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  • Type I and type II Fc receptors regulate innate and adaptive immunity

    Nature Immunology - Issue - nature.com science feeds
    Andrew Pincetic
    20 Jul 2014 | 5:00 pm
    Nature Immunology 15, 707 (2014). doi:10.1038/ni.2939 Authors: Andrew Pincetic, Stylianos Bournazos, David J DiLillo, Jad Maamary, Taia T Wang, Rony Dahan, Benjamin-Maximillian Fiebiger & Jeffrey V Ravetch
  • Alzheimer disease: Increased astrocytic γ-aminobutyric acid release in AD

    Nature Reviews Neurology - AOP - nature.com science feeds
    21 Jul 2014 | 5:00 pm
    Nature Reviews Neurology. doi:10.1038/nrneurol.2014.135
  • Mysterious Siberian crater attributed to methane

    NatureNews - Most recent articles - nature.com science feeds
    Katia Moskvitch
    30 Jul 2014 | 5:00 pm
    Build-up and release of gas from thawing permafrost most probable explanation, says Russian team.Nature News doi: 10.1038/nature.2014.15649
  • Safety doesn’t happen by accident

    Nature - Issue - nature.com science feeds
    28 Jul 2014 | 5:00 pm
    Safety doesn’t happen by accident Nature 511, 7511 (2014). doi:10.1038/511507a To create a strong biosafety culture, information on mishaps involving deadly pathogens must be reported and shared fully and transparently.
  • Clonal evolution in breast cancer revealed by single nucleus genome sequencing

    Nature - AOP - nature.com science feeds
    Yong Wang
    29 Jul 2014 | 5:00 pm
    Nature advance online publication 30 July 2014. doi:10.1038/nature13600 Authors: Yong Wang, Jill Waters, Marco L. Leung, Anna Unruh, Whijae Roh, Xiuqing Shi, Ken Chen, Paul Scheet, Selina Vattathil, Han Liang, Asha Multani, Hong Zhang, Rui Zhao, Franziska Michor, Funda Meric-Bernstam & Nicholas E. Navin
 
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    Nature - Issue - nature.com science feeds

  • Safety doesn’t happen by accident

    28 Jul 2014 | 5:00 pm
    Safety doesn’t happen by accident Nature 511, 7511 (2014). doi:10.1038/511507a To create a strong biosafety culture, information on mishaps involving deadly pathogens must be reported and shared fully and transparently.
  • Fishy business

    29 Jul 2014 | 5:00 pm
    Fishy business Nature 511, 7511 (2014). doi:10.1038/511507b Delays in approving genetically engineered salmon may be a taste of worse to come.
  • Cause is not everything in mental illness

    David Adam
    29 Jul 2014 | 5:00 pm
    Cause is not everything in mental illness Nature 511, 7511 (2014). http://www.nature.com/doifinder/10.1038/511509a Author: David Adam Welcome steps have been made in uncovering a biological basis for schizophrenia, but for many, the question of ‘why’ is unimportant, says David Adam.
  • Ecology: Predictable patterns for coral-reef pest

    29 Jul 2014 | 5:00 pm
    Ecology: Predictable patterns for coral-reef pest Nature 511, 7511 (2014). doi:10.1038/511510a Modelling how ocean currents spread the larvae of coral-eating starfish around Australia's Great Barrier Reef can help to identify areas that are prone to damaging epidemics of the pest.A team led by Karlo Hock of the University of Queensland in St Lucia, Australia, used
  • Glaciology: Data mix-up in sea-ice record

    29 Jul 2014 | 5:00 pm
    Glaciology: Data mix-up in sea-ice record Nature 511, 7511 (2014). doi:10.1038/511510b The recent, mysterious expansion of Antarctic ice could be overestimated because of a data-analysis error, according to US scientists.Ian Eisenman at the Scripps Institution of Oceanography in La Jolla, California, and his colleagues found the mistake when they compared two versions of satellite data
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  • Clonal evolution in breast cancer revealed by single nucleus genome sequencing

    Yong Wang
    29 Jul 2014 | 5:00 pm
    Nature advance online publication 30 July 2014. doi:10.1038/nature13600 Authors: Yong Wang, Jill Waters, Marco L. Leung, Anna Unruh, Whijae Roh, Xiuqing Shi, Ken Chen, Paul Scheet, Selina Vattathil, Han Liang, Asha Multani, Hong Zhang, Rui Zhao, Franziska Michor, Funda Meric-Bernstam & Nicholas E. Navin
  • Replaying evolutionary transitions from the dental fossil record

    Enni Harjunmaa
    29 Jul 2014 | 5:00 pm
    Nature advance online publication 30 July 2014. doi:10.1038/nature13613 Authors: Enni Harjunmaa, Kerstin Seidel, Teemu Häkkinen, Elodie Renvoisé, Ian J. Corfe, Aki Kallonen, Zhao-Qun Zhang, Alistair R. Evans, Marja L. Mikkola, Isaac Salazar-Ciudad, Ophir D. Klein & Jukka Jernvall
  • Ageing: Old blood stem cells feel the stress

    Jiri Bartek
    29 Jul 2014 | 5:00 pm
    Nature advance online publication 30 July 2014. doi:10.1038/nature13652 Authors: Jiri Bartek & Zdenek Hodny Ageing is accompanied by deterioration in the haematopoietic stem cells that are responsible for regenerating the blood system. Cellular stress in the aged stem cells could be a cause of this decline.
  • Retraction: Generation of pluripotent stem cells from adult human testis

    Sabine Conrad
    29 Jul 2014 | 5:00 pm
    Nature advance online publication 30 July 2014. doi:10.1038/nature13661 Authors: Sabine Conrad, Markus Renninger, Jörg Hennenlotter, Tina Wiesner, Lothar Just, Michael Bonin, Wilhelm Aicher, Hans-Jörg Bühring, Ulrich Mattheus, Andreas Mack, Hans-Joachim Wagner, Stephen Minger, Matthias Matzkies, Michael Reppel, Jürgen Hescheler, Karl-Dietrich Sievert, Arnulf Stenzl & Thomas Skutella
  • Cancer: One cell at a time

    Edward J. Fox
    29 Jul 2014 | 5:00 pm
    Nature advance online publication 30 July 2014. doi:10.1038/nature13650 Authors: Edward J. Fox & Lawrence A. Loeb Single-cell DNA sequencing of two breast-cancer types has shown extensive mutational variation in individual tumours, confirming that generation of genetic diversity may be inherent in how tumours evolve.
 
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    Nature Biotechnology - AOP - nature.com science feeds

  • Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

    Yanpeng Wang
    19 Jul 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2969 Authors: Yanpeng Wang, Xi Cheng, Qiwei Shan, Yi Zhang, Jinxing Liu, Caixia Gao & Jin-Long Qiu Sequence-specific nucleases have been applied to engineer targeted modifications in polyploid genomes, but simultaneous modification of multiple homoeoalleles has not been reported. Here we use transcription activator–like effector nuclease (TALEN) and clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 (refs. 4,5) technologies in hexaploid bread wheat to introduce targeted mutations in the three homoeoalleles that encode…
  • Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

    H Bjørn Nielsen
    5 Jul 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2939 Authors: H Bjørn Nielsen, Mathieu Almeida, Agnieszka Sierakowska Juncker, Simon Rasmussen, Junhua Li, Shinichi Sunagawa, Damian R Plichta, Laurent Gautier, Anders G Pedersen, Emmanuelle Le Chatelier, Eric Pelletier, Ida Bonde, Trine Nielsen, Chaysavanh Manichanh, Manimozhiyan Arumugam, Jean-Michel Batto, Marcelo B Quintanilha dos Santos, Nikolaj Blom, Natalia Borruel, Kristoffer S Burgdorf, Fouad Boumezbeur, Francesc Casellas, Joël Doré, Piotr Dworzynski, Francisco Guarner, Torben Hansen, Falk Hildebrand, Rolf S Kaas, Sean Kennedy,…
  • Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification

    Jeffrey J Quinn
    5 Jul 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2943 Authors: Jeffrey J Quinn, Ibrahim A Ilik, Kun Qu, Plamen Georgiev, Ci Chu, Asifa Akhtar & Howard Y Chang
  • An integrated catalog of reference genes in the human gut microbiome

    Junhua Li
    5 Jul 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2942 Authors: Junhua Li, Huijue Jia, Xianghang Cai, Huanzi Zhong, Qiang Feng, Shinichi Sunagawa, Manimozhiyan Arumugam, Jens Roat Kultima, Edi Prifti, Trine Nielsen, Agnieszka Sierakowska Juncker, Chaysavanh Manichanh, Bing Chen, Wenwei Zhang, Florence Levenez, Juan Wang, Xun Xu, Liang Xiao, Suisha Liang, Dongya Zhang, Zhaoxi Zhang, Weineng Chen, Hailong Zhao, Jumana Yousuf Al-Aama, Sherif Edris, Huanming Yang, Jian Wang, Torben Hansen, Henrik Bjørn Nielsen, Søren Brunak, Karsten Kristiansen, Francisco Guarner, Oluf Pedersen, Joel Doré, S…
  • Decoding long nanopore sequencing reads of natural DNA

    Andrew H Laszlo
    24 Jun 2014 | 5:00 pm
    Nature Biotechnology. doi:10.1038/nbt.2950 Authors: Andrew H Laszlo, Ian M Derrington, Brian C Ross, Henry Brinkerhoff, Andrew Adey, Ian C Nova, Jonathan M Craig, Kyle W Langford, Jenny Mae Samson, Riza Daza, Kenji Doering, Jay Shendure & Jens H Gundlach Nanopore sequencing of DNA is a single-molecule technique that may achieve long reads, low cost and high speed with minimal sample preparation and instrumentation. Here, we build on recent progress with respect to nanopore resolution and DNA control to interpret the procession of ion current levels observed during the translocation of DNA…
 
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    Nature Chemical Biology - AOP - nature.com science feeds

  • Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

    Alexandre Gidon
    26 Jul 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1589 Authors: Alexandre Gidon, Mohammad M Al-Bataineh, Frederic G Jean-Alphonse, Hilary P Stevenson, Tomoyuki Watanabe, Claire Louet, Ashok Khatri, Guillermo Calero, Núria M Pastor-Soler, Thomas J Gardella & Jean-Pierre Vilardaga The PTH receptor is to our knowledge one of the first G protein–coupled receptor (GPCR) found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely…
  • The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

    Georg E Winter
    26 Jul 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1590 Authors: Georg E Winter, Branka Radic, Cristina Mayor-Ruiz, Vincent A Blomen, Claudia Trefzer, Richard K Kandasamy, Kilian V M Huber, Manuela Gridling, Doris Chen, Thorsten Klampfl, Robert Kralovics, Stefan Kubicek, Oscar Fernandez-Capetillo, Thijn R Brummelkamp & Giulio Superti-Furga
  • Drug discovery: Tools and rules for macrocycles

    Christian Heinis
    19 Jul 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1605 Author: Christian Heinis The application of macrocycles to previously undruggable targets has aroused a great deal of interest in this structural class. Recent studies advance our understanding of the way macrocycles bind protein targets and provide new strategies and tools to generate peptide-based macrocycles.
  • How proteins bind macrocycles

    Elizabeth A Villar
    19 Jul 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1584 Authors: Elizabeth A Villar, Dmitri Beglov, Spandan Chennamadhavuni, John A Porco , Dima Kozakov, Sandor Vajda & Adrian Whitty
  • Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

    Jason Gavenonis
    19 Jul 2014 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1580 Authors: Jason Gavenonis, Bradley A Sheneman, Timothy R Siegert, Matthew R Eshelman & Joshua A Kritzer
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    Nature Chemistry

  • Anticancer agents: Sensitive after a knockdown

    Russell Johnson
    22 Jul 2014 | 5:00 pm
    Nature Chemistry 6, 657 (2014). doi:10.1038/nchem.2030 Author: Russell Johnson
  • Fluorescence microscopy: Strategic blinking

    Gražvydas Lukinavičius
    22 Jul 2014 | 5:00 pm
    Nature Chemistry 6, 663 (2014). doi:10.1038/nchem.2020 Authors: Gražvydas Lukinavičius & Kai Johnsson For decades chemists have focused on increasing the brightness of fluorophores. In super-resolution microscopy, however, fluorophores that preferentially exist in a non-fluorescent state, but occasionally re-arrange into a fluorescent form, can give better results.
  • Fresh air

    Timothy W. Lyons
    22 Jul 2014 | 5:00 pm
    Nature Chemistry 6, 655 (2014). doi:10.1038/nchem.2019 Author: Timothy W. Lyons
  • Asymmetric catalysis: A radical revolution in synthesis

    Andrew F. Parsons
    22 Jul 2014 | 5:00 pm
    Nature Chemistry 6, 659 (2014). doi:10.1038/nchem.2012 Author: Andrew F. Parsons A newly designed thiol catalyst for radical cyclization reactions is the result of a long and storied battle to control the reactivity of carbon-centred radicals.
  • Template-directed synthesis: Running rings around rings

    Stuart Cantrill
    22 Jul 2014 | 5:00 pm
    Nature Chemistry 6, 656 (2014). doi:10.1038/nchem.2027 Author: Stuart Cantrill
 
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    Nature Chemistry

  • Gram-scale synthesis of two-dimensional polymer crystals and their structure analysis by X-ray diffraction

    Max J. Kory
    26 Jul 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2007 Authors: Max J. Kory, Michael Wörle, Thomas Weber, Payam Payamyar, Stan W. van de Poll, Julia Dshemuchadse, Nils Trapp & A. Dieter Schlüter Accessing synthetic two-dimensional polymers that are analogous to graphene is synthetically and analytically challenging. Now, single crystals of a simple-to-make monomer have been grown and then photopolymerized to form layered single crystals of covalently bonded two-dimensional polymer. Much like natural graphite, these crystals can be exfoliated to form thin sheets and single layers of the polymer.
  • Harnessing redox activity for the formation of uranium tris(imido) compounds

    Nickolas H. Anderson
    26 Jul 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2009 Authors: Nickolas H. Anderson, Samuel O. Odoh, Yiyi Yao, Ursula J. Williams, Brian A. Schaefer, John J. Kiernicki, Andrew J. Lewis, Mitchell D. Goshert, Phillip E. Fanwick, Eric J. Schelter, Justin R. Walensky, Laura Gagliardi & Suzanne C. Bart Multi-electron redox chemistry is important in transition-metal-mediated processes, but is rarely observed with uranium due to its propensity to undergo single-electron reactions. Now, uranium can use its electrons, coupled with those stored in redox-active ligands, to perform multi electron reduction of…
  • A nanoporous two-dimensional polymer by single-crystal-to-single-crystal photopolymerization

    Patrick Kissel
    26 Jul 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2008 Authors: Patrick Kissel, Daniel J. Murray, William J. Wulftange, Vincent J. Catalano & Benjamin T. King Two-dimensional synthetic polymers can be produced through solid-state topochemical polymerization, but achieving this through a single-crystal-to-single-crystal transformation has not yet been demonstrated. Now, a fluorinated Y-shaped monomer has been preorganized in a lamellar crystal, which goes through two successive single-crystal-to-single-crystal phototransformations to give a 2D polymer; single-crystal X-ray diffraction has been used to…
  • Synthesis of hydroxyphthioceranic acid using a traceless lithiation–borylation–protodeboronation strategy

    Ramesh Rasappan
    26 Jul 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2010 Authors: Ramesh Rasappan & Varinder K. Aggarwal Coupling of carbamates with boronic esters followed by protodeboronation creates a new carbon–carbon bond, leaving behind no trace of the functional groups used to create it. Now, methodology for the protodeboronation of alkyl pinacol boronic esters has been developed and an iterative lithiation–borylation–protodeboronation strategy used in a 14-step stereocontrolled synthesis of hydroxyphthioceranic acid.
  • Two-dimensional materials: Crystallized creations in 2D

    Neil R. Champness
    26 Jul 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2015 Author: Neil R. Champness Two reports demonstrate that with the right molecules and the right crystalline arrangement, it is not only possible to create two-dimensional crystals, but also to separate them into single-molecule-thick sheets — so-called two-dimensional polymers.
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    Nature Genetics - AOP - nature.com science feeds

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    Mike A Nalls
    26 Jul 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3043 Authors: Mike A Nalls, Nathan Pankratz, Christina M Lill, Chuong B Do, Dena G Hernandez, Mohamad Saad, Anita L DeStefano, Eleanna Kara, Jose Bras, Manu Sharma, Claudia Schulte, Margaux F Keller, Sampath Arepalli, Christopher Letson, Connor Edsall, Hreinn Stefansson, Xinmin Liu, Hannah Pliner, Joseph H Lee, Rong Cheng, M Arfan Ikram, John P A Ioannidis, Georgios M Hadjigeorgiou, Joshua C Bis, Maria Martinez, Joel S Perlmutter, Alison Goate, Karen Marder, Brian Fiske, Margaret Sutherland, Georgia Xiromerisiou, Richard H Myers, Lorraine N Clark, Kari…
  • The genome of the stress-tolerant wild tomato species Solanum pennellii

    Anthony Bolger
    26 Jul 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3046 Authors: Anthony Bolger, Federico Scossa, Marie E Bolger, Christa Lanz, Florian Maumus, Takayuki Tohge, Hadi Quesneville, Saleh Alseekh, Iben Sørensen, Gabriel Lichtenstein, Eric A Fich, Mariana Conte, Heike Keller, Korbinian Schneeberger, Rainer Schwacke, Itai Ofner, Julia Vrebalov, Yimin Xu, Sonia Osorio, Saulo Alves Aflitos, Elio Schijlen, José M Jiménez-Goméz, Malgorzata Ryngajllo, Seisuke Kimura, Ravi Kumar, Daniel Koenig, Lauren R Headland, Julin N Maloof, Neelima Sinha, Roeland C H J van Ham, René Klein Lankhorst, Linyong…
  • The genome sequence of African rice (Oryza glaberrima) and evidence for independent domestication

    Muhua Wang
    26 Jul 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3044 Authors: Muhua Wang, Yeisoo Yu, Georg Haberer, Pradeep Reddy Marri, Chuanzhu Fan, Jose Luis Goicoechea, Andrea Zuccolo, Xiang Song, Dave Kudrna, Jetty S S Ammiraju, Rosa Maria Cossu, Carlos Maldonado, Jinfeng Chen, Seunghee Lee, Nick Sisneros, Kristi de Baynast, Wolfgang Golser, Marina Wissotski, Woojin Kim, Paul Sanchez, Marie-Noelle Ndjiondjop, Kayode Sanni, Manyuan Long, Judith Carney, Olivier Panaud, Thomas Wicker, Carlos A Machado, Mingsheng Chen, Klaus F X Mayer, Steve Rounsley & Rod A Wing
  • A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine

    Masahiro Nakajima
    26 Jul 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3045 Authors: Masahiro Nakajima, Atsushi Takahashi, Takashi Tsuji, Tatsuki Karasugi, Hisatoshi Baba, Kenzo Uchida, Shigenori Kawabata, Atsushi Okawa, Shigeo Shindo, Kazuhiro Takeuchi, Yuki Taniguchi, Shingo Maeda, Masafumi Kashii, Atsushi Seichi, Hideaki Nakajima, Yoshiharu Kawaguchi, Shunsuke Fujibayashi, Masahiko Takahata, Toshihiro Tanaka, Kei Watanabe, Kazunobu Kida, Tsukasa Kanchiku, Zenya Ito, Kanji Mori, Takashi Kaito, Sho Kobayashi, Kei Yamada, Masahito Takahashi, Kazuhiro Chiba, Morio Matsumoto, Ken-Ichi Furukawa, Michiaki Kubo, Yoshiaki Toyama &…
  • The common marmoset genome provides insight into primate biology and evolution

    Kim C Worley
    19 Jul 2014 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3042 Authors: Kim C Worley, Wesley C Warren, Jeffrey Rogers, Devin Locke, Donna M Muzny, Elaine R Mardis, George M Weinstock, Suzette D Tardif, Kjersti M Aagaard, Nicoletta Archidiacono, Nirmala Arul Rayan, Mark A Batzer, Kathryn Beal, Brona Brejova, Oronzo Capozzi, Saverio B Capuano, Claudio Casola, Mimi M Chandrabose, Andrew Cree, Marvin Diep Dao, Pieter J de Jong, Ricardo Cruz-Herrera del Rosario, Kim D Delehaunty, Huyen H Dinh, Evan E Eichler, Stephen Fitzgerald, Paul Flicek, Catherine C Fontenot, R Gerald Fowler, Catrina Fronick, Lucinda A Fulton, Robert S…
 
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    Nature Geoscience - AOP - nature.com science feeds

  • Strong tidal heating in an ultralow-viscosity zone at the core–mantle boundary of the Moon

    Yuji Harada
    26 Jul 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2211 Authors: Yuji Harada, Sander Goossens, Koji Matsumoto, Jianguo Yan, Jinsong Ping, Hirotomo Noda & Junichi Haruyama Tidal heating of a solid planetary body occurs by viscous dissipation, depending on its internal structure and thermal and orbital states. Calculations of the response of the Moon to tidal forces have considered lunar interior structure, but have not reproduced the geodetically observed dependence of dissipation on the lunar tidal period. The attenuation of seismic waves in the deep lunar interior is expected to be consistent with a…
  • Geomorphology: Emergent sculpture

    Chris Paola
    19 Jul 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2215 Author: Chris Paola Sandstone arches and other striking landforms are the showpieces of national parks around the globe. Experiments and numerical analyses show that they result from a self-organization process that involves vertical load, wind erosion and grain locking.
  • Sandstone landforms shaped by negative feedback between stress and erosion

    Jiri Bruthans
    19 Jul 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2209 Authors: Jiri Bruthans, Jan Soukup, Jana Vaculikova, Michal Filippi, Jana Schweigstillova, Alan L. Mayo, David Masin, Gunther Kletetschka & Jaroslav Rihosek Weathering and erosion of sandstone produces unique landforms such as arches, alcoves, pedestal rocks and pillars. Gravity-induced stresses have been assumed to not play a role in landform preservation and to instead increase weathering rates. Here we show that increased stress within a landform as a result of vertical loading reduces weathering and erosion rates, using laboratory experiments…
  • Mantle geochemistry: Small-scale stirrings

    David Graham
    19 Jul 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2216 Author: David Graham Rapid plate motions at fast-spreading ocean ridges mix the mantle, yet homogeneous lavas erupted at slow-spreading ocean ridges imply a well-mixed mantle there, too. Numerical modelling suggests that small-scale convection efficiently stirs the mantle beneath slow-moving plates.
  • Mixing at mid-ocean ridges controlled by small-scale convection and plate motion

    Henri Samuel
    19 Jul 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2208 Authors: Henri Samuel & Scott D. King Oceanic lavas are thought to be derived from different sources within the Earth’s mantle, each with a distinct composition. Large-scale plate motions provide the primary mechanism for mixing these sources, yet the geochemical signature of lavas erupted at different mid-ocean ridges can still vary significantly. Geochemical variability is low where plate spreading rates are high, consistent with plate-scale mixing. However, slow-spreading centres, such as the Southwest Indian Ridge in the Indian Ocean, are…
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    Nature Immunology - Issue - nature.com science feeds

  • Coinfection wakes up latent viruses

    Laurie A Dempsey
    20 Jul 2014 | 5:00 pm
    Nature Immunology 15, 706 (2014). doi:10.1038/ni.2951 Author: Laurie A Dempsey
  • cASCading specks

    Lori Broderick
    20 Jul 2014 | 5:00 pm
    Nature Immunology 15, 698 (2014). doi:10.1038/ni.2942 Authors: Lori Broderick & Hal M Hoffman Inflammasome-driven inflammation extends into the extracellular space and to neighboring cells through the passive release of specks consisting of the adaptor ASC; this perpetuates the innate immune response and adds a dimension beyond interleukin 1 to autoinflammation.
  • Type I and type II Fc receptors regulate innate and adaptive immunity

    Andrew Pincetic
    20 Jul 2014 | 5:00 pm
    Nature Immunology 15, 707 (2014). doi:10.1038/ni.2939 Authors: Andrew Pincetic, Stylianos Bournazos, David J DiLillo, Jad Maamary, Taia T Wang, Rony Dahan, Benjamin-Maximillian Fiebiger & Jeffrey V Ravetch
  • Peroxisomal MAVS activates IRF1-mediated IFN-λ production

    Siyuan Ding
    20 Jul 2014 | 5:00 pm
    Nature Immunology 15, 700 (2014). doi:10.1038/ni.2924 Authors: Siyuan Ding & Michael D Robek Infection with an RNA virus induces the interferons IFN-β and IFN-λ via the adaptor MAVS located in mitochondria, while peroxisomal MAVS selectively activates an IFN-λ response.
  • Writing well: lowering the barriers to success

    James C Gould
    20 Jul 2014 | 5:00 pm
    Nature Immunology 15, 695 (2014). doi:10.1038/ni.2923 Authors: James C Gould, Rafael E Luna & Donna L Vogel It is not enough to be a good scientist. One needs to be a good communicator. When publications are clear and a pleasure to read, they will advance both the field and the authors' reputation.
 
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    Nature Materials - Issue - nature.com science feeds

  • Stains of authenticity

    Andrea Taroni
    22 Jul 2014 | 5:00 pm
    Nature Materials 13, 769 (2014). doi:10.1038/nmat4054 Author: Andrea Taroni
  • The hidden structure of liquids

    Philip Ball
    22 Jul 2014 | 5:00 pm
    Nature Materials 13, 758 (2014). doi:10.1038/nmat4036 Author: Philip Ball From its earliest days, crystallography has been viewed as a means to probe order in matter. J. D. Bernal's work on the structure of water reframed it as a means of examining the extent to which matter can be regarded as orderly.
  • Screened DNA packs faster

    Pep Pàmies
    22 Jul 2014 | 5:00 pm
    Nature Materials 13, 769 (2014). doi:10.1038/nmat4052 Author: Pep Pàmies
  • Crystallography with powders

    Anthony K. Cheetham
    22 Jul 2014 | 5:00 pm
    Nature Materials 13, 760 (2014). doi:10.1038/nmat4044 Authors: Anthony K. Cheetham & Andrew L. Goodwin Over the course of its long history, powder diffraction has provided countless insights into the properties of materials. It will continue to do so in the future, but with an emphasis on elucidating how materials respond to external stimuli.
  • Complementary observables

    Olivia Nicoletti
    22 Jul 2014 | 5:00 pm
    Nature Materials 13, 769 (2014). doi:10.1038/nmat4056 Author: Olivia Nicoletti
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  • Surface-initiated self-healing of polymers in aqueous media

    B. Kollbe Ahn
    26 Jul 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4037 Authors: B. Kollbe Ahn, Dong Woog Lee, Jacob N. Israelachvili & J. Herbert Waite Polymeric materials that intrinsically heal at damage sites under wet or moist conditions are urgently needed for biomedical and environmental applications. Although hydrogels with self-mending properties have been engineered by means of mussel-inspired metal-chelating catechol-functionalized polymer networks, biological self-healing in wet conditions, as occurs in self-assembled holdfast proteins in mussels and other marine organisms, is generally thought to involve…
  • Realization of dynamic thermal emission control

    Takuya Inoue
    26 Jul 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4043 Authors: Takuya Inoue, Menaka De Zoysa, Takashi Asano & Susumu Noda Thermal emission in the infrared range is important in various fields of research, including chemistry, medicine and atmospheric science. Recently, the possibility of controlling thermal emission based on wavelength-scale optical structures has been intensively investigated with a view towards a new generation of thermal emission devices. However, all demonstrations so far have involved the ‘static’ control of thermal emission; high-speed modulation of thermal emission has proved…
  • Non-thermal separation of electronic and structural orders in a persisting charge density wave

    M. Porer
    19 Jul 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4042 Authors: M. Porer, U. Leierseder, J.-M. Ménard, H. Dachraoui, L. Mouchliadis, I. E. Perakis, U. Heinzmann, J. Demsar, K. Rossnagel & R. Huber The simultaneous ordering of different degrees of freedom in complex materials undergoing spontaneous symmetry-breaking transitions often involves intricate couplings that have remained elusive in phenomena as wide ranging as stripe formation, unconventional superconductivity or colossal magnetoresistance. Ultrafast optical, X-ray and electron pulses can elucidate the microscopic interplay between these orders…
  • Separation of rare gases and chiral molecules by selective binding in porous organic cages

    Linjiang Chen
    19 Jul 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4035 Authors: Linjiang Chen, Paul S. Reiss, Samantha Y. Chong, Daniel Holden, Kim E. Jelfs, Tom Hasell, Marc A. Little, Adam Kewley, Michael E. Briggs, Andrew Stephenson, K. Mark Thomas, Jayne A. Armstrong, Jon Bell, Jose Busto, Raymond Noel, Jian Liu, Denis M. Strachan, Praveen K. Thallapally & Andrew I. Cooper
  • Visualization of oscillatory behaviour of Pt nanoparticles catalysing CO oxidation

    S. B. Vendelbo
    19 Jul 2014 | 5:00 pm
    Nature Materials. doi:10.1038/nmat4033 Authors: S. B. Vendelbo, C. F. Elkjær, H. Falsig, I. Puspitasari, P. Dona, L. Mele, B. Morana, B. J. Nelissen, R. van Rijn, J. F. Creemer, P. J. Kooyman & S. Helveg
 
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    Nature Medicine - AOP - nature.com science feeds

  • An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

    Julie Gibbs
    26 Jul 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3599 Authors: Julie Gibbs, Louise Ince, Laura Matthews, Junjie Mei, Thomas Bell, Nan Yang, Ben Saer, Nicola Begley, Toryn Poolman, Marie Pariollaud, Stuart Farrow, Francesco DeMayo, Tracy Hussell, G Scott Worthen, David Ray & Andrew Loudon
  • Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

    Daisuke Yamane
    26 Jul 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3610 Authors: Daisuke Yamane, David R McGivern, Eliane Wauthier, MinKyung Yi, Victoria J Madden, Christoph Welsch, Iris Antes, Yahong Wen, Pauline E Chugh, Charles E McGee, Douglas G Widman, Ichiro Misumi, Sibali Bandyopadhyay, Seungtaek Kim, Tetsuro Shimakami, Tsunekazu Oikawa, Jason K Whitmire, Mark T Heise, Dirk P Dittmer, C Cheng Kao, Stuart M Pitson, Alfred H Merrill, Lola M Reid & Stanley M Lemon
  • Intracellular calcium regulates nonsense-mediated mRNA decay

    Andrew Nickless
    26 Jul 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3620 Authors: Andrew Nickless, Erin Jackson, Jayne Marasa, Patrick Nugent, Robert W Mercer, David Piwnica-Worms & Zhongsheng You
  • The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

    Jeongmin Ryoo
    19 Jul 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3626 Authors: Jeongmin Ryoo, Jongsu Choi, Changhoon Oh, Sungchul Kim, Minji Seo, Seok-Young Kim, Daekwan Seo, Jongkyu Kim, Tommy E White, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Cheol-Heui Yun, Joseph A Hollenbaugh, Baek Kim, Daehyun Baek & Kwangseog Ahn The HIV-1 restriction factor SAM domain– and HD domain–containing protein 1 (SAMHD1) is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool. However, phosphorylation of SAMHD1 regulates its ability to restrict HIV-1 without decreasing cellular dNTP levels,…
  • Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

    Pengpeng Bi
    19 Jul 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3615 Authors: Pengpeng Bi, Tizhong Shan, Weiyi Liu, Feng Yue, Xin Yang, Xin-Rong Liang, Jinghua Wang, Jie Li, Nadia Carlesso, Xiaoqi Liu & Shihuan Kuang
 
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    Nature Methods - AOP - nature.com science feeds

  • Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity

    Sébastien A Smallwood
    19 Jul 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3035 Authors: Sébastien A Smallwood, Heather J Lee, Christof Angermueller, Felix Krueger, Heba Saadeh, Julian Peat, Simon R Andrews, Oliver Stegle, Wolf Reik & Gavin Kelsey We report a single-cell bisulfite sequencing (scBS-seq) method that can be used to accurately measure DNA methylation at up to 48.4% of CpG sites. Embryonic stem cells grown in serum or in 2i medium displayed epigenetic heterogeneity, with '2i-like' cells present in serum culture. Integration of 12 individual mouse oocyte datasets largely recapitulated the whole DNA methylome,…
  • High-resolution reconstruction of the beating zebrafish heart

    Michaela Mickoleit
    19 Jul 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3037 Authors: Michaela Mickoleit, Benjamin Schmid, Michael Weber, Florian O Fahrbach, Sonja Hombach, Sven Reischauer & Jan Huisken The heart′s continuous motion makes it difficult to capture high-resolution images of this organ in vivo. We developed tools based on high-speed selective plane illumination microscopy (SPIM), offering pristine views into the beating zebrafish heart. We captured three-dimensional cardiac dynamics with postacquisition synchronization of multiview movie stacks, obtained static high-resolution reconstructions by briefly…
  • Optimized cell transplantation using adult rag2 mutant zebrafish

    Qin Tang
    19 Jul 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3031 Authors: Qin Tang, Nouran S Abdelfattah, Jessica S Blackburn, John C Moore, Sarah A Martinez, Finola E Moore, Riadh Lobbardi, Inês M Tenente, Myron S Ignatius, Jason N Berman, Robert S Liwski, Yariv Houvras & David M Langenau Cell transplantation into adult zebrafish has lagged behind mouse models owing to the lack of immunocompromised strains. Here we have created rag2E450fs mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund. Mutant fish engraft muscle, blood stem cells and various cancers.
  • Isolation of rare recombinants without using selectable markers for one-step seamless BAC mutagenesis

    George T Lyozin
    12 Jul 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3030 Authors: George T Lyozin, Paul C Bressloff, Amit Kumar, Yasuhiro Kosaka, Bradley L Demarest, H Joseph Yost, Michael R Kuehn & Luca Brunelli
  • RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP)

    Nathan A Siegfried
    12 Jul 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3029 Authors: Nathan A Siegfried, Steven Busan, Greggory M Rice, Julie A E Nelson & Kevin M Weeks
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    Nature Neuroscience - Issue - nature.com science feeds

  • A selector orchestrates cortical function

    Masaki Ueno
    27 Jul 2014 | 5:00 pm
    Nature Neuroscience 17, 1016 (2014). doi:10.1038/nn.3765 Authors: Masaki Ueno, Ryosuke Fujiki & Toshihide Yamashita Molecular orchestration mediated by Fezf2, a master transcriptional regulator of a particular type of cortical neurons, directly determines both their identity and axonal routing, and thus their connectivity.
  • Sleep replay meets brain–machine interface

    Kenneth D Harris
    27 Jul 2014 | 5:00 pm
    Nature Neuroscience 17, 1019 (2014). doi:10.1038/nn.3769 Author: Kenneth D Harris Brain–machine interfaces provide not only potential therapies, but also new tools for studying neuronal processing. A study now uses them to investigate how learning affects sleep activity in motor cortex.
  • Something wicked this way comes: huntingtin

    Albert R La Spada
    27 Jul 2014 | 5:00 pm
    Nature Neuroscience 17, 1014 (2014). doi:10.1038/nn.3770 Author: Albert R La Spada Does cell-to-cell spreading of misfolded proteins occur in all neurodegenerative disorders? A study in this issue of Nature Neuroscience now demonstrates propagation of mutant huntingtin in brain slice cultures and in vivo, thereby extending the process of cell-to-cell propagation of misfolded proteins to Huntington's disease.
  • Getting it through your thick skull

    Ikuko T Smith
    27 Jul 2014 | 5:00 pm
    Nature Neuroscience 17, 1018 (2014). doi:10.1038/nn.3766 Authors: Ikuko T Smith & Spencer L Smith Neural activity up to 3 mm deep in mouse brain can now be inhibited optogenetically through the intact cranium with a red-shifted opsin called Jaws.
  • A common affective code

    P. Alexander Arguello
    27 Jul 2014 | 5:00 pm
    Nature Neuroscience 17, 1021 (2014). doi:10.1038/nn0814-1021 Author: P. Alexander Arguello
 
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    Nature Photonics - Issue - nature.com science feeds

  • Quantum cascade celebration

    30 Jul 2014 | 5:00 pm
    Nature Photonics 8, 577 (2014). doi:10.1038/nphoton.2014.178 Twenty years ago, researchers at Bell Labs in the USA stunned the optics world by reporting a new type of semiconductor laser — the quantum cascade laser. This laser transformed mid- and far-infrared photonics.
  • Semiconductor lasers: Monolithic terahertz source

    Noriaki Horiuchi
    30 Jul 2014 | 5:00 pm
    Nature Photonics 8, 585 (2014). doi:10.1038/nphoton.2014.185 Author: Noriaki Horiuchi
  • The commercialization of silicon photonics

    Andrew Rickman
    30 Jul 2014 | 5:00 pm
    Nature Photonics 8, 579 (2014). doi:10.1038/nphoton.2014.175 Author: Andrew Rickman Silicon photonics is the optical analogue of silicon microelectronics. It promises to use photons to detect, process and transmit information more efficiently than electrical signals, and yet have low manufacturing costs as a result of using conventional silicon-integrated-circuit processes.
  • Secure quantum key distribution

    Hoi-Kwong Lo
    30 Jul 2014 | 5:00 pm
    Nature Photonics 8, 595 (2014). doi:10.1038/nphoton.2014.149 Authors: Hoi-Kwong Lo, Marcos Curty & Kiyoshi Tamaki
  • New titles at a glance

    30 Jul 2014 | 5:00 pm
    Nature Photonics 8, 583 (2014). doi:10.1038/nphoton.2014.170
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    Nature Physics - Issue - nature.com science feeds

  • Raise a glass

    Luke Fleet
    30 Jul 2014 | 5:00 pm
    Nature Physics 10, 547 (2014). doi:10.1038/nphys3065 Author: Luke Fleet
  • Spin for heat

    Bart Verberck
    30 Jul 2014 | 5:00 pm
    Nature Physics 10, 547 (2014). doi:10.1038/nphys3069 Author: Bart Verberck
  • All the colours of the rainbow

    Hannah E. Smithson
    30 Jul 2014 | 5:00 pm
    Nature Physics 10, 540 (2014). doi:10.1038/nphys3052 Authors: Hannah E. Smithson, Giles E. M. Gasper & Tom C. B. McLeish Our perception of colour has always been a source of fascination, so it's little wonder that studies of the phenomenon date back hundreds of years. What, though, can modern scientists learn from medieval literature — and how do we go about it?
  • Protein power

    Abigail Klopper
    30 Jul 2014 | 5:00 pm
    Nature Physics 10, 547 (2014). doi:10.1038/nphys3067 Author: Abigail Klopper
  • Equivalence principle

    Mark Buchanan
    30 Jul 2014 | 5:00 pm
    Nature Physics 10, 543 (2014). doi:10.1038/nphys3064 Author: Mark Buchanan
 
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  • Intrinsic Josephson junctions in the iron-based multi-band superconductor (V2Sr4O6)Fe2As2

    Philip J. W. Moll
    26 Jul 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3034 Authors: Philip J. W. Moll, Xiyu Zhu, Peng Cheng, Hai-Hu Wen & Bertram Batlogg In layered superconductors, Josephson junctions may be formed within the unit cell as a result of sufficiently low inter-layer coupling. These intrinsic Josephson junction (iJJ) systems have attracted considerable interest for their application potential in quantum computing as well as efficient sources of THz radiation, closing the famous ‘THz gap’. So far, iJJ have been demonstrated in single-band, copper-based high-Tc superconductors, mainly in…
  • Physics of water: Crystal-clear transition

    Francis W. Starr
    26 Jul 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3059 Author: Francis W. Starr Liquid–liquid phase separation is counted among the peculiar phenomena attributed to pure water, but rapid crystallization has rendered its existence hard to prove. Evidence of a 'naked' liquid–liquid transition in a system unencumbered by crystallization encourages us to keep searching.
  • Quantum principal component analysis

    Seth Lloyd
    26 Jul 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3029 Authors: Seth Lloyd, Masoud Mohseni & Patrick Rebentrost The usual way to reveal properties of an unknown quantum state, given many copies of a system in that state, is to perform measurements of different observables and to analyse the results statistically. For non-sparse but low-rank quantum states, revealing eigenvectors and corresponding eigenvalues in classical form scales super-linearly with the system dimension. Here we show that multiple copies of a quantum system with density matrix ρ can be used to construct the unitary transformation…
  • Erasing no-man’s land by thermodynamically stabilizing the liquid–liquid transition in tetrahedral particles

    Frank Smallenburg
    26 Jul 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3030 Authors: Frank Smallenburg, Laura Filion & Francesco Sciortino One of the most controversial hypotheses for explaining the origin of the thermodynamic anomalies characterizing liquid water postulates the presence of a metastable second-order liquid–liquid critical point located in the ‘no-man’s land’. In this scenario, two liquids with distinct local structure emerge near the critical temperature. Unfortunately, as spontaneous crystallization is rapid in this region, experimental support for this hypothesis relies on…
  • Quantum information: Show, don't tell

    Yi-Kai Liu
    26 Jul 2014 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3058 Author: Yi-Kai Liu Probing an unknown quantum state is a resource-intensive endeavour. Now, it is shown that it may be faster to record observations that are themselves quantum superpositions, rather than classical data.
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Transcription: The transcriptional effects of MYC

    Gemma K. Alderton
    23 Jul 2014 | 5:00 pm
    Nature Reviews Cancer 14, 513 (2014). doi:10.1038/nrc3790 Author: Gemma K. Alderton Two papers question the proposed role of MYC as a transcriptional amplifier.
  • Tumour detection: Molecular detection to improve surgery

    Gemma K. Alderton
    23 Jul 2014 | 5:00 pm
    Nature Reviews Cancer 14, 515 (2014). doi:10.1038/nrc3796 Author: Gemma K. Alderton Using desorption electrospray ionization (DESI) mass spectrometry to detect the oncometabolite 2-hydroxyglutarate (2-HG) in surgically resected gliomas, Santagata, Eberlin and colleagues showed that those gliomas with mutant isocitrate dehydrogenase (IDH) could be rapidly identified during surgery. Detection of 2-HG revealed the tumour margins and could
  • Genomic instability: Suppressing CIN promotes growth

    Gemma K. Alderton
    23 Jul 2014 | 5:00 pm
    Nature Reviews Cancer 14, 515 (2014). doi:10.1038/nrc3795 Author: Gemma K. Alderton Ertych, Stolz et al. found an increase in microtubule assembly rates in colorectal cancer cells, and reducing microtubule assembly to the rate of normal cells suppressed chromosomal instability (CIN). The increased microtubule assembly rates were associated with transient spindle geometry defects and promoted lagging
  • Oncogenes: All eyes on YAP1

    Sarah Seton-Rogers
    23 Jul 2014 | 5:00 pm
    Nature Reviews Cancer 14, 514 (2014). doi:10.1038/nrc3791 Author: Sarah Seton-Rogers Three recent papers have uncovered links between oncogenic KRAS signalling and the transcriptional coactivator Yes-associated protein 1 (YAP1).
  • Microenvironment: Stromal metabolism has paracrine effects

    Gemma K. Alderton
    23 Jul 2014 | 5:00 pm
    Nature Reviews Cancer 14, 515 (2014). doi:10.1038/nrc3794 Author: Gemma K. Alderton Valencia et al. investigated the role of p62 in tumour-associated stromal cells, in which its expression is frequently reduced in tumour samples. The growth of prostate cancer cells in syngeneic p62-knockout mice was significantly increased compared to growth in control mice. p62 loss in
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • RNA-directed DNA methylation: an epigenetic pathway of increasing complexity

    Marjori A. Matzke
    17 Jul 2014 | 5:00 pm
    Nature Reviews Genetics 15, 570 (2014). doi:10.1038/nrg3794 Author: Marjori A. Matzke & Rebecca A. Mosher Nature Reviews Genetics15, 394–408 (2014)In this article, on page 394 and in the footnote of Table 1 (page 397) the sequence contexts of DNA methylation were incorrectly defined. For CHG and CHH sequences, H
  • Technology: Progress in nanopore sequencing

    Isabel Lokody
    14 Jul 2014 | 5:00 pm
    Nature Reviews Genetics 15, 514 (2014). doi:10.1038/nrg3792 Author: Isabel Lokody Nanopore sequencing is based on ion current changes that are generated by DNA passing through a genetically modified bacterial pore. Traditionally, this technique suffers from imprecision in identifying individual nucleotides, as four nucleotides pass through the pore at once. In a new study, researchers characterized
  • Clinical genetics: Facing disease — new algorithm to aid diagnosis

    Isabel Lokody
    14 Jul 2014 | 5:00 pm
    Nature Reviews Genetics 15, 514 (2014). doi:10.1038/nrg3791 Author: Isabel Lokody Ferry et al. have developed a new computer algorithm that extracts phenotypic information from patient photographs to facilitate diagnosis of genetic diseases with known facial morphologies. This algorithm does not require clinical photographs or special three-dimensional imaging and can instead use two-dimensional images from
  • Molecular genetics: DNA binding drives nuclear receptor architecture

    Isabel Lokody
    14 Jul 2014 | 5:00 pm
    Nature Reviews Genetics 15, 514 (2014). doi:10.1038/nrg3789 Author: Isabel Lokody Nuclear receptors are crucial regulators of gene expression that directly bind to DNA. Now, Maletta et al. describe the structure of ultraspiracle protein/ecdysone receptor (USP/EcR) bound to inverted repeat DNA. Although these inverted repeats of DNA are palindromic, upon binding to the receptor the
  • Model organisms: Increasing the specificity of genetic signatures

    Isabel Lokody
    14 Jul 2014 | 5:00 pm
    Nature Reviews Genetics 15, 514 (2014). doi:10.1038/nrg3790 Author: Isabel Lokody Decreased growth is often used as a phenotypic measure in gene perturbation experiments in model systems such as yeast. O'Duibhir et al. have now shown that various mutant yeast strains exhibit slow growth that is characterized by a specific gene signature. This signature was
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Assembly and localization of Toll-like receptor signalling complexes

    Nicholas J. Gay
    24 Jul 2014 | 5:00 pm
    Nature Reviews Immunology 14, 546 (2014). doi:10.1038/nri3713 Authors: Nicholas J. Gay, Martyn F. Symmons, Monique Gangloff & Clare E. Bryant Signal transduction by the Toll-like receptors (TLRs) is central to host defence against many pathogenic microorganisms and also underlies a large burden of human disease. Thus, the mechanisms and regulation of signalling by TLRs are of considerable interest. In this Review, we discuss the molecular
  • Immune modulation by butyrophilins

    Heather A. Arnett
    24 Jul 2014 | 5:00 pm
    Nature Reviews Immunology 14, 559 (2014). doi:10.1038/nri3715 Authors: Heather A. Arnett & Joanne L. Viney The B7 family of co-stimulatory molecules has an important role in driving the activation and inhibition of immune cells. Evolving data have shown that a related family of molecules — the butyrophilins — have similar immunomodulatory functions to B7 family members and may represent a
  • T cell recognition: A hidden heavy metal

    Elisabeth Kugelberg
    24 Jul 2014 | 5:00 pm
    Nature Reviews Immunology 14, 518 (2014). doi:10.1038/nri3724 Author: Elisabeth Kugelberg CD4+ T cells detect beryllium hidden within peptide–MHC class II complexes.
  • Developmental gene networks: a triathlon on the course to T cell identity

    Mary A. Yui
    24 Jul 2014 | 5:00 pm
    Nature Reviews Immunology 14, 529 (2014). doi:10.1038/nri3702 Authors: Mary A. Yui & Ellen V. Rothenberg Cells acquire their ultimate identities by activating combinations of transcription factors that initiate and sustain expression of the appropriate cell type-specific genes. T cell development depends on the progression of progenitor cells through three major phases, each of which is associated with distinct transcription factor
  • T cell memory: Metabolic self-reliance

    Kirsty Minton
    17 Jul 2014 | 5:00 pm
    Nature Reviews Immunology 14, 518 (2014). doi:10.1038/nri3721 Author: Kirsty Minton Memory T cells synthesize the substrates for metabolic reprogramming to fatty acid oxidation in a cell-intrinsic manner.
 
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Bacterial physiology: How LysM binds to peptidoglycan

    Cláudio Nunes-Alves
    15 Jul 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 532 (2014). doi:10.1038/nrmicro3322 Author: Cláudio Nunes-Alves LysM is a highly conserved carbohydrate binding module that is present in proteins from all kingdoms, but how LysM binds its substrates is unknown. Mesnage et al. now show how a LysM domain from AtlA, an autolysin from Enterococcus faecalis, recognizes peptidoglycan. By
  • Bacterial pathogenesis: Bartonella gets under the skin

    Sheilagh Molloy
    15 Jul 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 529 (2014). doi:10.1038/nrmicro3321 Author: Sheilagh Molloy An antagonistic interaction between two Bartonella effector proteins is essential for Bartonella bloodstream infection in a reservoir host.
  • Microbiome: New bacteria associated with diarrhoea

    Cláudio Nunes-Alves
    15 Jul 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 532 (2014). doi:10.1038/nrmicro3323 Author: Cláudio Nunes-Alves Diarrhoeal diseases are a major cause of childhood mortality in developing countries, yet in most cases no known pathogens can be identified by conventional diagnostic methods. Pop et al. used high throughput 16S rRNA sequencing to compare the faecal microbiota composition in 992 children
  • Fungal pathogenicity: Dissecting effector effects

    Sheilagh Molloy
    15 Jul 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 532 (2014). doi:10.1038/nrmicro3324 Author: Sheilagh Molloy The genome of the fungal phytopathogen Ustilago maydis contains several large gene clusters encoding putative secreted effector proteins. Brefort et al. present a functional analysis of the largest cluster, cluster 19A, which encodes 24 effectors. Although the virulence of a U. maydis
  • Adding new dimensions: towards an integrative understanding of HIV-1 spread

    Oliver T. Fackler
    15 Jul 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 563 (2014). doi:10.1038/nrmicro3309 Authors: Oliver T. Fackler, Thomas T. Murooka, Andrea Imle & Thorsten R. Mempel In vitro studies in primary or immortalized cells continue to be used to elucidate the essential principles that govern the interactions between HIV-1 and isolated target cells. However, until recently, substantial technical barriers prevented this information from being efficiently translated to the more complex
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • Multiplexed enzyme activity screening

    Eytan Zlotorynski
    22 Jul 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 500 (2014). doi:10.1038/nrm3848 Author: Eytan Zlotorynski Enzyme inhibitors are widely screened for potency; however, selectivity is often tested only on lead candidates, resulting in many clinical failures. The authors developed EnPlex for multiplexed, high-throughput screening of compound potency and specificity. In EnPlex, small quantities of purified enzymes are coupled to colour-coded
  • The growing landscape of lysine acetylation links metabolism and cell signalling

    Chunaram Choudhary
    22 Jul 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 536 (2014). doi:10.1038/nrm3841 Authors: Chunaram Choudhary, Brian T. Weinert, Yuya Nishida, Eric Verdin & Matthias Mann Lysine acetylation is a conserved protein post-translational modification that links acetyl-coenzyme A metabolism and cellular signalling. Recent advances in the identification and quantification of lysine acetylation by mass spectrometry have increased our understanding of lysine acetylation, implicating it in many biological processes through the regulation
  • Chromosomes: Epigenetics of kinetochore assembly

    Kim Baumann
    22 Jul 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 499 (2014). doi:10.1038/nrm3851 Author: Kim Baumann Vertebrate centromeres are specified by the deposition of the histone H3 variant centromeric protein A (CENPA), but whether other epigenetic marks are important for centromeric chromatin function was unclear. Hori et al. now show that centromeric monomethylation of histone H4 at Lys20 (H4K20me1) is
  • Small RNAs break out: the molecular cell biology of mobile small RNAs

    Peter Sarkies
    22 Jul 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 525 (2014). doi:10.1038/nrm3840 Authors: Peter Sarkies & Eric A. Miska Small RNAs that function in a non-cell autonomous manner are becoming increasingly recognized as regulatory molecules with the potential to transmit information between cells, organisms and species. In plants and nematodes, small RNA mobility can be genetically dissected to provide information about the nature of
  • DNA replication: DNA Pol θ controls replication timing

    Andrea Du Toit
    22 Jul 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 499 (2014). doi:10.1038/nrm3849 Author: Andrea Du Toit Although DNA polymerase θ (Pol θ) has been implicated in translesion synthesis and DNA repair, its physiological function remained elusive. Fernandez-Vidal et al. now report that DNA Pol θ has a role in the timing of DNA replication. They showed that in human cells
 
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Techniques: Optogenetics in the red

    Katherine Whalley
    17 Jul 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 496 (2014). doi:10.1038/nrn3798 Author: Katherine Whalley The use of optogenetics to inhibit the activity of defined populations of neurons with high temporal precision is of enormous value for researchers attempting to dissect inaccessible neural circuits in the brain. Chuong et al. now report the development of a red-light-sensitive chloride pump,
  • Neural circuits: Mating decisions

    Katherine Whalley
    17 Jul 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 496 (2014). doi:10.1038/nrn3796 Author: Katherine Whalley Female flies targeted by courting males integrate sensory information provided in the form of courtship 'cues' by male flies with an evaluation of their own reproductive status before deciding whether to accept or reject these advances. Three papers now shed light on the populations of
  • Development of multisensory integration from the perspective of the individual neuron

    Barry E. Stein
    17 Jul 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 520 (2014). doi:10.1038/nrn3742 Authors: Barry E. Stein, Terrence R. Stanford & Benjamin A. Rowland The ability to use cues from multiple senses in concert is a fundamental aspect of brain function. It maximizes the brain's use of the information available to it at any given moment and enhances the physiological salience of external events. Because each sense conveys a
  • Pain: Reversing hyperalgesia

    Darran Yates
    17 Jul 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 495 (2014). doi:10.1038/nrn3790 Author: Darran Yates In mice with mechanical hyperalgesia, reactivation of the sensitized pain pathways renders the hyperalgesic state labile and susceptible to being reversed.
  • Cognitive neuroscience: Taking no action triggers firing

    Katherine Whalley
    17 Jul 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 496 (2014). doi:10.1038/nrn3797 Author: Katherine Whalley Neurons in the premotor and motor cortex fire when an individual performs an action, and thus it might be expected that these neurons are silenced when the individual is required to refrain from a particular action. However, Bonini et al. show that, in macaque
 
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    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • Breast cancer: Improving cancer detection rates

    Alessia Errico
    14 Jul 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 440 (2014). doi:10.1038/nrclinonc.2014.120 Author: Alessia Errico Screening mammography has a key role in early breast cancer detection; however, it is associated with excessive false-positives and limited sensitivity. The group led by Sarah Friedewald has now shown that the combination of tomosynthesis with digital mammography reduces the recall rate (proportion of patients
  • Genetics: Driver genes are mutated early in the course of oesophageal adenocarcinoma

    Natalie J. Wood
    14 Jul 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 439 (2014). doi:10.1038/nrclinonc.2014.121 Author: Natalie J. Wood Contrary to expectations, a study in Nature Genetics has found that most recurrently mutated genes present in oesophageal adenocarcinoma (EAC) are mutated early in development of the disease, which has implications for both diagnosis and therapy.Rebecca Fitzgerald and colleagues wanted to understand at
  • Pancreatic cancer: CONKO conquers

    M. Teresa Villanueva
    14 Jul 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 441 (2014). doi:10.1038/nrclinonc.2014.119 Author: M. Teresa Villanueva The aggressive nature of pancreatic adenocarcinoma, its difficulty in being detected at early stages, and its propensity to develop resistance to chemotherapy makes of this cancer one of the deadliest types. Since gemcitabine became the first-line standard of care for metastatic pancreatic cancer nearly 20
  • Haematological cancer: ALL classification—integration of genomic and cytogenetic data

    Alessia Errico
    7 Jul 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 440 (2014). doi:10.1038/nrclinonc.2014.117 Author: Alessia Errico Acute lymphoblastic leukaemia (ALL) is characterized by several chromosomal abnormalities that have an important diagnostic and prognostic value, and by numerous genomic copy number alterations with a yet unknown clinical relevance. Anthony Moorman and colleagues have integrated these genomic data with cytogenetic data to refine
  • Breast cancer: Why do women opt for contralateral prophylactic mastectomy?

    Aron Goldhirsch
    7 Jul 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 443 (2014). doi:10.1038/nrclinonc.2014.116 Authors: Aron Goldhirsch & Shari Gelber The decision of patients with breast cancer to have contralateral mastectomies is often related to their genetic risk. However, the increasing frequency of this surgical approach is also associated with social and psychological issues such as celebrity experiences and fear of contralateral breast cancer. Appropriate counselling may better inform patients' surgical choices.
 
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    Nature Reviews Nephrology - Issue - nature.com science feeds

  • Nephrotic syndrome: Rituximab is safe and effective in FRNS and SDNS—but where to go from here?

    Mina Razzak
    7 Jul 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 421 (2014). doi:10.1038/nrneph.2014.119 Author: Mina Razzak Although the anti-CD20 B-cell depleting biological agent rituximab has been shown in small series and single-arm studies to effectively treat frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome (SDNS), only now has a multicentre, double-blind, randomized, placebo-controlled trial been reported with >3 months follow-up
  • Pre-eclampsia part 1: current understanding of its pathophysiology

    Tinnakorn Chaiworapongsa
    7 Jul 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 466 (2014). doi:10.1038/nrneph.2014.102 Authors: Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Lami Yeo & Roberto Romero Pre-eclampsia is characterized by new-onset hypertension and proteinuria at ≥20 weeks of gestation. In the absence of proteinuria, hypertension together with evidence of systemic disease (such as thrombocytopenia or elevated levels of liver transaminases) is required for diagnosis. This multisystemic disorder targets several organs, including
  • Transplantation: IgG reactivity to apoptotic cells—role in presensitization revealed

    Peter Sidaway
    30 Jun 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 423 (2014). doi:10.1038/nrneph.2014.118 Author: Peter Sidaway Presensitization, a long-standing cause of graft failure in solid organ transplantation, is largely attributed to anti-HLA and anti-ABO antibody-mediated reactions. Now, pretransplant levels of apoptotic-cell-reactive IgG have been found to correlate with late kidney allograft loss. “These antibodies have never been associated with presensitization before,”
  • Genetics: Mapping pathways of CKD

    Ellen F. Carney
    30 Jun 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 423 (2014). doi:10.1038/nrneph.2014.117 Author: Ellen F. Carney Although genome-wide association studies (GWAS) have identified genetic loci that are significantly associated with chronic kidney disease (CKD), molecular understanding of the mechanisms by which single nucleotide polymorphisms might affect renal function is often lacking. Now, researchers have combined GWAS data, renal transcription profiles and
  • Glomerular disease: The search goes on: suPAR is not the elusive FSGS factor

    Jeroen K. Deegens
    23 Jun 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 431 (2014). doi:10.1038/nrneph.2014.113 Authors: Jeroen K. Deegens & Jack F. Wetzels New research indicates that intact soluble urokinase plasminogen activator receptor (suPAR) does not induce albuminuria in mice. These data corroborate the most recent clinical findings, showing that intact suPAR is not the plasma permeability factor responsible for recurrence of focal segmental glomerulosclerosis after renal transplantation.
 
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    Nature Reviews Rheumatology - Issue - nature.com science feeds

  • Connective tissue diseases: Stem cell transplant prolongs systemic sclerosis survival

    Nicholas J. Bernard
    14 Jul 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 444 (2014). doi:10.1038/nrrheum.2014.117 Author: Nicholas J. Bernard 12-year multicentre clinical trial data now reported in JAMA show haematopoietic stem cell transplantation (HSCT) has long-term survival benefits compared with pulsed cyclophosphamide for treating systemic sclerosis (SSc). “No therapy has previously been shown to improve long-term survival,” say corresponding authors of the study,
  • Experimental arthritis: Inflammasome-driven arthritis: a new model of RA?

    Sarah Onuora
    14 Jul 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 445 (2014). doi:10.1038/nrrheum.2014.116 Author: Sarah Onuora Should rheumatoid arthritis (RA) be considered a syndrome, rather than a single disease? In several widely used experimental models of arthritis, such as collagen-induced and antigen-induced arthritis, pathology occurs independently of the inflammasome. However, research now published in Nature describes an experimental model of
  • Rheumatoid arthritis: Citrullination alters the inflammatory properties of chemokines in inflammatory arthritis

    Jenny Buckland
    7 Jul 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 446 (2014). doi:10.1038/nrrheum.2014.112 Author: Jenny Buckland Chemokine citrullination in inflamed joints, and the resultant monocyte recruitment, could accelerate disease progression in rheumatoid arthritis (RA), according to a study by Yoshida et al. published in Arthritis & Rheumatology.Chemokines are involved in recruiting monocytes and polymorphonuclear cells (PMNs) to
  • Rheumatoid arthritis: Can tofacitinib be used as first-line monotherapy for RA?

    Sarah Onuora
    7 Jul 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 443 (2014). doi:10.1038/nrrheum.2014.108 Author: Sarah Onuora The Janus kinase inhibitor tofacitinib was originally approved by the FDA for use in patients with rheumatoid arthritis (RA) who did not achieve a sufficient response to (or who did not tolerate) methotrexate, the most widely used antirheumatic drug. However, the 24-month results of the
  • Eosinophils in vasculitis: characteristics and roles in pathogenesis

    Paneez Khoury
    7 Jul 2014 | 5:00 pm
    Nature Reviews Rheumatology 10, 474 (2014). doi:10.1038/nrrheum.2014.98 Authors: Paneez Khoury, Peter C. Grayson & Amy D. Klion Eosinophils are multifunctional granular leukocytes that are implicated in the pathogenesis of a wide variety of disorders, including asthma, helminth infection, and rare hypereosinophilic syndromes. Although peripheral and tissue eosinophilia can be a feature of many types of small-vessel and medium-vessel vasculitis, the role of
 
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    Naturejobs - Search results

  • Chief Editor - Nature Neuroscience

    31 Jul 2014 | 12:48 pm
    The Nature Publishing Group is looking for a Chief Editor for Nature Neuroscience, the leading biomedical research journal devoted to publishing the latest and most exciting advances in neuroscience. The journal covers all areas of neuroscience, including molecular, cellular, systems and cognitive neuroscience, as well as psychophysics, computational modeling and diseases of the nervous system. The position of Chief Editor is a senior appointment, reporting to the Executive Editor, and is bac…
  • Scientist II Cell Biology

    31 Jul 2014 | 10:25 am
    Position Objective Provide support to a team of scientists engaged in the development of physiologically relevant cell culture systems, including induced pluripotent stem cells (iPSC), precursor and somatic cells. Key focus areas include identification of conditions which promote efficient differentiation and in functional characterization of diverse cell types. Specific duties will include culture of stem cells (iPSC and embryonic) and other cells types, close interaction with R&D staff to coo...
  • Sr. Support Services Coordinator

    31 Jul 2014 | 10:25 am
    Communication interne : Communiquer et faire circuler les informations émanants de la Direction Générale et des membres du comité de direction à l’attention de l’ensemble des salariés du site français (affichage du service communication). Préparer et gérer l’agenda du comité de Direction en lien avec le Directeur Général Délégué. Rédiger et communiquer aux employées de la filiale le compte-rendu des réunions du comité de Direction. Recognition & Rewards : Veiller au suivi et à la ...
  • Business Analyst

    31 Jul 2014 | 10:25 am
    Expertise Information Technology Job Type Full-time Location United States - Ohio - Marietta Job Level Experienced Posting date: July 18, 2014 Position Summary: A business analyst (BA) works in IT as a liaison between IT and the specific business functions he or she supports. A successful BA has a unique set of qualifications that combines in-depth functional domain knowledge with a passion and aptitude for technology and continuous improvement. The business analyst requires a thoroug...
  • Associate Developer

    31 Jul 2014 | 10:25 am
    Software Dev - eCommerce, Comergent, Web Apps'- Primary duties include working with a team of application developers and consultants who are responsible for contributing to project requirements, writing secure, tight, and scalable code, working with corporate IT and partners on creating innovative solutions to technical and business challenges, and ultimately ensuring the quality and performance of Thermo Fisher web sites.- Contribute to technical leadership and subject matter expertise on web e...
 
 
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    British Journal of Pharmacology

  • Dopamine D1 and corticotrophin releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells

    J Fuenzalida, P Galaz, K A Araya, P G Slater, E H Blanco, J M Campusano, F Ciruela, K Gysling
    30 Jul 2014 | 2:30 am
    Summary Background And PurposeDopamine and corticotrophin releasing hormone (CRH) are key neurotransmitters in the interaction between stress and addiction. Repeated treatment with cocaine potentiates glutamatergic transmission in the rat basolateral amygdala/cortex pathway through a synergistic action of D1-like dopamine receptor and corticotrophin releasing hormone type-2α receptor (CRH2αR). We hypothesized that this observed synergism could be instrumented by heteromers containing dopamine D1 receptor (D1R) and CRH2αR. Experimental ApproachD1R/CRH2αR heteromerization was evidenced in…
  • Selective Na+/Ca2+ exchanger inhibition prevents Ca2+ overload induced triggered arrhythmias

    Norbert Nagy, Anita Kormos, Zsófia Kohajda, Áron Szebeni, Judit Szepesi, Piero Pollesello, Jouko Levijoki, Károly Acsai, László Virág, Péter P. Nánási, Julius Gy. Papp, András Varró, András Tóth
    30 Jul 2014 | 2:30 am
    Summary Background and purposeA crucial role for augmented Na/Ca2+ exchanger (NCX) activity in cardiac arrhythmogenesis is often suggested, however, in related studies the antiarrhythmic efficacy of NCX inhibition was apparently controversial. Feasible explanations could be the unsatisfactory selectivity of NCX inhibitors and/or experimental model dependence of the degree of Ca2+i overload. In the present study, using NCX inhibitors SEA0400 and the more selective ORM10103, we evaluated the efficacy of NCX inhibition against arrhythmogenic Ca2+i rise in conditions when [Ca2+]i was augmented…
  • Endothelial atypical cannabinoid receptor: do we have enough evidence?

    Alexander I. Bondarenko
    30 Jul 2014 | 2:30 am
    Abstract Cannabinoids and their synthetic analogs affect a broad range of physiological functions, including cardiovascular variables. Although direct evidence is still missing, the relaxation to cannabinoids of a vast range of vascular beds is believed to involve still unidentified non-CB1, non-CB2 Gi/o protein-coupled receptor Ta located on endothelial cells, so called endothelial cannabinoid receptor (eCBR). Indication for the presence of eCBR comes mainly from vascular relaxation studies, which commonly employ pertussis toxin as an indicator for GPCR-mediated signaling. In addition,…
  • Epigenetics in the Perioperative Period

    P Lirk, H Fiegl, N.C. Weber, M W Hollmann
    30 Jul 2014 | 2:30 am
    Summary The perioperative period is characterized by profound changes in the body's homoeostatic processes. This review seeks to address whether epigenetic mechanisms may influence an individual's reaction to surgery and anaesthesia. Evidence from animal and human studies suggests that epigenetic mechanisms can explain many facets of susceptibility to acute and chronic pain, making them potential therapeutic targets. Modern pain management is still based upon opiates, and both the developmental expression of opioid receptors and opioid-induced hyperalgesia have been linked to epigenetic…
  • Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes

    Philipp Y. Maximov, Russell E. McDaniel, Daphne J. Fernandes, Valeriy R. Korostyshevskiy, Puspanjali Bhatta, Thomas E. Muerdter, David A. Flockhart, V. Craig Jordan
    30 Jul 2014 | 2:30 am
    Summary Background and PurposeTAM is a prodrug that is metabolically activated by 4-hydroxylation to the potent primary metabolite 4-hydroxytamoxifen (4OHT) or via another primary metabolite N-desmethytamoxifen (NDMTAM) to a biologically active secondary metabolite endoxifen through a cytochrome P450 variant 2D6 system (CYP2D6). We have determined the antioestrogenic efficacy of TAM and its metabolites, including endoxifen, at concentrations corresponding to serum levels measured in breast cancer patients with various CYP2D6 genotypes, simulating TAM treatment. This could provide new data to…
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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    PSI-Nature Structural Biology Knowledgebase

  • Quorum Sensing: E. coli Gets Involved

    Claudia Lupp
    16 Jul 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.213 Author: Claudia Lupp The crystal structure of E. coli SdiA provides insights into substrate selectivity and oxidation-dependent regulation.
  • Quorum Sensing: A Groovy New Component

    Anita M. Engh
    16 Jul 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.214 Author: Anita M. Engh A first-in-family structure of a Pseudomonas-specific protein provides clues to its role in quorum sensing.
  • The human proteome takes the spotlight

    Allison Doerr
    26 Jun 2014 | 5:00 pm
    Nature Methods 11, 709 (2014). doi:10.1038/nmeth.3017 Author: Allison Doerr Two papers report mass spectrometry–based draft maps of the human proteome and provide broadly accessible resources.
  • Putting it out there

    Cláudio Nunes-Alves
    29 Jun 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 530 (2014). doi:10.1038/nrmicro3311 Author: Cláudio Nunes-Alves Two studies solve the structure of the LptD-LptE complex and elucidate how LPS is transported across the bacterial outer membrane.
  • Structures Without Damage

    Allison Doerr
    16 Jul 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.215 Author: Allison Doerr Radiation damage-free protein structures can be solved using an X-ray free-electron laser and large single crystals.
 
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