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  • A critique of methods for temperature imaging in single cells

    Nature Methods - Issue - nature.com science feeds
    Guillaume Baffou
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 899 (2014). doi:10.1038/nmeth.3073 Authors: Guillaume Baffou, Hervé Rigneault, Didier Marguet & Ludovic Jullien We argue that standard thermodynamic considerations and scaling laws show that a single cell cannot substantially raise its temperature by endogenous thermogenesis. This statement seriously questions the interpretations of recent work reporting temperature heterogeneities measured in single living cells.
  • Virology: Polio killed the vaccinated

    Nature - Issue - nature.com science feeds
    26 Aug 2014 | 5:00 pm
    Virology: Polio killed the vaccinated Nature 512, 7515 (2014). doi:10.1038/512351c The poliovirus strain that caused an outbreak in the Republic of the Congo in 2010 is able to resist the immune responses generated by a commonly used vaccine. The finding could explain why the outbreak, which killed nearly half of the 445 people infected, was
  • Bidirectional switch of the valence associated with a hippocampal contextual memory engram

    Nature - AOP - nature.com science feeds
    Roger L. Redondo
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13725 Authors: Roger L. Redondo, Joshua Kim, Autumn L. Arons, Steve Ramirez, Xu Liu & Susumu Tonegawa The valence of memories is malleable because of their intrinsic reconstructive property. This property of memory has been used clinically to treat maladaptive behaviours. However, the neuronal mechanisms and brain circuits that enable the switching of the valence of memories remain largely unknown. Here we investigated these mechanisms by applying the recently developed memory engram cell- manipulation technique. We…
  • A global strategy for road building

    Nature - AOP - nature.com science feeds
    William F. Laurance
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13717 Authors: William F. Laurance, Gopalasamy Reuben Clements, Sean Sloan, Christine S. O’Connell, Nathan D. Mueller, Miriam Goosem, Oscar Venter, David P. Edwards, Ben Phalan, Andrew Balmford, Rodney Van Der Ree & Irene Burgues Arrea The number and extent of roads will expand dramatically this century. Globally, at least 25 million kilometres of new roads are anticipated by 2050; a 60% increase in the total length of roads over that in 2010. Nine-tenths of all road construction is expected to occur in developing…
  • Cost to control Ebola shoots up

    NatureNews - Most recent articles - nature.com science feeds
    Sara Reardon
    27 Aug 2014 | 5:00 pm
    World Health Organization projects 20,000 deaths and requests $490 million to control epidemic.Nature News doi: 10.1038/nature.2014.15790
 
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    Nature - Issue - nature.com science feeds

  • People power

    26 Aug 2014 | 5:00 pm
    People power Nature 512, 7515 (2014). doi:10.1038/512347b Climate models must consider how humans are responding to a warming world.
  • Bold moves

    Peter Fiske
    26 Aug 2014 | 5:00 pm
    Bold moves Nature 512, 7515 (2014). doi:10.1038/nj7515-457a Author: Peter Fiske People seeking non-academic jobs may need to try something unexpected to be noticed, says Peter Fiske.
  • Virology: Polio killed the vaccinated

    26 Aug 2014 | 5:00 pm
    Virology: Polio killed the vaccinated Nature 512, 7515 (2014). doi:10.1038/512351c The poliovirus strain that caused an outbreak in the Republic of the Congo in 2010 is able to resist the immune responses generated by a commonly used vaccine. The finding could explain why the outbreak, which killed nearly half of the 445 people infected, was
  • Marine ecology: Sick reefs repel young coral

    26 Aug 2014 | 5:00 pm
    Marine ecology: Sick reefs repel young coral Nature 512, 7515 (2014). doi:10.1038/512350a Coral larvae actively avoid the smell of degraded marine ecosystems — potentially impeding efforts to rebuild damaged reefs.Mark Hay at the Georgia Institute of Technology in Atlanta and his team studied coral reefs near Fiji (pictured). They focused on the behaviour of coral larvae
  • Seven days: 22–28 August 2014

    26 Aug 2014 | 5:00 pm
    Seven days: 22–28 August 2014 Nature 512, 7515 (2014). http://www.nature.com/doifinder/10.1038/512352a The week in science: Botched launch for Europe’s GPS satellites; Iran’s science minister dismissed; and marmosets judged best model for MERS virus.
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  • A global strategy for road building

    William F. Laurance
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13717 Authors: William F. Laurance, Gopalasamy Reuben Clements, Sean Sloan, Christine S. O’Connell, Nathan D. Mueller, Miriam Goosem, Oscar Venter, David P. Edwards, Ben Phalan, Andrew Balmford, Rodney Van Der Ree & Irene Burgues Arrea The number and extent of roads will expand dramatically this century. Globally, at least 25 million kilometres of new roads are anticipated by 2050; a 60% increase in the total length of roads over that in 2010. Nine-tenths of all road construction is expected to occur in developing…
  • OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis

    Fang Yuan
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13593 Authors: Fang Yuan, Huimin Yang, Yan Xue, Dongdong Kong, Rui Ye, Chijun Li, Jingyuan Zhang, Lynn Theprungsirikul, Tayler Shrift, Bryan Krichilsky, Douglas M. Johnson, Gary B. Swift, Yikun He, James N. Siedow & Zhen-Ming Pei Water is crucial to plant growth and development. Environmental water deficiency triggers an osmotic stress signalling cascade, which induces short-term cellular responses to reduce water loss and long-term responses to remodel the transcriptional network and physiological and developmental…
  • Sensory systems: Sound processing takes motor control

    Uri Livneh
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13658 Authors: Uri Livneh & Anthony Zador Neurons linking the brain region that controls movement to the region involved in auditory control have been found to suppress auditory responses when mice move, but the reason for this inhibition is unclear.
  • Bidirectional switch of the valence associated with a hippocampal contextual memory engram

    Roger L. Redondo
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13725 Authors: Roger L. Redondo, Joshua Kim, Autumn L. Arons, Steve Ramirez, Xu Liu & Susumu Tonegawa The valence of memories is malleable because of their intrinsic reconstructive property. This property of memory has been used clinically to treat maladaptive behaviours. However, the neuronal mechanisms and brain circuits that enable the switching of the valence of memories remain largely unknown. Here we investigated these mechanisms by applying the recently developed memory engram cell- manipulation technique. We…
  • Sustainable Development: The promise and perils of roads

    Stephen G. Perz
    26 Aug 2014 | 5:00 pm
    Nature advance online publication 27 August 2014. doi:10.1038/nature13744 Author: Stephen G. Perz A global map of the potential economic benefits of roads together with the environmental damage they can inflict provides a planning tool for sustainable development.
 
 
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    Nature Chemistry

  • Blogroll: Life in the lab

    Matthew Hartings
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 755 (2014). doi:10.1038/nchem.2036 Author: Matthew Hartings
  • Carboboration: Addition to alkynoates

    Stephen Davey
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 754 (2014). doi:10.1038/nchem.2051 Author: Stephen Davey
  • An ode to the atomic weights

    Juris Meija
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 749 (2014). doi:10.1038/nchem.2047 Author: Juris Meija They might not be fundamental constants of nature, but atomic weights are one of the foundations on which modern chemistry is built, explains Juris Meija.
  • Enzyme catalysis: Evolution made easy

    Eugene J. H. Wee
    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 756 (2014). doi:10.1038/nchem.2046 Authors: Eugene J. H. Wee & Matt Trau Directed evolution is a powerful tool for the development of improved enzyme catalysts. Now, a method that enables an enzyme, its encoding DNA and a fluorescent reaction product to be encapsulated in a gel bead enables the application of directed evolution in an ultra-high-throughput format.
  • The chemists behind the crystals

    20 Aug 2014 | 5:00 pm
    Nature Chemistry 6, 751 (2014). doi:10.1038/nchem.2033 Benjamin King and Dieter Schlüter, the corresponding authors of two Articles in this issue that describe single-crystal characterization of two-dimensional polymers, talk to Nature Chemistry about the background, challenges and prospects of their work.
 
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    Nature Chemistry

  • Efficient discovery of bioactive scaffolds by activity-directed synthesis

    George Karageorgis
    23 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2034 Authors: George Karageorgis, Stuart Warriner & Adam Nelson A discovery approach termed activity-directed synthesis is described; it exploits arrays of reactions whose outcome is critically dependent on the conditions used, and prioritizes reactions that yield bioactive product mixtures. The discovery of both bioactive small molecules and associated synthetic routes thus occurs in parallel.
  • Electron transfer through rigid organic molecular wires enhanced by electronic and electron–vibration coupling

    Junpei Sukegawa
    23 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2026 Authors: Junpei Sukegawa, Christina Schubert, Xiaozhang Zhu, Hayato Tsuji, Dirk M. Guldi & Eiichi Nakamura The relationship between electron-transfer properties and the structure of molecular electronics is still not fully understood. Now, a rigid and flat molecular wire has been shown to significantly enhance the rate of electron transfer compared with conventional flexible molecular wires. This enhancement is attributable to both conjugation-induced electronic coupling and inelastic electron tunnelling-enabled electron–vibration coupling.
  • Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells

    Sung-Kyun Ko
    10 Aug 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2021 Authors: Sung-Kyun Ko, Sung Kuk Kim, Andrew Share, Vincent M. Lynch, Jinhong Park, Wan Namkung, Wim Van Rossom, Nathalie Busschaert, Philip A. Gale, Jonathan L. Sessler & Injae Shin Anion transporters that disrupt cellular ion homeostasis could represent a new approach for generating therapeutic lead compounds. Now, two pyridine diamide-strapped calix[4]pyrroles have been shown to induce coupled chloride anion and sodium cation transport in liposomal models and cells. These compounds promote cell death by increasing intracellular chloride and…
  • Harnessing redox activity for the formation of uranium tris(imido) compounds

    Nickolas H. Anderson
    26 Jul 2014 | 5:00 pm
    Nature Chemistry. doi:10.1038/nchem.2009 Authors: Nickolas H. Anderson, Samuel O. Odoh, Yiyi Yao, Ursula J. Williams, Brian A. Schaefer, John J. Kiernicki, Andrew J. Lewis, Mitchell D. Goshert, Phillip E. Fanwick, Eric J. Schelter, Justin R. Walensky, Laura Gagliardi & Suzanne C. Bart Multi-electron redox chemistry is important in transition-metal-mediated processes, but is rarely observed with uranium due to its propensity to undergo single-electron reactions. Now, uranium can use its electrons, coupled with those stored in redox-active ligands, to perform multi electron reduction of…
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    Nature Genetics - Issue - nature.com science feeds

  • Corrigendum: Genome-wide genetic changes during modern breeding of maize

    Yinping Jiao
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 1039 (2014). doi:10.1038/ng0914-1039 Author: Yinping Jiao, Hainan Zhao, Longhui Ren, Weibin Song, Biao Zeng, Jinjie Guo, Baobao Wang, Zhipeng Liu, Jing Chen, Wei Li, Mei Zhang, Shaojun Xie & Jingsheng Lai
  • Cancer gene discovery goes mobile

    Louise van der Weyden
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 928 (2014). doi:10.1038/ng.3072 Authors: Louise van der Weyden, Marco Ranzani & David J Adams A new study describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this system in combination with cancer genome data to define new genes and pathways involved in sarcoma development. Gene discovery in this way suggests that we are far from a complete catalog of cancer drivers.
  • Corrigendum: Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions

    Chen Wu
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 1040 (2014). doi:10.1038/ng0914-1040b Author: Chen Wu, Peter Kraft, Kan Zhai, Jiang Chang, Zhaoming Wang, Yun Li, Zhibin Hu, Zhonghu He, Weihua Jia, Christian C Abnet, Liming Liang, Nan Hu, Xiaoping Miao, Yifeng Zhou, Zhihua Liu, Qimin Zhan, Yu Liu, Yan Qiao, Yuling Zhou, Guangfu Jin, Chuanhai Guo, Changdong Lu, Haijun Yang, Jianhua Fu, Dianke Yu, Neal D Freedman, Ti Ding, Wen Tan, Alisa M Goldstein, Tangchun Wu, Hongbing Shen, Yang Ke, Yixin Zeng, Stephen J Chanock, Philip R Taylor & Dongxin Lin
  • RNA switch at enhancers

    Jeffrey J Quinn
    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 929 (2014). doi:10.1038/ng.3074 Authors: Jeffrey J Quinn & Howard Y Chang Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.
  • Data use under the NIH GWAS Data Sharing Policy and future directions

    26 Aug 2014 | 5:00 pm
    Nature Genetics 46, 934 (2014). doi:10.1038/ng.3062 Authors:
 
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    Nature Geoscience - Issue - nature.com science feeds

  • Journal-to-journal shortcuts

    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 613 (2014). doi:10.1038/ngeo2246 At Nature Publishing Group we offer a transfer system that allows authors to move papers between our journals at the click of a button if their first-choice journal declined. We encourage authors to use that service.
  • Wedge approach to water stress

    Yoshihide Wada
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 615 (2014). doi:10.1038/ngeo2241 Authors: Yoshihide Wada, Tom Gleeson & Laurent Esnault Water availability and use are inherently regional concerns. However, a global-scale approach to evaluating strategies to reduce water stress can help maximize mitigation.
  • Carbon sequestration: Tiny potential

    Amy Whitchurch
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 623 (2014). doi:10.1038/ngeo2242 Author: Amy Whitchurch
  • Corrigendum: Lusi mud eruption triggered by geometric focusing of seismic waves

    M. Lupi
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 687 (2014). doi:10.1038/ngeo2239 Authors: M. Lupi, E. H. Saenger, F. Fuchs & S. A. Miller
  • Deep earth: Post-perovskite at ten

    Sang-Heon Shim
    27 Aug 2014 | 5:00 pm
    Nature Geoscience 7, 621 (2014). doi:10.1038/ngeo2237 Authors: Sang-Heon Shim & Thorne Lay In 2004, a phase transition was discovered in the most abundant lower-mantle mineral. A decade of focused experiments, computations and seismic imaging stimulated by this discovery has revealed previously unknown complexities in Earth's deep mantle.
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  • Resilience of Pacific pelagic fish across the Cretaceous/Palaeogene mass extinction

    Elizabeth C. Sibert
    23 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2227 Authors: Elizabeth C. Sibert, Pincelli M. Hull & Richard D. Norris Open-ocean ecosystems experienced profound disruptions to biodiversity and ecological structure during the Cretaceous/Palaeogene mass extinction about 66 million years ago. It has been suggested that during this mass extinction, a collapse of phytoplankton production rippled up the food chain, causing the wholesale loss of consumers and top predators. Pelagic fish represent a key trophic link between primary producers and top predators, and changes in their abundance provide a means…
  • Widespread methane leakage from the sea floor on the northern US Atlantic margin

    A. Skarke
    23 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2232 Authors: A. Skarke, C. Ruppel, M. Kodis, D. Brothers & E. Lobecker Methane emissions from the sea floor affect methane inputs into the atmosphere, ocean acidification and de-oxygenation, the distribution of chemosynthetic communities and energy resources. Global methane flux from seabed cold seeps has only been estimated for continental shelves, at 8 to 65 Tg CH4 yr−1, yet other parts of marine continental margins are also emitting methane. The US Atlantic margin has not been considered an area of widespread seepage, with only three methane…
  • Record of the ancient martian hydrosphere and atmosphere preserved in zircon from a martian meteorite

    A. A. Nemchin
    23 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2231 Authors: A. A. Nemchin, M. Humayun, M. J. Whitehouse, R. H. Hewins, J-P. Lorand, A. Kennedy, M. Grange, B. Zanda, C. Fieni & D. Deldicque Mars exhibits ample evidence for an ancient surface hydrosphere. The oxygen isotope compositions of carbonate minerals and alteration products in martian meteorites suggest that this ancient hydrosphere was not in isotopic equilibrium with the martian lithosphere. Martian meteorite NWA 7533 is composed of regolith breccia from the heavily cratered terrains of ancient Mars and contains zircon grains for which…
  • Seafloor methane: Atlantic bubble bath

    John Kessler
    23 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2238 Author: John Kessler The release of large quantities of methane from ocean sediments might affect global climate change. The discovery of expansive methane seeps along the US Atlantic margin provides an ideal test bed for such a marine methane–climate connection.
  • Optimum vegetation height and density for inorganic sedimentation in deltaic marshes

    William Nardin
    23 Aug 2014 | 5:00 pm
    Nature Geoscience. doi:10.1038/ngeo2233 Authors: William Nardin & Douglas A. Edmonds River deltas support a disproportionate percentage of the world’s population and some are drowning as sea level rises. Resilient deltas theoretically balance relative sea-level rise with vertical growth from surface sedimentation. Vegetation generally enhances inorganic sedimentation and resiliency in some settings, such as tidal saltwater marshes, but the effect of vegetation on freshwater marshes in river deltas is less clear. Here we use a hydrodynamic numerical model to simulate deposition in a…
 
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    Nature Materials - Issue - nature.com science feeds

  • Mapping in-cell topology

    Pep Pàmies
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 843 (2014). doi:10.1038/nmat4078 Author: Pep Pàmies
  • Acoustic metamaterials: Nearly perfect sound absorbers

    Mathias Fink
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 848 (2014). doi:10.1038/nmat4067 Author: Mathias Fink Membrane-based acoustic resonators of subwavelength dimensions achieve nearly perfect acoustic absorption.
  • The light and shade of perovskite solar cells

    Michael Grätzel
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 838 (2014). doi:10.1038/nmat4065 Author: Michael Grätzel The rise of metal halide perovskites as light harvesters has stunned the photovoltaic community. As the efficiency race continues, questions on the control of the performance of perovskite solar cells and on its characterization are being addressed.
  • Perovskite solar cells: Continuing to soar

    Michael D. McGehee
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 845 (2014). doi:10.1038/nmat4050 Author: Michael D. McGehee The dream of printing highly efficient solar cells is closer than ever to being realized. Solvent engineering has enabled the deposition of uniform perovskite semiconductor films that yield greater than 15% power-conversion efficiency.
  • Boron clusters

    Alison Stoddart
    20 Aug 2014 | 5:00 pm
    Nature Materials 13, 843 (2014). doi:10.1038/nmat4074 Author: Alison Stoddart
 
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    Nature Medicine - AOP - nature.com science feeds

  • The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

    Xuelian He
    23 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3666 Authors: Xuelian He, Liguo Zhang, Ying Chen, Marc Remke, David Shih, Fanghui Lu, Haibo Wang, Yaqi Deng, Yang Yu, Yong Xia, Xiaochong Wu, Vijay Ramaswamy, Tom Hu, Fan Wang, Wenhao Zhou, Dennis K Burns, Se Hoon Kim, Marcel Kool, Stefan M Pfister, Lee S Weinstein, Scott L Pomeroy, Richard J Gilbertson, Joshua B Rubin, Yiping Hou, Robert Wechsler-Reya, Michael D Taylor & Q Richard Lu
  • Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

    Robert Fledrich
    23 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3664 Authors: Robert Fledrich, Ruth M Stassart, Axel Klink, Lennart M Rasch, Thomas Prukop, Lauren Haag, Dirk Czesnik, Theresa Kungl, Tamer A M Abdelaal, Naureen Keric, Christine Stadelmann, Wolfgang Brück, Klaus-Armin Nave & Michael W Sereda Duplication of the gene encoding the peripheral myelin protein of 22 kDa (PMP22) underlies the most common inherited neuropathy, Charcot-Marie-Tooth 1A (CMT1A), a disease without a known cure. Although demyelination represents a characteristic feature, the clinical phenotype of CMT1A is determined by the degree of…
  • An implantable microfluidic device for self-monitoring of intraocular pressure

    Ismail E Araci
    23 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3621 Authors: Ismail E Araci, Baolong Su, Stephen R Quake & Yossi Mandel
  • In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors

    Phil Oh
    16 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3623 Authors: Phil Oh, Jacqueline E Testa, Per Borgstrom, Halina Witkiewicz, Yan Li & Jan E Schnitzer
  • Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

    Luzhou Xing
    16 Aug 2014 | 5:00 pm
    Nature Medicine. doi:10.1038/nm.3645 Authors: Luzhou Xing, Zhenpeng Dai, Ali Jabbari, Jane E Cerise, Claire A Higgins, Weijuan Gong, Annemieke de Jong, Sivan Harel, Gina M DeStefano, Lisa Rothman, Pallavi Singh, Lynn Petukhova, Julian Mackay-Wiggan, Angela M Christiano & Raphael Clynes Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated…
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    Nature Methods - Issue - nature.com science feeds

  • Points of Significance: Replication

    Paul Blainey
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 879 (2014). doi:10.1038/nmeth.3091 Authors: Paul Blainey, Martin Krzywinski & Naomi Altman Quality is often more important than quantity.
  • Change at Nature Methods

    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 875 (2014). doi:10.1038/nmeth.3097 We announce a change in leadership at Nature Methods and wish Daniel Evanko, our departing chief editor and the new head of editorial services at Nature Publishing Group, every success.
  • The Author File: Richard Neutze

    Vivien Marx
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 877 (2014). doi:10.1038/nmeth.3074 Author: Vivien Marx Proteins 'breathe' in an ultrafast way that can be captured with XFELs.
  • A critique of methods for temperature imaging in single cells

    Guillaume Baffou
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 899 (2014). doi:10.1038/nmeth.3073 Authors: Guillaume Baffou, Hervé Rigneault, Didier Marguet & Ludovic Jullien We argue that standard thermodynamic considerations and scaling laws show that a single cell cannot substantially raise its temperature by endogenous thermogenesis. This statement seriously questions the interpretations of recent work reporting temperature heterogeneities measured in single living cells.
  • Improved reproducibility by assuring confidence in measurements in biomedical research

    Anne L Plant
    27 Aug 2014 | 5:00 pm
    Nature Methods 11, 895 (2014). doi:10.1038/nmeth.3076 Authors: Anne L Plant, Laurie E Locascio, Willie E May & Patrick D Gallagher 'Irreproducibility' is symptomatic of a broader challenge in measurement in biomedical research. From the US National Institute of Standards and Technology (NIST) perspective of rigorous metrology, reproducibility is only one aspect of establishing confidence in measurements. Appropriate controls, reference materials, statistics and informatics are required for a robust measurement process. Research is required to establish these tools for biological…
 
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  • Multiplexed aberration measurement for deep tissue imaging in vivo

    Chen Wang
    16 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3068 Authors: Chen Wang, Rui Liu, Daniel E Milkie, Wenzhi Sun, Zhongchao Tan, Aaron Kerlin, Tsai-Wen Chen, Douglas S Kim & Na Ji We describe an adaptive optics method that modulates the intensity or phase of light rays at multiple pupil segments in parallel to determine the sample-induced aberration. Applicable to fluorescent protein–labeled structures of arbitrary complexity, it allowed us to obtain diffraction-limited resolution in various samples in vivo. For the strongly scattering mouse brain, a single aberration correction improved structural…
  • Accurate de novo and transmitted indel detection in exome-capture data using microassembly

    Giuseppe Narzisi
    16 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3069 Authors: Giuseppe Narzisi, Jason A O'Rawe, Ivan Iossifov, Han Fang, Yoon-ha Lee, Zihua Wang, Yiyang Wu, Gholson J Lyon, Michael Wigler & Michael C Schatz We present an open-source algorithm, Scalpel (http://scalpel.sourceforge.net/), which combines mapping and assembly for sensitive and specific discovery of insertions and deletions (indels) in exome-capture data. A detailed repeat analysis coupled with a self-tuning k-mer strategy allows Scalpel to outperform other state-of-the-art approaches for indel discovery, particularly in regions containing…
  • Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

    David Arnlund
    9 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3067 Authors: David Arnlund, Linda C Johansson, Cecilia Wickstrand, Anton Barty, Garth J Williams, Erik Malmerberg, Jan Davidsson, Despina Milathianaki, Daniel P DePonte, Robert L Shoeman, Dingjie Wang, Daniel James, Gergely Katona, Sebastian Westenhoff, Thomas A White, Andrew Aquila, Sadia Bari, Peter Berntsen, Mike Bogan, Tim Brandt van Driel, R Bruce Doak, Kasper Skov Kjær, Matthias Frank, Raimund Fromme, Ingo Grotjohann, Robert Henning, Mark S Hunter, Richard A Kirian, Irina Kosheleva, Christopher Kupitz, Mengning Liang, Andrew V Martin, Martin…
  • Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum

    Jeffrey C Wagner
    9 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3063 Authors: Jeffrey C Wagner, Randall J Platt, Stephen J Goldfless, Feng Zhang & Jacquin C Niles Malaria is a major cause of global morbidity and mortality, and new strategies for treating and preventing this disease are needed. Here we show that the Streptococcus pyogenes Cas9 DNA endonuclease and single guide RNAs (sgRNAs) produced using T7 RNA polymerase (T7 RNAP) efficiently edit the Plasmodium falciparum genome. Targeting the genes encoding native knob-associated histidine-rich protein (kahrp) and erythrocyte binding antigen 175 (eba-175), we…
  • Epiviz: interactive visual analytics for functional genomics data

    Florin Chelaru
    2 Aug 2014 | 5:00 pm
    Nature Methods. doi:10.1038/nmeth.3038 Authors: Florin Chelaru, Llewellyn Smith, Naomi Goldstein & Héctor Corrada Bravo Visualization is an integral aspect of genomics data analysis. Algorithmic-statistical analysis and interactive visualization are most effective when used iteratively. Epiviz (http://epiviz.cbcb.umd.edu/), a web-based genome browser, and the Epivizr Bioconductor package allow interactive, extensible and reproducible visualization within a state-of-the-art data-analysis platform.
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    Nature Nanotechnology - Issue - nature.com science feeds

  • Our choice from the recent literature

    4 Aug 2014 | 5:00 pm
    Nature Nanotechnology 9, 567 (2014). doi:10.1038/nnano.2014.170
  • Bioimaging: Sensed at the gut level

    Jesse V. Jokerst
    4 Aug 2014 | 5:00 pm
    Nature Nanotechnology 9, 569 (2014). doi:10.1038/nnano.2014.159 Author: Jesse V. Jokerst Naphthalocyanine nanoparticles offer intense photoacoustic signals for mapping the gastrointestinal tract.
  • Put more 'nano' in robotics

    Christian Martin
    4 Aug 2014 | 5:00 pm
    Nature Nanotechnology 9, 566 (2014). doi:10.1038/nnano.2014.163 Author: Christian Martin DNA nanotechnology has proven to be a powerful approach for fabricating active nanostructures with biological functionality. Now, it is time to investigate more solutions from biology to downscale robotics, says Christian Martin.
  • Gene delivery: Cell-specific therapy on target

    Daniel T. W. Clarke
    4 Aug 2014 | 5:00 pm
    Nature Nanotechnology 9, 568 (2014). doi:10.1038/nnano.2014.155 Authors: Daniel T. W. Clarke & Nigel A. J. McMillan A polymer–lipid nanoparticle with a low molecular weight can preferentially deliver small interfering RNA to endothelial cells, offering an opportunity to treat many diseases.
  • Graphene: Electrons en masse

    Fengnian Xia
    4 Aug 2014 | 5:00 pm
    Nature Nanotechnology 9, 575 (2014). doi:10.1038/nnano.2014.161 Author: Fengnian Xia Massless electrons in graphene exhibit a mass when considered as collective excitations known as plasmons.
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    Nature Neuroscience - Issue - nature.com science feeds

  • All that glitters is not reward signal

    Benjamin Y Hayden
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1142 (2014). doi:10.1038/nn.3795 Authors: Benjamin Y Hayden & Sarah R Heilbronner In this issue, Shenhav et al. critically evaluate the idea that neural correlates of value actually represent value. They describe how, in many situations, value correlates can reflect other cognitive factors, such as decisional difficulty.
  • The epigenetic landscape of Alzheimer's disease

    Jenny Lord
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1138 (2014). doi:10.1038/nn.3792 Authors: Jenny Lord & Carlos Cruchaga Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.
  • Reward processing by the lateral habenula in normal and depressive behaviors

    Christophe D Proulx
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1146 (2014). doi:10.1038/nn.3779 Authors: Christophe D Proulx, Okihide Hikosaka & Roberto Malinow
  • CLEARance wars: PolyQ strikes back

    X William Yang
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1140 (2014). doi:10.1038/nn.3793 Authors: X William Yang & Ai Yamamoto Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.
  • Scenting Waldo: analyzing olfactory scenes

    Timothy E Holy
    25 Aug 2014 | 5:00 pm
    Nature Neuroscience 17, 1144 (2014). doi:10.1038/nn.3796 Author: Timothy E Holy Olfaction has often been described as a 'synthetic' sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects.
 
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    Nature Photonics - AOP - nature.com science feeds

  • Quantum nonlinear optics — photon by photon

    Darrick E. Chang
    23 Aug 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.192 Authors: Darrick E. Chang, Vladan Vuletić & Mikhail D. Lukin
  • Ternary blend polymer solar cells with enhanced power conversion efficiency

    Luyao Lu
    16 Aug 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.172 Authors: Luyao Lu, Tao Xu, Wei Chen, Erik S. Landry & Luping Yu
  • Band filling with free charge carriers in organometal halide perovskites

    Joseph S. Manser
    9 Aug 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.171 Authors: Joseph S. Manser & Prashant V. Kamat
  • Sequentially timed all-optical mapping photography (STAMP)

    K. Nakagawa
    9 Aug 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.163 Authors: K. Nakagawa, A. Iwasaki, Y. Oishi, R. Horisaki, A. Tsukamoto, A. Nakamura, K. Hirosawa, H. Liao, T. Ushida, K. Goda, F. Kannari & I. Sakuma High-speed photography is a powerful tool for studying fast dynamics in photochemistry, spintronics, phononics, fluidics and plasma physics. Currently, the pump–probe method is the gold standard for time-resolved imaging, but it requires repetitive measurements for image construction and therefore falls short in probing non-repetitive or difficult-to-reproduce events. Here, we present a…
  • Non-reciprocal phase shift induced by an effective magnetic flux for light

    Lawrence D. Tzuang
    2 Aug 2014 | 5:00 pm
    Nature Photonics. doi:10.1038/nphoton.2014.177 Authors: Lawrence D. Tzuang, Kejie Fang, Paulo Nussenzveig, Shanhui Fan & Michal Lipson Photons are neutral particles that do not interact directly with a magnetic field. However, recent theoretical work has shown that an effective magnetic field for photons can exist if the phase of light changes with its direction of propagation. This direction-dependent phase indicates the presence of an effective magnetic field, as shown experimentally for electrons in the Aharonov–Bohm experiment. Here, we replicate this experiment using photons. To…
 
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    Nature Reviews Cancer - Issue - nature.com science feeds

  • Tumorigenesis: FBP1 is suppressed in kidney tumours

    Gemma K. Alderton
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 575 (2014). doi:10.1038/nrc3810 Author: Gemma K. Alderton Li et al. find that fructose-1,6-bisphosphatase 1 (FBP1) levels are uniformly reduced in clear cell renal cell carcinoma (ccRCC), identifying a new mechanism of metabolic reprogramming in this cancer type.
  • The impact of the endoplasmic reticulum protein-folding environment on cancer development

    Miao Wang
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 581 (2014). doi:10.1038/nrc3800 Authors: Miao Wang & Randal J. Kaufman The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage and regulated release of calcium and as the entrance to the secretory pathway. Protein misfolding in the ER causes accumulation of misfolded proteins (ER stress) and activation of the unfolded protein
  • Tumour suppressors: p53 and cellular plasticity

    Sarah Seton-Rogers
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 577 (2014). doi:10.1038/nrc3814 Author: Sarah Seton-Rogers Suppression of the liver cancers hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) by p53 was investigated by Tschaharganeh et al. p53 loss promoted dedifferentiation of mature hepatocytes by indirectly promoting the expression of nestin, a protein associated with stem and progenitor cells. The resulting progenitor-like
  • RNA dynamics: Destabilizing mRNAs promotes metastasis

    Isabel Lokody
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 578 (2014). doi:10.1038/nrc3809 Author: Isabel Lokody Goodarzi et al. highlight the regulation of RNA stability as a crucial mechanism in breast cancer metastasis.
  • Metastasis: Regulating brain metastasis

    Isabel Lokody
    21 Aug 2014 | 5:00 pm
    Nature Reviews Cancer 14, 577 (2014). doi:10.1038/nrc3813 Author: Isabel Lokody Sevenich et al. have shown that the protease cathepsin S regulates breast cancer metastasis to the brain in mice by cleaving junctional adhesion protein B (JAM-B) in cells that form the blood–brain barrier (BBB) to facilitate extravasation of breast cancer cells across the BBB.
 
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    Nature Reviews Genetics - Issue - nature.com science feeds

  • Evolutionary genetics: Homing in on anthropoid evolution

    Bryony Jones
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 575 (2014). doi:10.1038/nrg3812 Author: Bryony Jones To investigate the genetic factors that drove anthropoid primate evolution, researchers have identified 23,949 anthropoid-specific constrained (ASC) regions in the genome. ASC regions are enriched in loci previously associated with brain development, vision and neurotransmission; notably, almost all of these regions are non-coding. In addition,
  • Non-coding RNA: MicroRNA stimulates mitochondrial translation

    Linda Koch
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 572 (2014). doi:10.1038/nrg3806 Author: Linda Koch The muscle-specific microRNA miR-1 stimulates translation of various transcripts encoded by mitochondrial DNA, while repressing its nuclear DNA-encoded targets in the cytoplasm, report Zhang and colleagues. The observed effect is dependent on specific base-pairing between miR-1 and its target transcripts, as well as on the
  • Model organisms: Sexual conflict in nematodes

    Isabel Lokody
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 575 (2014). doi:10.1038/nrg3811 Author: Isabel Lokody A new study in Caenorhabditis nematodes has shown that the species barrier is maintained by highly aggressive sperm. Rather than producing infertile offspring as a result of interspecific mating, as observed in other species, interspecific mating in Caenorhabditis spp. results in maternal infertility
  • Technology: Using DNA repair to detect modified bases

    Darren J. Burgess
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 572 (2014). doi:10.1038/nrg3805 Author: Darren J. Burgess There is great interest in characterizing the locations and functions of chemically modified bases in genomes. Bryan et al. report their Excision-seq method, in which DNA repair enzymes are used to cut genomic DNA at sites of the particular damaged bases they recognize, followed
  • Therapeutics: Targeting huntingtin through morpholino oligomers

    Darren J. Burgess
    11 Aug 2014 | 5:00 pm
    Nature Reviews Genetics 15, 572 (2014). doi:10.1038/nrg3804 Author: Darren J. Burgess Huntington's disease is caused by a mutant huntingtin (HTT) gene that contains an expanded tract of poly(CAG) repeats. Sun et al. designed phosphorodiamidate morpholino oligomers (PMOs, which are stable nucleic acid mimics) as antisense reagents to target the CAG tract in HTT
 
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    Nature Reviews Immunology - Issue - nature.com science feeds

  • Inflammasomes: New LPS receptors discovered

    Cláudio Nunes-Alves
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 582 (2014). doi:10.1038/nri3736 Author: Cláudio Nunes-Alves A new study identifies inflammatory caspases as the cytoplasmic LPS receptors that trigger non-canonical inflammasome activation.
  • The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

    Sarah L. Gaffen
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 585 (2014). doi:10.1038/nri3707 Authors: Sarah L. Gaffen, Renu Jain, Abhishek V. Garg & Daniel J. Cua Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In
  • Phenotypic models of T cell activation

    Melissa Lever
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 619 (2014). doi:10.1038/nri3728 Authors: Melissa Lever, Philip K. Maini, P. Anton van der Merwe & Omer Dushek T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors (TCRs) and peptide–MHC complexes (pMHC complexes). Despite extensive experimental studies, the relationship between the TCR–pMHC binding parameters and T
  • A long-awaited merger of the pathways mediating host defence and programmed cell death

    J. Magarian Blander
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 601 (2014). doi:10.1038/nri3720 Author: J. Magarian Blander Historically, cell death and inflammation have been closely linked, but the necessary divergence of the fields in the past few decades has enriched our molecular understanding of the signalling pathways that mediate various programmes of cell death and multiple types of inflammatory responses. The fields
  • Regulatory T cells: Alarmin(g) control

    Elisabeth Kugelberg
    21 Aug 2014 | 5:00 pm
    Nature Reviews Immunology 14, 579 (2014). doi:10.1038/nri3733 Author: Elisabeth Kugelberg In response to intestinal tissue damage, the alarmin interleukin-33 enhances local regulatory T cell responses.
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    Nature Reviews Microbiology - Issue - nature.com science feeds

  • Bacterial pathogenesis: More to CRISPR than adaptive immunity

    Christina Tobin Kåhrström
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 596 (2014). doi:10.1038/nrmicro3338 Author: Christina Tobin Kåhrström A new study shows that the type II CRISPR–Cas (clustered, regularly interspaced short palindromic repeats–CRISPR-associated proteins) system of the intracellular pathogen Francisella novicida downregulates the expression of an immunostimulatory bacterial lipoprotein (BLP), which increases the integrity of the cell envelope, resulting in antibiotic resistance
  • Uniting the classification of cultured and uncultured bacteria and archaea using 16S rRNA gene sequences

    Pablo Yarza
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 635 (2014). doi:10.1038/nrmicro3330 Authors: Pablo Yarza, Pelin Yilmaz, Elmar Pruesse, Frank Oliver Glöckner, Wolfgang Ludwig, Karl-Heinz Schleifer, William B. Whitman, Jean Euzéby, Rudolf Amann & Ramon Rosselló-Móra Publicly available sequence databases of the small subunit ribosomal RNA gene, also known as 16S rRNA in bacteria and archaea, are growing rapidly, and the number of entries currently exceeds 4 million. However, a unified classification and nomenclature framework for all bacteria and archaea does
  • RAB11-mediated trafficking in host–pathogen interactions

    Annabel Guichard
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 624 (2014). doi:10.1038/nrmicro3325 Authors: Annabel Guichard, Victor Nizet & Ethan Bier Many bacterial and viral pathogens block or subvert host cellular processes to promote successful infection. One host protein that is targeted by invading pathogens is the small GTPase RAB11, which functions in vesicular trafficking. RAB11 functions in conjunction with a protein complex known as the
  • Voyage to the bottom of the 'seaquence'

    Rachael Wash
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 597 (2014). doi:10.1038/nrmicro3341 Authors: Rachael Wash & Carmen Diaz Soria This month's Genome Watch highlights the use of deep sequencing metagenomics to identify bacteriophages that carry sulphur-oxidizing genes in deep-sea hydrothermal vent plumes.
  • Viral infection: Seeding the HIV-1 reservoir

    Cláudio Nunes-Alves
    13 Aug 2014 | 5:00 pm
    Nature Reviews Microbiology 12, 594 (2014). doi:10.1038/nrmicro3342 Author: Cláudio Nunes-Alves A new study shows that the HIV viral reservoir is seeded rapidly, even before the establishment of viraemia.
 
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    Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

  • RNA localization: Promoters of mRNA fate

    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 563 (2014). doi:10.1038/nrm3865 Cells respond to stress by transcribing survival genes. Zid and O'shea found that, in response to glucose starvation in budding yeast, the translation of a subset of transcriptionally activated mRNAs was increased, and that of another subset was decreased. Transcripts of the first subset were
  • Endocytosis: Unlocking AP2 activity

    Katharine H. Wrighton
    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 560 (2014). doi:10.1038/nrm3863 Author: Katharine H. Wrighton The clathrin adaptor assembly polypeptide 2 (AP2) cannot bind to clathrin in the cytoplasm owing to an autoinhibitory mechanism.
  • Nuclear envelope: ATR senses mechanical stress

    Kim Baumann
    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 559 (2014). doi:10.1038/nrm3864 Author: Kim Baumann Mechanical stress activates an ATR pathway at the nuclear envelope that is important for chromatin condensation and nuclear envelope breakdown.
  • Cell migration: The forces that close wounds

    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 563 (2014). doi:10.1038/nrm3866 Epithelial tissues repair wounds through the collective movement of epithelial cells into the damaged area. This involves extension of the leading edge of cells, which exerts traction on the substrate to propel the cells forward, and the contraction of a supracellular actomyosin ring around the
  • Stem cells: A role for nuclear p120 catenin in differentiation

    21 Aug 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 563 (2014). doi:10.1038/nrm3867 p120 catenin interacts with E-cadherin and functions at adherens junctions; it can also modulate gene expression in the nucleus. Lee et al. reveal that nuclear p120 catenin binds to REST and Co-REST, components of a transcriptional repressor complex. Depleting mouse embryonic stem (ES) cells
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    Nature Reviews Neuroscience - Issue - nature.com science feeds

  • Oscillations: A dynamic role for astrocytes

    Katherine Whalley
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3810 Author: Katherine Whalley Astrocytes contribute to the maintenance of fast synchronous activity in the hippocampus and have a role in recognition memory.
  • Sensory processing: Mixed-up mitral cells

    Sian Lewis
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3813 Author: Sian Lewis In this study, whole-cell recordings of mitral/tufted cells (M/TCs) in the olfactory bulb of awake mice revealed greater hetereogeneity of activity compared with that in mice in an anaesthetized state, including in a subpopulation of cells with high spontaneous baseline activity and a subpopulation with
  • Pain: Finding motivation in pain

    Sian Lewis
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3814 Author: Sian Lewis People with chronic pain can experience reduced motivation to complete goal-directed tasks, but the mechanism is poorly understood. In this study, the decreased motivation that occurred in two mouse models of chronic pain was associated with reduced activity in medium spiny neurons of the nucleus
  • Decision making: Off the hook

    Sian Lewis
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 566 (2014). doi:10.1038/nrn3816 Author: Sian Lewis It has been suggested that the state of mind of the perpetrator of a crime plays a strong part in people's judgement of what constitutes an appropriate punishment. This functional MRI study showed that when people are shown an intentionally harmful act, activity in their
  • Metabolism: Sugar on the brain

    Leonie Welberg
    19 Aug 2014 | 5:00 pm
    Nature Reviews Neuroscience 15, 563 (2014). doi:10.1038/nrn3812 Author: Leonie Welberg High levels of central transforming growth factor-β1 induce hypothalamic inflammation and lead to hyperglycaemia and glucose intolerance.
 
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    Nature Reviews Cardiology - Issue - nature.com science feeds

  • Emerging innovation towards safety in the clinical application of ESCs and iPSCs

    Shigeo Masuda
    4 Aug 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 553 (2014). doi:10.1038/nrcardio.2014.9-c1 Authors: Shigeo Masuda, Shigeru Miyagawa, Satsuki Fukushima, Nagako Sougawa, Emiko Ito, Maki Takeda, Atsuhiro Saito & Yoshiki Sawa The Review by Behfar and colleagues (Cell therapy for cardiac repair—lessons from clinical trials. Nat. Rev. Cardiol.11, 232–246; 2014) summarized that 'first-generation' cell therapies for heart failure using autologous cells are safe for use in humans. Conversely, 'next-generation' cell therapies,
  • Reply: Translation of regenerative technologies into clinical paradigms

    Atta Behfar
    4 Aug 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 553 (2014). doi:10.1038/nrcardio.2014.9-c2 Authors: Atta Behfar, Ruben Crespo-Diaz, Andre Terzic & Bernard J. Gersh We thank Shigeo Masuda et al. for their Correspondence (Emerging innovation towards safety in the clinical application of ESCs and iPCs.
  • Surgery: β-Blockers—still a trusted ally or time for retirement?

    Prashant Vaishnava
    28 Jul 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 502 (2014). doi:10.1038/nrcardio.2014.112 Authors: Prashant Vaishnava & Kim A. Eagle Uncertainty surrounds the benefit of β-blocker treatment in various clinical settings. The researchers in a new retrospective analysis of preoperative β-blocker use in CABG surgery now add to the debate, and suggest that these drugs might not improve perioperative outcomes.
  • Heart failure: BMD a predictor of incident heart failure

    Tim Geach
    28 Jul 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 497 (2014). doi:10.1038/nrcardio.2014.108 Author: Tim Geach Heart failure is a known risk factor for osteoporosis. In a new paper, investigators now identify an independent association between bone mineral density (BMD) and incident heart failure in a large population-based cohort. The results might suggest a common pathophysiology between the two diseases.The
  • Dyslipidaemia: Fasting before blood lipid testing might be unnecessary

    Gregory B. Lim
    28 Jul 2014 | 5:00 pm
    Nature Reviews Cardiology 11, 497 (2014). doi:10.1038/nrcardio.2014.107 Author: Gregory B. Lim A new study indicates that measuring the level of LDL cholesterol in the blood of a patient who has not previously fasted has the same prognostic value as measuring it after fasting, as currently recommended in clinical guidelines. Fasting for 8–12 h before phlebotomy can
 
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    Nature Reviews Clinical Oncology - Issue - nature.com science feeds

  • Drug therapy: Keeping rats in the dark sheds light on tamoxifen resistance

    David Killock
    11 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 500 (2014). doi:10.1038/nrclinonc.2014.139 Author: David Killock New data from a rat model of oestrogen receptor (ER)-positive human breast cancer indicate that exposure to light at night might underlie intrinsic resistance to tamoxifen, which is a common cause of treatment failure in patients with this disease.Circadian melatonin has been implicated as
  • Genetics: New molecular classification of gastric adenocarcinoma proposed by The Cancer Genome Atlas

    Mina Razzak
    11 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 499 (2014). doi:10.1038/nrclinonc.2014.138 Author: Mina Razzak Currently, two histological classification systems are available to characterize gastric adenocarcinomas, which represents the majority of gastric tumours. The Lauren classification system comprises two subtypes (intestinal and diffuse) and the WHO classification has four subtypes (papillary, tubular, mucinous and poorly cohesive). Neither system is particularly
  • Skin cancer: Less is as good as more in refractory melanoma

    Lisa Hutchinson
    4 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 502 (2014). doi:10.1038/nrclinonc.2014.132 Author: Lisa Hutchinson Although great strides have been made in the treatment of advanced-stage melanoma, resistance to new protein kinase pathway inhibitors—such as vemurafenib, dabrafenib and trametinib—ultimately results in patient relapse or disease progression. Even patients who initially respond to the use of combination therapies with BRAF and
  • CNS cancer: It takes two to tango

    M. Teresa Villanueva
    4 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 502 (2014). doi:10.1038/nrclinonc.2014.133 Author: M. Teresa Villanueva One of the main characteristics of malignant glioblastoma is the rapid formation of new, leaky blood vessels, which are responsible for the oedema that contributes to the numerous neurological symptoms associated with this disease. Hence, multiple studies have assessed targeting the VEGF pathway in patients
  • Targeted therapies: Redefining the primary objective of phase I oncology trials

    Mark J. Ratain
    4 Aug 2014 | 5:00 pm
    Nature Reviews Clinical Oncology 11, 503 (2014). doi:10.1038/nrclinonc.2014.135 Author: Mark J. Ratain Cytotoxic agents are conventionally dosed on the basis of the maximum tolerated dose defined in phase I trials. A study assessing adverse events in over 2,000 patients treated with molecularly targeted agents suggests a need to redefine criteria for dosing of molecularly targeted agents, which should be based on randomized, dose-ranging phase II trials.
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    Nature Reviews Endocrinology - Issue - nature.com science feeds

  • Obesity: CPAP effects in sleep apnoea—what should be expected?

    Patrick Lévy
    4 Aug 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 517 (2014). doi:10.1038/nrendo.2014.131 Authors: Patrick Lévy & Jean-Louis Pépin Patients with obesity and obstructive sleep apnoea have increased morbidity. Now, one study has reported limited beneficial effects of continuous positive airway pressure (CPAP) in patients with both these conditions. However, in another study, the reduction in blood pressure obtained with CPAP was not observed when nocturnal hypoxia was suppressed with supplemental oxygen.
  • Diabetes: Safety and efficacy of albiglutide—results from two trials

    Giuseppe Derosa
    28 Jul 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 514 (2014). doi:10.1038/nrendo.2014.126 Authors: Giuseppe Derosa & Pamela Maffioli Type 2 diabetes mellitus is associated with a poor quality of life and considerable health-care costs and can be difficult to control. The recent results from the HARMONY 3 and HARMONY 6 trials suggest that albiglutide is a safe and effective treatment option for patients with type 2 diabetes mellitus.
  • Reproductive endocrinology: You are what your grandmother ate—inherited effects of in utero undernourishment

    Jennifer Sargent
    28 Jul 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 509 (2014). doi:10.1038/nrendo.2014.127 Author: Jennifer Sargent Nutritional perturbations during in utero development have long-lasting effects that are passed through multiple generations. Alterations of methylation patterns in male germline DNA are markers of compromised sperm in this process, reveals new research.The nutritional status of a pregnant mother influences in utero
  • VEGF-targeted cancer therapeutics—paradoxical effects in endocrine organs

    Yihai Cao
    21 Jul 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 530 (2014). doi:10.1038/nrendo.2014.114 Author: Yihai Cao Systemic administration of antiangiogenic drugs that target components of the vascular endothelial growth factor A (VEGF-A; VEGF) signal transduction pathway has become a viable therapeutic option for patients with various types of cancer. Nevertheless, these drugs can drive alterations in healthy vasculatures, which in turn
  • Diabetes: Gpr120 agonist has anti-inflammatory and insulin-sensitizing effects

    Claire Greenhill
    21 Jul 2014 | 5:00 pm
    Nature Reviews Endocrinology 10, 510 (2014). doi:10.1038/nrendo.2014.118 Author: Claire Greenhill A team of researchers from the USA has developed a novel small-molecule Gpr120 agonist, cpdA, that has anti-inflammatory and insulin-sensitizing effects similar to ω-3 fatty acids in obese mice.ω-3 fatty acids are known to have anti-inflammatory effects and to be able to increase insulin
 
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    Nature Reviews Gastroenterology and Hepatology - AOP

  • Imaging: Dynamic imaging of gut function—allowing the blind to see

    Bishnu P. Joshi
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.149 Authors: Bishnu P. Joshi & Thomas D. Wang Improved methods are needed to dynamically image gut behaviour to assess whether neuromuscular degenerative disease is present. So-called nanonaps (soluble nanoformulated naphthalocyanines) have been developed for oral administration to pass through the intestines and provide high contrast for visualizing bowel motion on photoacoustic imaging. Moreover, radiotracer labelling of these nanoparticles facilitates multimodal detection using PET.
  • Screening: Colorectal cancer screening—insights and challenges

    Stephen P. Halloran
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.150 Author: Stephen P. Halloran Colorectal cancer (CRC) screening, the decade's most promising cancer-related public health development, is evolving. Faecal immunochemical tests (FIT) will be the primary population-based CRC screening biomarker for the next 10–15 years. Will the international community exploit the full potential of FIT and other CRC risk indicators to enable a revolution in the effectiveness of screening?
  • Imaging techniques in IBD and their role in follow-up and surveillance

    Rami Eliakim
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.144 Authors: Rami Eliakim & Fernando Magro
  • Gut microbiota: Ordered development of gut microbiota observed in premature infants

    Isobel Leake
    25 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.152 Author: Isobel Leake
  • Genetics of gastric cancer

    Mairi H. McLean
    18 Aug 2014 | 5:00 pm
    Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.143 Authors: Mairi H. McLean & Emad M. El-Omar
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    Nature Reviews Nephrology - Issue - nature.com science feeds

  • Reply: Nephrons are generated via a series of committed progenitors

    Paola Romagnani
    11 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 491 (2014). doi:10.1038/nrneph.2012.290-c2 Authors: Paola Romagnani, Laura Lasagni & Giuseppe Remuzzi We thank Fujian Zhang and colleagues for their interesting comment (The Drosophila nephrocyte has a glomerular filtration system. Nat. Rev. Nephrol., 12 August 2014; doi:10.1038/nrneph.2012.290-c1) on our Review (Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat. Rev. Nephrol
  • The Drosophila nephrocyte has a glomerular filtration system

    Fujian Zhang
    11 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 491 (2014). doi:10.1038/nrneph.2012.290-c1 Authors: Fujian Zhang & Xiangmei Chen We read with interest the Review by Paola Romagnani and colleagues (Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat Rev Nephrol.9, 137–146; 2013), which discusses the importance of the evolutionarily conserved nephron structure in kidney regeneration. Nephrology students
  • Anaemia: FIND-CKD: intravenous iron in predialysis CKD

    Steven Fishbane
    4 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 488 (2014). doi:10.1038/nrneph.2014.139 Authors: Steven Fishbane & Azzour D. Hazzan A new study has advanced our understanding of iron management in chronic kidney disease (CKD) by comparing oral iron to high-dose and low-dose intravenous ferric carboxymaltose (FCM) in patients with predialysis CKD. Intravenous FCM treatment to achieve a higher serum ferritin target improved patient haemoglobin levels and reduced initiation of other anaemia treatments.
  • Polycystic kidney disease: Kidney volume—a crystal ball for ADPKD prognosis?

    Emilie Cornec-Le Gall
    4 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 485 (2014). doi:10.1038/nrneph.2014.132 Authors: Emilie Cornec-Le Gall & Yannick Le Meur A new study has addressed a key question in autosomal dominant polycystic kidney disease (ADPKD): can we predict renal outcome at an early disease stage? Indeed, this information is useful for any patient with ADPKD. Moreover, while targeted therapies continue to emerge, optimal selection of patients for clinical trials remains a challenge.
  • Diabetes: Intensive glucose-lowering: long-lasting benefits on albuminuria in patients with type 1 diabetes

    Susan J. Allison
    4 Aug 2014 | 5:00 pm
    Nature Reviews Nephrology 10, 481 (2014). doi:10.1038/nrneph.2014.140 Author: Susan J. Allison Studies have shown that intensive regimens to lower blood glucose levels in patients with diabetes mellitus provide microvascular protection that lasts beyond the duration of treatment; however, the extent to which these effects persist is unknown. A new report published in The Lancet Diabetes &
 
 
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    Naturejobs - Search results

  • Research scientist - Chemistry

    29 Aug 2014 | 1:36 am
    In order to strengthen its research in the field of chemistry, the Nordic Institute of Dental Materials (NIOM) has created a new, permanent position as research scientist. NIOM has research staff in a wide range of sciences, and the research scientist will be part of this group. The applicant must at least have a master’s degree, and preferably a PhD. We seek an active researcher with authorship of relevant publications. The position requires collaboration with other research organizations i…
  • Post-doctoral position in Cognitive Neuroscience

    29 Aug 2014 | 1:34 am
    Applications are invited for a full-time post-doctoral research position in the Speech Acquisition and Perception Group (SAP), led by Núria Sebastián Gallés, at the Pompeu Fabra University (Barcelona). The position is covered by a European Research Council Advanced grant on Mechanisms of cognitive control and language learning (project number 323961) We seek candidates working in Cognitive Neuroscience, preferably Developmental Cognitive Neuroscience, with strong programming skills (advance…
  • Electronics Engineer

    29 Aug 2014 | 1:10 am
    Electronics Engineer Rutherford Appleton Laboratory, Didcot £28,384 – £29,566 plus up to £5000 Retention Allowance About Us The Science and Technology Facilities Council is a world-leading multi-disciplinary science organisation, and our goal is to deliver economic, societal, scientific and international benefits to the UK and its people – and more broadly to the world. Due to an increase in the number of Big Science Projects being undertaken, the Technology Department at the Rutherfor…
  • Post-Doctoral Research Fellowship in molecular biology/medical sciences, 2 positions

    29 Aug 2014 | 1:01 am
    Institute of Clinical Medicine Post-Doctoral Research Fellowship in molecular biology/medical sciences Two 3-year postdoctoral research fellowship positions (SKO1352) are available in the research group of Professor Bjarne Bogen. The two postdoctoral researchers will work on the project “Novel Malaria Vaccines”, funded by GLOBVAC and The Research Council of Norway. The project will start October 1st of 2014. The two postdoc positions will be associated with the K.G. Jebsen Centre for Influen…
  • FY14 Market Development Manager Biopharma SH 13051

    29 Aug 2014 | 12:17 am
    Job Code : 15725 Location : Shanghai SH CN Category : Marketing Career Level : Manager (Manager/Supervisor of Staff) Job Type : Full Time Job Description : Job Title: Market Development Manager --Biopharma Business Unit: Marketing (China) Location: Shanghai, China Reports To: Strategic Market Development Director, China Job Functions: a) Lead Biopharma Market Development: Build up market insight to fully capture Biopharma busine...
 
 
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    British Journal of Pharmacology

  • UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations

    I Hassan-Mohamed, C Giorgio, M Incerti, S Russo, D Pala, E B Pasquale, I Zanotti, P Vicini, E Barocelli, S Rivara, M Mor, A Lodola, M Tognolini
    28 Aug 2014 | 4:26 am
    Background and PurposeThe Eph receptor tyrosine kinases and their ephrin ligands are key players in tumorigenesis and many reports have correlated changes in their expression with a poor clinical prognosis in many solid tumours. Agents targeting the Eph-ephrin system might emerge as new tools useful for the inhibition of different components of cancer progression. Even if different classes of small molecules targeting Eph-ephrin interactions have been reported, their use is hampered by poor chemical stability and low potency. Stable and potent ligands are crucial to achieve robust…
  • Modulation of K2P2.1 and K2P10.1 K+ channel sensitivity to carvedilol by alternative mRNA translation initiation

    J Kisselbach, C Seyler, P A Schweizer, R Gerstberger, R Becker, H A Katus, D Thomas
    28 Aug 2014 | 4:24 am
    Background and PurposeThe β-receptor antagonist carvedilol blocks a range of ion channels. K2P2.1 (TREK1) and K2P10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first objective was to investigate acute effects of carvedilol on human K2P2.1 and K2P10.1 channels. Second, we sought to study ATI-dependent modulation of K2P K current sensitivity to carvedilol. Experimental ApproachUsing standard electrophysiological techniques, we recorded currents from wild-type and…
  • Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats

    G H Zhang, Z L Liu, B J Zhang, W Y Geng, N N Song, W Zhou, Y X Cao, S Q Li, Z L Huang, L L Shen
    28 Aug 2014 | 4:14 am
    Background and PurposeOrexins have been demonstrated to play important roles in many physiological processes. However, it is not known how orexin A affects the activity of the hypoglossal motoneuron (HMN) and genioglossus (GG) muscle. Experimental ApproachGG muscle electromyograms (GG-EMG) were recorded in anaesthetized adult rats after orexin A or orexin receptor antagonists were applied to the hypoglossal nucleus, and in adult rats in which orexin neurons were lesioned with the neurotoxin orexin-saporin (orexin-SAP). HMN membrane potential and firing were recorded from neonatal rat brain…
  • Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine – a quantitative EEG study in rats

    S C Leiser, A L Pehrson, P J Robichaud, C Sanchez
    28 Aug 2014 | 4:14 am
    Background and PurposeEEG studies show that 5-HT is involved in regulation of sleep–wake state and modulates cortical oscillations. Vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist, 5-HT1B partial agonist, 5-HT1A agonist, and 5-HT transporter inhibitor. Preclinical (animal) and clinical studies with vortioxetine show positive impact on cognitive metrics involving cortical function. Here we assess vortioxetine's effect on cortical neuronal oscillations in actively awake rats. Experimental ApproachTelemetric EEG recordings were obtained with the following treatments (mg·kg−1,…
  • Therapeutic use of botulinum toxin in migraine: mechanisms of action

    Roshni Ramachandran, Tony L Yaksh
    28 Aug 2014 | 4:14 am
    Migraine pain represents sensations arising from the activation of trigeminal afferents, which innervate the meningeal vasculature and project to the trigeminal nucleus caudalis (TNC). Pain secondary to meningeal input is referred to extracranial regions innervated by somatic afferents that project to homologous regions in the TNC. Such viscerosomatic convergence accounts for referral of migraine pain arising from meningeal afferents to particular extracranial dermatomes. Botulinum toxins (BoNTs) delivered into extracranial dermatomes are effective in and approved for treating chronic…
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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    PSI-Nature Structural Biology Knowledgebase

  • Drug Targets: Bile Acids in Motion

    Claudia Lupp
    20 Aug 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.218 Author: Claudia Lupp Crystal structures of sodium-dependent bile acid transporters provide insight into transport mechanism.
  • Drug Targets: S1R's Ligands and Partners

    Anita M. Engh
    20 Aug 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.219 Author: Anita M. Engh Stabilization of oligomers by small-molecule ligands suggests a mechanism for regulating a membrane protein chaperone.
  • Structural insight into autophagy initiation

    Katharine H. Wrighton
    22 May 2014 | 5:00 pm
    Nature Reviews Molecular Cell Biology 15, 367 (2014). doi:10.1038/nrm3815 Author: Katharine H. Wrighton Structural work offers insight into starvation-induced assembly of the autophagy initiation complex.
  • Displaying membrane proteins for cryo-EM

    26 Jun 2014 | 5:00 pm
    Nature Methods 11, 714 (2014). doi:10.1038/nmeth.3012
  • Complex Search

    Irene Kaganman
    20 Aug 2014 | 5:00 pm
    PSI-Nature Structural Biology Knowledgebase (2014). doi:10.1038/sbkb.2014.220 Author: Irene Kaganman A search engine identifies assemblies with structural similarities, providing biologically relevant insights not accessible by comparison of individual proteins.
 
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