virus–host interactions at these sites are poorly understood. In this study, Roux et al. used a combination of metagenomics and single-cell amplified genome (SAG) sequencing to
 
  • add this feed to my.Alltop

    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Signalling dynamics in vertebrate segmentation

    Alexis Hubaud
    21 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 709 (2014). doi:10.1038/nrm3891 Authors: Alexis Hubaud & Olivier Pourquié Segmentation of the paraxial mesoderm is a major event of vertebrate development that establishes the metameric patterning of the body axis. This process involves the periodic formation of sequential units, termed somites, from the presomitic mesoderm. Somite formation relies on a molecular oscillator, the segmentation
  • Epigenetics: Enhancers under TET control

    Kim Baumann
    21 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 699 (2014). doi:10.1038/nrm3901 Author: Kim Baumann The ten-eleven-tanslocation (TET) family of proteins regulates enhancer methylation and activity in embryonic stem cells.
  • Technology: RNA targeting by Cas9

    Eytan Zlotorynski
    14 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 701 (2014). doi:10.1038/nrm3895 Author: Eytan Zlotorynski Cas9, a component of the genome editing tool CRISPR–Cas9, is a DNA endonuclease. It is targeted by guide RNAs (gRNAs), and its activity depends on recognizing a short sequence known as the protospacer adjacent motif (PAM). O'Connell et al. show that Cas9 also targets
  • Cell adhesion: Winning mechanism for angiogenesis

    Kirsty Minton
    14 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 702 (2014). doi:10.1038/nrm3893 Author: Kirsty Minton Angiogenic factors induce podosome rosettes in endothelial cells that mediate focal degradation of the basement membrane and blood vessel branching.
  • Protein quality control: Nuclear membrane proteins in check

    Kim Baumann
    14 Oct 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 700 (2014). doi:10.1038/nrm3898 Author: Kim Baumann The Asi complex defines an ERAD branch that is specific for inner nuclear membrane protein quality control in yeast.
  • add this feed to my.Alltop

    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Perception: A decisive response

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3853 Author: Darran Yates Certain neurons in the medial temporal lobe (MTL) respond to different images and even the name of a given individual. Here, the authors assessed MTL neuron responses in a face adaptation task. Participants were shown the face of one of two well-known people (who were
  • Learning and memory: The left–right divide

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3851 Author: Darran Yates Several studies in mice have revealed that there are differences in the molecular make-up of and plasticity at CA3–CA1 pyramidal neuron synapses that depend on whether the presynaptic input comes from the left or right CA3. To detect any functional effects of this asymmetry, Shipton
  • Learning and memory: Actively compensating

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3854 Author: Darran Yates Alzheimer's disease is characterized by episodic memory impairments and brain deposition of the peptide amyloid-β (Aβ). However, not all older people with Aβ pathology exhibit memory deficits. Elman et al.examined whether brain hyperactivity, which has been observed in such individuals, might compensate for this
  • Neural circuits: Getting colder

    Darran Yates
    19 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 701 (2014). doi:10.1038/nrn3852 Author: Darran Yates The neural circuitry that underlies the perception of skin cooling is unclear. To examine this, the authors trained mice to report temperature drops (delivered by a thermal probe applied to the forepaw skin) by licking a water dispenser. Cooling induced activity in the primary somatosensory
  • Neurotransmission: Transmission takes two

    Darran Yates
    14 Oct 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 700 (2014). doi:10.1038/nrn3848 Author: Darran Yates Two studies in rodents show that lateral habenula activity is regulated by neurons that co-release glutamate and GABA.
 
  • add this feed to my.Alltop

    Nature Reviews Cardiology - Issue - nature.com science feeds

  • Celebrating the first 10 years of Nature Reviews Cardiology

    Gregory B. Lim
    16 Oct 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 617 (2014). doi:10.1038/nrcardio.2014.158 Author: Gregory B. Lim The inaugural issue of Nature Reviews Cardiology was published in November 2004 under the title of Nature Clinical Practice Cardiovascular Medicine. As reviewed in this 10-year anniversary issue, much has changed in cardiology over the past decade and, during this period, Nature Reviews
  • Decade in review—peripheral vascular disease: 10 Years of breakthroughs in peripheral vascular disease

    Mark A. Creager
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 635 (2014). doi:10.1038/nrcardio.2014.153 Author: Mark A. Creager Clinical trials published during the past decade have had substantial effects on the treatment of peripheral vascular diseases. In this article, I discuss ten important trials that have influenced treatment for common vascular disorders, including peripheral artery disease, abdominal aortic aneurysm, renal artery disease, extracranial carotid artery disease, and venous thromboembolism.
  • Top 10 cardiovascular therapies and interventions for the next decade

    Valentin Fuster
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 671 (2014). doi:10.1038/nrcardio.2014.137 Author: Valentin Fuster Cardiovascular disease (CVD) has become the most-common cause of death worldwide. The Western lifestyle does not promote healthy living, and the consequences are most devastating when social inequalities are combined with economic factors and population growth. The expansion of poor nutritional habits, obesity, and associated
  • Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation?

    Yutang Wang
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 638 (2014). doi:10.1038/nrcardio.2014.70-c1 Author: Yutang Wang I read with great interest the News & Views article by Schmieder (How should data from SYMPLICITY HTN-3 be interpreted? Nat. Rev. Cardiol.11, 375–376; 2014). Schmieder provided an excellent overview of the randomized, sham-controlled, single-blinded SYMPLICITY HTN-3 trial, and provided
  • Renal denervation—a valid treatment option despite SYMPLICITY HTN-3

    Roland E. Schmieder
    29 Sep 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 638 (2014). doi:10.1038/nrcardio.2014.70-c2 Author: Roland E. Schmieder I thank Yutang Wang for his Correspondence (Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation? Nat. Rev. Cardiol. doi:10.1038/nrcardio.2014.70-c1) on my News & Views article (How should data from SYMPLICITY HTN-3 be interpreted? Nat. Rev. Cardiol.11
 
  • add this feed to my.Alltop

    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • Celebrating 10 years since launch

    Lisa Hutchinson
    23 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 619 (2014). doi:10.1038/nrclinonc.2014.164 Author: Lisa Hutchinson It has been 10 years since the launch of Nature Reviews Clinical Oncology in November 2004, formerly branded Nature Clinical Practice Oncology. The journal's founding Editor-in-Chief, Vincent T. DeVita Jr, wrote an opening editorial, which stated “We live in the most exciting time
  • Breast cancer: Combining bevacizumab with chemotherapy—from maintenance to second-line treatment

    Alessia Errico
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 621 (2014). doi:10.1038/nrclinonc.2014.179 Author: Alessia Errico Bevacizumab is a VEGF-neutralizing antibody that blocks angiogenesis, a crucial process in the growth of both primary tumours and metastases. Bevacizumab has been used for the treatment of several cancer types, including colon and breast cancer.The combination of bevacizumab with chemotherapy, in the first-line
  • SLNB in melanoma—DFS a true and cost-effective benefit?

    Alexander C. J. van Akkooi
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 680 (2014). doi:10.1038/nrclinonc.2014.65-c3 Authors: Alexander C. J. van Akkooi & Alexander M. M. Eggermont With great interest have we noticed the correspondence of Faries et al. (
  • MSLT-I—response of clinical trial investigators

    Mark B. Faries
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 680 (2014). doi:10.1038/nrclinonc.2014.65-c1 Authors: Mark B. Faries, Alistair J. Cochran & John F. Thompson Three recent News & Views articles that were published back-to-back in the May 2014 issue of this journal commented on the final analysis of the first Multicenter Selective Lymphadenectomy Trial (MSLT-I). The authors of these articles recognized the size and quality of the
  • Decade in review—funding in cancer research: National Cancer Institute awards—a work in progress

    Tito Fojo
    13 Oct 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 634 (2014). doi:10.1038/nrclinonc.2014.173 Authors: Tito Fojo & Paraskevi Giannakakou Over the past decade, funding for cancer research by the US government—and others—has stagnated, while the demand for investment has grown because of the increasing cancer incidence worldwide. We discuss how National Cancer Institute funding efforts have developed during this period, and the contemporary and future impact of these measures on cancer research in the USA.
  • add this feed to my.Alltop

    Nature Reviews Endocrinology - Issue - nature.com science feeds

  • Epidemiology: Obesity and cancer—the evidence is fattening up

    Rudolf Kaaks
    29 Sep 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 644 (2014). doi:10.1038/nrendo.2014.168 Authors: Rudolf Kaaks & Tilman Kühn A large-scale study with 5.24 million participants has found statistically significant associations between increased BMI and 17 of 22 frequent cancers. The strongest associations were observed for cancers of the endometrium, kidney, gallbladder and uterus. Questions remain as to whether several of the weaker associations reported in this study reflect genuinely causal relationships.
  • Genetic regulation of mammalian gonad development

    Stefanie Eggers
    22 Sep 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 673 (2014). doi:10.1038/nrendo.2014.163 Authors: Stefanie Eggers, Thomas Ohnesorg & Andrew Sinclair Sex-specific gonadal development starts with formation of the bipotential gonad, which then differentiates into either a mature testis or an ovary. This process is dependent on activation of either the testis-specific or the ovary-specific pathway while the opposite pathway is continuously repressed. A network of
  • Gut microbiota: Not so sweet—artificial sweeteners can cause glucose intolerance by affecting the gut microbiota

    Claire Greenhill
    22 Sep 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 637 (2014). doi:10.1038/nrendo.2014.167 Author: Claire Greenhill Noncaloric artificial sweeteners (NAS) have been linked with glucose intolerance in a new study published in Nature. Furthermore, the researchers have demonstrated that the metabolic changes underlying glucose intolerance are the result of consumed NAS altering the composition of the gut microbiota.The incidence
  • Nutrition: High-fat diet and dysbiosis accelerate tumorigenesis in mice

    Claire Greenhill
    15 Sep 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 638 (2014). doi:10.1038/nrendo.2014.164 Author: Claire Greenhill In mice with a predisposition to develop intestinal cancer, dysbiosis as a result of a high-fat diet accelerates the development of intestinal tumours, reports a new study in Nature.“We were interested to see if the caloric input or constituents of a diet could
  • Mitochondrial dynamics in the central regulation of metabolism

    Carole M. Nasrallah
    8 Sep 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 650 (2014). doi:10.1038/nrendo.2014.160 Authors: Carole M. Nasrallah & Tamas L. Horvath The ability of an organism to convert organic molecules from the environment into energy is essential for the development of cellular structures, cell differentiation and growth. Mitochondria have a fundamental role in regulating metabolic pathways, and tight control of mitochondrial functions and dynamics is critical
 
  • add this feed to my.Alltop

    Nature Reviews Nephrology - Issue - nature.com science feeds

  • Transplantation: Steroid-free immunosuppression reduces 5-year morbidity

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.188 A randomized, prospective study has compared the effects of corticosteroid use (≥6 months) versus no corticosteroid use, both in combination with standard immunosuppression in renal transplant recipients. A reduction in morbidity in the steroid-free group was detected after 5 years. Renal function at 5 years
  • Renal fibrosis: Renal interstitial fibrosis predicted by mathematical model

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.189 New research shows that the progression of renal fibrosis, as observed in patients with lupus nephritis, can be accurately simulated using mathematical modelling. The model was used to accurately predict the urinary concentrations of the putative biomarkers monocyte chemotactic protein-1 and transforming growth factor β
  • Renal artery stenosis: Routine renal revascularization after stenosis: no benefit

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.186 An update of a previous meta-analysis, in light of the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) trial, has revealed that routine renal revascularization following stenosis in patients with hypertension and/or chronic kidney disease has little effect on the risk of cardiovascular or renal outcomes
  • Risk factors: AKI after CABG increases risk of ESRD

    6 Oct 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 612 (2014). doi:10.1038/nrneph.2014.187 New data from a study of 29,330 patients who received isolated coronary artery bypass grafting (CABG) surgery show that occurrence of postoperative acute kidney injury (AKI) results in an almost threefold increase in risk of end-stage renal disease (ESRD), after a mean follow-up of 4.3
  • Stones: Ultrasonography and computed tomography: performance in detection of kidney stones

    Susan J. Allison
    29 Sep 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 611 (2014). doi:10.1038/nrneph.2014.182 Author: Susan J. Allison The most appropriate imaging method for the diagnosis of kidney stones in patients with suspected nephrolithiasis is unclear. Computed tomography (CT) is the most commonly used imaging modality owing to its high sensitivity for the detection of stones, but this approach is more expensive than
 
 
  • add this feed to my.Alltop

    Naturejobs - Search results

  • Warehouse Worker

    25 Oct 2014 | 12:15 am
    Expertise Operations Education High School/GED Job Type Full-time Location United States - Tennessee - Memphis Job Level Entry Level Posting date: October 10, 2014 Position Summary: Reads production schedule, customer order, work order, shipping order, or requisition to determine items to be moved, gathered, or distributed. Follows work instructions for pick to light, put to light pack and void fill outbound shipments, order checking via voice verification units, pick to label, over p...
  • H\F Ingénieur Services Après Vente CMD

    25 Oct 2014 | 12:15 am
    Job Code : 15995 Location : Villebon sur Yvette Essonne FR Category : Service - Maintenance - Réparation Career Level : Cadre supérieur Job Type : CDI Job Description : Org Unit : CMD Services - ULS Product Lines : CHROM LC Location (Country) : France – Ile de France principalement (dépts : 75, 93, 77, 94, 51) Based (Field/Home) : Basé depuis l’Ile-de-France, rattaché à Villebon (91) Reports t...
  • Industrial Controls Technician

    25 Oct 2014 | 12:15 am
    Expertise Engineering Education High School/GED Job Type Full-time Location United States - Virginia - Middletown Job Level Experienced Posting date: October 1, 2014 Position Summary: Performs corrective and preventive maintenance on production, utility, and facility equipment and instrumentation. Works independently in performing various tasks. Assists other maintenance personnel to resolve technical issues. Troubleshoots and repairs the following: PLC-based control systems...
  • Product Development Leadership Program Associate Engineer Mechanical

    25 Oct 2014 | 12:15 am
    Expertise Engineering Education Bachelors Job Type Full-time Location United States - All Job Level Entry Level Posting date: October 16, 2014 Program Summary The Thermo Fisher Scientific Product Development Leadership Program is designed to accelerate the development of high potential college graduates and prepare them for dynamic careers within research and development at Thermo Fisher Scientific. Stakeholders The program is managed by a dedicated Program Manager with oversight ...
  • Director North America LSG Sales Operations

    25 Oct 2014 | 12:15 am
    Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Our four premier brands - Life Technologies, Thermo Scientific, Fisher Scientific and Unity Lab Services...
 
 
 
  • add this feed to my.Alltop

    British Journal of Pharmacology

  • Small-molecule modulators of the OX40–OX40 ligand co-stimulatory protein–protein interaction

    Yun Song, Emilio Margolles-Clark, Allison Bayer, Peter Buchwald
    24 Oct 2014 | 4:36 am
    Background and PurposeThe OX40–OX40L protein–protein interaction (PPI) is an important cell-surface signalling co-stimulatory regulator within the TNFR superfamily (TNFRSF) and a promising therapeutic target for immunomodulation. PPIs are difficult to modulate using small-molecules. Here, we describe the identification of a small-molecule OX40 modulator and confirm its partial agonist character. Experimental ApproachCell-free screening assays were developed and used to identify OX40–OX40L inhibitors. Modified versions of this assay were used to elucidate the binding partner and the…
  • Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

    C Norez, C Vandebrouck, J Bertrand, S Noel, E Durieu, N Oumata, H Galons, F Antigny, A Chatelier, P Bois, L Meijer, F Becq
    24 Oct 2014 | 4:36 am
    Background and PurposeThe most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF is an orphan disease, therapeutic strategies aimed at improving mutant CFTR functions are needed to target the root cause of CF. Experimental ApproachHuman CF airway epithelial cells were treated with roscovitine 100 μM for 2 h before CFTR maturation, expression and activity were examined. The mechanism of action of roscovitine was explored by recording the effect of…
  • An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate

    L J Williams, D Mukherjee, M Fisher, C C Reyes-Aldasoro, S Akerman, C Kanthou, G M Tozer
    24 Oct 2014 | 4:36 am
    Background and PurposeCombretastatin A-4 3-O-phosphate (CA4P) is in clinical trial as a tumour vascular disrupting agent (VDA) but the cause of blood flow disruption is unclear. We tested the hypothesis that activation of Rho/Rho kinase (ROCK) is fundamental to the effects of this drug in vivo. Experimental ApproachMouse models of human colorectal carcinoma (SW1222 and LS174T) were used. Effects of the ROCK inhibitor, Y27632, alone or in combination with CA4P, on ROCK activity, vascular function, necrosis and immune cell infiltration in solid tumours were determined. Mean arterial BP (MABP)…
  • Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization

    David A Sykes, Darren M Riddy, Craig Stamp, Michelle E Bradley, Neil McGuiness, Afrah Sattikar, Danilo Guerini, Ines Rodrigues, Albrecht Glaenzel, Mark R Dowling, Florian Mullershausen, Steven J Charlton
    24 Oct 2014 | 4:36 am
    Background and PurposeThe molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated whether receptor binding kinetics and β-arrestin recruitment could play a role in the persistent internalization of the S1P1R by FTY720-P. Experimental Approach[3H]-FTY720-P and [33P]-S1P were used to label CHO-S1P1/3Rs for binding studies. Ligand efficacy was assessed through [35S]-GTPγS binding and β-arrestin recruitment. Metabolic stability was evaluated using a…
  • Issue Information

    24 Oct 2014 | 4:36 am
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • add this feed to my.Alltop

    PSI-Nature Structural Biology Knowledgebase

  • Microbiome: Artificial Sweeteners Induce Unhealthy Metabolism

    Anita M. Engh
    15 Oct 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.228 Author: Anita M. Engh Artificial sweeteners alter metabolism through shifts in the distribution of gut microbiota species.
  • Microbiome: When Form Doesn't Equal Function

    Catherine Goodman
    15 Oct 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.229 Author: Catherine Goodman The characterization of three proteins from the human microbiome extends our understanding of PLP-dependent enzymes.
  • Commensally sourced antibiotics

    Cláudio Nunes-Alves
    21 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology , (2014). doi:10.1038/nrmicro3363 Author: Cláudio Nunes-Alves A study analyzes the distribution of biosynthetic gene clusters in the human microbiome.
  • First aid kit for cholera

    Andrea Du Toit
    28 Sep 2014 | 5:00 pm
    Nature Reviews Microbiology , (2014). doi:10.1038/nrmicro3366 Author: Andrea Du Toit The role of the human gut microbiota in Vibrio cholerae infection is investigated.
  • Microbiome: Expanding the Gut Gene Catalog

    Tal Nawy
    15 Oct 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.230 Author: Tal Nawy An international effort has identified nearly ten million genes belonging to microbes hosted by diverse human guts.
Log in