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  • Missing iris effect as a possible cause of muted hydrological change and high climate sensitivity in models

    Nature Geoscience - AOP - nature.com science feeds
    Thorsten Mauritsen
    19 Apr 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2414 Authors: Thorsten Mauritsen & Bjorn Stevens
  • Oldest stone tools raise questions about their creators

    NatureNews - Most recent articles - nature.com science feeds
    Ewen Callaway
    20 Apr 2015 | 5:00 pm
    The 3.3-million-year-old implements predate the first members of the Homo genus.Nature 520 421 doi: 10.1038/520421a
  • Close the deal

    Nature - Issue - nature.com science feeds
    13 Apr 2015 | 5:00 pm
    Close the deal Nature 520, 7547 (2015). doi:10.1038/520263a Science-based evidence and enlightened diplomacy have brought within reach a historic opportunity for nuclear détente with Iran. It must be seized.
  • Sensory systems: The yin and yang of cortical oxytocin

    Nature - AOP - nature.com science feeds
    Robert C. Liu
    14 Apr 2015 | 5:00 pm
    Nature advance online publication 15 April 2015. doi:10.1038/nature14386 Author: Robert C. Liu Female mice can learn to respond to distress calls from young mice — an ability that has now been found to be improved through signalling by the hormone oxytocin in the left auditory cortex of the brain.
  • Academic partnerships 2014

    Nature Biotechnology - Issue - nature.com science feeds
    Brady Huggett
    6 Apr 2015 | 5:00 pm
    Nature Biotechnology 33, 333 (2015). doi:10.1038/nbt.3189 Author: Brady Huggett
 
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    Nature - Issue - nature.com science feeds

  • Close the deal

    13 Apr 2015 | 5:00 pm
    Close the deal Nature 520, 7547 (2015). doi:10.1038/520263a Science-based evidence and enlightened diplomacy have brought within reach a historic opportunity for nuclear détente with Iran. It must be seized.
  • Numbers matter

    14 Apr 2015 | 5:00 pm
    Numbers matter Nature 520, 7547 (2015). doi:10.1038/520263b Researchers need help in making the statistical power of animal experiments clear.
  • Announcement: Time to tackle cells’ mistaken identity

    14 Apr 2015 | 5:00 pm
    Announcement: Time to tackle cells’ mistaken identity Nature 520, 7547 (2015). doi:10.1038/520264a The differences between a cow and a monkey are clear. It is easy to tell a moth from a mosquito. So why are there still scientific studies that mix them up? The answer is simple: hundreds of cell lines stored and used by modern laboratories
  • Scientists must speak up on fossil-fuel divestment

    Alan Rusbridger
    14 Apr 2015 | 5:00 pm
    Scientists must speak up on fossil-fuel divestment Nature 520, 7547 (2015). http://www.nature.com/doifinder/10.1038/520265a Author: Alan Rusbridger Alan Rusbridger wants researchers to help convince powerful philanthropic organizations to set an example and stop propelling carbon emissions.
  • Imaging: A 3D map of skin microbes and molecules

    14 Apr 2015 | 5:00 pm
    Imaging: A 3D map of skin microbes and molecules Nature 520, 7547 (2015). doi:10.1038/520266a Researchers have glimpsed the complexities of human skin by creating a three-dimensional (3D) map of the chemicals and microbes found on the body's largest organ.Pieter Dorrestein of the University of California in San Diego and his colleagues swabbed 400 locations on the skin of
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  • Sensory systems: The yin and yang of cortical oxytocin

    Robert C. Liu
    14 Apr 2015 | 5:00 pm
    Nature advance online publication 15 April 2015. doi:10.1038/nature14386 Author: Robert C. Liu Female mice can learn to respond to distress calls from young mice — an ability that has now been found to be improved through signalling by the hormone oxytocin in the left auditory cortex of the brain.
  • The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

    Ditte S. Andersen
    14 Apr 2015 | 5:00 pm
    Nature advance online publication 15 April 2015. doi:10.1038/nature14298 Authors: Ditte S. Andersen, Julien Colombani, Valentina Palmerini, Krittalak Chakrabandhu, Emilie Boone, Michael Röthlisberger, Janine Toggweiler, Konrad Basler, Marina Mapelli, Anne-Odile Hueber & Pierre Léopold Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila…
  • Microbiology: Malaria runs rings round artemisinin

    Jeremy Burrows
    14 Apr 2015 | 5:00 pm
    Nature advance online publication 15 April 2015. doi:10.1038/nature14387 Author: Jeremy Burrows In parts of southeast Asia, malaria parasites are showing resistance to the active ingredient in artemisinin-based antimalarial drugs. Delineation of a cell-signalling pathway might help to explain this phenomenon.
  • Oxytocin enables maternal behaviour by balancing cortical inhibition

    Bianca J. Marlin
    14 Apr 2015 | 5:00 pm
    Nature advance online publication 15 April 2015. doi:10.1038/nature14402 Authors: Bianca J. Marlin, Mariela Mitre, James A. D’amour, Moses V. Chao & Robert C. Froemke
  • A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

    Alassane Mbengue
    14 Apr 2015 | 5:00 pm
    Nature advance online publication 15 April 2015. doi:10.1038/nature14412 Authors: Alassane Mbengue, Souvik Bhattacharjee, Trupti Pandharkar, Haining Liu, Guillermina Estiu, Robert V. Stahelin, Shahir S. Rizk, Dieudonne L. Njimoh, Yana Ryan, Kesinee Chotivanich, Chea Nguon, Mehdi Ghorbal, Jose-Juan Lopez-Rubio, Michael Pfrender, Scott Emrich, Narla Mohandas, Arjen M. Dondorp, Olaf Wiest & Kasturi Haldar Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and…
 
 
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    Nature Chemical Biology - AOP - nature.com science feeds

  • Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

    Philip D Kiser
    19 Apr 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1799 Authors: Philip D Kiser, Jianye Zhang, Mohsen Badiee, Qingjiang Li, Wuxian Shi, Xuewu Sui, Marcin Golczak, Gregory P Tochtrop & Krzysztof Palczewski
  • Pharmacodynamics: Which trails are your drugs taking?

    Rumin Zhang
    19 Apr 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1795 Author: Rumin Zhang Binding kinetics (BK) has an indispensable role in pharmacodynamics (PD). Incorporating slow BK into a mechanistic PD model is shown to have predictive value for in vitro cellular and in vivo animal antibacterial efficacy.
  • Translating slow-binding inhibition kinetics into cellular and in vivo effects

    Grant K Walkup
    19 Apr 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1796 Authors: Grant K Walkup, Zhiping You, Philip L Ross, Eleanor K H Allen, Fereidoon Daryaee, Michael R Hale, John O'Donnell, David E Ehmann, Virna J A Schuck, Ed T Buurman, Allison L Choy, Laurel Hajec, Kerry Murphy-Benenato, Valerie Marone, Sara A Patey, Lena A Grosser, Michele Johnstone, Stephen G Walker, Peter J Tonge & Stewart L Fisher
  • The use of ene adducts to study and engineer enoyl-thioester reductases

    Raoul G Rosenthal
    12 Apr 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1794 Authors: Raoul G Rosenthal, Bastian Vögeli, Nick Quade, Guido Capitani, Patrick Kiefer, Julia A Vorholt, Marc-Olivier Ebert & Tobias J Erb An improved understanding of enzymes' catalytic proficiency and stereoselectivity would further enable applications in chemistry, biocatalysis and industrial biotechnology. We use a chemical probe to dissect individual catalytic steps of enoyl-thioester reductases (Etrs), validating an active site tyrosine as the cryptic proton donor and explaining how it had eluded definitive identification. This…
  • Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

    Malia B Potts
    12 Apr 2015 | 5:00 pm
    Nature Chemical Biology. doi:10.1038/nchembio.1797 Authors: Malia B Potts, Elizabeth A McMillan, Tracy I Rosales, Hyun Seok Kim, Yi-Hung Ou, Jason E Toombs, Rolf A Brekken, Mark D Minden, John B MacMillan & Michael A White
 
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    Nature Chemistry

  • Functionalization of cobalt porphyrin–phospholipid bilayers with his-tagged ligands and antigens

    Shuai Shao
    19 Apr 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2236 Authors: Shuai Shao, Jumin Geng, Hyun Ah Yi, Shobhit Gogia, Sriram Neelamegham, Amy Jacobs & Jonathan F. Lovell Lipid bilayers containing porphyin-phospholipid that is chelated with cobalt have been shown to capture his-tagged proteins and peptides. This method offers a simple route for functionalizing pre-formed lipid bilayers without disrupting their integrity. Using this approach homing peptides were attached to cargo-loaded liposomes to enable tumour targeting, and an HIV-derived protein fragment elicited antibodies following binding to…
  • Stabilization of elusive silicon oxides

    Yuzhong Wang
    19 Apr 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2234 Authors: Yuzhong Wang, Mingwei Chen, Yaoming Xie, Pingrong Wei, Henry F. Schaefer, Paul von R. Schleyer & Gregory H. Robinson Molecular SiO2 and other simple silicon oxides have remained elusive despite the importance of silicon dioxide materials in advanced electronic devices. Clusters Si2O3 and Si2O4 have now been experimentally realized by direct oxidation of a carbene-stabilized disilicon using N2O and O2, respectively.
  • Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

    Kelsey R. Schramma
    19 Apr 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2237 Authors: Kelsey R. Schramma, Leah B. Bushin & Mohammad R. Seyedsayamdost Structural elucidation of a peptide natural product has revealed an unprecedented post-translational modification involving formation of a carbon–carbon bond between the side-chains of lysine and tryptophan. This motif defines a new family of cyclic peptides. Biochemical studies reveal that this C-C bond is generated by a radical SAM enzyme, and delineate its catalytic mechanism.
  • All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane

    Neil S. Keddie
    12 Apr 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2232 Authors: Neil S. Keddie, Alexandra M. Z. Slawin, Tomas Lebl, Douglas Philp & David O'Hagan The highest-energy stereoisomer of 1,2,3,4,5,6-hexafluorocyclohexane, with all the fluorines ‘up’, has been prepared in a 12-step protocol. The molecule adopts a chair conformation with three triaxial C–F bonds on one face generating a polarized ring. In the solid state the molecules pack in an orientation consistent with electrostatic ordering.
  • Reversal of Hückel (anti)aromaticity in the lowest triplet states of hexaphyrins and spectroscopic evidence for Baird's rule

    Young Mo Sung
    12 Apr 2015 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2233 Authors: Young Mo Sung, Min-Chul Yoon, Jong Min Lim, Harapriya Rath, Koji Naoda, Atsuhiro Osuka & Dongho Kim In the ground state, aromatic rings contain [4n + 2] π electrons whereas antiaromatic systems have [4n] π-electrons. Baird's rule states that this situation is reversed in the lowest triplet excited state. It has now been shown using a combination of spectroscopy and quantum chemical calculations that two closely related bis-rhodium hexaphyrins exhibit properties consistent with Baird's rule.
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    Nature Genetics - Issue - nature.com science feeds

  • ALS susceptibility genes

    Kyle Vogan
    26 Mar 2015 | 5:00 pm
    Nature Genetics 47, 311 (2015). doi:10.1038/ng.3266 Author: Kyle Vogan
  • New genomes clarify mimicry evolution

    James Mallet
    26 Mar 2015 | 5:00 pm
    Nature Genetics 47, 306 (2015). doi:10.1038/ng.3260 Author: James Mallet For over 100 years, it has been known that polymorphic mimicry is often switched by simple mendelian factors, yet the physical nature of these loci had escaped characterization. Now, the genome sequences of two swallowtail butterfly (Papilio) species have enabled the precise identification of a locus underlying mimicry, adding to unprecedented recent discoveries in mimicry genetics.
  • The two sides of GIGANTEA

    Brooke LaFlamme
    26 Mar 2015 | 5:00 pm
    Nature Genetics 47, 311 (2015). doi:10.1038/ng.3264 Author: Brooke LaFlamme
  • Transcriptional mimicry by tumor-associated stroma

    Hoon Kim
    26 Mar 2015 | 5:00 pm
    Nature Genetics 47, 307 (2015). doi:10.1038/ng.3255 Authors: Hoon Kim & Roel G W Verhaak Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.
  • CRISPR screen for metastasis

    Tiago Faial
    26 Mar 2015 | 5:00 pm
    Nature Genetics 47, 311 (2015). doi:10.1038/ng.3263 Author: Tiago Faial
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  • Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

    Javier Gutierrez-Achury
    19 Apr 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3268 Authors: Javier Gutierrez-Achury, Alexandra Zhernakova, Sara L Pulit, Gosia Trynka, Karen A Hunt, Jihane Romanos, Soumya Raychaudhuri, David A van Heel, Cisca Wijmenga & Paul I W de Bakker Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associations that account for 18% of the genetic risk.
  • COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

    Levi B Watkin
    19 Apr 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3279 Authors: Levi B Watkin, Birthe Jessen, Wojciech Wiszniewski, Timothy J Vece, Max Jan, Youbao Sha, Maike Thamsen, Regie L P Santos-Cortez, Kwanghyuk Lee, Tomasz Gambin, Lisa R Forbes, Christopher S Law, Asbjørg Stray-Pedersen, Mickie H Cheng, Emily M Mace, Mark S Anderson, Dongfang Liu, Ling Fung Tang, Sarah K Nicholas, Karen Nahmod, George Makedonas, Debra L Canter, Pui-Yan Kwok, John Hicks, Kirk D Jones, Samantha Penney, Shalini N Jhangiani, Michael D Rosenblum, Sharon D Dell, Michael R Waterfield, Feroz R Papa, Donna M Muzny, Noah Zaitlen, Suzanne M…
  • DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

    Jeremy M Rock
    19 Apr 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3269 Authors: Jeremy M Rock, Ulla F Lang, Michael R Chase, Christopher B Ford, Elias R Gerrick, Richa Gawande, Mireia Coscolla, Sebastien Gagneux, Sarah M Fortune & Meindert H Lamers The DNA replication machinery is an important target for antibiotic development in increasingly drug-resistant bacteria, including Mycobacterium tuberculosis. Although blocking DNA replication leads to cell death, disrupting the processes used to ensure replication fidelity can accelerate mutation and the evolution of drug resistance. In Escherichia coli, the proofreading…
  • Transposon mutagenesis identifies genetic drivers of BrafV600E melanoma

    Michael B Mann
    12 Apr 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3275 Authors: Michael B Mann, Michael A Black, Devin J Jones, Jerrold M Ward, Christopher Chin Kuan Yew, Justin Y Newberg, Adam J Dupuy, Alistair G Rust, Marcus W Bosenberg, Martin McMahon, Cristin G Print, Neal G Copeland & Nancy A Jenkins
  • Mutational landscape and clonal architecture in grade II and III gliomas

    Hiromichi Suzuki
    12 Apr 2015 | 5:00 pm
    Nature Genetics. doi:10.1038/ng.3273 Authors: Hiromichi Suzuki, Kosuke Aoki, Kenichi Chiba, Yusuke Sato, Yusuke Shiozawa, Yuichi Shiraishi, Teppei Shimamura, Atsushi Niida, Kazuya Motomura, Fumiharu Ohka, Takashi Yamamoto, Kuniaki Tanahashi, Melissa Ranjit, Toshihiko Wakabayashi, Tetsuichi Yoshizato, Keisuke Kataoka, Kenichi Yoshida, Yasunobu Nagata, Aiko Sato-Otsubo, Hiroko Tanaka, Masashi Sanada, Yutaka Kondo, Hideo Nakamura, Masahiro Mizoguchi, Tatsuya Abe, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Satoru Miyano, Atsushi Natsume & Seishi Ogawa
 
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    Nature Geoscience - Issue - nature.com science feeds

  • Palaeoclimate: Maritime cooling

    Alicia Newton
    30 Mar 2015 | 5:00 pm
    Nature Geoscience 8, 259 (2015). doi:10.1038/ngeo2411 Author: Alicia Newton
  • Tying down eruption risk

    Stephen Self
    30 Mar 2015 | 5:00 pm
    Nature Geoscience 8, 248 (2015). doi:10.1038/ngeo2403 Authors: Stephen Self & Ralf Gertisser 200 years after the eruption of Mount Tambora, the eruption volume remains poorly known, as is true for other volcanic eruptions over past millennia. We need better records of size and occurrence if we are to predict future large eruptions more accurately.
  • Eruption politics

    Clive Oppenheimer
    30 Mar 2015 | 5:00 pm
    Nature Geoscience 8, 244 (2015). doi:10.1038/ngeo2408 Author: Clive Oppenheimer The impact of a volcanic eruption depends on more than just its size. We need more interdisciplinary research to understand the global societal consequences of past and future volcanic eruptions.
  • Wringing food from the world

    Prabhu Pingali
    30 Mar 2015 | 5:00 pm
    Nature Geoscience 8, 252 (2015). doi:10.1038/ngeo2410 Author: Prabhu Pingali
  • The year without a summer

    J. Luterbacher
    30 Mar 2015 | 5:00 pm
    Nature Geoscience 8, 246 (2015). doi:10.1038/ngeo2404 Authors: J. Luterbacher & C. Pfister The 1815 eruption of Tambora caused an unusually cold summer in much of Europe in 1816. The extreme weather led to poor harvests and malnutrition, but also demonstrated the capability of humans to adapt and help others in worse conditions.
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  • Future productivity and carbon storage limited by terrestrial nutrient availability

    William R. Wieder
    19 Apr 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2413 Authors: William R. Wieder, Cory C. Cleveland, W. Kolby Smith & Katherine Todd-Brown The size of the terrestrial sink remains uncertain. This uncertainty presents a challenge for projecting future climate–carbon cycle feedbacks. Terrestrial carbon storage is dependent on the availability of nitrogen for plant growth, and nitrogen limitation is increasingly included in global models. Widespread phosphorus limitation in terrestrial ecosystems may also strongly regulate the global carbon cycle, but explicit considerations of phosphorus limitation…
  • Slab melting beneath the Cascade Arc driven by dehydration of altered oceanic peridotite

    K. J. Walowski
    19 Apr 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2417 Authors: K. J. Walowski, P. J. Wallace, E. H. Hauri, I. Wada & M. A. Clynne
  • Missing iris effect as a possible cause of muted hydrological change and high climate sensitivity in models

    Thorsten Mauritsen
    19 Apr 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2414 Authors: Thorsten Mauritsen & Bjorn Stevens
  • Water column methanotrophy controlled by a rapid oceanographic switch

    Lea Steinle
    19 Apr 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2420 Authors: Lea Steinle, Carolyn A. Graves, Tina Treude, Bénédicte Ferré, Arne Biastoch, Ingeborg Bussmann, Christian Berndt, Sebastian Krastel, Rachael H. James, Erik Behrens, Claus W. Böning, Jens Greinert, Célia-Julia Sapart, Markus Scheinert, Stefan Sommer, Moritz F. Lehmann & Helge Niemann Large amounts of the greenhouse gas methane are released from the seabed to the water column, where it may be consumed by aerobic methanotrophic bacteria. The size and activity of methanotrophic communities, which determine the amount of…
  • Transient liquid water and water activity at Gale crater on Mars

    F. Javier Martín-Torres
    12 Apr 2015 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2412 Authors: F. Javier Martín-Torres, María-Paz Zorzano, Patricia Valentín-Serrano, Ari-Matti Harri, Maria Genzer, Osku Kemppinen, Edgard G. Rivera-Valentin, Insoo Jun, James Wray, Morten Bo Madsen, Walter Goetz, Alfred S. McEwen, Craig Hardgrove, Nilton Renno, Vincent F. Chevrier, Michael Mischna, Rafael Navarro-González, Jesús Martínez-Frías, Pamela Conrad, Tim McConnochie, Charles Cockell, Gilles Berger, Ashwin R. Vasavada, Dawn Sumner & David Vaniman Water is a requirement for life as we know it. Indirect evidence…
 
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    Nature Medicine - AOP - nature.com science feeds

  • Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion

    Caroline Bonner
    19 Apr 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3828 Authors: Caroline Bonner, Julie Kerr-Conte, Valéry Gmyr, Gurvan Queniat, Ericka Moerman, Julien Thévenet, Cédric Beaucamps, Nathalie Delalleau, Iuliana Popescu, Willy J Malaisse, Abdullah Sener, Benoit Deprez, Amar Abderrahmani, Bart Staels & François Pattou Type 2 diabetes (T2D) is characterized by chronic hyperglycemia resulting from a deficiency in insulin signaling, because of insulin resistance and/or defects in insulin secretion; it is also associated with increases in glucagon and endogenous glucose production (EGP).
  • Homeostatic regulation of T cell trafficking by a B cell–derived peptide is impaired in autoimmune and chronic inflammatory disease

    Myriam Chimen
    19 Apr 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3842 Authors: Myriam Chimen, Helen M McGettrick, Bonita Apta, Sahithi J Kuravi, Clara M Yates, Amy Kennedy, Arjun Odedra, Mohammed Alassiri, Matthew Harrison, Ashley Martin, Francesca Barone, Saba Nayar, Jessica R Hitchcock, Adam F Cunningham, Karim Raza, Andrew Filer, David A Copland, Andrew D Dick, Joseph Robinson, Neena Kalia, Lucy S K Walker, Christopher D Buckley, Gerard B Nash, Parth Narendran & G Ed Rainger
  • Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

    Razvan Cristescu
    19 Apr 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3850 Authors: Razvan Cristescu, Jeeyun Lee, Michael Nebozhyn, Kyoung-Mee Kim, Jason C Ting, Swee Seong Wong, Jiangang Liu, Yong Gang Yue, Jian Wang, Kun Yu, Xiang S Ye, In-Gu Do, Shawn Liu, Lara Gong, Jake Fu, Jason Gang Jin, Min Gew Choi, Tae Sung Sohn, Joon Ho Lee, Jae Moon Bae, Seung Tae Kim, Se Hoon Park, Insuk Sohn, Sin-Ho Jung, Patrick Tan, Ronghua Chen, James Hardwick, Won Ki Kang, Mark Ayers, Dai Hongyue, Christoph Reinhard, Andrey Loboda, Sung Kim & Amit Aggarwal
  • Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization

    Nicolas Rama
    19 Apr 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3849 Authors: Nicolas Rama, Alexandre Dubrac, Thomas Mathivet, Róisín-Ana Ní Chárthaigh, Gael Genet, Brunella Cristofaro, Laurence Pibouin-Fragner, Le Ma, Anne Eichmann & Alain Chédotal
  • Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity

    Carolina S Ilkow
    19 Apr 2015 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3848 Authors: Carolina S Ilkow, Monique Marguerie, Cory Batenchuk, Justin Mayer, Daniela Ben Neriah, Sophie Cousineau, Theresa Falls, Victoria A Jennings, Meaghan Boileau, David Bellamy, Donald Bastin, Christiano Tanese de Souza, Almohanad Alkayyal, Jiqing Zhang, Fabrice Le Boeuf, Rozanne Arulanandam, Lawton Stubbert, Padma Sampath, Steve H Thorne, Piriya Paramanthan, Avijit Chatterjee, Robert M Strieter, Marie Burdick, Christina L Addison, David F Stojdl, Harold L Atkins, Rebecca C Auer, Jean-Simon Diallo, Brian D Lichty & John C Bell Tumors are complex…
 
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    Nature Nanotechnology - Issue - nature.com science feeds

  • Nanomaterials in art conservation

    Piero Baglioni
    8 Apr 2015 | 5:00 pm
    Nature Nanotechnology 10, 287 (2015). doi:10.1038/nnano.2015.38 Authors: Piero Baglioni, Emiliano Carretti & David Chelazzi Tackling the degradation of cultural heritage requires a global effort. We call on all material scientists to develop new nanomaterials and methods for the preservation of artwork.
  • Our choice from the recent literature

    8 Apr 2015 | 5:00 pm
    Nature Nanotechnology 10, 293 (2015). doi:10.1038/nnano.2015.80
  • Pre-market testing of nanomaterials in food is both practical and necessary

    Jeremy Tager
    8 Apr 2015 | 5:00 pm
    Nature Nanotechnology 10, 285 (2015). doi:10.1038/nnano.2015.49 Author: Jeremy Tager
  • Thank you, Royal Society

    Chris Toumey
    8 Apr 2015 | 5:00 pm
    Nature Nanotechnology 10, 291 (2015). doi:10.1038/nnano.2015.62 Author: Chris Toumey More than a decade after it was first published, Chris Toumey revisits a report from the Royal Society on the opportunities and uncertainties of nanotechnology, and finds that it still has plenty to offer.
  • Correction

    8 Apr 2015 | 5:00 pm
    Nature Nanotechnology 10, 302 (2015). doi:10.1038/nnano.2015.55
 
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    Nature Neuroscience - Issue - nature.com science feeds

  • Carrot or stick in motor learning

    Dagmar Sternad
    25 Mar 2015 | 5:00 pm
    Nature Neuroscience 18, 480 (2015). doi:10.1038/nn.3978 Authors: Dagmar Sternad & Konrad Paul Körding A study shows that reward and punishment have distinct influences on motor adaptation. Punishing mistakes accelerates adaptation, whereas rewarding good behavior improves retention.
  • Forming artificial memories during sleep

    Brigitta Gundersen
    25 Mar 2015 | 5:00 pm
    Nature Neuroscience 18, 483 (2015). doi:10.1038/nn1504-483 Author: Brigitta Gundersen
  • Cocaine shapes chromatin landscapes via Tet1

    Anne E West
    25 Mar 2015 | 5:00 pm
    Nature Neuroscience 18, 478 (2015). doi:10.1038/nn.3985 Author: Anne E West Chronic cocaine exposure induces long-lasting, transcription-dependent changes in neuronal function. A genome-wide sequencing study shows how cocaine changes the epigenome to exert specific, long-lasting effects on neuronal transcription.
  • The compass within

    Nathan W Schultheiss
    25 Mar 2015 | 5:00 pm
    Nature Neuroscience 18, 482 (2015). doi:10.1038/nn.3977 Authors: Nathan W Schultheiss & A David Redish Head direction cells have been hypothesized to form representations of an animal's spatial orientation through internal network interactions. New data from mice show the predicted signatures of these internal dynamics.
  • Sugar and Alzheimer's disease: a bittersweet truth

    Costantino Iadecola
    25 Mar 2015 | 5:00 pm
    Nature Neuroscience 18, 477 (2015). doi:10.1038/nn.3986 Author: Costantino Iadecola Reductions in brain glucose metabolism have long been associated with Alzheimer's disease. A study now demonstrates that the endothelial glucose transporter GLUT1 is vital for maintaining brain energy metabolism and vascular clearance of amyloid-β.
 
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    Nature Photonics - AOP - nature.com science feeds

  • Spontaneous mirror-symmetry breaking in coupled photonic-crystal nanolasers

    Philippe Hamel
    19 Apr 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.65 Authors: Philippe Hamel, Samir Haddadi, Fabrice Raineri, Paul Monnier, Gregoire Beaudoin, Isabelle Sagnes, Ariel Levenson & Alejandro M. Yacomotti Multi-cavity photonic systems, also known as photonic molecules, exhibit multi-well potentials that may prove useful for advanced quantum and nonlinear optics. A key phenomenon arising in double-well potentials is the spontaneous breaking of inversion symmetry, with a transition to two localized states in the wells, which are mirror images of each other. Although a few theoretical studies have…
  • Single-beam spectrally controlled two-dimensional Raman spectroscopy

    Hadas Frostig
    19 Apr 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.64 Authors: Hadas Frostig, Tim Bayer, Nirit Dudovich, Yonina C. Eldar & Yaron Silberberg
  • Controllable spatiotemporal nonlinear effects in multimode fibres

    Logan G. Wright
    12 Apr 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.61 Authors: Logan G. Wright, Demetrios N. Christodoulides & Frank W. Wise Multimode fibres are of interest for next-generation telecommunications systems and the construction of high-energy fibre lasers. However, relatively little work has explored nonlinear pulse propagation in multimode fibres. Here, we consider highly nonlinear ultrashort pulse propagation in the anomalous-dispersion regime of a graded-index multimode fibre. Low modal dispersion and strong nonlinear coupling between the fibre's many spatial modes result in interesting…
  • Quantum many-body models with cold atoms coupled to photonic crystals

    J. S. Douglas
    5 Apr 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.57 Authors: J. S. Douglas, H. Habibian, C.-L. Hung, A. V. Gorshkov, H. J. Kimble & D. E. Chang
  • Subwavelength vacuum lattices and atom–atom interactions in two-dimensional photonic crystals

    A. González-Tudela
    5 Apr 2015 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2015.54 Authors: A. González-Tudela, C.-L. Hung, D. E. Chang, J. I. Cirac & H. J. Kimble
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    Nature Physics - Issue - nature.com science feeds

  • On the interface of it

    Bart Verberck
    1 Apr 2015 | 5:00 pm
    Nature Physics 11, 297 (2015). doi:10.1038/nphys3307 Author: Bart Verberck
  • To pinch a cloud

    May Chiao
    1 Apr 2015 | 5:00 pm
    Nature Physics 11, 297 (2015). doi:10.1038/nphys3305 Author: May Chiao
  • Read the fine print

    Scott Aaronson
    1 Apr 2015 | 5:00 pm
    Nature Physics 11, 291 (2015). doi:10.1038/nphys3272 Author: Scott Aaronson New quantum algorithms promise an exponential speed-up for machine learning, clustering and finding patterns in big data. But to achieve a real speed-up, we need to delve into the details.
  • Head first

    Abigail Klopper
    1 Apr 2015 | 5:00 pm
    Nature Physics 11, 297 (2015). doi:10.1038/nphys3309 Author: Abigail Klopper
  • Quantum optics route to market

    Jürgen Stuhler
    1 Apr 2015 | 5:00 pm
    Nature Physics 11, 293 (2015). doi:10.1038/nphys3292 Author: Jürgen Stuhler Research in quantum optics has already led to commercial technologies, but the gap between the lab and market products is still large. Looking from the industrial side, one can see ways of bridging this gap.
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    Nature Physics - AOP - nature.com science feeds

  • Surface electron perturbations and the collective behaviour of atoms adsorbed on a cylinder

    Boris Dzyubenko
    19 Apr 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3302 Authors: Boris Dzyubenko, Hao-Chun Lee, Oscar E. Vilches & David H. Cobden A single-walled carbon nanotube presents a seamless cylindrical graphene surface and is thus an ideal adsorption substrate for investigating the physics of atoms and molecules in two dimensions and approaching the one-dimensional limit. When a suspended nanotube is made into a transistor, frequency shifts of its mechanical resonances allow precise measurement of the adsorbed mass down to the single-atom level. Here we show that its electrical characteristics are also modified…
  • Persistence of magnetic field driven by relativistic electrons in a plasma

    A. Flacco
    19 Apr 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3303 Authors: A. Flacco, J. Vieira, A. Lifschitz, F. Sylla, S. Kahaly, M. Veltcheva, L. O. Silva & V. Malka The onset and evolution of magnetic fields in laboratory and astrophysical plasmas is determined by several mechanisms, including instabilities, dynamo effects and ultrahigh-energy particle flows through gas, plasma and interstellar media. These processes are relevant over a wide range of conditions, from cosmic ray acceleration and gamma ray bursts to nuclear fusion in stars. The disparate temporal and spatial scales where each process operates can…
  • Direct measurements of growing amorphous order and non-monotonic dynamic correlations in a colloidal glass-former

    K. Hima Nagamanasa
    12 Apr 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3289 Authors: K. Hima Nagamanasa, Shreyas Gokhale, A. K. Sood & Rajesh Ganapathy The transformation of flowing liquids into rigid glasses is thought to involve increasingly cooperative relaxation dynamics as the temperature approaches that of the glass transition. However, the precise nature of this motion is unclear, and a complete understanding of vitrification thus remains elusive. Of the numerous theoretical perspectives devised to explain the process, random first-order theory (RFOT; refs , ) is a well-developed thermodynamic approach, which…
  • Amorphous solids: Glasses pinned down

    Eric R. Weeks
    12 Apr 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3316 Author: Eric R. Weeks Laser tweezers can be used to control particles in a colloidal glass, thereby influencing the dynamics of their neighbours. The range of this influence — and how it changes — may provide a structural mechanism to explain the solidity of glasses.
  • Broadband magnetometry and temperature sensing with a light-trapping diamond waveguide

    Hannah Clevenson
    5 Apr 2015 | 5:00 pm
    Nature Physics. doi:10.1038/nphys3291 Authors: Hannah Clevenson, Matthew E. Trusheim, Carson Teale, Tim Schröder, Danielle Braje & Dirk Englund Solid-state quantum sensors are attracting wide interest because of their sensitivity at room temperature. In particular, the spin properties of individual nitrogen–vacancy (NV) colour centres in diamond make them outstanding nanoscale sensors of magnetic fields, electric fields and temperature under ambient conditions. Recent work on NV ensemble-based magnetometers, inertial sensors, and clocks has employed unentangled colour centres…
 
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    Nature Reviews Drug Discovery - Issue - nature.com science feeds

  • AbbVie pays $21 billion for Pharmacyclics' BTK inhibitor

    Asher Mullard
    31 Mar 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 227 (2015). doi:10.1038/nrd4605 Author: Asher Mullard When the US Food and Drug Administration approved Pharmacyclics' Bruton tyrosine kinase (BTK) inhibitor ibrutinib in November 2013, just 3 short years after it had entered into clinical testing, it was clear the small molecule was destined for a big future. AbbVie's purchase of Pharmacyclics
  • The Roadmap Epigenomics Project opens new drug development avenues

    Asher Mullard
    31 Mar 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 223 (2015). doi:10.1038/nrd4582 Author: Asher Mullard The US National Institutes of Health's US$240-million epigenomics investment could improve the study of disease biology, the identification of new drug targets, the validation of animal models and more.
  • Oral GLP1 analogue rounds Phase II corner

    Asher Mullard
    31 Mar 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 227 (2015). doi:10.1038/nrd4607 Author: Asher Mullard Novo Nordisk's oral formulation of semaglutide met its primary end point in a Phase II trial, suggesting changes could be coming for the increasingly crowded antidiabetic glucagon-like peptide 1 (GLP1) drug class.The US Food and Drug Administration approved AstraZeneca's first-in-class GLP1 analogue exenatide for
  • HDAC inhibitors still need a home run, despite recent approval

    Malini Guha
    31 Mar 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 225 (2015). doi:10.1038/nrd4583 Author: Malini Guha A beleaguered class of epigenetic modulators continues to struggle for oncology success, but new insights into their mechanisms in cancer may yet offer hope.
  • Industry head-to-head trials favour sponsor

    Asher Mullard
    31 Mar 2015 | 5:00 pm
    Nature Reviews Drug Discovery 14, 227 (2015). doi:10.1038/nrd4606 Author: Asher Mullard With payers increasingly pushing back against high drug prices, head-to-head trials provide one way to prove the value of a new drug. An analysis by Stanford's John Ioannidis and colleagues now shows, however, that not all head-to-head trials are created equal. Key differences in trial
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Model organisms: 100 S. cerevisiae genomes

    Orli G. Bahcall
    16 Apr 2015 | 5:00 pm
    Nature Reviews Genetics 16, 257 (2015). doi:10.1038/nrg3948 Author: Orli G. Bahcall Strope et al. present a new “100-genomes” strains resource for the model organism Saccharomyces cerevisiae. For a selected 93 strains, representing a diversity of geographical and environmental origins, the authors report whole-genome sequencing, de novo assembly and manual annotation to near-reference quality.
  • Population genomics: Population-scale sequencing in Iceland

    Orli G. Bahcall
    16 Apr 2015 | 5:00 pm
    Nature Reviews Genetics 16, 257 (2015). doi:10.1038/nrg3946 Author: Orli G. Bahcall The largest genome sequencing effort for a single population is reported in a focus issue of Nature Genetics (http://www.nature.com/ng/focus/icelanders/index.html). The research included whole-genome sequencing of 2,636 individuals from Iceland, as well as characterization of patterns of genetic variation, population structure, mutation rate
  • Clinical genetics: Sequencing for tailored melanoma immunotherapy

    Bryony Jones
    16 Apr 2015 | 5:00 pm
    Nature Reviews Genetics 16, 259 (2015). doi:10.1038/nrg3945 Author: Bryony Jones Missense mutations that cause amino acid substitutions in tumours can be recognized as foreign by the immune system, thereby initiating a tumour-specific T cell response. In a new approach to melanoma treatment, sequencing has been used to identify specific antigens that are expressed in patients'
  • The big medical data miss: challenges in establishing an open medical resource

    Eric J. Topol
    16 Apr 2015 | 5:00 pm
    Nature Reviews Genetics 16, 253 (2015). doi:10.1038/nrg3943 Author: Eric J. Topol I call for an international open medical resource to provide a database for every individual's genomic, metabolomic, microbiomic, epigenomic and clinical information. This resource is needed in order to facilitate genetic diagnoses and transform medical care.
  • DNA elements: Shaping up transcription factor binding

    Darren J. Burgess
    16 Apr 2015 | 5:00 pm
    Nature Reviews Genetics 16, 258 (2015). doi:10.1038/nrg3944 Author: Darren J. Burgess DNA-binding proteins such as transcription factors typically display binding specificity for particular DNA sequence contexts. As the DNA sequence intrinsically influences the shape of the DNA double helix, it has been challenging to dissect the extent to which preferred binding sequences are a result of
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Neutrophils: New sensor of bacterial DNA

    Elisabeth Kugelberg
    24 Mar 2015 | 5:00 pm
    Nature Reviews Immunology 15, 200 (2015). doi:10.1038/nri3840 Author: Elisabeth Kugelberg The transcription factor SOX2 detects bacterial DNA in neutrophils, which leads to the activation of pro-inflammatory cytokines.
  • Neonatal immunity: Fetal immune repertoire

    Olive Leavy
    24 Mar 2015 | 5:00 pm
    Nature Reviews Immunology 15, 201 (2015). doi:10.1038/nri3841 Author: Olive Leavy Determining the ontogeny of the human fetal adaptive immune system has important implications for defining the infectious risk of prematurely born infants. However, due to technical limitations, little is known about the full diversity of the fetal immune repertoire. In this study, the authors used
  • Neuroimmunology: TREM2 in Alzheimer disease

    Olive Leavy
    24 Mar 2015 | 5:00 pm
    Nature Reviews Immunology 15, 201 (2015). doi:10.1038/nri3842 Author: Olive Leavy Several variants in TREM2 (triggering receptor expressed on myeloid cells 2), including an Arg47His mutation, are associated with increased risk of Alzheimer disease (AD). Two recent papers have examined the effect of Trem2 deficiency in mouse models of AD (APP/PS1 and 5XFAD mice)
  • Regulation of antiviral T cell responses by type I interferons

    Josh Crouse
    19 Mar 2015 | 5:00 pm
    Nature Reviews Immunology 15, 231 (2015). doi:10.1038/nri3806 Authors: Josh Crouse, Ulrich Kalinke & Annette Oxenius Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different cell types during viral infections. The consequences of type I IFN signalling include direct antiviral activity, innate immune cell activation and regulation of adaptive immune responses. In this Review, we discuss recent
  • HIV: On the road to an HIV vaccine?

    Olive Leavy
    19 Mar 2015 | 5:00 pm
    Nature Reviews Immunology 15, 202 (2015). doi:10.1038/nri3836 Author: Olive Leavy A new construct termed eCD4-Ig neutralizes all tested HIV isolates and protects macaques from multiple SHIV challenges.
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Bacterial genetics: Pneumococci switch it up

    Andrea Du Toit
    15 Apr 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 251 (2015). doi:10.1038/nrmicro3484 Author: Andrea Du Toit Streptococcus pneumoniae isolates express one of more than 90 polysaccharide capsule variants (known as serotypes, which can be further classified into serogroups) that are the target of current vaccines. However, bacteria can change their serotype through recombination to evade vaccine-induced immunity. Croucher et al
  • Structural biology: Where to make the cut

    Andrea Du Toit
    15 Apr 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 251 (2015). doi:10.1038/nrmicro3483 Author: Andrea Du Toit The CRISPR–Cas system is an archaeal and bacterial adaptive immune system that provides sequence-specific defence against foreign nucleic acids. Whereas type I and type II systems recognize and cleave double-stranded DNA, the type III complex (known as Cmr) targets single-stranded RNA (ssRNA), and comprises six
  • Living in the matrix: assembly and control of Vibrio cholerae biofilms

    Jennifer K. Teschler
    15 Apr 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 255 (2015). doi:10.1038/nrmicro3433 Authors: Jennifer K. Teschler, David Zamorano-Sánchez, Andrew S. Utada, Christopher J. A. Warner, Gerard C. L. Wong, Roger G. Linington & Fitnat H. Yildiz Nearly all bacteria form biofilms as a strategy for survival and persistence. Biofilms are associated with biotic and abiotic surfaces and are composed of aggregates of cells that are encased by a self-produced or acquired extracellular matrix. Vibrio cholerae has been studied as a
  • Archaeal genetics: Increasing diversity

    Andrea Du Toit
    15 Apr 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 251 (2015). doi:10.1038/nrmicro3482 Author: Andrea Du Toit Diversity-generating retroelements (DGRs) facilitate the rapid diversification of DNA sequences through a process involving reverse transcription and retrohoming, which generates multiple variants of a target gene. To date, DGRs have only been identified in bacteria and bacteriophages, but Paul et al. now report the
  • An evolutionary link between capsular biogenesis and surface motility in bacteria

    Rym Agrebi
    15 Apr 2015 | 5:00 pm
    Nature Reviews Microbiology 13, 318 (2015). doi:10.1038/nrmicro3431 Authors: Rym Agrebi, Morgane Wartel, Céline Brochier-Armanet & Tâm Mignot Studying the evolution of macromolecular assemblies is important to improve our understanding of how complex cellular structures evolved, and to identify the functional building blocks that are involved. Recent studies suggest that the macromolecular complexes that are involved in two distinct processes in Myxococcus xanthus
 
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Astrocyte barriers to neurotoxic inflammation

    Michael V. Sofroniew
    19 Apr 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 249 (2015). doi:10.1038/nrn3898 Author: Michael V. Sofroniew Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function studies reveal that astrocyte borders and scars serve as functional barriers that restrict the entry of inflammatory cells into CNS parenchyma in
  • Stress and the social brain: behavioural effects and neurobiological mechanisms

    Carmen Sandi
    19 Apr 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 290 (2015). doi:10.1038/nrn3918 Authors: Carmen Sandi & József Haller Stress often affects our social lives. When undergoing high-level or persistent stress, individuals frequently retract from social interactions and become irritable and hostile. Predisposition to antisocial behaviours — including social detachment and violence — is also modulated by early life adversity; however, the effects of
  • Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy

    Ivan Soltesz
    19 Apr 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 264 (2015). doi:10.1038/nrn3937 Authors: Ivan Soltesz, Bradley E. Alger, Masanobu Kano, Sang-Hun Lee, David M. Lovinger, Takako Ohno-Shosaku & Masahiko Watanabe Endocannabinoids are lipid-derived messengers, and both their synthesis and breakdown are under tight spatiotemporal regulation. As retrograde signalling molecules, endocannabinoids are synthesized postsynaptically but activate presynaptic cannabinoid receptor 1 (CB1) receptors to inhibit neurotransmitter release. In turn, CB1-expressing inhibitory and excitatory synapses act as strategically
  • Neurogenesis: Support from the cortex

    Fiona Carr
    14 Apr 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 248 (2015). doi:10.1038/nrn3958 Author: Fiona Carr Adult neurogenesis is supported by the vasculature, but the contribution of different vascular cell types to this support is not clear. Here, the authors found that both pericytes and endothelial cells from the mouse ventricular–subventricular zone (V–SVZ), a key neurogenic niche, promoted proliferation and differentiation
  • Myelination: Promoting polarity

    Fiona Carr
    14 Apr 2015 | 5:00 pm
    Nature Reviews Neuroscience 16, 248 (2015). doi:10.1038/nrn3960 Author: Fiona Carr Oligodendrocytes change shape during myelination, suggesting that correct modulation of cell polarity is essential to their function. Jarjour et al. showed that the protein Scribble, an evolutionarily conserved regulator of cell polarity, is increased in mouse oligodendrocytes as they differentiate. Oligodendrocyte-specific deletion of the
 
 
 
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    Nature Reviews Urology - Issue - nature.com science feeds

  • The inconspicuous penis in children

    Marcello Cimador
    6 Apr 2015 | 5:00 pm
    Nature Reviews Urology 12, 205 (2015). doi:10.1038/nrurol.2015.49 Authors: Marcello Cimador, Pieralba Catalano, Rita Ortolano & Mario Giuffrè The term 'inconspicuous penis' refers to a group of anatomical abnormalities in which the penis looks smaller than is expected. Micropenis can be defined as 'true micropenis'—which results from a defect in the hypothalamic–pituitary–gonadal axis—and 'micropenis secondary to congenital anatomical anomalies of the surrounding and
  • Synergistic action of image-guided radiotherapy and androgen deprivation therapy

    Jennifer A. Locke
    23 Mar 2015 | 5:00 pm
    Nature Reviews Urology 12, 193 (2015). doi:10.1038/nrurol.2015.50 Authors: Jennifer A. Locke, Alan Dal Pra, Stéphane Supiot, Padraig Warde & Robert G. Bristow The combined use of androgen deprivation therapy (ADT) and image-guided radiotherapy (IGRT) can improve overall survival in aggressive, localized prostate cancer. However, owing to the adverse effects of prolonged ADT, it is imperative to identify the patients who would benefit from this combined-modality therapy relative
  • Robotic pelvic organ prolapse surgery

    Kamran P. Sajadi
    23 Mar 2015 | 5:00 pm
    Nature Reviews Urology 12, 216 (2015). doi:10.1038/nrurol.2015.51 Authors: Kamran P. Sajadi & Howard B. Goldman Robotic sacrocolpopexy (RSC) has rapidly gained popularity over the past 10 years, owing to claims that it is associated with a reduced learning curve compared with standard laparoscopic sacrocolpopexy (LSC) and that it has equal efficacy to the gold-standard treatment, abdominal sacrocolpopexy (ASC). The specifics
  • Regenerative medicine: Rapid 3D bladder model engineering

    Clemens Thoma
    23 Mar 2015 | 5:00 pm
    Nature Reviews Urology 12, 178 (2015). doi:10.1038/nrurol.2015.60 Author: Clemens Thoma A new tissue-engineering method using submerged-culture conditions yields 3D bladder constructs that share histological and functional properties with native bladder within 15 days.In their study, the team of researchers from the Université Lavale in Québec, Canada, used a four-step production process. First, porcine bladder
  • Expert consensus document: Consensus statement on best practice management regarding the use of intravesical immunotherapy with BCG for bladder cancer

    Ashish M. Kamat
    23 Mar 2015 | 5:00 pm
    Nature Reviews Urology 12, 225 (2015). doi:10.1038/nrurol.2015.58 Authors: Ashish M. Kamat, Thomas W. Flaig, H. Barton Grossman, Badrinath Konety, Donald Lamm, Michael A. O'Donnell, Edward Uchio, Jason A. Efstathiou & John A. Taylor Multiple clinical trials have demonstrated that intravesical Bacillus Calmette–Guérin (BCG) treatment reduces recurrences and progression in patients with non-muscle-invasive bladder cancer (NMIBC). However, although BCG has been in use for almost 40 years, this agent is often underutilized and practice patterns of administration vary. This
 
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    Naturejobs - Search results

  • Associate Professor (Reader)/Professor in Medical Statistics

    21 Apr 2015 | 4:14 am
    Plymouth University Peninsula Schools of Medicine and Dentistry Institute of Translational & Stratified Medicine Associate Professor (Reader)/Professor in Medical Statistics Salary: Senior Management Payscale Ref: A4224 Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD) is seeking to appoint an outstanding individual to lead our existing Biostatistics, Bioinformatics and Biomarkers group. PU PSMD is committed to exceptional clinical learning, strong social engag…
  • Associate Professor in Economics and Policy in Global Development

    21 Apr 2015 | 2:40 am
    Associate Professor in Economics and Policy in Global DevelopmentDepartment of Food and Resource Economics Faculty of ScienceUniversity of Copenhagen The Department of Food and Resource Economics, University of Copenhagen, invites applicants for a position as associate professor in the field related to economics of development.We are looking for scholars to complement the Department’s research profile within the areas of Global Development and Environmental Economics and Policy….
  • Associate Professor in Development and Resource Governance, Institutions and Conflict

    21 Apr 2015 | 2:34 am
    Associate Professor in Development and Resource Governance, Institutions and Conflict Department of Food and Resource Economics Faculty of Science University of CopenhagenThe Department of Food and Resource Economics, University of Copenhagen, invites applicants for a position as Associate Professor in the field of Development and Resource Governance, Institutions and Conflict. We are looking for a researcher to complement the research profile of the Global Development Section. T…
  • Scientific Programmer "PDB-SAS"

    21 Apr 2015 | 12:20 am
    Job Description We are seeking to recruit an experienced Scientific Programmer to work on the incorporation of small-angle scattering (SAS) data into the wwPDB Deposition and Annotation system and on dissemination of SAS data through the PDBe website. The project will involve extensive collaboration with the wwPDB partners, members of the wwPDB SAS Task Force and the wider community and is based at the European Bioinformatics Institute (EMBL-EBI) located on the Wellcome Trust Genome Campus n...
  • Scientific Curator

    21 Apr 2015 | 12:20 am
    Job Description We are looking to recruit an experienced and motivated Scientific Curator to join the ArrayExpress/Expression Atlas content team.  You will be working with various production databases including ArrayExpress and Expression Atlas. The team is part of the Functional Genomics group within the European Molecular Biology Laboratory  - European Bioinformatics Institute (EMBL-EBI) located on the Wellcome Trust Genome Campus near Cambridge in the UK. The post holder will participate ...
 
 
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    British Journal of Pharmacology

  • Transparency in Research involving Animals: The Basel Declaration and new principles for reporting research in BJP manuscripts

    John C McGrath, Elspeth M McLachlan, Rolf Zeller
    21 Apr 2015 | 3:07 am
    This article discusses the background to the need for change in the reporting of experiments involving animals, including a report of a consensus meeting organised by the Basel Declaration Society and Understanding Animal Research UK that sought to Internationalise guidelines for reporting experiments involving animals. A commentary on the evolution of BJP's attempts to implement the ARRIVE guidelines and details of our new guidance for authors is published separately (McGrath, 2014).This is one of a series of editorials discussing updates to the BJP Instructions to Authors Linked…
  • Issue Information

    21 Apr 2015 | 3:07 am
  • Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells

    Wing S. To, Susan R. Aungier, Alison Cartwright, Kazuhiro Ito, Kim S. Midwood
    17 Apr 2015 | 3:05 am
    Summary Background and PurposeTo investigate whether a narrow spectrum kinase inhibitor (NSKI), RV1088, which simultaneously targets selected MAPKs, Src and Syk, is more effective at inhibiting inflammatory signalling in rheumatoid arthritis (RA) than single kinase inhibitors (SKIs). Experimental approachELISAs were used to determine the efficacy of RV1088, clinically relevant SKIs and the biologic, Humira, on pro-inflammatory cytokine production by activated RA synovial fibroblasts, primary human monocytes and macrophages, as well as spontaneous cytokine synthesis by synovial membrane cells…
  • The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors

    K W Andressen, O Manfra, C H Brevik, A H Ulsund, P Vanhoenacker, F O Levy, K A Krobert
    17 Apr 2015 | 3:01 am
    Summary Background and purposeClassically, ligands of G-protein-coupled receptors have been classified primarily upon their affinity and efficacy to activate a signal transduction pathway. Recent reports indicate that the efficacy of a particular ligand can vary depending on the receptor-mediated response measured (e.g. activating G proteins, other down-stream responses, internalization). Previously, we have reported that inverse agonists induce both homo- and heterologous desensitization, similar to agonist-stimulation, at the Gs-coupled 5-HT7 receptor. The primary objective of this study…
  • Rapamycin impaired HPD-induced beneficial effects on glucose homeostasis

    Geng-Ruei Chang, Yi-Shin Chiu, Ying-Ying Wu, Yu-Chi Lin, Po-Hsun Hou, Frank Chiahung Mao
    17 Apr 2015 | 3:01 am
    Abstract BACKGROUND AND PURPOSERapamycin (RAPA), clinically used to treat graft rejection, has also been proposed to have an effect on metabolic syndrome; however, very little information is available on its role in lean animals/human. The purpose of this study was to characterize further the effects of continual use of rapamycin on glucose homeostasis in lean C57BL6/J mice. EXPERIMENTAL APPROACHMice were fed with a high protein diet (HPD) for 12 weeks to develop a lean model, and then they were treated daily with RAPA for 5 weeks while remaining on a HPD. Metabolic parameters, endocrine…
 
 
 
 
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    European Journal of Human Genetics - AOP - nature.com science feeds

  • Clinical Utility Gene Card for: autosomal recessive cone-rod dystrophy

    Maria Pia Manitto
    14 Apr 2015 | 5:00 pm
    Clinical Utility Gene Card for: autosomal recessive cone-rod dystrophy European Journal of Human Genetics advance online publication, April 15 2015. doi:10.1038/ejhg.2015.67 Authors: Maria Pia Manitto, Susanne Roosing, Camiel J F Boon, Eric H Souied, Francesco Bandello & Giuseppe Querques
  • Regulating biobanking with children’s tissue: a legal analysis and the experts’ view

    Elcke J Kranendonk
    14 Apr 2015 | 5:00 pm
    Regulating biobanking with children’s tissue: a legal analysis and the experts’ view European Journal of Human Genetics advance online publication, April 15 2015. doi:10.1038/ejhg.2015.59 Authors: Elcke J Kranendonk, M Corrette Ploem & Raoul C M Hennekam
  • Collapsed haplotype pattern method for linkage analysis of next-generation sequence data

    Gao T Wang
    14 Apr 2015 | 5:00 pm
    Collapsed haplotype pattern method for linkage analysis of next-generation sequence data European Journal of Human Genetics advance online publication, April 15 2015. doi:10.1038/ejhg.2015.64 Authors: Gao T Wang, Di Zhang, Biao Li, Hang Dai & Suzanne M Leal
  • Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

    Stéphanie Baert-Desurmont
    14 Apr 2015 | 5:00 pm
    Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk European Journal of Human Genetics advance online publication, April 15 2015. doi:10.1038/ejhg.2015.72 Authors: Stéphanie Baert-Desurmont, Françoise Charbonnier, Estelle Houivet, Lorena Ippolito, Jacques Mauillon, Marion Bougeard, Caroline Abadie, David Malka, Jacqueline Duffour, Françoise Desseigne, Chrystelle Colas, Pascal Pujol, Sophie Lejeune, Catherine Dugast, Bruno Buecher, Laurence Faivre, Dominique Leroux, Paul Gesta, Isabelle Coupier, Rosine Guimbaud, Pascaline Berthet, Sylvie…
  • Association of mutations in FLNA with craniosynostosis

    Nathalie Fennell
    14 Apr 2015 | 5:00 pm
    Association of mutations in FLNA with craniosynostosis European Journal of Human Genetics advance online publication, April 15 2015. doi:10.1038/ejhg.2015.31 Authors: Nathalie Fennell, Nicola Foulds, Diana S Johnson, Louise C Wilson, Michelle Wyatt, Stephen P Robertson, David Johnson, Steven A Wall & Andrew OM Wilkie
 
 
 
 
 
 
 
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    Journal of Human Genetics

  • Polymorphisms in DCDC2 and S100B associate with developmental dyslexia

    Hans Matsson
    15 Apr 2015 | 5:00 pm
    Polymorphisms in DCDC2 and S100B associate with developmental dyslexia Journal of Human Genetics advance online publication, April 16 2015. doi:10.1038/jhg.2015.37 Authors: Hans Matsson, Mikael Huss, Helena Persson, Elisabet Einarsdottir, Ettore Tiraboschi, Jaana Nopola-Hemmi, Johannes Schumacher, Nina Neuhoff, Andreas Warnke, Heikki Lyytinen, Gert Schulte-Körne, Markus M Nöthen, Paavo HT Leppänen, Myriam Peyrard-Janvid & Juha Kere
  • Associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic in the residents exposed to low-level arsenic in drinking water in China

    Jinyou Yang
    15 Apr 2015 | 5:00 pm
    Associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic in the residents exposed to low-level arsenic in drinking water in China Journal of Human Genetics advance online publication, April 16 2015. doi:10.1038/jhg.2015.39 Authors: Jinyou Yang, Li Yan, Min Zhang, Yijun Wang, Chun Wang & Quanyong Xiang
  • A dual origin of Tibetans: evidence from mitochondrial genomes

    Yu-Chun Li
    15 Apr 2015 | 5:00 pm
    A dual origin of Tibetans: evidence from mitochondrial genomes Journal of Human Genetics advance online publication, April 16 2015. doi:10.1038/jhg.2015.40 Authors: Yu-Chun Li, Jiao-Yang Tian & Qing-Peng Kong
  • Biotin-responsive basal ganglia disease: a case diagnosed by whole exome sequencing

    Kensaku Kohrogi
    15 Apr 2015 | 5:00 pm
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