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  • Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

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    Irfan A. Asangani
    22 Apr 2014 | 5:00 pm
    Nature advance online publication 23 April 2014. doi:10.1038/nature13229 Authors: Irfan A. Asangani, Vijaya L. Dommeti, Xiaoju Wang, Rohit Malik, Marcin Cieslik, Rendong Yang, June Escara-Wilke, Kari Wilder-Romans, Sudheer Dhanireddy, Carl Engelke, Mathew K. Iyer, Xiaojun Jing, Yi-Mi Wu, Xuhong Cao, Zhaohui S. Qin, Shaomeng Wang, Felix Y. Feng & Arul M. Chinnaiyan Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR)…
  • Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

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    Lorena Riol-Blanco
    22 Apr 2014 | 5:00 pm
    Nature advance online publication 23 April 2014. doi:10.1038/nature13199 Authors: Lorena Riol-Blanco, Jose Ordovas-Montanes, Mario Perro, Elena Naval, Aude Thiriot, David Alvarez, John N. Wood & Ulrich H. von Andrian The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbours specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17-producing γδ T (γδT17) cells, the aberrant activation of which by IL-23 can provoke psoriasis-like…
  • Seven days: 18–24 April 2014

    NatureNews - Most recent articles - nature.com science feeds
    22 Apr 2014 | 5:00 pm
    The week in science: NIH allows reuse of rejected grant ideas; China’s land pollution revealed; and NASA’s LADEE probe crashes into the Moon.Nature 508 436 doi: 10.1038/508436a
  • Statistical power and significance testing in large-scale genetic studies

    Nature Reviews Genetics - Issue - nature.com science feeds
    Pak C. Sham
    16 Apr 2014 | 5:00 pm
    Nature Reviews Genetics 15, 335 (2014). doi:10.1038/nrg3706 Authors: Pak C. Sham & Shaun M. Purcell Significance testing was developed as an objective method for summarizing statistical evidence for a hypothesis. It has been widely adopted in genetic studies, including genome-wide association studies and, more recently, exome sequencing studies. However, significance testing in both genome-wide and exome-wide studies must adopt stringent
  • R&D productivity: on the comeback trail

    Nature Reviews Drug Discovery - AOP - nature.com science feeds
    Ulrik Schulze
    21 Apr 2014 | 5:00 pm
    Nature Reviews Drug Discovery. doi:10.1038/nrd4320 Authors: Ulrik Schulze, Mathias Baedeker, Yen Ting Chen & David Greber
 
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  • Seven days: 18–24 April 2014

    22 Apr 2014 | 5:00 pm
    Seven days: 18–24 April 2014 Nature 508, 7497 (2014). http://www.nature.com/doifinder/10.1038/508436a The week in science: NIH allows reuse of rejected grant ideas; China’s land pollution revealed; and NASA’s LADEE probe crashes into the Moon.
  • Physics: Liquid bubbles stop sound

    22 Apr 2014 | 5:00 pm
    Physics: Liquid bubbles stop sound Nature 508, 7497 (2014). doi:10.1038/508435b Liquid foam can block the transmission of ultrasound, report Valentin Leroy at Paris Diderot University and his colleagues.The French team created the foam by bubbling an insoluble gas, perfluorohexane, into water containing a surfactant, and then sent ultrasound through the foam.The elastic, thin
  • A question of trust

    22 Apr 2014 | 5:00 pm
    A question of trust Nature 508, 7497 (2014). doi:10.1038/508432a NASA’s decision to renege on SOFIA project casts doubts over its reliability as a partner.
  • Astronomy: Earth twin spotted in habitable zone

    22 Apr 2014 | 5:00 pm
    Astronomy: Earth twin spotted in habitable zone Nature 508, 7497 (2014). doi:10.1038/508434e Astronomers have discovered a planet that is a similar size to Earth orbiting a cool, dim star at just the right distance for liquid water to exist. It is the most Earth-like planet found so far that could potentially host life.A team led by
  • Take care

    22 Apr 2014 | 5:00 pm
    Take care Nature 508, 7497 (2014). doi:10.1038/508432b The United States must tread carefully when building a health-data system.
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  • Elevated CO2 further lengthens growing season under warming conditions

    Melissa Reyes-Fox
    22 Apr 2014 | 5:00 pm
    Nature advance online publication 23 April 2014. doi:10.1038/nature13207 Authors: Melissa Reyes-Fox, Heidi Steltzer, M. J. Trlica, Gregory S. McMaster, Allan A. Andales, Dan R. LeCain & Jack A. Morgan Observations of a longer growing season through earlier plant growth in temperate to polar regions have been thought to be a response to climate warming. However, data from experimental warming studies indicate that many species that initiate leaf growth and flowering earlier also reach seed maturation and senesce earlier, shortening their active and reproductive periods. A conceptual model…
  • Widespread decline of Congo rainforest greenness in the past decade

    Liming Zhou
    22 Apr 2014 | 5:00 pm
    Nature advance online publication 23 April 2014. doi:10.1038/nature13265 Authors: Liming Zhou, Yuhong Tian, Ranga B. Myneni, Philippe Ciais, Sassan Saatchi, Yi Y. Liu, Shilong Piao, Haishan Chen, Eric F. Vermote, Conghe Song & Taehee Hwang Tropical forests are global epicentres of biodiversity and important modulators of climate change, and are mainly constrained by rainfall patterns. The severe short-term droughts that occurred recently in Amazonia have drawn attention to the vulnerability of tropical forests to climatic disturbances. The central African rainforests, the second-largest…
  • Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

    Irfan A. Asangani
    22 Apr 2014 | 5:00 pm
    Nature advance online publication 23 April 2014. doi:10.1038/nature13229 Authors: Irfan A. Asangani, Vijaya L. Dommeti, Xiaoju Wang, Rohit Malik, Marcin Cieslik, Rendong Yang, June Escara-Wilke, Kari Wilder-Romans, Sudheer Dhanireddy, Carl Engelke, Mathew K. Iyer, Xiaojun Jing, Yi-Mi Wu, Xuhong Cao, Zhaohui S. Qin, Shaomeng Wang, Felix Y. Feng & Arul M. Chinnaiyan Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR)…
  • Ecology: Drought in the Congo Basin

    Jeffrey Q. Chambers
    22 Apr 2014 | 5:00 pm
    Nature advance online publication 23 April 2014. doi:10.1038/nature13330 Authors: Jeffrey Q. Chambers & Dar A. Roberts A remote-sensing analysis of tropical forests in the Congo Basin that are experiencing chronic drought reveals consistent patterns of reduced vegetation greenness, increased temperatures and decreased water storage.
  • Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

    Lorena Riol-Blanco
    22 Apr 2014 | 5:00 pm
    Nature advance online publication 23 April 2014. doi:10.1038/nature13199 Authors: Lorena Riol-Blanco, Jose Ordovas-Montanes, Mario Perro, Elena Naval, Aude Thiriot, David Alvarez, John N. Wood & Ulrich H. von Andrian The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbours specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17-producing γδ T (γδT17) cells, the aberrant activation of which by IL-23 can provoke psoriasis-like…
 
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    Nature China - nature.com science feeds

  • Plant biology: Jumpy DNA's role in rice traits

    Piao Li
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.27 Author: Piao Li Small interfering RNA affects agricultural traits by promoting plant hormone synthesis
  • Molecular neuroscience: Live long, live healthy

    Edward Duca
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.31 Author: Edward Duca High levels of the neurotransmitters dopamine and serotonin prevent ageing-related behavioural decline in roundworms
  • Cell biology: Magic fingers

    Piao Li
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.22 Author: Piao Li A zinc finger protein functions as a binding partner and chaperone for a protein crucial to proper cell division
  • Polymers: Patterning without burning

    Lara Reid
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.29 Author: Lara Reid A novel annealing method uses near-infrared light to produce patterns on polymers without burning
  • Structural biology: A different treatment

    Edward Duca
    8 Apr 2014 | 5:00 pm
    Nature China(2014). doi:10.1038/nchina.2014.23 Author: Edward Duca The exosome complex uses its core to bind RNA molecules with longer ends
 
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    Nature Biotechnology - AOP - nature.com science feeds

  • Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

    Hyungsoon Im
    19 Apr 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2886 Authors: Hyungsoon Im, Huilin Shao, Yong Il Park, Vanessa M Peterson, Cesar M Castro, Ralph Weissleder & Hakho Lee Exosomes show potential for cancer diagnostics because they transport molecular contents of the cells from which they originate. Detection and molecular profiling of exosomes is technically challenging and often requires extensive sample purification and labeling. Here we describe a label-free, high-throughput approach for quantitative analysis of exosomes. Our nano-plasmonic exosome (nPLEX) assay is based on transmission surface…
  • GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins

    Leander Meuris
    19 Apr 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2885 Authors: Leander Meuris, Francis Santens, Greg Elson, Nele Festjens, Morgane Boone, Anaëlle Dos Santos, Simon Devos, François Rousseau, Evelyn Plets, Erica Houthuys, Pauline Malinge, Giovanni Magistrelli, Laura Cons, Laurence Chatel, Bart Devreese & Nico Callewaert Heterogeneity in the N-glycans on therapeutic proteins causes difficulties for protein purification and process reproducibility and can lead to variable therapeutic efficacy. This heterogeneity arises from the multistep process of mammalian complex-type N-glycan synthesis.
  • Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

    Xuebing Wu
    19 Apr 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2889 Authors: Xuebing Wu, David A Scott, Andrea J Kriz, Anthony C Chiu, Patrick D Hsu, Daniel B Dadon, Albert W Cheng, Alexandro E Trevino, Silvana Konermann, Sidi Chen, Rudolf Jaenisch, Feng Zhang & Phillip A Sharp
  • Sailfish enables alignment-free isoform quantification from RNA-seq reads using lightweight algorithms

    Rob Patro
    19 Apr 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2862 Authors: Rob Patro, Stephen M Mount & Carl Kingsford
  • Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

    Jens G Lohr
    19 Apr 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2892 Authors: Jens G Lohr, Viktor A Adalsteinsson, Kristian Cibulskis, Atish D Choudhury, Mara Rosenberg, Peter Cruz-Gordillo, Joshua M Francis, Cheng-Zhong Zhang, Alex K Shalek, Rahul Satija, John J Trombetta, Diana Lu, Naren Tallapragada, Narmin Tahirova, Sora Kim, Brendan Blumenstiel, Carrie Sougnez, Alarice Lowe, Bang Wong, Daniel Auclair, Eliezer M Van Allen, Mari Nakabayashi, Rosina T Lis, Gwo-Shu M Lee, Tiantian Li, Matthew S Chabot, Amy Ly, Mary-Ellen Taplin, Thomas E Clancy, Massimo Loda, Aviv Regev, Matthew Meyerson, William C Hahn, Philip W…
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    Nature Chemical Biology - AOP - nature.com science feeds

  • Antimicrobial mechanisms: A sponge against fungal infections

    Karl Lohner
    19 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1518 Author: Karl Lohner The finding that the antifungal activity of amphotericin B is primarily due to its ability to extract ergosterol from fungal membranes suggests a new rationale for drug design, which should lead to advanced treatments, particularly for invasive fungal infections.
  • Pharmacological chaperones stabilize retromer to limit APP processing

    Vincent J Mecozzi
    19 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1508 Authors: Vincent J Mecozzi, Diego E Berman, Sabrina Simoes, Chris Vetanovetz, Mehraj R Awal, Vivek M Patel, Remy T Schneider, Gregory A Petsko, Dagmar Ringe & Scott A Small
  • The role of distant mutations and allosteric regulation on LovD active site dynamics

    Gonzalo Jiménez-Osés
    12 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1503 Authors: Gonzalo Jiménez-Osés, Sílvia Osuna, Xue Gao, Michael R Sawaya, Lynne Gilson, Steven J Collier, Gjalt W Huisman, Todd O Yeates, Yi Tang & K N Houk
  • Glycobiology: Drifting toward polymer perfection

    Karen J Colley
    12 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1506 Author: Karen J Colley The addition of polysialic acid to proteins and cells is emerging as a promising therapeutic strategy. Polysialyltransferases synthesize polymers of widely varying lengths not optimal for therapeutic reagents, but the development of enzyme variants using neutral genetic drift offers a new way to overcome this problem.
  • Dynamics and hydration explain failed functional transformation in dehalogenase design

    Jan Sykora
    12 Apr 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1502 Authors: Jan Sykora, Jan Brezovsky, Tana Koudelakova, Maryna Lahoda, Andrea Fortova, Tatsiana Chernovets, Radka Chaloupkova, Veronika Stepankova, Zbynek Prokop, Ivana Kuta Smatanova, Martin Hof & Jiri Damborsky We emphasize the importance of dynamics and hydration for enzymatic catalysis and protein design by transplanting the active site from a haloalkane dehalogenase with high enantioselectivity to nonselective dehalogenase. Protein crystallography confirms that the active site geometry of the redesigned dehalogenase matches that of the…
 
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    Nature Chemistry

  • Proton-coupled electron transfer: Free radicals under control

    Bridgette A. Barry
    21 Apr 2014 | 5:00 pm
    Nature Chemistry 6, 376 (2014). doi:10.1038/nchem.1936 Author: Bridgette A. Barry Biological solar energy conversion requires the coordinated and rapid movement of protons and electrons through complex proteins, called reaction centres. Now, an artificial and structurally simple reaction centre has been synthesized that mimics an important, photosynthetic charge relay.
  • Cycloparaphenylenes: Closing the loop

    Graham J. Bodwell
    21 Apr 2014 | 5:00 pm
    Nature Chemistry 6, 383 (2014). doi:10.1038/nchem.1932 Author: Graham J. Bodwell The synthesis of [5]CPP, the smallest and by far the most strained member of the family of macrocycles known as cycloparaphenylenes, has been reported in quick succession by two different research groups. But how long will the new record holder retain its title?
  • Reductive amination: H2 free reduction

    Enda Bergin
    21 Apr 2014 | 5:00 pm
    Nature Chemistry 6, 374 (2014). doi:10.1038/nchem.1940 Author: Enda Bergin
  • Synthetic Biology: Two-for-one designer labels

    E. James Petersson
    21 Apr 2014 | 5:00 pm
    Nature Chemistry 6, 379 (2014). doi:10.1038/nchem.1935 Authors: E. James Petersson & John B. Warner Labelling of proteins with pairs of fluorophores enables their conformations to be studied; however, complete incorporation of labels in multiple, pre-defined locations is very difficult. Now, a combination of double unnatural amino acid mutagenesis and selective chemical modification offers a general method to achieve this.
  • Molecular recognition: Mutually exclusive

    Claire Hansell
    21 Apr 2014 | 5:00 pm
    Nature Chemistry 6, 374 (2014). doi:10.1038/nchem.1942 Author: Claire Hansell
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    Nature Chemistry

  • Reactions of xenon with iron and nickel are predicted in the Earth's inner core

    Li Zhu
    19 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1925 Authors: Li Zhu, Hanyu Liu, Chris J. Pickard, Guangtian Zou & Yanming Ma Studies of the Earth's atmosphere have shown that more than 90% of xenon is depleted — the so-called missing Xe paradox. Now a theoretical study shows that Xe and Fe/Ni can form inter-metallic compounds of XeFe3 and XeNi3 under conditions found in the Earth's inner core, and could provide a solution to the puzzle.
  • A mitochondrial pathway for biosynthesis of lipid mediators

    Yulia Y. Tyurina
    19 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1924 Authors: Yulia Y. Tyurina, Samuel M. Poloyac, Vladimir A. Tyurin, Alexander A. Kapralov, Jianfei Jiang, Tamil Selvan Anthonymuthu, Valentina I. Kapralova, Anna S. Vikulina, Mi-Yeon Jung, Michael W. Epperly, Dariush Mohammadyani, Judith Klein-Seetharaman, Travis C. Jackson, Patrick M. Kochanek, Bruce R. Pitt, Joel S. Greenberger, Yury A. Vladimirov, Hülya Bayır & Valerian E. Kagan The biosynthesis of lipid mediators has not previously been identified in mitochondria. Here, polyunsaturated cardiolipins are shown to be oxidized in the mitochondria…
  • Fatty acid membrane assembly on coacervate microdroplets as a step towards a hybrid protocell model

    T-Y. Dora Tang
    19 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1921 Authors: T-Y. Dora Tang, C. Rohaida Che Hak, Alexander J. Thompson, Marina K. Kuimova, D. S. Williams, Adam W. Perriman & Stephen Mann A hybrid protocell model is described in which a fatty acid membrane spontaneously assembles on the surface of coacervate microdroplets with molecularly crowded interiors. The membrane-enclosed protocells exhibit uptake and exclusion properties that differ from the uncoated droplets. The internal structure can be disassembled at high ionic strength without loss of membrane integrity. This model may help to reconcile…
  • Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET

    Kaihang Wang
    19 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1919 Authors: Kaihang Wang, Amit Sachdeva, Daniel J. Cox, Nabil W. Wilf, Kathrin Lang, Stephen Wallace, Ryan A. Mehl & Jason W. Chin A series of quadruplet decoding tRNAs are developed to form an optimized orthogonal translation system. These tRNAs enable efficient, site-specific incorporation of multiple unnatural amino acids into a protein, with a substantial increase in yield over previous methods. The amino acids are then used to site-specifically label a protein with a pair of fluorophores, enabling studies of the protein's dynamics.
  • Templated assembly of photoswitches significantly increases the energy-storage capacity of solar thermal fuels

    Timothy J. Kucharski
    12 Apr 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.1918 Authors: Timothy J. Kucharski, Nicola Ferralis, Alexie M. Kolpak, Jennie O. Zheng, Daniel G. Nocera & Jeffrey C. Grossman Solar thermal fuels have recently attracted an increasing amount of attention as a potential method for solar energy capture, conversion, storage and utilization. Azobenzene-functionalized single-walled carbon nanotubes demonstrate the proof-of-principle for increasing kinetic stability and energy densities by templating photoswitchable molecules on nanostructures to achieve highly (con)strained configurations.
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    Nature Genetics - Issue - nature.com science feeds

  • Inflammatory syndrome ADA2 deficiency

    Kyle Vogan
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 325 (2014). doi:10.1038/ng.2943 Author: Kyle Vogan
  • Zinc transport and diabetes risk

    Ewan Pearson
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 323 (2014). doi:10.1038/ng.2934 Author: Ewan Pearson Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc transporter ZnT8, associated with diabetes risk. A rare variant association study has now established the direction of effect, surprisingly showing that loss-of-function mutations in SLC30A8 are protective against diabetes.
  • Global optimization of somatic variant identification in cancer genomes with a global community challenge

    Paul C Boutros
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 318 (2014). doi:10.1038/ng.2932 Authors: Paul C Boutros, Adam D Ewing, Kyle Ellrott, Thea C Norman, Kristen K Dang, Yin Hu, Michael R Kellen, Christine Suver, J Christopher Bare, Lincoln D Stein, Paul T Spellman, Gustavo Stolovitzky, Stephen H Friend, Adam A Margolin & Joshua M Stuart
  • Ancient human oral plaque preserves a wealth of biological data

    Jessica L Metcalf
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 321 (2014). doi:10.1038/ng.2930 Authors: Jessica L Metcalf, Luke K Ursell & Rob Knight A new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. The authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen Tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins.
  • RHOA mutations in peripheral T cell lymphoma

    Jan Cools
    26 Mar 2014 | 5:00 pm
    Nature Genetics 46, 320 (2014). doi:10.1038/ng.2937 Author: Jan Cools Peripheral T cell lymphomas are rare but aggressive non-Hodgkin lymphomas derived from mature T lymphocytes or natural killer (NK) cells. New studies identify recurrent dominant-negative mutation of the RHOA GTPase gene in these lymphomas.
 
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  • Integrated genomic characterization of adrenocortical carcinoma

    Guillaume Assié
    19 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2953 Authors: Guillaume Assié, Eric Letouzé, Martin Fassnacht, Anne Jouinot, Windy Luscap, Olivia Barreau, Hanin Omeiri, Stéphanie Rodriguez, Karine Perlemoine, Fernande René-Corail, Nabila Elarouci, Silviu Sbiera, Matthias Kroiss, Bruno Allolio, Jens Waldmann, Marcus Quinkler, Massimo Mannelli, Franco Mantero, Thomas Papathomas, Ronald De Krijger, Antoine Tabarin, Véronique Kerlan, Eric Baudin, Frédérique Tissier, Bertrand Dousset, Lionel Groussin, Laurence Amar, Eric Clauser, Xavier Bertagna, Bruno Ragazzon, Felix…
  • Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors

    Gerald Goh
    19 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2956 Authors: Gerald Goh, Ute I Scholl, James M Healy, Murim Choi, Manju L Prasad, Carol Nelson-Williams, John W Kuntsman, Reju Korah, Anna-Carinna Suttorp, Dimo Dietrich, Matthias Haase, Holger S Willenberg, Peter Stålberg, Per Hellman, Göran Åkerström, Peyman Björklund, Tobias Carling & Richard P Lifton Adrenal tumors autonomously producing cortisol cause Cushing's syndrome. We performed exome sequencing of 25 tumor-normal pairs and identified 2 subgroups. Eight tumors (including three carcinomas) had many somatic copy number…
  • Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

    Andrew A Lane
    19 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2949 Authors: Andrew A Lane, Bjoern Chapuy, Charles Y Lin, Trevor Tivey, Hubo Li, Elizabeth C Townsend, Diederik van Bodegom, Tovah A Day, Shuo-Chieh Wu, Huiyun Liu, Akinori Yoda, Gabriela Alexe, Anna C Schinzel, Timothy J Sullivan, Sébastien Malinge, Jordan E Taylor, Kimberly Stegmaier, Jacob D Jaffe, Michael Bustin, Geertruy te Kronnie, Shai Izraeli, Marian H Harris, Kristen E Stevenson, Donna Neuberg, Lewis B Silverman, Stephen E Sallan, James E Bradner, William C Hahn, John D Crispino, David Pellman & David M Weinstock Down syndrome confers a…
  • De novo mutations in HCN1 cause early infantile epileptic encephalopathy

    Caroline Nava
    19 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2952 Authors: Caroline Nava, Carine Dalle, Agnès Rastetter, Pasquale Striano, Carolien G F de Kovel, Rima Nabbout, Claude Cancès, Dorothée Ville, Eva H Brilstra, Giuseppe Gobbi, Emmanuel Raffo, Delphine Bouteiller, Yannick Marie, Oriane Trouillard, Angela Robbiano, Boris Keren, Dahbia Agher, Emmanuel Roze, Suzanne Lesage, Aude Nicolas, Alexis Brice, Michel Baulac, Cornelia Vogt, Nady El Hajj, Eberhard Schneider, Arvid Suls, Sarah Weckhuysen, Padhraig Gormley, Anna-Elina Lehesjoki, Peter De Jonghe, Ingo Helbig, Stéphanie Baulac, Federico…
  • Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia

    Julia Wallmeier
    19 Apr 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.2961 Authors: Julia Wallmeier, Dalal A Al-Mutairi, Chun-Ting Chen, Niki Tomas Loges, Petra Pennekamp, Tabea Menchen, Lina Ma, Hanan E Shamseldin, Heike Olbrich, Gerard W Dougherty, Claudius Werner, Basel H Alsabah, Gabriele Köhler, Martine Jaspers, Mieke Boon, Matthias Griese, Sabina Schmitt-Grohé, Theodor Zimmermann, Cordula Koerner-Rettberg, Elisabeth Horak, Chris Kintner, Fowzan S Alkuraya & Heymut Omran Using a whole-exome sequencing strategy, we identified recessive CCNO (encoding cyclin O) mutations in 16 individuals suffering from chronic…
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    Nature Geoscience - AOP - nature.com science feeds

  • Geochemistry: A piece of the deep carbon puzzle

    Craig E. Manning
    19 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2152 Author: Craig E. Manning Carbon loss from subducting slabs is thought to be insufficient to balance carbon dioxide emissions at arc volcanoes. Analyses of ancient subducted rocks in Greece suggest that fluid dissolution of slab carbonate can help solve this carbon-cycle conundrum.
  • Retraction: High predictability of the winter Euro–Atlantic climate from cryospheric variability

    J. García-Serrano
    19 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2164 Authors: J. García-Serrano & C. Frankignoul
  • Carbon dioxide released from subduction zones by fluid-mediated reactions

    Jay J. Ague
    19 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2143 Authors: Jay J. Ague & Stefan Nicolescu The balance between the subduction of carbonate mineral-bearing rocks into Earth’s mantle and the return of CO2 to the atmosphere by volcanic and metamorphic degassing is critical to the carbon cycle. Carbon is thought to be released from subducted rocks mostly by simple devolatilization reactions. However, these reactions will also retain large amounts of carbon within the subducting slab and have difficulty in accounting for the mass of CO2 emitted from volcanic arcs. Carbon release may therefore occur…
  • Mega-heatwave temperatures due to combined soil desiccation and atmospheric heat accumulation

    Diego G. Miralles
    19 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2141 Authors: Diego G. Miralles, Adriaan J. Teuling, Chiel C. van Heerwaarden & Jordi Vilà-Guerau de Arellano The recent European mega-heatwaves of 2003 and 2010 broke temperature records across Europe. Although events of this magnitude were unprecedented from a historical perspective, they are expected to become common by the end of the century. However, our understanding of extreme heatwave events is limited and their representation in climate models remains imperfect. Here we investigate the physical processes underlying recent mega-heatwaves…
  • Sand as a stable and sustainable resource for nourishing the Mississippi River delta

    Jeffrey A. Nittrouer
    19 Apr 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2142 Authors: Jeffrey A. Nittrouer & Enrica Viparelli The Mississippi River delta is undergoing a catastrophic drowning, whereby 5,000 km2 of low-lying wetlands have converted to open water over at least the past eight decades, as a result of many anthropogenic and natural factors. Continued net land loss has been thought inevitable due to a decline in the load of total suspended sediment—both sand and mud—carried by the river. However, sand—which accounts for 50–70% of modern and ancient Mississippi delta deposits but…
 
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    Nature Materials - Issue - nature.com science feeds

  • Oxide heterostructures: Thin spin ice under investigation

    Oleg Petrenko
    21 Apr 2014 | 5:00 pm
    Nature Materials 13, 430 (2014). doi:10.1038/nmat3957 Author: Oleg Petrenko It is now possible to fabricate high-quality thin films of spin ice materials. At higher temperatures, they exhibit the hallmarks of a regular spin ice, but at lower temperatures their physics deviate significantly from the properties observed in the bulk.
  • Bone's bridged layers

    Pep Pàmies
    21 Apr 2014 | 5:00 pm
    Nature Materials 13, 428 (2014). doi:10.1038/nmat3967 Author: Pep Pàmies
  • Natural materials: Armoured oyster shells

    Robert O. Ritchie
    21 Apr 2014 | 5:00 pm
    Nature Materials 13, 435 (2014). doi:10.1038/nmat3956 Author: Robert O. Ritchie The remarkable properties of a bivalve shell that enable it to protect the animal against its predators could inspire the design of new lightweight armour materials.
  • Seismic cloaks

    Olivia Nicoletti
    21 Apr 2014 | 5:00 pm
    Nature Materials 13, 428 (2014). doi:10.1038/nmat3968 Author: Olivia Nicoletti
  • Metallic glasses: Fast track to production

    Dan B. Miracle
    21 Apr 2014 | 5:00 pm
    Nature Materials 13, 432 (2014). doi:10.1038/nmat3958 Author: Dan B. Miracle A high-throughput approach combining combinatorial deposition of materials with parallel blow-forming speeds up the discovery rate of bulk metallic glasses that can be easily formed into complex shapes.
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  • Auxetic nuclei in embryonic stem cells exiting pluripotency

    Stefano Pagliara
    19 Apr 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3943 Authors: Stefano Pagliara, Kristian Franze, Crystal R. McClain, George W. Wylde, Cynthia L. Fisher, Robin J. M. Franklin, Alexandre J. Kabla, Ulrich F. Keyser & Kevin J. Chalut
  • Scalable production of large quantities of defect-free few-layer graphene by shear exfoliation in liquids

    Keith R. Paton
    19 Apr 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3944 Authors: Keith R. Paton, Eswaraiah Varrla, Claudia Backes, Ronan J. Smith, Umar Khan, Arlene O’Neill, Conor Boland, Mustafa Lotya, Oana M. Istrate, Paul King, Tom Higgins, Sebastian Barwich, Peter May, Pawel Puczkarski, Iftikhar Ahmed, Matthias Moebius, Henrik Pettersson, Edmund Long, João Coelho, Sean E. O’Brien, Eva K. McGuire, Beatriz Mendoza Sanchez, Georg S. Duesberg, Niall McEvoy, Timothy J. Pennycook, Clive Downing, Alison Crossley, Valeria Nicolosi & Jonathan N. Coleman
  • Optical Fano resonance of an individual semiconductor nanostructure

    Pengyu Fan
    19 Apr 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3927 Authors: Pengyu Fan, Zongfu Yu, Shanhui Fan & Mark L. Brongersma Fano resonances with a characteristic asymmetric line shape can be observed in light scattering, transmission and reflection spectra of resonant optical systems. They result from interference between direct and indirect, resonance-assisted pathways. In the nanophotonics field, Fano effects have been observed in a wide variety of systems, including metallic nanoparticle assemblies, metamaterials and photonic crystals. Their unique properties find extensive use in applications, including…
  • Layered materials: Scaling up exfoliation

    James M. Tour
    19 Apr 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3961 Author: James M. Tour High-shear mixing is now shown to be an effective approach for the exfoliation of large quantities of graphene and other two-dimensional materials, providing a viable route for the industrial scaling of applications based on these layered crystals.
  • Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

    Yubing Sun
    12 Apr 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat3945 Authors: Yubing Sun, Koh Meng Aw Yong, Luis G. Villa-Diaz, Xiaoli Zhang, Weiqiang Chen, Renee Philson, Shinuo Weng, Haoxing Xu, Paul H. Krebsbach & Jianping Fu Our understanding of the intrinsic mechanosensitive properties of human pluripotent stem cells (hPSCs), in particular the effects that the physical microenvironment has on their differentiation, remains elusive. Here, we show that neural induction and caudalization of hPSCs can be accelerated by using a synthetic microengineered substrate system consisting of poly(dimethylsiloxane) micropost…
 
 
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  • Validation of noise models for single-cell transcriptomics

    Dominic Grün
    19 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2930 Authors: Dominic Grün, Lennart Kester & Alexander van Oudenaarden Single-cell transcriptomics has recently emerged as a powerful technology to explore gene expression heterogeneity among single cells. Here we identify two major sources of technical variability: sampling noise and global cell-to-cell variation in sequencing efficiency. We propose noise models to correct for this, which we validate using single-molecule FISH. We demonstrate that gene expression variability in mouse embryonic stem cells depends on the culture condition.
  • Controlling protein adsorption on graphene for cryo-EM using low-energy hydrogen plasmas

    Christopher J Russo
    19 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2931 Authors: Christopher J Russo & Lori A Passmore Despite its many favorable properties as a sample support for biological electron microscopy, graphene is not widely used because its hydrophobicity precludes reliable protein deposition. We describe a method to modify graphene with a low-energy hydrogen plasma, which reduces hydrophobicity without degrading the graphene lattice. Use of plasma-treated graphene enables better control of protein distribution in ice for electron cryo-microscopy and improves image quality by reducing radiation-induced sample…
  • An infrared reporter to detect spatiotemporal dynamics of protein-protein interactions

    Emmanuelle Tchekanda
    19 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2934 Authors: Emmanuelle Tchekanda, Durga Sivanesan & Stephen W Michnick We report a protein-fragment complementation assay (PCA) based on the engineered Deinococcus radiodurans infrared fluorescent protein IFP1.4. Unlike previous fluorescent protein PCAs, the IFP PCA is reversible, allowing analysis of spatiotemporal dynamics of hormone-induced signaling complexes in living yeast and mammalian cells at nanometer resolution. The inherently low background of infrared fluorescence permitted detection of subcellular reorganization of a signaling complex…
  • Efficient Bayesian-based multiview deconvolution

    Stephan Preibisch
    19 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2929 Authors: Stephan Preibisch, Fernando Amat, Evangelia Stamataki, Mihail Sarov, Robert H Singer, Eugene Myers & Pavel Tomancak Light-sheet fluorescence microscopy is able to image large specimens with high resolution by capturing the samples from multiple angles. Multiview deconvolution can substantially improve the resolution and contrast of the images, but its application has been limited owing to the large size of the data sets. Here we present a Bayesian-based derivation of multiview deconvolution that drastically improves the convergence time, and…
  • Multiscale representation of genomic signals

    Theo A Knijnenburg
    12 Apr 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.2924 Authors: Theo A Knijnenburg, Stephen A Ramsey, Benjamin P Berman, Kathleen A Kennedy, Arian F A Smit, Lodewyk F A Wessels, Peter W Laird, Alan Aderem & Ilya Shmulevich
 
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    Nature Physics - Issue - nature.com science feeds

  • No coincidence

    Iulia Georgescu
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2950 Author: Iulia Georgescu
  • Electrons of a different stripe

    May Chiao
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2948 Author: May Chiao
  • Great leap outwards

    Mark Buchanan
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 243 (2014). doi:10.1038/nphys2943 Author: Mark Buchanan
  • Two by two

    Alison Wright
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2947 Author: Alison Wright
  • Razzle dazzle 'em

    Abigail Klopper
    31 Mar 2014 | 5:00 pm
    Nature Physics 10, 244 (2014). doi:10.1038/nphys2946 Author: Abigail Klopper
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  • Adaptive pumping for spectral control of random lasers

    Nicolas Bachelard
    19 Apr 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2939 Authors: Nicolas Bachelard, Sylvain Gigan, Xavier Noblin & Patrick Sebbah A laser is not necessarily a sophisticated device: pumping an amplifying medium randomly filled with scatterers makes a perfectly viable ‘random laser’. The absence of mirrors greatly simplifies laser design, but control over the emission wavelength and directionality is lost, seriously hindering prospects for this otherwise simple laser. Recently, we proposed an approach to tame random lasers, inspired by coherent light control in complex media. Here, we implement…
  • Random lasers: Playing pinball with light

    Stefan Rotter
    19 Apr 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2960 Author: Stefan Rotter Without a well-defined cavity, there is no obvious way to control the resonant modes in a random laser. Experiments now show that shaping the optical pump allows for controlled single-mode operation at predetermined lasing wavelengths.
  • Spin–orbit interactions: Hide and seek

    Bart Partoens
    12 Apr 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2956 Author: Bart Partoens It is commonly believed that solids with spatial inversion symmetry do not display spin–orbit effects. However, first-principles calculations now reveal unexpected spin structure for centrosymmetric crystals.
  • Spin–orbitronics: A new moment for Berry

    Aurelien Manchon
    12 Apr 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2957 Author: Aurelien Manchon The standard description of spin–orbit torques neglects geometric phase effects. But recent experiments suggest that the Berry curvature gives rise to an anti-damping torque in systems with broken inversion symmetry.
  • Remarkable effects of disorder on superconductivity of single atomic layers of lead on silicon

    C. Brun
    12 Apr 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys2937 Authors: C. Brun, T. Cren, V. Cherkez, F. Debontridder, S. Pons, D. Fokin, M. C. Tringides, S. Bozhko, L. B. Ioffe, B. L. Altshuler & D. Roditchev
 
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • Regulators defend incretin drugs

    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 247 (2014). doi:10.1038/nrd4307 GLP1 mimetics and DPP4 inhibitors do not seem to be associated with pancreatic safety events, say US and European regulators in a joint paper.The lowdown: Last year, US and European drug regulators initiated safety reviews of two approved classes of incretin-based drugs: glucagon-like
  • BioMarin nabs first paediatric priority review voucher

    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 247 (2014). doi:10.1038/nrd4305 Regulators reward company for developing an enzyme replacement therapy for a rare paediatric indication with only 800 estimated patients in the United States.The lowdown: In 2012, the FDA Safety and Innovation Act (FDASIA) introduced a new priority review voucher (PRV) to
  • Integrative knowledge management to enhance pharmaceutical R&D

    Maria Marti-Solano
    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 239 (2014). doi:10.1038/nrd4290 Authors: Maria Marti-Solano, Ewan Birney, Antoine Bril, Oscar Della Pasqua, Hiroaki Kitano, Barend Mons, Ioannis Xenarios & Ferran Sanz Information technologies already have a key role in pharmaceutical research and development (R&D), but achieving substantial advances in their use and effectiveness will depend on overcoming current challenges in sharing, integrating and jointly analysing the range of data generated at different stages of the R&D process.
  • Schizophrenia drug gets negative results for negative symptoms

    Katie Kingwell
    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 244 (2014). doi:10.1038/nrd4294 Author: Katie Kingwell Roche's bitopertin failed to improve the negative symptoms of schizophrenia in two pivotal trials, raising questions about the therapeutic potential of glycinergic neuromodulation.
  • Drug makers and NIH team up to find and validate targets

    Asher Mullard
    31 Mar 2014 | 5:00 pm
    Nature Reviews Drug Discovery 13, 241 (2014). doi:10.1038/nrd4293 Author: Asher Mullard The $230 million AMP stakes out new target ground in Alzheimer's disease, type 2 diabetes, rheumatoid arthritis and lupus.
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Disease genetics: Non-invasive monitoring of resistance mutations

    Darren J. Burgess
    16 Apr 2014 | 5:00 pm
    Nature Reviews Genetics 15, 291 (2014). doi:10.1038/nrg3732 Author: Darren J. Burgess Cancers frequently develop resistance to anticancer therapies, but opportunities to obtain tissue samples for molecular analyses of resistance mutations are typically limited. Mohan et al. used high-throughput sequencing to analyse the tumour-derived DNA in the blood of ten patients with colorectal cancer who were
  • Statistical power and significance testing in large-scale genetic studies

    Pak C. Sham
    16 Apr 2014 | 5:00 pm
    Nature Reviews Genetics 15, 335 (2014). doi:10.1038/nrg3706 Authors: Pak C. Sham & Shaun M. Purcell Significance testing was developed as an objective method for summarizing statistical evidence for a hypothesis. It has been widely adopted in genetic studies, including genome-wide association studies and, more recently, exome sequencing studies. However, significance testing in both genome-wide and exome-wide studies must adopt stringent
  • Technology: In vivo correction of genetic disease in adult mice

    Darren J. Burgess
    16 Apr 2014 | 5:00 pm
    Nature Reviews Genetics 15, 291 (2014). doi:10.1038/nrg3731 Author: Darren J. Burgess The CRISPR–Cas9 gene editing system can introduce or correct specific mutations in various species. Yin et al. used a mouse model of hereditary tyrosinemia type 1, which is a liver disease caused by a homozygous mutation in the fumarylacetoacetate hydrolase (Fah) gene.
  • Transposable elements: A pluripotency role for a retroviral element

    Darren J. Burgess
    16 Apr 2014 | 5:00 pm
    Nature Reviews Genetics 15, 291 (2014). doi:10.1038/nrg3733 Author: Darren J. Burgess Human endogenous retroviruses (HERVs) are kept silent to a large extent to minimize retrotransposition and genomic instability. Lu et al. studied the HERV-H subfamily, which are selectively re-expressed in embryonic stem cells. They found that HERV-H knockdown induced differentiation, indicating that HERV-H expression has
  • DNA Elements: Determinants of site-specific hypermutation

    Darren J. Burgess
    16 Apr 2014 | 5:00 pm
    Nature Reviews Genetics 15, 291 (2014). doi:10.1038/nrg3730 Author: Darren J. Burgess Rearranged antibody genes in B lymphocytes are subjected to somatic hypermutation mediated by activation-induced cytidine deaminase (AID) in order to increase antibody diversity. Buerstedde et al. used a fluorescent reporter system for somatic hypermutation in a B cell line to test the ability of
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Synthetic biology: Building a designer yeast genome

    Christina Tobin Kåhrström
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 313 (2014). doi:10.1038/nrmicro3264 Author: Christina Tobin Kåhrström An international team of researchers has embarked on the creation of a synthetic eukaryotic genome and now report the synthesis of a redesigned Saccharomyces cerevisiae chromosome. Boeke and colleagues built a fully functional chromosome III (which they term synIII) that contained hundreds of alterations,
  • Ebola virus in West Africa

    Andrea Du Toit
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 312 (2014). doi:10.1038/nrmicro3267 Author: Andrea Du Toit Ebola virus disease is spreading in West African countries.
  • Clinical Microbiology: Recombination turns one clade into two

    Christina Tobin Kåhrström
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 313 (2014). doi:10.1038/nrmicro3265 Author: Christina Tobin Kåhrström Clinical isolates of carbapenem-resistant Klebsiella pneumoniae that belong to multilocus sequence type 258 (ST258) have emerged as important nosocomial pathogens, and it has been proposed that all of these isolates are derived from a single genetic clone that has spread globally. However, genome sequencing
  • Biotechnological domestication of pseudomonads using synthetic biology

    Pablo I. Nikel
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 368 (2014). doi:10.1038/nrmicro3253 Authors: Pablo I. Nikel, Esteban Martínez-García & Víctor de Lorenzo Much of contemporary synthetic biology research relies on the use of bacterial chassis for plugging-in and plugging-out genetic circuits and new-to-nature functionalities. However, the microorganisms that are the easiest to manipulate in the laboratory are often suboptimal for downstream industrial applications, which can involve physicochemical
  • Bacterial pathogenesis: sRNA promotes S. aureus persistence

    Christina Tobin Kåhrström
    15 Apr 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 313 (2014). doi:10.1038/nrmicro3266 Author: Christina Tobin Kåhrström Romilly et al. report the first example of a conserved, small non-coding RNA (sRNA) that functions as a virulence suppressor in Staphylococcus aureus. The authors found that the RsaA sRNA inhibits the expression of MgrA — a master regulator of transcription — primarily
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Protein folding: Protein aggregation inhibits endocytosis

    Katharine H. Wrighton
    22 Apr 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 299 (2014). doi:10.1038/nrm3799 Author: Katharine H. Wrighton The molecular chaperone HSC70 is required for multiple steps of clathrin-mediated endocytosis (CME). Yu et al. now show that CME is inhibited in prostate cancer cells and neuronal cells by aggregates of neurodegenerative disease-related proteins, including those formed by polyglutamine (polyQ) expansions such as
  • Post-translational modification: A new histone mark

    Andrea Du Toit
    22 Apr 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 299 (2014). doi:10.1038/nrm3798 Author: Andrea Du Toit The role of known histone modifications, such as Lys acetylation and methylation, in transcriptional control and epigenetics is well-established. Now, Dai et al. identify a novel histone mark, Lys 2-hydroxyisobutyrylation (Khib), and find that this modification is highly abundant and evolutionarily conserved in eukaryotic
  • Cell cycle: Cnn as a scaffold for centrosome maturation

    Kim Baumann
    22 Apr 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 299 (2014). doi:10.1038/nrm3800 Author: Kim Baumann Centrosomes comprise two centrioles that are surrounded by pericentriolar material (PCM). The PCM increases in size during mitosis, as centrioles recruit new PCM from the cytosol — a process known as centrosome maturation. Raff and colleagues studied PCM assembly in mitotic centrosomes of Drosophila melanogaster
  • What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory

    Philipp A. Steffen
    22 Apr 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 340 (2014). doi:10.1038/nrm3789 Authors: Philipp A. Steffen & Leonie Ringrose In any biological system with memory, the state of the system depends on its history. Epigenetic memory maintains gene expression states through cell generations without a change in DNA sequence and in the absence of initiating signals. It is immensely powerful in biological systems —
  • Plant and animal stem cells: similar yet different

    Renze Heidstra
    22 Apr 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 301 (2014). doi:10.1038/nrm3790 Authors: Renze Heidstra & Sabrina Sabatini The astonishingly long lives of plants and their regeneration capacity depend on the activity of plant stem cells. As in animals, stem cells reside in stem cell niches, which produce signals that regulate the balance between self-renewal and the generation of daughter cells that differentiate
 
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Gap junctions: Inputs alter coupling strength

    Leonie Welberg
    16 Apr 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 282 (2014). doi:10.1038/nrn3741 Author: Leonie Welberg Both GABAergic and glutamatergic projections can modulate the strength of electrical coupling between inferior olive neurons and alter neuron synchronization in the cerebellar inferior olive.
  • Restoring sensorimotor function through intracortical interfaces: progress and looming challenges

    Sliman J. Bensmaia
    16 Apr 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 313 (2014). doi:10.1038/nrn3724 Authors: Sliman J. Bensmaia & Lee E. Miller The loss of a limb or paralysis resulting from spinal cord injury has devastating consequences on quality of life. One approach to restoring lost sensory and motor abilities in amputees and patients with tetraplegia is to supply them with implants that provide a direct interface
  • Astrocyte Ca2+ signalling: an unexpected complexity

    Andrea Volterra
    16 Apr 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 327 (2014). doi:10.1038/nrn3725 Authors: Andrea Volterra, Nicolas Liaudet & Iaroslav Savtchouk Astrocyte Ca2+ signalling has been proposed to link neuronal information in different spatial–temporal dimensions to achieve a higher level of brain integration. However, some discrepancies in the results of recent studies challenge this view and highlight key insufficiencies in our current understanding. In
  • Nuclear and cytosolic JNK signalling in neurons

    Eleanor T. Coffey
    16 Apr 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 285 (2014). doi:10.1038/nrn3729 Author: Eleanor T. Coffey It has been over 20 years since JUN amino-terminal kinases (JNKs) were identified as protein kinases that are strongly activated by cellular stress and that have a key role in apoptosis. Examination of Jnk-knockout mice and characterization of JNK behaviour in neuronal cells has
  • How does the bilingual experience sculpt the brain?

    Albert Costa
    16 Apr 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 336 (2014). doi:10.1038/nrn3709 Authors: Albert Costa & Núria Sebastián-Gallés The ability to speak two languages often marvels monolinguals, although bilinguals report no difficulties in achieving this feat. Here, we examine how learning and using two languages affect language acquisition and processing as well as various aspects of cognition. We do so by addressing three
 
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    Nature Reviews Endocrinology - Issue - nature.com science feeds

  • Diabetes: Cognitive decline and T2DM—a disconnect in the evidence?

    Mark W. J. Strachan
    31 Mar 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 258 (2014). doi:10.1038/nrendo.2014.38 Authors: Mark W. J. Strachan & Jacqueline F. Price Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. Observational data suggest that hyperglycaemia, hypertension and dyslipidaemia might be involved in the causal pathway underlying this link, but data from the ACCORD MIND investigators challenge these findings. Why are the findings of observational and intervention studies so disconnected?
  • Bone: Maximizing bone health—magnesium, BMD and fractures

    Jeri W. Nieves
    31 Mar 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 255 (2014). doi:10.1038/nrendo.2014.39 Author: Jeri W. Nieves The contribution of nutrition to bone health has been heavily debated for many years resulting in unclear recommendations for patients regarding prevention of bone loss and subsequent fractures. A recent cohort study has examined the relationships between magnesium intake, BMD and fractures.
  • Obesity: Looking at the epigenetic link between obesity and its consequences—the promise of EWAS

    Joana Osório
    31 Mar 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 249 (2014). doi:10.1038/nrendo.2014.42 Author: Joana Osório Epigenome-wide association studies (EWAS) provide an opportunity to uncover novel molecular mechanisms underlying human disease. The results of a new study of genome-wide DNA methylation patterns, published in The Lancet, highlight the usefulness of EWAS in the study of epigenetic effects of obesity in
  • Insulin resistance and hyperglycaemia in cardiovascular disease development

    Markku Laakso
    24 Mar 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 293 (2014). doi:10.1038/nrendo.2014.29 Authors: Markku Laakso & Johanna Kuusisto The prevalence of diabetes mellitus will likely increase globally from 371 million individuals in 2013 to 552 million individuals in 2030. This epidemic is mainly attributable to type 2 diabetes mellitus (T2DM), which represents about 90–95% of all cases. Cardiovascular disease is the leading cause
  • Thyroid function: Pathogenesis of Graves ophthalmopathy—a role for TSH-R?

    Jack R. Wall
    24 Mar 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 256 (2014). doi:10.1038/nrendo.2014.37 Author: Jack R. Wall A new study highlights the complexities of anti-TSH-receptor antibody function and the differences between adult and paediatric patients with Graves disease, adding to the controversy regarding the possible role of these antibodies in the development of ophthalmopathy.
 
 
 
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    Naturejobs - Search results

  • Research Technician II

    23 Apr 2014 | 9:08 am
    A full-time Research Technologist position is available in the field of Neuroimaging of Multiple Sclerosis (MS) at the A. A. Martinos Center for Biomedical Imaging of Massachusetts General Hospital (MGH). Duties will include acquiring and analyzing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI) and high-resolution morphometric data acquired at high-field (3T) and ultra-high-field (7T) MRI in studies of patients with MS. The cen…
  • Sales Executive – Data Acquisition and Analysis – Academia and Research

    23 Apr 2014 | 8:59 am
    Salary: Up to €55,000 basic salary + €8,000 on target earnings + Uncapped earnings for over achievement of targets + 42c Per Kilometre Travel Expenses + 25 Days Holiday + Laptop + Mobile Phone + Excellent Career Progression + Autonomy + Relaxed Working Culture Would you like to work for the Number One manufacturer of flexible Life Science Data Acquisition and Analysis Software and Hardware globally? With a $30m turnover and 80% client retention rate a great opportunity to really capi…
  • Sales Executive – Data Acquisition and Analysis – Academia and Research

    23 Apr 2014 | 8:57 am
    Location: Based in France or Germany to cover the Benelux territory Salary: Up to €55,000 basic salary + €8,000 on target earnings + Uncapped earnings for over achievement of targets + 42c Per Kilometre Travel Expenses + 25 Days Holiday + Laptop + Mobile Phone + Excellent Career Progression + Autonomy + Relaxed Working Culture Would you like to work for the Number One manufacturer of flexible Life Science Data Acquisition and Analysis Software and Hardware globally? With a $30m t…
  • Electronics Design Engineer

    23 Apr 2014 | 8:52 am
    Ativa Medical is a rapidly growing startup company developing in vitro medical diagnostic products. We harness state of the art technology to redefine how, when, and where patient diagnostics are performed. Our team is made of the best and brightest minds in the fields of biochemistry, fluidics, engineering, and more. The company has an immediate opening for a highly-skilled Electronics Design Engineer that thrives in a challenging, fun, and fast-paced work environment. This person will be respo…
  • Sales Specialist – Life Science Consumables and Equipment

    23 Apr 2014 | 8:35 am
    Basic Salary: £30,000-35,000 (DOE) + 25 % Commission + Car + Pension + Holidays + Healthcare + Would you like to work for a Global Leading Laboratory Supplies Company who has experienced 12% growth last year alone and has a turnover of £120 Million in the UK and $4.1 Billion Globally? With the strategic acquisition of three companies last year the portfolio of products and services offered by this company has been significantly strengthened to incorporate Service Engineers and a small …
 
 
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    British Journal of Pharmacology

  • The α1B-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium

    Tobias Böhmer, Caroline Manicam, Andreas Steege, Martin C. Michel, Norbert Pfeiffer, Adrian Gericke
    21 Apr 2014 | 7:02 pm
    Abstract Background and PurposeThe α1-adrenoceptor (α1-AR) family plays a critical role in regulating ocular perfusion by mediating responses to catecholamines. The purpose of the present study was to determine the contribution of individual α1-AR subtypes to adrenergic vasoconstricton of retinal arterioles using gene-targeted mice deficient in one of the three receptor subtypes (α1A-AR, α1B-AR, α1D-AR, respectively). Experimental ApproachUsing real-time PCR, mRNA expression for individual α1-AR subtypes was determined in murine retinal arterioles. To assess the functional relevance of…
  • Novel therapeutic targets in myeloma bone disease

    S L Webb, C M Edwards
    21 Apr 2014 | 7:02 pm
    Summary Multiple myeloma is a neoplastic disorder of plasma cells characterised by clonal proliferation within the bone marrow. One of the major clinical features of multiple myeloma is the destructive osteolytic bone disease that occurs in the majority of patients. Myeloma bone disease is associated with increased osteoclast activity and suppression of osteoblastogenesis. Bisphosphonates have been the mainstay of treatment for many years, however are limited by their inability to repair existing bone loss. Therefore, research into novel approaches for the treatment of myeloma bone disease is…
  • The alpha3beta4* nicotinic acetylcholine receptor subtype mediates physical dependence to morphine: mouse and human studies

    P P Muldoon, K J Jackson, E Perez, J L Harenza, S Molas, B Rais, H Anwar, N T Zaveri, R Maldonado, U Maskos, J M McIntosh, M Dierssen, M F Miles, X Chen, M De Biasi, M I Damaj
    21 Apr 2014 | 7:02 pm
    Abstract Background and PurposeRecent data have indicated that α3β4* neuronal nicotinic acetylcholine receptors (nAChRs) may play a role in morphine dependence. Here we investigated if nAChRs modulate morphine physical withdrawal. Experimental ApproachesTo assess the role of α3β4* neuronal nicotinic acetylcholine receptors in morphine withdrawal, we used a genetic correlation approach using publically available data sets within the GeneNetwork web resource, genetic knockout and pharmacological tools. Lastly, male and female European-American (n=2,772) and African-American (n=1,309)…
  • Crucial role of androgen receptor in vascular H2S biosynthesis induced by testosterone

    V Brancaleone, V Vellecco, D Matassa, R d'Emmanuele di Villa Bianca, R Sorrentino, A Ianaro, M Bucci, F Esposito, G Cirino
    21 Apr 2014 | 7:02 pm
    Summary Background and purposeHydrogen sulphide (H2S) is a gaseous mediator strongly involved in cardiovascular homeostasis, where it provokes vasodilation. Having previously shown that H2S contributes to testosterone (T) induced vasorelaxation, here we aim to uncover the mechanisms underlying this effect. Experimental approachH2S biosynthesis was evaluated in rat isolated aorta rings following androgen receptor (AR) stimulation. Co-immunoprecipitation and surface plasmon resonance analysis have been performed to investigate mechanisms involved in AR activation. Key resultsH2S biosynthesis is…
  • Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and P53

    Baihe Chen, Di Lu, Yujuan Fu, Jingwen Zhang, Xiaobo Huang, Shiping Cao, Dingli Xu, Jianping Bin, Masafumi Kitakaze, Qiaobing Huang, Yulin Liao
    17 Apr 2014 | 11:25 pm
    BACKGROUND AND PURPOSECardiac rupture is a catastrophic complication after acute myocardial infarction and lacks effective pharmacological prevention. Here we investigated the effect of angiotensin II receptor blocker (ARB) olmesartan (Olm) on post-infarct cardiac rupture and the underlying mechanisms. EXPERIMENTAL APPROACHC57Bl/6 mice with myocardial infarction (MI) were treated with Olm or aldosterone (Aldo) or vehicle. Cultured neonatal cardiomyocytes and fibroblasts were exposed to normoxia or anoxia and treated with angiotensin II (Ang II), RNH6270 (active ingredient of Olm), or Aldo.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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    PSI-Nature Structural Biology Knowledgebase

  • Novel Proteins and Networks: Polysaccharide Metabolism in the Human Gut

    Stéphane Larochelle
    16 Apr 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.198 Author: Stéphane Larochelle Comparative genomics identifies new components and regulatory networks for the utilization of complex carbohydrates by Bacteroides thetaiotaomicron.
  • Novel Proteins and Networks: Assigning Function

    Irene Kaganman
    16 Apr 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.199 Author: Irene Kaganman Structural modeling and docking of substrates identifies a biochemical pathway that is validated experimentally.
  • Two-for-one strike at incretins

    Charlotte Harrison
    12 Dec 2013 | 4:00 pm
    Nature Reviews Drug Discovery 13, 18 (2014). doi:10.1038/nrd4208 Author: Charlotte Harrison Structure-based design led to the development of a peptide that targets two members of the incretin family of hormone receptors
  • Activating and guiding Cas9

    Andrea Du Toit
    23 Feb 2014 | 4:00 pm
    Nature Reviews Microbiology 12, 236 (2014). doi:10.1038/nrmicro3237 Author: Andrea Du Toit Structural studies reveal that Cas9 activation requires guide-RNA loading and offer insight into target recognition and cleavage.
  • A Refined Refinement Strategy

    Timothy Silverstein
    16 Apr 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.200 Author: Timothy Silverstein Combinatorial use of refinement algorithms leads to improved structure determination.
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